KEGG   ORTHOLOGY: K04556Help
Entry
K04556                      KO                                     

Name
PARK2
Definition
parkin [EC:2.3.2.31]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04137  Mitophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko05012  Parkinson's disease
Disease
H00057  Parkinson's disease (PD)
H00344  Leprosy
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04556  PARK2; parkin
   04120 Ubiquitin mediated proteolysis
    K04556  PARK2; parkin
 Cellular Processes
  Transport and catabolism
   04137 Mitophagy - animal
    K04556  PARK2; parkin
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04556  PARK2; parkin
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K04556  PARK2; parkin
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K04556  PARK2; parkin
  Aggrephagy
   Other aggrephagy associated proteins
    K04556  PARK2; parkin
  Xenophagy
   Other xenophagy associated proteins
    K04556  PARK2; parkin
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K04556  PARK2; parkin
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K04556  PARK2; parkin
BRITE hierarchy
Genes
HSA: 5071(PRKN)
PTR: 741350(PRKN)
PPS: 100978701(PARK2)
GGO: 101154322(PARK2)
PON: 100172433(PRKN)
NLE: 100589757(PARK2)
MCC: 710899(PARK2)
MCF: 102134446(PARK2)
CSAB: 103240862(PARK2)
RRO: 104669996(PARK2)
RBB: 108527984(PARK2)
CJC: 100390242(PARK2)
SBQ: 101029277(PARK2)
MMU: 50873(Park2)
RNO: 56816(Park2)
CGE: 100764359(Park2)
NGI: 103729225 103737054(Park2)
HGL: 101700770(Park2)
CCAN: 109688031
OCU: 100358886(PARK2)
TUP: 102469732(PARK2)
CFA: 612316(PARK2)
AML: 100465415(PARK2)
UMR: 103660821(PARK2)
ORO: 101385500(PARK2)
FCA: 101098228(PRKN)
PTG: 102964689(PARK2)
AJU: 106985022(PARK2)
BTA: 530858(PARK2)
BIU: 109564101(PARK2)
PHD: 102323493(PARK2)
CHX: 102172812(PARK2)
OAS: 101113503(PARK2)
SSC: 733673(PRKN)
CFR: 102508809 102509317(PARK2)
CDK: 105086287(PARK2)
BACU: 103006032(PARK2)
LVE: 103072488(PARK2) 103083735
OOR: 101286051(PARK2)
ECB: 100057832(PRKN)
EAI: 106842050(PARK2)
MYB: 102255484(PARK2)
MYD: 102757960(PARK2)
RSS: 109456779(PARK2)
PALE: 102888747(PARK2)
LAV: 100665442(PRKN)
TMU: 101340669
MDO: 100032502(PARK2)
SHR: 100928463(PRKN)
GGA: 421577(PARK2)
MGP: 100549457(PARK2)
CJO: 107311526(PARK2)
APLA: 101796091(PARK2) 106018730
ACYG: 106039539(PARK2)
TGU: 100221229(PARK2)
GFR: 102043879(PARK2)
FAB: 101810988(PARK2)
PHI: 102105199(PARK2)
PMAJ: 107202287(PARK2)
CCW: 104684351(PRKN)
FPG: 101918371(PARK2) 101924490
FCH: 102048210(PARK2)
CLV: 102084040(PRKN)
AAM: 106486766(PARK2)
ASN: 102381887(PARK2)
AMJ: 102573688(PARK2)
PSS: 102451562(PARK2)
CMY: 102935998(PARK2)
CPIC: 101941171(PARK2) 101948163
ACS: 100559435(park2)
PVT: 110087285(PRKN)
PBI: 103051791 103060385(PARK2)
GJA: 107113335(PARK2) 107118842
DRE: 550328(prkn)
SRX: 107739476
SGH: 107586494(park2)
CCAR: 109081461(park2) 109085397
IPU: 108263700(park2)
AMEX: 103027813(prkn)
TRU: 101073892(park2)
LCO: 104934697(park2)
MZE: 101482320(prkn)
OLA: 101170614(prkn)
XMA: 102219281(prkn)
NFU: 107396230(park2)
CSEM: 103387132(park2)
BPEC: 110168027(prkn)
SASA: 106576740(park2)
ELS: 105025493(park2)
SFM: 108942718(park2)
CMK: 103176050(park2)
SPU: 594188
APLC: 110978897
SKO: 100368482
DME: Dmel_CG10523(park)
DSI: Dsimw501_GD12138(Dsim_GD12138)
MDE: 101899448
AAG: 5564457
AME: 412975
BIM: 100747344
BTER: 100649117
SOC: 105205525
AEC: 105144380
ACEP: 105622910
PBAR: 105428684
HST: 105187377
CFO: 105251913
LHU: 105667495
PGC: 109857665
NVI: 100122062
TCA: 657490
DPA: 109546411
NVL: 108569438
API: 100166503
DNX: 107171531
ZNE: 110826528
FCD: 110855883
TUT: 107362791
CEL: CELE_K08E3.7(pdr-1)
CBR: CBG18262(Cbr-pdr-1)
BMY: Bm1_57385
CRG: 105335799
MYI: 110463400
OBI: 106875888
LAK: 106166390
SHX: MS3_08427
EPA: 110243769
ADF: 107339248
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R
  Title
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
  Journal
Mol Cell 10:55-67 (2002)
DOI:10.1016/S1097-2765(02)00583-X
  Sequence
[hsa:5071]
Reference
  Authors
Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM
  Title
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.
  Journal
Science 304:1328-31 (2004)
DOI:10.1126/science.1093891
  Sequence
[hsa:5071] [mmu:50873]

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