KEGG   ORTHOLOGY: K04570Help
Entry
K04570                      KO                                     

Name
BCL2L1, bcl-xL
Definition
Bcl-2-like 1 (apoptosis regulator Bcl-X)
Pathway
Ras signaling pathway
NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Apoptosis - multiple species
Jak-STAT signaling pathway
Amyotrophic lateral sclerosis (ALS)
Toxoplasmosis
HTLV-I infection
Pathways in cancer
Transcriptional misregulation in cancer
Pancreatic cancer
Chronic myeloid leukemia
Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04630 Jak-STAT signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04064 NF-kappa B signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04151 PI3K-Akt signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04215 Apoptosis - multiple species
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05202 Transcriptional misregulation in cancers
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05212 Pancreatic cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05220 Chronic myeloid leukemia
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05222 Small cell lung cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Infectious diseases
   05166 HTLV-I infection
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05145 Toxoplasmosis
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
BRITE hierarchy
Other DBs
Genes
HSA: 
598(BCL2L1)
PTR: 
458156(BCL2L1)
PPS: 
100979809(BCL2L1)
GGO: 
101142025(BCL2L1)
PON: 
100453051(BCL2L1)
NLE: 
100595330(BCL2L1)
MCC: 
713035(BCL2L1)
MCF: 
102140222(BCL2L1)
RRO: 
104653720(BCL2L1)
CJC: 
100401978(BCL2L1)
MMU: 
12048(Bcl2l1)
RNO: 
24888(Bcl2l1)
CGE: 
100689371(Bcl2l1)
NGI: 
103731080(Bcl2l1)
HGL: 
OCU: 
100008875(BCL2L1)
TUP: 
102486626(BCL2L1)
CFA: 
403618(BCL2L1)
AML: 
100469922(BCL2L1)
UMR: 
103674345(BCL2L1)
FCA: 
493701(BCL2L1)
PTG: 
102950221(BCL2L1)
BTA: 
282152(BCL2L1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
397536(BCL2L1)
CFR: 
102504996(BCL2L1)
BACU: 
103017903(BCL2L1)
LVE: 
103080887(BCL2L1)
ECB: 
100053597(BCL2L1)
MYB: 
102260460(BCL2L1)
MYD: 
102753986(BCL2L1)
PALE: 
102887704(BCL2L1)
MDO: 
100010654(BCL2L1)
SHR: 
100915548(BCL2L1)
GGA: 
373954(BCL2L1)
MGP: 
100539573(BCL2L1)
APLA: 
TGU: 
100224900(BCL2L1)
GFR: 
102036419(BCL2L1)
FAB: 
101814183(BCL2L1)
PHI: 
102102822(BCL2L1)
CCW: 
104687705(BCL2L1)
FPG: 
101924628(BCL2L1)
FCH: 
102056509(BCL2L1)
CLV: 
102097802(BCL2L1)
ASN: 
102370658(BCL2L1)
AMJ: 
102559904(BCL2L1)
PSS: 
102460215(BCL2L1)
CMY: 
102942240(BCL2L1)
ACS: 
100561922(bcl2l1)
PBI: 
103061849(BCL2L1)
XLA: 
398251(bcl2l1)
XTR: 
447991(bcl2l1)
DRE: 
114401(bcl2l1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102358181(BCL2L1)
CMK: 
103186250(bcl2l1)
BFO: 
SPU: 
TSP: 
HRO: 
CRG: 
OBI: 
HMG: 
TAD: 
AQU: 
VG: 
26100394(AQ624_gp09)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kim R
  Title
Unknotting the roles of Bcl-2 and Bcl-xL in cell death.
  Journal
Biochem Biophys Res Commun 333:336-43 (2005)
Reference
  Authors
Wang J, Beauchemin M, Bertrand R
  Title
Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.
  Journal
Cell Signal 23:2030-8 (2011)
Reference
  Authors
Terrano DT, Upreti M, Chambers TC
  Title
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.
  Journal
Mol Cell Biol 30:640-56 (2010)
  Sequence
[hsa:598]

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