KEGG   ORTHOLOGY: K04556Help
Entry
K04556                      KO                                     

Name
PARK2
Definition
parkin [EC:6.3.2.19]
Pathway
Ubiquitin mediated proteolysis
Protein processing in endoplasmic reticulum
Parkinson's disease
Disease
H00057  
Parkinson's disease (PD)
H00344  
Leprosy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04556  PARK2; parkin
   04120 Ubiquitin mediated proteolysis
    K04556  PARK2; parkin
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04556  PARK2; parkin
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.19  ubiquitin---protein ligase
     K04556  PARK2; parkin
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   RBR proteins
    K04556  PARK2; parkin
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K04556  PARK2; parkin
BRITE hierarchy
Genes
HSA: 
5071(PARK2)
PTR: 
741350(PARK2)
PPS: 
100978701(PARK2)
GGO: 
PON: 
100172433(PARK2)
MCC: 
MCF: 
102134446(PARK2)
MMU: 
50873(Park2)
RNO: 
56816(Park2)
CGE: 
100764359(Park2)
HGL: 
101700770(Park2)
TUP: 
102469732(PARK2)
CFA: 
612316(PARK2)
AML: 
100465415(PARK2)
FCA: 
101098228(PARK2)
PTG: 
102964689(PARK2)
BTA: 
530858(PARK2)
BOM: 
PHD: 
102323493(PARK2)
CHX: 
102172812(PARK2)
OAS: 
101113503(PARK2)
SSC: 
733673(PARK2)
CFR: 
BACU: 
103006032(PARK2)
LVE: 
ECB: 
100057832(PARK2)
MYB: 
102255484(PARK2)
MYD: 
102757960(PARK2)
PALE: 
102888747(PARK2)
MDO: 
100032502(PARK2)
SHR: 
GGA: 
421577(PARK2)
MGP: 
TGU: 
100221229(PARK2)
FAB: 
101810988(PARK2)
PHI: 
102105199(PARK2)
APLA: 
101796091(PARK2)
FPG: 
FCH: 
102048210(PARK2)
CLV: 
102084040(PARK2)
ASN: 
102381887(PARK2)
AMJ: 
102573688(PARK2)
PSS: 
102451562(PARK2)
CMY: 
102935998(PARK2)
ACS: 
100559435(park2)
PBI: 
DRE: 
550328(park2)
TRU: 
MZE: 
OLA: 
XMA: 
CMK: 
103176050(park2)
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412975(GB10292)
NVI: 
TCA: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG18262(Cbr-pdr-1)
BMY: 
LOA: 
SMM: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R
  Title
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
  Journal
Mol Cell 10:55-67 (2002)
  Sequence
[hsa:5071]
Reference
  Authors
Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM
  Title
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.
  Journal
Science 304:1328-31 (2004)
  Sequence
[hsa:5071] [mmu:50873]

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