KEGG ORTHOLOGY: K04539

ORTHOLOGY: K04539

Entry

K04539                      KO

Symbol

GNB5

Name

guanine nucleotide-binding protein subunit beta-5

Pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04151

PI3K-Akt signaling pathway

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04926

Relaxin signaling pathway

map05032

Morphine addiction

map05034

Alcoholism

map05163

Human cytomegalovirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H02463

Syndromic intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04371 Apelin signaling pathway
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04151 PI3K-Akt signaling pathway
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
  09156 Nervous system
   04724 Glutamatergic synapse
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04727 GABAergic synapse
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04725 Cholinergic synapse
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04728 Dopaminergic synapse
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04726 Serotonergic synapse
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04723 Retrograde endocannabinoid signaling
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   05163 Human cytomegalovirus infection
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
  09165 Substance dependence
   05032 Morphine addiction
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   05034 Alcoholism
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
   04031 GTP-binding proteins
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    K04539  GNB5; guanine nucleotide-binding protein subunit beta-5

Genes

HSA:	10681(GNB5)

PTR:	745402(GNB5)

PPS:	100990010(GNB5)

GGO:	101145049(GNB5)

PON:	100171833(GNB5)

NLE:	100594371(GNB5)

HMH:	116481481(GNB5)

MCC:	695441(GNB5)

MCF:	101866657(GNB5)

MTHB:

126959042

MNI:	105490201(GNB5)

CSAB:

103245611(GNB5)

CATY:

105601141(GNB5)

PANU:

101004338(GNB5) 116275838

TGE:	112627568(GNB5)

MLEU:

105544043(GNB5)

RRO:	104660908(GNB5)

RBB:	108538179(GNB5)

TFN:	117070643(GNB5)

PTEH:

111552767(GNB5)

CANG:

105502226(GNB5)

CJC:	100415506(GNB5)

SBQ:	101038619(GNB5)

CIMI:

108286649(GNB5)

CSYR:

103275187(GNB5)

MMUR:

105870695(GNB5)

LCAT:

123622795(GNB5)

PCOQ:

105821386(GNB5)

OGA:	100954252(GNB5)

MMU:	14697(Gnb5)

MCAL:

110301552(Gnb5)

MPAH:

110327390(Gnb5)

RNO:	83579(Gnb5)

MCOC:

116073026(Gnb5)

ANU:	117712557(Gnb5)

MUN:	110545481(Gnb5)

CGE:	100764899(Gnb5)

MAUA:

101839471(Gnb5)

PROB:

127231981(Gnb5)

PLEU:

114690390(Gnb5)

MORG:

121466217(Gnb5)

MFOT:

126491703

AAMP:

119809908(Gnb5)

NGI:	103731407(Gnb5)

HGL:	101698655(Gnb5)

CPOC:

100719049(Gnb5)

CCAN:

109685278(Gnb5)

DORD:

105981056(Gnb5)

DSP:	122114508(Gnb5)

PLOP:

125340508(Gnb5)

NCAR:

124978030

MMMA:

107137620(Gnb5)

OCU:	100008941(GNB5)

OPI:	101532346(GNB5)

TUP:	102487568(GNB5)

GVR:	103601724(GNB5)

CFA:	608623(GNB5)

CLUD:

112675918(GNB5)

VVP:	112917058(GNB5)

VLG:	121485344(GNB5)

NPO:	129506463(GNB5)

AML:	100467255(GNB5)

UMR:	103676755(GNB5)

UAH:	113269635(GNB5)

UAR:	123801797(GNB5)

ELK:

111140421

LLV:

125104139

MPUF:

101680687(GNB5)

MNP:	131999766(GNB5)

MLK:	131836300(GNB5)

NVS:	122892946(GNB5)

ORO:	101362117(GNB5)

EJU:	114206513(GNB5)

ZCA:	113910139(GNB5)

MLX:	118003742(GNB5)

NSU:	110583964(GNB5)

LWW:	102725604(GNB5)

FCA:	101081809(GNB5)

PYU:	121041716(GNB5)

PCOO:

112854988(GNB5)

PBG:	122468635(GNB5)

PVIV:

125168849(GNB5)

LRUF:

124508581

PTG:	102954935(GNB5)

PPAD:

109262977(GNB5)

PUC:

125910003

AJU:

106967264

HHV:	120235024(GNB5)

BTA:	535365(GNB5)

BOM:	102273730(GNB5)

BIU:	109565125(GNB5)

BBUB:

102400794(GNB5)

BBIS:

104986263(GNB5)

CHX:	102174574(GNB5)

OAS:	101106267(GNB5)

BTAX:

128054091(GNB5)

ODA:	120853003(GNB5)

CCAD:

122443592(GNB5)

MBEZ:

129562435(GNB5)

SSC:	100157949(GNB5)

CFR:	102519051(GNB5)

CBAI:

105080494(GNB5)

CDK:	105086620(GNB5)

VPC:	102533271(GNB5)

BACU:

103000160(GNB5)

BMUS:

118890489(GNB5)

LVE:	103088923(GNB5)

OOR:	101270085(GNB5)

DLE:	111177624(GNB5)

PCAD:

102995518(GNB5)

PSIU:

116748817(GNB5)

NASI:

112405787(GNB5)

ECB:	100146498(GNB5)

EPZ:	103548465(GNB5)

EAI:	106837154(GNB5)

MYB:	102242731(GNB5)

MYD:	102765079(GNB5)

MMYO:

118651993(GNB5)

MLF:	102420203(GNB5)

PKL:	118721115(GNB5)

EFUS:

103287561(GNB5)

MNA:	107546541(GNB5)

DRO:	112311263(GNB5)

SHON:

118992638(GNB5)

AJM:	119047600(GNB5)

PDIC:

114492968(GNB5)

PHAS:

123808220(GNB5)

MMF:	118617165(GNB5)

PPAM:

129063670(GNB5)

HAI:	109394673(GNB5)

RFQ:	117023601(GNB5)

PALE:

102881664(GNB5)

PGIG:

120623087(GNB5)

PVP:	105288758(GNB5)

RAY:	107519728(GNB5)

MJV:	108395258(GNB5)

TOD:	119238634(GNB5)

SARA:

101542101(GNB5)

SETR:

126002081(GNB5)

LAV:	100674665(GNB5)

TMU:

101341327

ETF:	101663735(GNB5)

DNM:

101413194

MDO:	100031383(GNB5)

GAS:	123237937(GNB5)

SHR:	100931703(GNB5)

AFZ:

127551163

PCW:	110204813(GNB5)

OAA:	100081114(GNB5)

GGA:	415417(GNB5)

PCOC:

116244684(GNB5)

MGP:	100539413(GNB5)

CJO:	107318696(GNB5)

TPAI:

128075525(GNB5)

LMUT:

125698488(GNB5)

NMEL:

110403596(GNB5)

APLA:

101797269(GNB5)

ACYG:

106033663(GNB5)

CATA:

118251720(GNB5)

AFUL:

116493289(GNB5)

TGU:	100222562(GNB5)

LSR:	110474222(GNB5)

SCAN:

103816188(GNB5)

PMOA:

120509066(GNB5)

OTC:	121343393(GNB5)

PRUF:

121354510(GNB5)

GFR:	102041555(GNB5)

FAB:	101807033(GNB5)

OMA:	130257453(GNB5)

PHI:	102114475(GNB5)

PMAJ:

107209411(GNB5)

CCAE:

111933885(GNB5)

CCW:	104684108(GNB5)

CBRC:

103621240(GNB5)

ETL:	114057156(GNB5)

ZAB:	102063118(GNB5)

ACHL:

103808007(GNB5)

SVG:	106851853(GNB5)

MMEA:

130575744(GNB5)

HRT:	120758557(GNB5)

FPG:	101919047(GNB5)

FCH:	102057221(GNB5)

CLV:	102088084(GNB5)

EGZ:	104130900(GNB5)

NNI:	104017269(GNB5)

PCRI:

104036250(GNB5)

PLET:

104616103(GNB5)

EHS:	104504435(GNB5)

PCAO:

104050243(GNB5)

ACUN:

113484224(GNB5)

TALA:

104363485(GNB5)

PADL:

103922797(GNB5)

AFOR:

103896696(GNB5)

ACHC:

115341204(GNB5)

HLE:	104834479(GNB5)

AGEN:

126043792

GCL:

127020446

CCRI:

104155744(GNB5)

CSTI:

104550809(GNB5)

CMAC:

104474589(GNB5)

MUI:	104534361(GNB5)

BREG:

104637974(GNB5)

FGA:	104075224(GNB5)

GSTE:

104254324(GNB5)

LDI:	104340909(GNB5)

MNB:	103768820(GNB5)

OHA:	104334578(GNB5)

NNT:	104399558(GNB5)

SHAB:

115613361(GNB5)

DPUB:

104305589(GNB5)

PGUU:

104459032(GNB5)

ACAR:

104522708(GNB5)

CPEA:

104386013(GNB5)

AVIT:

104268408(GNB5)

CVF:	104287100(GNB5)

RTD:	128915205(GNB5)

CUCA:

104055250(GNB5)

TEO:	104372802(GNB5)

BRHI:

104490157(GNB5)

AAM:	106496570(GNB5)

AROW:

112963533(GNB5)

NPD:	112952799(GNB5)

TGT:	104571113(GNB5)

DNE:	112981428(GNB5)

SCAM:

104148284(GNB5)

ASN:	102381699(GNB5)

AMJ:	106737105(GNB5)

CPOO:

109309013(GNB5)

GGN:	109288614(GNB5)

PSS:	102445959(GNB5)

CMY:	102939844(GNB5)

CCAY:

125643955(GNB5)

DCC:	119862880(GNB5)

CPIC:

101948608(GNB5)

TST:	117883539(GNB5)

CABI:

116823781(GNB5)

MRV:	120373844(GNB5)

ACS:	100564875(gnb5)

ASAO:

132762505(GNB5)

PVT:	110077262(GNB5)

SUND:

121935181(GNB5)

PBI:	103056125(GNB5)

PMUR:

107294473(GNB5)

CTIG:

120306399(GNB5)

TSR:	106556121(GNB5)

PGUT:

117674585(GNB5)

APRI:

131184613(GNB5)

PTEX:

113442176(GNB5)

NSS:	113422933(GNB5)

VKO:	123027726(GNB5)

PMUA:

114584401(GNB5)

PRAF:

128402146(GNB5)

ZVI:	118093142(GNB5)

HCG:	128334844(GNB5)

GJA:	107116688(GNB5)

STOW:

125446187(GNB5)

EMC:	129345717(GNB5)

XLA:	108711385 108712921(gnb5.S)

XTR:	733883(gnb5)

NPR:	108804345(GNB5)

RTEM:

120931352(GNB5)

BBUF:

120985801(GNB5)

BGAR:

122923097(GNB5)

MUO:	115459503(GNB5)

GSH:	117348388(GNB5)

DRE:	393719(gnb5b) 562813(gnb5a)

SRX:	107746953 107747620 107748320 107754347(gnb5)

SANH:

107655147(gnb5) 107674814 107700591 107704270

SGH:	107550626 107561150 107571342 107588534

CCAR:

109068444 109068451 109106329

CAUA:

113042871 113061822 113066535 113066641 113082822 113118566

CGIB:

127933978 127944366 127947071 127977628 128013914

PTET:

122330674(gnb5a) 122362881(gnb5b)

LROH:

127156360(gnb5a) 127180662(gnb5b)

OMC:	131523886(gnb5b) 131534956(gnb5a)

PPRM:

120477772(gnb5a) 120486039(gnb5b)

RKG:	130089407(gnb5b) 130106481(gnb5a)

MAMB:

125247705(gnb5a) 125253977(gnb5b)

CIDE:

127499875 127507122

MASI:

127417035 127436257 127437272 127456334

TROS:

130551800(gnb5a) 130562397(gnb5b)

TDW:	130413980(gnb5a) 130436011(gnb5b)

MANU:

129419156(gnb5b) 129433101(gnb5a)

IPU:	108274523(gnb5a) 124627794

IFU:	128607119(gnb5b) 128618684(gnb5a)

PHYP:

113529490 113534765(gnb5)

SMEO:

124392935(gnb5a) 124395416(gnb5b)

TFD:	113653964(gnb5a) 113658644(gnb5b)

TVC:	132851739(gnb5b) 132856854(gnb5a)

AMEX:

103032917 103042250

CMAO:

118804012(gnb5b) 118811903(gnb5a)

EEE:	113568349 113584500(gnb5)

CHAR:

105888989(gnb5b) 105892356(gnb5a)

TRU:	101074575 101077498

TFS:	130520163(gnb5b) 130535904(gnb5a)

TNG:	GSTEN00019372G001 GSTEN00025593G001

LCO:	104927313 104932824(gnb5)

NCC:	104946313 104960109(gnb5)

TBEN:

117471234 117491921(gnb5a)

CGOB:

115009669(gnb5) 115028338

PGEO:

117447767(gnb5a) 117461090

GACU:

117538807 117558964(gnb5b)

EMAC:

134862538(gnb5b) 134877262(gnb5a)

ELY:	117261801(gnb5a) 117267053(gnb5b)

EFO:	125886867(gnb5a) 125902882(gnb5b)

PLEP:

121943381(gnb5b) 121950248(gnb5a)

SLUC:

116037627(gnb5b) 116038514(gnb5a)

ECRA:

117946175(gnb5b) 117949654(gnb5a)

ESP:	116689854 116693883(gnb5)

PFLV:

114555598 114560166(gnb5)

GAT:	120808704(gnb5a) 120812432(gnb5b)

PPUG:

119196284(gnb5a) 119227534(gnb5b)

AFB:	129108232(gnb5a) 129108840

CLUM:

117732477(gnb5a) 117749706(gnb5b)

PSWI:

130193162(gnb5b) 130195629

MSAM:

119889955(gnb5b) 119893902(gnb5a)

SCHU:

122875407(gnb5a) 122879756(gnb5b)

CUD:	121510715 121515768(gnb5a)

ALAT:

119018681(gnb5b) 119023696(gnb5a)

MZE:	101465914(gnb5) 101479181

ONL:	100693864(gnb5) 100702054

OAU:	116322849(gnb5b) 116326677(gnb5a)

OLA:	101156727 101162678(gnb5)

OML:	112141216 112150354 112152297(gnb5a) 112160378(gnb5b)

CSAI:

133421647(gnb5b) 133444144(gnb5a)

XMA:	102225297 102236273(gnb5)

XCO:	114136820(gnb5) 114143252

XHE:	116711478(gnb5) 116718080

PRET:

103462170 103466457(gnb5)

PFOR:

103135985(gnb5) 103156493

PLAI:

106947723 106952420(gnb5)

PMEI:

106916681(gnb5) 106932415

GAF:	122819842(gnb5b) 122835561

PPRL:

129369634(gnb5b) 129371594(gnb5a)

CVG:	107096879 107099434

CTUL:

119771634(gnb5b) 119792468

GMU:	124867238(gnb5b) 124881715(gnb5a)

NFU:	107388636(gnb5) 107397179

KMR:	108230150(gnb5a) 108237408(gnb5b)

ALIM:

106518983 106521143(gnb5)

NWH:	119416359(gnb5a) 119430115(gnb5b)

AOCE:

111562840 111577264(gnb5)

MCEP:

125004906(gnb5b) 125014733(gnb5a)

CSEM:

103379425 103380486

POV:	109624152(gnb5) 109624843

SSEN:

122771941(gnb5b) 122776511(gnb5a)

HHIP:

117758244(gnb5b) 117762610(gnb5a)

HSP:	118108319(gnb5b) 118109477(gnb5a)

SMAU:

118302068(gnb5b) 118315267(gnb5a)

LCF:	108876683(gnb5a) 108876959(gnb5b)

SDU:	111219619 111229600(gnb5)

SLAL:

111659167 111666882(gnb5)

XGL:	120788808 120793568(gnb5a)

HCQ:	109507521(gnb5) 109513847

SSCV:

125967528 125970125

SBIA:

133498241(gnb5b) 133502368(gnb5a)

PEE:	133397457(gnb5b) 133402414(gnb5a)

PTAO:

133474228 133478544(gnb5a)

BPEC:

110169457 110175369

MALB:

109955809 109972228(gnb5)

BSPL:

114852729(gnb5b) 114857599(gnb5a)

SJO:	128356024(gnb5b) 128359360(gnb5a)

SASA:

106561786 106562494 106584742 106587671

STRU:

115166976 115192893 115196590 115203340

OTW:	112219067 112249618(gnb5b) 112265015(gnb5a)

OMY:	110500941 110514837 110521204(gnb5a) 110526647

OGO:	124031883 124033540(gnb5b) 124033545 124036988(gnb5a)

ONE:	115118373 115125271

OKI:	109885086 109893795 109897437 116374887

OKE:	118359377(gnb5a) 118375901(gnb5b)

SALP:

112068483(gnb5) 112070359

SNH:	120024702 120024704 120051665 120066763

CCLU:

121540730 121568060 121579923(gnb5b)

ELS:	105018176 105022646

SFM:	108926695 108929057

PKI:	111845113 111846713

AANG:

118214808 118228524

LOC:	102686407(gnb5)

PSPA:

121294306 121298779

ARUT:

117427690 117429294 117964228 117964299

PSEX:

120539937(gnb5b)

LCM:	102360347(GNB5)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116940082(GNB5)

LRJ:	133359082(GNB5)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918397 587675

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG10763(Gbeta5)

DER:

6550317

DSE:

6620177

DSI:	Dsimw501_GD16125(Dsim_GD16125)

DYA:	Dyak_GE17476

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14411

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119669784 119669786

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110678909 110680477 5572857

AALB:

109397781 109428784 115254229

CQU:	CpipJ_CPIJ002520

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_210506

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

126837337 126840496 126844573

DVT:

126904658

BTAB:

109042312

DCI:	103510700 103523530

CLEC:

106666666

HHAL:

106685332

NLU:

111047799

HVI:	124355502 124374489

MQU:

128996502

PHU:	Phum_PHUM371020

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_190617(Gnb2)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F52A8.2(gpb-2)

CBR:	CBG_11904(Cbr-gpb-2)

CRQ:	GCK72_000141

NAI:	NECAME_00755

BMY:	BM_BM4239(Bma-gpb-2)

LOA:	LOAG_06596

HRO:	HELRODRAFT_115679

LGI:	LOTGIDRAFT_162493

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_075130

SHX:	MS3_00005178(GNB5)

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

HMG:

HSY:

TAD:	TRIADDRAFT_49804

AQU:

100635338

» show all

Reference

PMID:9606987

Authors

Jones PG, Lombardi SJ, Cockett MI

Title

Cloning and tissue distribution of the human G protein beta 5 cDNA.

Journal

Biochim Biophys Acta 1402:288-91 (1998)
DOI:10.1016/S0167-4889(98)00017-2

Sequence

[hsa:10681]

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