KEGG ORTHOLOGY: K04520

ORTHOLOGY: K04520

Entry

K04520                      KO

Symbol

APP

Name

amyloid beta A4 protein

Pathway

map04726

Serotonergic synapse

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00056

Alzheimer disease

H01185

Cerebral amyloid angiopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K04520  APP; amyloid beta A4 protein
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04520  APP; amyloid beta A4 protein
   05022 Pathways of neurodegeneration - multiple diseases
    K04520  APP; amyloid beta A4 protein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04520  APP; amyloid beta A4 protein
  09183 Protein families: signaling and cellular processes
   00535 Proteoglycans
    K04520  APP; amyloid beta A4 protein
   00536 Glycosaminoglycan binding proteins
    K04520  APP; amyloid beta A4 protein
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   K04520  APP; amyloid beta A4 protein
Proteoglycans [BR:ko00535]
Cell surface proteoglycans
  Others
   K04520  APP; amyloid beta (A4) protein
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Others
   K04520  APP; amyloid beta A4 protein

Other DBs

GO:

0004867

Genes

HSA:

351(APP)

PTR:	473931(APP)

PPS:	100971121(APP)

GGO:	101132687(APP)

PON:	100174038(APP)

NLE:	100587944(APP)

HMH:	116481858(APP)

MCC:	100427716(APP)

MCF:

101926433

MTHB:

126950748

MNI:	105472804(APP)

CSAB:

103217727(APP)

CATY:

105571836(APP)

PANU:

101003817(APP)

TGE:	112620386(APP)

MLEU:

105552598(APP)

RRO:	104678203(APP)

RBB:	108518214(APP)

TFN:	117095628(APP)

PTEH:

111524713(APP)

CANG:

105500815(APP)

CJC:	100407052(APP)

SBQ:	101032971(APP)

CIMI:

108313502

CSYR:

103251367(APP)

MMUR:

105871215(APP)

LCAT:

123630660

PCOQ:

105806913(APP)

OGA:	100948156(APP)

MMU:	11820(App)

MCAL:

110311452(App)

MPAH:

110329604(App)

RNO:	54226(App)

MCOC:

116086086(App)

ANU:	117717816(App)

MUN:	110561809(App)

CGE:	100689222(App)

MAUA:

101836288

PROB:

127227455(App)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103745264(App)

HGL:	101724743(App)

CPOC:

100715302(App)

CCAN:

109700792(App)

DORD:

105996812(App)

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100009546(APP)

OPI:

101518476

TUP:	102489280(APP)

GVR:	103604174(APP)

CFA:	403407(APP)

CLUD:

112661802

VVP:	112917675(APP)

VLG:

121479288

NPO:	129502077(APP)

AML:	100466827(APP)

UMR:

103673071

UAH:	113269215(APP)

UAR:

123784172

ELK:

111152475

LLV:

125095266

MPUF:

101686001(APP)

MNP:	132012327(APP)

MLK:	131825283(APP)

NVS:

122908359

ORO:	101376189(APP)

EJU:	114218412(APP)

ZCA:

113916785

MLX:	118018789(APP)

NSU:

110570121

LWW:	102748193(APP)

FCA:	101085564(APP)

PYU:

121036049

PCOO:

112849787(APP)

PBG:

122491270

PVIV:

125175654(APP)

LRUF:

124526224

PTG:	102960478(APP)

PPAD:

109277861(APP)

PUC:

125921721

AJU:

106974329

HHV:

120235132

BTA:	280722(APP)

BOM:	102267321(APP)

BIU:	109558723(APP)

BBUB:

102416140

BBIS:

104987491(APP)

CHX:	102186997(APP)

OAS:	101111593(APP)

BTAX:

128055528(APP)

ODA:

120853653

CCAD:

122428625

MBEZ:

129553058(APP)

SSC:	397663(APP)

CFR:	102507265(APP)

CBAI:

105070278(APP)

CDK:	105086807(APP)

VPC:	102533052(APP)

BACU:

103006217(APP)

BMUS:

118894510

LVE:	103090092(APP)

OOR:	101270984(APP)

DLE:	111174611(APP)

PCAD:

102995649(APP)

PSIU:

116752813(APP)

NASI:

112390938(APP)

ECB:	100066294(APP)

EPZ:	103547122(APP)

EAI:

106842471

MYB:	102238735(APP)

MYD:	102751589(APP)

MMYO:

118677629

MLF:	102432337(APP)

PKL:

118724175

EFUS:

103289750(APP)

MNA:	107525473(APP)

DRO:	112306663(APP)

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

129075422(APP)

HAI:	109393097(APP)

RFQ:	117034292(APP)

PALE:

102878629(APP)

PGIG:

120598931

PVP:	105290808(APP)

RAY:	107498323(APP)

MJV:

108391271

TOD:	119257256(APP)

SARA:

101542803(APP)

SETR:

126026048(APP)

LAV:	100677270(APP)

TMU:

101347228

ETF:	101649379 101656411

DNM:	101413574(APP)

MDO:	100021944(APP)

GAS:

123242484

SHR:	100932185(APP)

AFZ:

127553819

PCW:	110214782(APP)

OAA:

100090292

GGA:	374198(APP)

PCOC:

116241955(APP)

MGP:	100547713(APP)

CJO:	107322621(APP)

TPAI:

128072792(APP)

LMUT:

125703482

NMEL:

110402060(APP)

APLA:

101804251

ACYG:

106037003

CATA:

118247539(APP)

AFUL:

116486762(APP)

TGU:	100220100(APP)

LSR:	110471638(APP)

SCAN:

103823757(APP)

PMOA:

120500562

OTC:

121341331

PRUF:

121353422

GFR:	102035016(APP)

FAB:	101811303(APP)

OMA:	130255061(APP)

PHI:	102108517(APP)

PMAJ:

107201974(APP)

CCAE:

111940966(APP)

CCW:

104686955

CBRC:

103613824(APP)

ETL:	114066989(APP)

ZAB:	102068511(APP)

ACHL:

103799985(APP)

SVG:	106859393(APP)

MMEA:

130576878(APP)

HRT:	120748762(APP)

FPG:	101924306(APP)

FCH:	102057007(APP)

CLV:	102084867(APP)

EGZ:	104128210(APP)

NNI:	104020104(APP)

PCRI:

104032085(APP)

PLET:

104628477(APP)

EHS:	104506933(APP)

PCAO:

104046151(APP)

ACUN:

113491090(APP)

TALA:

104363994

PADL:

103920137(APP)

AFOR:

103901950(APP)

ACHC:

115343587

HLE:	104842753(APP)

AGEN:

126053237

GCL:

127029741

CSTI:

104557779(APP)

BREG:

104634445

MNB:	103780315(APP)

OHA:	104328329(APP)

NNT:	104405435(APP)

SHAB:

115604313(APP)

DPUB:

104304892(APP)

PGUU:

104463620

CPEA:

104386772(APP)

AVIT:

104271822(APP)

CVF:	104295191(APP)

RTD:	128901242(APP)

CUCA:

104064778(APP)

BRHI:

104494665(APP)

AAM:	106494942(APP)

NPD:	112942677(APP)

TGT:	104570890(APP)

DNE:	112980968(APP)

SCAM:

104141609(APP)

ASN:	102385872(APP)

AMJ:	102571861(APP)

CPOO:

109305731(APP)

GGN:	109302499(APP)

PSS:	102444626(APP)

CMY:

CCAY:

DCC:

CPIC:

TST:	117889196(APP)

CABI:

116825711(APP)

MRV:

120399100

ACS:	100553307(app)

ASAO:

132771916(APP)

PVT:	110076980(APP)

SUND:

121925384

PBI:	103052290(APP)

PMUR:

107292284(APP)

CTIG:

120314547

TSR:	106541697(APP)

PGUT:

117671384(APP)

APRI:

131200217(APP)

PTEX:

113436300(APP)

NSS:	113409852(APP)

VKO:

123029243

PMUA:

114596012(APP)

PRAF:

128412942(APP)

ZVI:	118084828(APP)

HCG:	128350010(APP)

GJA:	107121303(APP)

STOW:

125430957

EMC:	129325476(APP)

XLA:	379251(app.S) 398223(app.L)

XTR:	448208(app)

NPR:	108792096(APP)

RTEM:

120927870

BBUF:

120994554

BGAR:

122930768

MUO:	115470762(APP)

GSH:	117358999(APP)

DRE:	170846(appb) 58083(appa)

SRX:	107728004(app) 107748127 107751095 107756757

SANH:

107665808(app) 107695460 107698920

SGH:	107557257(app) 107582259 107593741 107595805 107597486

CCAR:

109056376 109056413 109065275 109090599

CAUA:

113044670 113053080 113081566(app) 113108133 113108470

CGIB:

127948783 127965506 127992895 128019985

PTET:

122345903(appa) 122351451(appb)

LROH:

127162956(appa) 127171159(appb)

OMC:	131537786(appa) 131546627(appb)

PPRM:

120489048(appa) 120490018(appb)

RKG:	130069176(appb)

MAMB:

125270172(appb) 125272980(appa)

CIDE:

127518630 127521108 127521122

MASI:

127443768 127445341 127447500 127448493

TROS:

130552689(appa) 130556206(appb)

TDW:	130428033(appb) 130435370(appa)

MANU:

129445134(appa) 129451406(appb)

IPU:	108258852(appa) 108266463(appb)

IFU:	128601802(appa) 128608749(appb)

PHYP:

113537234(app) 113546423

SMEO:

124378638(appa) 124382449(appb)

TFD:	113648738(appa) 113654473(appb)

TVC:	132839759(appa) 132850130(appb)

AMEX:

103044691(app) 103046668

CMAO:

118798224(appa) 118821037(appb)

EEE:	113567924 113574579(app)

CHAR:

105889592(appa) 105907928(appb)

TRU:	101066792 101078447

TFS:	130522427(appa) 130522667

TNG:	GSTEN00025991G001 GSTEN00027170G001

LCO:	104932346 104937711

NCC:	104945593 104954656

TBEN:

117481442 117499117(appa)

CGOB:

115019800(app) 115026240

PGEO:

117459626(appa) 117466687(appb)

GACU:

117546677(appa) 117556872

EMAC:

134860651(appa) 134867488(appb)

ELY:	117249893(appa) 117251207(appb)

EFO:	125884907(appa) 125899208

PLEP:

121949599 121963038(appa)

SLUC:

116044635(appa) 116046636(appb)

ECRA:

117939197(appa) 117953348(appb)

ESP:	116673939(app) 116697735

PFLV:

114550761(app) 114564701

GAT:	120824652(appa) 120834357

PPUG:

119219323(appa) 119229137(appb)

AFB:	129105056(appb) 129111914(appa)

CLUM:

117741067(appa) 117750089(appb)

PSWI:

130201021 130204360(appa)

MSAM:

119902450(appa) 119904244

SCHU:

122871848(appa) 122885470

CUD:	121506050(appa) 121522826(appb)

ALAT:

119015581(appa) 119026189

MZE:	101473127(app) 101478308

ONL:	100694218 100709268

OAU:	116316063 116319222(appa)

OLA:	101162104 101172288

OML:	112154862 112159995(appa)

CSAI:

133424880(appa) 133445846

XMA:	102232739 102232862

XCO:	114137601(app) 114147977

XHE:	116715798 116722913

PRET:

103459816 103475742(app)

PFOR:

103140299 103147106

PLAI:

106940919 106958320

PMEI:

106927431 106930156

GAF:	122827195(appa) 122839399

PPRL:

129360937(appb) 129379018(appa)

CVG:	107094739(app) 107104503

CTUL:

119781804(appa) 119786351

GMU:	124861541(appa) 124871500

NFU:	107381083(app) 107389838

KMR:	108232458 108248770(appa)

ALIM:

106523944 106524657 106533086

NWH:	119419670 119428958(appa)

AOCE:

111568091 111575428

MCEP:

125001131(appA) 125018012

CSEM:

103389699(app) 103391597

POV:	109631268(app) 109640224 109642832

SSEN:

122761289 122765448

HHIP:

117755417(appb) 117776814(appa)

HSP:	118103347(appa) 118119675

SMAU:

118283162(appb) 118300896(appa)

LCF:	108872952(appa) 108880432 108880489

SDU:	111218784 111222650(app)

SLAL:

111646183(app) 111662051

XGL:	120798014(appa) 120801306

HCQ:	109520870(app) 109524673

SSCV:

125973761 125988539

SBIA:

133491751(appa) 133512476(appb)

PEE:	133410412 133410492(appa)

PTAO:

133487108(appb) 133489466(appa)

BPEC:

110166290(app) 110173110

MALB:

109965420 109973228(app)

BSPL:

114846772(appb) 114870397(appa)

SJO:	128354404(appa) 128368417

SASA:

106574335 106575113(app) 106582144 106586687

STRU:

115156313 115161211 115179148(app) 115195916

OTW:	112225405 112241784 112253908 112254014(appa)

OMY:	110495970 110502007(appb) 110520491 110527583(appa)

OGO:	124007658(appa) 124010529 124044150

ONE:	115112824 115125132 115129609 115134468

OKI:	109869985 109871012 109890713(app) 109906642

OKE:	118363662 118366612 118370123(appa) 118386185

SALP:

111953228 111959686 111971030(app) 111979392

SNH:	120033751(appa) 120051216 120058466 120064178

CCLU:

121536506 121553666(appa) 121571616

ELS:	105009137(app) 105027332

SFM:	108931713 108938103(app)

PKI:	111855882(app)

AANG:

118213932

LOC:	102689007(app)

PSPA:

121320521(appa) 121327542

ARUT:

117405677 117407049

PSEX:

120522557

LCM:	102350152(APP)

CMK:	103185176(appa)

RTP:	109935395(appa)

CPLA:

122555414(appa)

HOC:	132821198(appa)

LERI:

129703041

PMRN:

116957700

LRJ:	133340128 133340130

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG7727(Appl)

DER:

6555540

DSE:

6615873

DSI:	Dsimw501_GD16511(Dsim_GD16511)

DYA:	Dyak_GE16620

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14839

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ014395

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM287170

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_313180

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111702878 111714978

LSM:

TCF:

PPOI:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_C42D8.8(apl-1)

CBR:	CBG_14611(Cbr-apl-1)

NAI:	NECAME_00101

BMY:	BM_BM2713(Bma-apl-1)

LOA:	LOAG_05890

TSP:	Tsp_02062 Tsp_02070

HRO:	HELRODRAFT_192286

LGI:	LOTGIDRAFT_204381

PCAN:

BGT:

GAE:

HRJ:

CRG:	105344242 117686223

CVN:	111124717 111127229

CANU:

OED:

MYI:

OBI:

LAK:

SMM:	Smp_149740

OVI:	T265_04117

NVE:

EPA:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_55959

» show all

Reference

PMID:12859342

Authors

Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N

Title

Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.

Journal

Eur J Neurosci 18:102-8 (2003)
DOI:10.1046/j.1460-9568.2003.02731.x

Sequence

[hsa:351]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (3340)   
   KEGG GENES (762)   
   KEGG MGENES (305)   
   RefGene (2269)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (3354)   

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