KEGG   ORTHOLOGY: K04522Help
Entry
K04522                      KO                                     

Name
PSEN2, PS2
Definition
presenilin 2 [EC:3.4.23.-]
Pathway
Notch signaling pathway
Neurotrophin signaling pathway
Alzheimer's disease
Disease
H00056  
Alzheimer's disease (AD)
H00294  
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K04522  PSEN2, PS2; presenilin 2
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K04522  PSEN2, PS2; presenilin 2
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04522  PSEN2, PS2; presenilin 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.-  
     K04522  PSEN2, PS2; presenilin 2
Peptidases [BR:ko01002]
 Aspartic Peptidases
  Family A22: presenilin family
   K04522  PSEN2, PS2; presenilin 2
BRITE hierarchy
Genes
HSA: 
5664(PSEN2)
PTR: 
457790(PSEN2)
PPS: 
100975191(PSEN2)
GGO: 
101137786(PSEN2)
PON: 
100172138(PSEN2)
MCC: 
698770(PSEN2)
MCF: 
102117766(PSEN2)
MMU: 
19165(Psen2)
RNO: 
81751(Psen2)
CGE: 
100752237(Psen2)
HGL: 
TUP: 
102490523(PSEN2)
CFA: 
490382(PSEN2)
AML: 
FCA: 
101081693(PSEN2)
PTG: 
102972248(PSEN2)
BTA: 
282010(PSEN2)
BOM: 
102284134(PSEN2)
PHD: 
CHX: 
102190980(PSEN2)
SSC: 
780410(PSEN2)
CFR: 
102516800(PSEN2)
BACU: 
102998556(PSEN2)
LVE: 
ECB: 
100054506(PSEN2)
MYB: 
102242706(PSEN2)
MYD: 
102772354(PSEN2)
PALE: 
102888829(PSEN2)
MDO: 
100026453(PSEN2)
SHR: 
100928719(PSEN2)
OAA: 
100076299(PSEN2)
GGA: 
374188(PSEN2)
MGP: 
TGU: 
100232599(PSEN2)
FAB: 
101821118(PSEN2)
PHI: 
102107717(PSEN2)
APLA: 
101791857(PSEN2)
FPG: 
101914026(PSEN2)
FCH: 
102052189(PSEN2)
CLV: 
102086670(PSEN2)
ASN: 
102387066(PSEN2)
AMJ: 
102572042(PSEN2)
PSS: 
102444598(PSEN2)
CMY: 
102932404(PSEN2)
ACS: 
PBI: 
103051424(PSEN2)
XLA: 
397713(psen2)
XTR: 
549935(psen2)
DRE: 
58026(psen2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103178605(psen2)
ISC: 
DPP: 
ACAN: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C
  Title
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide  production and notch signaling.
  Journal
J Biol Chem 274:28669-73 (1999)

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