KEGG ORTHOLOGY: K04603

ORTHOLOGY: K04603

Entry

K04603                      KO

Symbol

GRM1

Name

metabotropic glutamate receptor 1

Pathway

map04020

Calcium signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04540

Gap junction

map04720

Long-term potentiation

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04730

Long-term depression

map04742

Taste transduction

map04915

Estrogen signaling pathway

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00063

Spinocerebellar ataxia (SCA)

H01891

Autosomal recessive spinocerebellar ataxias

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04020 Calcium signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04072 Phospholipase D signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04603  GRM1; metabotropic glutamate receptor 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04603  GRM1; metabotropic glutamate receptor 1
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K04603  GRM1; metabotropic glutamate receptor 1
   04720 Long-term potentiation
    K04603  GRM1; metabotropic glutamate receptor 1
   04730 Long-term depression
    K04603  GRM1; metabotropic glutamate receptor 1
   04723 Retrograde endocannabinoid signaling
    K04603  GRM1; metabotropic glutamate receptor 1
  09157 Sensory system
   04742 Taste transduction
    K04603  GRM1; metabotropic glutamate receptor 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04603  GRM1; metabotropic glutamate receptor 1
   05022 Pathways of neurodegeneration - multiple diseases
    K04603  GRM1; metabotropic glutamate receptor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04603  GRM1; metabotropic glutamate receptor 1
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04603  GRM1; metabotropic glutamate receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04603  GRM1; metabotropic glutamate receptor 1
G protein-coupled receptors [BR:ko04030]
Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   K04603  GRM1; metabotropic glutamate receptor 1

Other DBs

GO:

0001639

TC:	9.A.14.7.1

Genes

HSA:	2911(GRM1)

PTR:	463049(GRM1)

PPS:	100968079(GRM1)

GGO:	101150458(GRM1)

PON:	100451342(GRM1)

NLE:	100592587(GRM1)

HMH:	116463111 116463144

MCC:	698736(GRM1)

MCF:	102145647(GRM1)

MTHB:

126952576

MNI:	105488979(GRM1)

CSAB:

103240205(GRM1)

CATY:

105588798(GRM1)

PANU:

101005483(GRM1)

TGE:	112622646(GRM1)

MLEU:

105535378(GRM1)

RRO:	104653776(GRM1)

TFN:	117097320(GRM1)

PTEH:

111528139(GRM1)

CANG:

105524250(GRM1)

CJC:	100410312(GRM1)

SBQ:	101036619(GRM1)

CIMI:

108285804(GRM1)

CSYR:

103269071

MMUR:

105864337(GRM1)

LCAT:

123633346(GRM1)

PCOQ:

105819328(GRM1)

OGA:	100959023(GRM1)

MMU:	14816(Grm1)

MCAL:

110303088(Grm1)

MPAH:

110338039(Grm1)

RNO:	24414(Grm1)

MCOC:

116097763(Grm1)

ANU:	117700268(Grm1)

MUN:	110566206(Grm1)

CGE:	100751598(Grm1)

MAUA:

101831018(Grm1)

PROB:

127237692 127237766

PLEU:

114686464(Grm1)

MORG:

121466446(Grm1)

MFOT:

126513312

AAMP:

119821203(Grm1)

NGI:	103737030(Grm1)

HGL:	101712477(Grm1)

CPOC:

100730891(Grm1)

DORD:

105993642(Grm1)

DSP:	122125197(Grm1)

PLOP:

125357375(Grm1)

NCAR:

124989681

MMMA:

107156011(Grm1)

OCU:

100356201

OPI:	101516509(GRM1)

TUP:	102479064(GRM1)

GVR:

103592255

CFA:	484024(GRM1)

CLUD:

112644259(GRM1)

VVP:	112919501(GRM1)

VLG:	121479810(GRM1)

NPO:	129500488(GRM1)

AML:	100479929(GRM1)

UMR:	103666935(GRM1)

UAH:	113259527(GRM1)

UAR:	123797395(GRM1)

ELK:

111147676

LLV:

125103220

MPUF:

101686929(GRM1)

MNP:	132018219(GRM1)

MLK:	131833708(GRM1)

NVS:	122905689(GRM1)

EJU:	114209321(GRM1)

ZCA:	113928053(GRM1)

MLX:	118001000(GRM1)

NSU:	110583350(GRM1)

LWW:	102733766(GRM1)

FCA:	101094104(GRM1)

PYU:	121013347(GRM1)

PCOO:

112862043(GRM1)

PBG:	122490065(GRM1)

PVIV:

125165971(GRM1)

LRUF:

124528740

PTG:	102961964(GRM1)

PPAD:

109252510(GRM1)

PUC:

125938983

AJU:

106965803

HHV:	120231041(GRM1)

BTA:	540485(GRM1)

BOM:	102280395(GRM1)

BIU:	109563668(GRM1)

BBUB:

102414394(GRM1)

BBIS:

104997048 105004836

OAS:	443101(GRM1)

BTAX:

128053357(GRM1)

ODA:	120862584(GRM1)

CCAD:

122434178(GRM1)

MBEZ:

129561218(GRM1)

SSC:	100625610(GRM1)

CFR:	102523079(GRM1)

CBAI:

105077300(GRM1)

CDK:	105092074(GRM1)

VPC:	102535537(GRM1)

BMUS:

118905468(GRM1)

LVE:	103085587(GRM1)

OOR:	101286756(GRM1)

DLE:	111166689(GRM1)

PCAD:

102978027(GRM1)

PSIU:

116763496(GRM1)

NASI:

112401627(GRM1)

ECB:	100060603(GRM1)

EPZ:	103564725(GRM1)

EAI:	106837226(GRM1)

MMYO:

118660637(GRM1)

MLF:	102428336(GRM1)

PKL:	118705702(GRM1)

EFUS:

103303960(GRM1)

DRO:	112297397(GRM1)

SHON:

118978955 118978978

AJM:	119049056(GRM1)

PDIC:

114495128(GRM1)

PHAS:

123821691(GRM1)

MMF:	118621105(GRM1)

PPAM:

129067827(GRM1)

HAI:	109380898(GRM1)

RFQ:	117020443(GRM1)

PALE:

102878912(GRM1)

PGIG:

120589402(GRM1)

PVP:	105289441(GRM1)

RAY:	107518526(GRM1)

MJV:	108401022(GRM1)

TOD:	119252954(GRM1)

SARA:

101542044(GRM1)

SETR:

126031051(GRM1)

TMU:

101357087

ETF:	101644342(GRM1)

DNM:

101447287

MDO:	100026724(GRM1)

GAS:	123246629(GRM1)

SHR:	100919608(GRM1)

AFZ:

127562301

PCW:	110208519(GRM1)

OAA:	100075372(GRM1)

GGA:	421614(GRM1)

PCOC:

116241737(GRM1)

MGP:	100540165(GRM1)

CJO:	107311576(GRM1)

TPAI:

128074784(GRM1)

LMUT:

125689387(GRM1)

NMEL:

110396806(GRM1)

APLA:

101803914(GRM1)

ACYG:

106034294(GRM1)

CATA:

118243935(GRM1)

AFUL:

116487901(GRM1)

TGU:	751999(GRM1)

LSR:	110468842(GRM1)

SCAN:

103818453(GRM1)

PMOA:

120501378(GRM1)

OTC:	121346039(GRM1)

PRUF:

121354867(GRM1)

GFR:	102038278(GRM1)

FAB:	101807135(GRM1)

OMA:	130251746(GRM1)

PHI:	102107527(GRM1)

PMAJ:

107202384(GRM1)

CCAE:

111927059(GRM1)

CCW:	104689210(GRM1)

CBRC:

103617635(GRM1)

ZAB:	102070841(GRM1)

ACHL:

103800092

SVG:	106863475(GRM1)

MMEA:

130572359(GRM1)

HRT:	120750107(GRM1)

FPG:	101920400(GRM1)

CLV:	102091439(GRM1)

EGZ:	104133563(GRM1)

NNI:	104013781(GRM1)

PCRI:

104037592(GRM1)

PLET:

104623282

EHS:	104503170(GRM1)

PCAO:

104041151(GRM1)

TALA:

104361564(GRM1)

PADL:

103918143(GRM1)

AFOR:

103901593(GRM1)

ACHC:

115345049(GRM1)

HALD:

104322436(GRM1)

HLE:	104842275(GRM1)

AGEN:

126038614

GCL:

127014508

CSTI:

104554555(GRM1)

CMAC:

104476227(GRM1)

MUI:	104540752(GRM1)

BREG:

104632761(GRM1)

FGA:	104069295(GRM1)

GSTE:

104257896(GRM1)

LDI:	104346684(GRM1)

MNB:	103774961(GRM1)

OHA:	104327220(GRM1)

NNT:	104405018(GRM1)

SHAB:

115613817(GRM1)

DPUB:

104298683(GRM1)

PGUU:

104467478(GRM1)

ACAR:

104522004(GRM1)

CPEA:

104390781(GRM1)

AVIT:

104279115(GRM1)

CVF:	104295746(GRM1)

RTD:	128907048(GRM1)

CUCA:

104056752(GRM1)

TEO:	104383678(GRM1)

BRHI:

104495331(GRM1)

AAM:	106486778(GRM1)

AROW:

112974150(GRM1)

NPD:	112951956(GRM1)

TGT:	104577169(GRM1)

DNE:	112983279(GRM1)

SCAM:

104140181(GRM1)

ASN:	102378290(GRM1)

AMJ:	102563002(GRM1)

CPOO:

109319121(GRM1)

GGN:	109304791(GRM1)

PSS:	102460135(GRM1)

CMY:	102932638(GRM1)

CCAY:

125634082(GRM1)

DCC:	119853891(GRM1)

CPIC:

101940955(GRM1)

TST:	117874861(GRM1)

CABI:

116833187(GRM1)

MRV:	120402034(GRM1)

ACS:	100564433(grm1)

ASAO:

132761035(GRM1)

PVT:	110088369(GRM1)

SUND:

121919479(GRM1)

CTIG:

120309532(GRM1)

TSR:	106543622(GRM1)

PGUT:

117666344(GRM1)

APRI:

131191690(GRM1)

PTEX:

113439670(GRM1)

NSS:	113411273(GRM1)

VKO:	123032748(GRM1)

PMUA:

114594222(GRM1)

PRAF:

128410628(GRM1)

ZVI:	118082832(GRM1)

HCG:	128342968(GRM1)

STOW:

125437609

EMC:	129328528(GRM1)

XLA:	108716694 108717837

XTR:	100495945(grm1)

NPR:	108787741(GRM1)

RTEM:

120937555(GRM1)

BBUF:

120999276(GRM1)

BGAR:

122935464(GRM1)

MUO:	115466646(GRM1)

GSH:	117356433(GRM1)

DRE:	100150246(grm1b) 555576(grm1a)

SRX:	107710424 107726479 107726606 107733655

SANH:

107653974 107679500 107692633 107696122

SGH:	107586570 107601209(grm1) 107602522

CCAR:

109108722

CAUA:

113060871 113063098 113117609 113117709 113120775 113120926

CGIB:

127938943 127975768 127983433 128031792

PTET:

122324766(grm1a) 122362237(grm1b)

LROH:

127179873(grm1b) 127182797(grm1a)

OMC:	131523116(grm1b) 131527293(grm1a)

PPRM:

120480202(grm1b) 120494051(grm1a)

RKG:	130088976(grm1b) 130104299(grm1a)

MAMB:

125268361(grm1b) 125278093(grm1a)

CIDE:

127498452 127502626

MASI:

127410302 127411451 127415530 127454812

TROS:

130560635(grm1b) 130566056(grm1a)

TDW:	130434782(grm1a) 130437073(grm1b)

MANU:

129417979(grm1b) 129430063(grm1a)

IPU:	108270069(grm1b) 108279026(grm1a)

IFU:	128613036(grm1b) 128616748(grm1a)

PHYP:

113529136 113538963

SMEO:

124390628(grm1b) 124401793(grm1a)

TFD:	113643380(grm1a) 113659571(grm1b)

TVC:	132852094(grm1b) 132854550(grm1a)

AMEX:

103045488 103047809

CMAO:

118815893(grm1a) 118824045(grm1b)

EEE:	113578142 113580773

CHAR:

105895730(grm1b) 105897707

TRU:	101065368(grm1) 101071408

TFS:	130515792(grm1a) 130539856(grm1b)

TNG:	GSTEN00023057G001 GSTEN00035748G001

LCO:	104929400 104934310(grm1)

TBEN:

117471154 117492338

CGOB:

115004925 115028830(grm1)

PGEO:

117439759(grm1a)

GACU:

117537539(grm1a) 117557570

EMAC:

134876691(grm1a) 134881157(grm1b)

ELY:	117267639(grm1b) 117271197(grm1a)

EFO:	125896647(grm1a) 125900357(grm1b)

PLEP:

121954147(grm1b) 121955656(grm1a)

SLUC:

116057666(grm1b) 116066169(grm1a)

ECRA:

117935939(grm1b) 117961555(grm1a)

ESP:	116670337 116705868(grm1)

PFLV:

114546747 114572847(grm1)

GAT:	120807652(grm1a) 120833264(grm1b)

PPUG:

119195374(grm1a) 119227715(grm1b)

AFB:	129103464(grm1b) 129107288(grm1a)

CLUM:

117727397(grm1a) 117751091(grm1b)

PSWI:

130201693(grm1b) 130203014(grm1a)

MSAM:

119908408(grm1a) 119910801

SCHU:

122861998(grm1b) 122863172(grm1a)

CUD:	121521017(grm1a) 121525845

ALAT:

119012531(grm1a) 119034234(grm1b)

MZE:	101467938 101483242(grm1)

ONL:	100697502 100701745(grm1)

OAU:	116310668(grm1a) 116318116(grm1b)

OLA:	101165118(grm1) 101170976

OML:	112142945(grm1b) 112157966(grm1a)

CSAI:

133461932 133464405(grm1a)

XMA:	102224833(grm1) 102226132

XCO:	114134732 114158865(grm1)

XHE:	116709324 116734017(grm1)

PRET:

103457526(grm1) 103458356

PFOR:

103134970 103144691

PLAI:

106956585 106959109

PMEI:

106928558 106928760

GAF:	122825690(grm1a) 122846438(grm1b)

PPRL:

129352436(grm1a) 129357887

CVG:	107086032(grm1) 107091581

CTUL:

119792758(grm1b) 119795948(grm1a)

GMU:	124855863(grm1b) 124882406(grm1a)

NFU:	107377567(grm1) 107391977

KMR:	108239081(grm1b) 108240124(grm1a)

ALIM:

106519782(grm1)

NWH:	119418222(grm1a) 119427470(grm1b)

AOCE:

111572587(grm1) 111578565

MCEP:

124999070(grm1a) 125023521(grm1b)

CSEM:

103380242 103381085(grm1)

POV:	109636085(grm1)

SSEN:

122782935 122784448(grm1a)

HHIP:

117756137(grm1b) 117758227(grm1a)

HSP:	118099176(grm1a) 118116980(grm1b)

SMAU:

118286703(grm1b) 118289737(grm1a)

LCF:	108880909 108902017

SDU:	111225349 111240111(grm1)

SLAL:

111655604(grm1) 111665818

XGL:	120789204(grm1a) 120795478(grm1b)

HCQ:	109527746(grm1)

SSCV:

125990035

SBIA:

133496371(grm1a) 133513519(grm1b)

PEE:	133413028(grm1b) 133416788(grm1a)

PTAO:

133468116(grm1a) 133488087(grm1b)

BPEC:

110155964(grm1)

MALB:

109954042(grm1)

BSPL:

114848636(grm1b) 114849174(grm1a)

SJO:	128375091(grm1b) 128377256(grm1a)

SASA:

106603413 106607995

STRU:

115161988 115172241 115174449 115179270

OTW:	112217708 112232976(grm1a) 112261499(grm1b)

OMY:	110497585(grm1b) 110504240 110522380 110530914(grm1a)

OGO:	123991025(grm1a) 123995242 124001165 124046699

ONE:	115108031 115138749 115139274 115145920

OKI:	109866113 109893867 109900996 109903232

OKE:	118362842 118368065 118372347 118398376

SALP:

111954626 111963537 111972819

SNH:	120019327 120023657 120023924 120059949

CCLU:

121539609 121548777 121552485(grm1a)

ELS:	105029905(grm1)

SFM:	108921046 108923354

PKI:

111857957

AANG:

118228541(grm1b) 118229128(grm1a)

LOC:	102687262(grm1)

PSPA:

121315834 121316952

ARUT:

117403393 117411081 117428206

PSEX:

120525332(grm1b)

LCM:	102359097(GRM1)

CMK:	103179290(grm1b)

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133352874 133356939

BFO:

118422754

BBEL:

109464724

SPU:	577623 756752

AALB:

109410169 115256505

CQU:	CpipJ_CPIJ008111

CPII:

NVI:

TPRE:

LHT:

LBD:

FAS:

DAM:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

PPYR:

SLIU:

NLU:

HVI:

ZNE:

CSEC:

DMK:	116923854 116935354

HAME:

DSV:

RMP:

HRF:

MMER:

RPHI:

DPOL:

OSN:

XEN:

HMG:

TAD:	TRIADDRAFT_54290 TRIADDRAFT_59560

» show all

Reference

PMID:1847995

Authors

Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S

Title

Sequence and expression of a metabotropic glutamate receptor.

Journal

Nature 349:760-5 (1991)
DOI:10.1038/349760a0

Sequence

[rno:24414]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   TC (1)   
Pathway (26)   
   KEGG PATHWAY (26)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (1349)   
   KEGG GENES (553)   
   KEGG MGENES (323)   
   RefGene (469)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (1383)   

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