KEGG   ORTHOLOGY: K04630Help
Entry
K04630                      KO                                     

Name
GNAI
Definition
guanine nucleotide-binding protein G(i) subunit alpha
Pathway
Rap1 signaling pathway
Chemokine signaling pathway
Adrenergic signaling in cardiomyocytes
Axon guidance
Tight junction
Gap junction
Leukocyte transendothelial migration
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Gastric acid secretion
Parkinson's disease
Cocaine addiction
Morphine addiction
Alcoholism
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Disease
H00033  
Adrenal carcinoma
H01019  
Catecholaminergic polymorphic ventricular tachycardia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Cellular Processes
  Cell communication
   04530 Tight junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04540 Gap junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04062 Chemokine signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Endocrine system
   04915 Estrogen signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04914 Progesterone-mediated oocyte maturation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04921 Oxytocin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04916 Melanogenesis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Digestive system
   04971 Gastric acid secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04727 GABAergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04725 Cholinergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04728 Dopaminergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04726 Serotonergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04730 Long-term depression
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Development
   04360 Axon guidance
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Substance dependence
   05030 Cocaine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05032 Morphine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05034 Alcoholism
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Infectious diseases
   05133 Pertussis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05145 Toxoplasmosis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [Table]
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
BRITE hierarchy
Genes
HSA: 
2770(GNAI1) 2771(GNAI2) 2773(GNAI3)
PTR: 
457093(GNAI3) 472425(GNAI1) 744773(GNAI2)
PPS: 
100968961(GNAI3) 100974334(GNAI2) 100985590(GNAI1)
GGO: 
101125616(GNAI3) 101150178(GNAI2) 101154597(GNAI1)
PON: 
100172679(GNAI1) 100456074(GNAI3) 100458137(GNAI2)
MCC: 
699310(GNAI3) 703780(GNAI2) 708940
MCF: 
101926144(GNAI2) 102119905(GNAI3) 102140224(GNAI1)
MMU: 
14677(Gnai1) 14678(Gnai2) 14679(Gnai3)
RNO: 
25643(Gnai3) 25686(Gnai1) 81664(Gnai2)
CGE: 
100689068(Gnai2) 100689070(Gnai1) 100689072(Gnai3)
HGL: 
101698645(Gnai2) 101702965(Gnai1) 101703043(Gnai3)
TUP: 
102475420(GNAI2) 102479323(GNAI1)
CFA: 
442957(GNAI2) 478227(GNAI1) 611810(GNAI3)
AML: 
FCA: 
101089679(GNAI2) 101092837(GNAI1) 101100320(GNAI3)
BTA: 
281790(GNAI1) 281791(GNAI2) 539521(GNAI3)
BOM: 
102273920(GNAI1) 102274651(GNAI2) 102285228(GNAI3)
PHD: 
102319715(GNAI1) 102322883(GNAI2) 102326697(GNAI3)
CHX: 
100860765(GI2) 102185804(GNAI1)
SSC: 
100144419(GBI1) 100144421(GNAI3) 397523(GNAI2)
CFR: 
102504487(GNAI3) 102522331(GNAI2)
ECB: 
100055673(GNAI1) 100058238(GNAI3) 100062085(GNAI2)
MYB: 
102239557(GNAI3) 102249318(GNAI2) 102256872(GNAI1)
MDO: 
SHR: 
OAA: 
GGA: 
374097(GNAI3) 396367(GNAI2) 396368(GNAI1)
MGP: 
TGU: 
100219656(GNAI1) 100225910(GNAI2) 100232622(GNAI3)
FAB: 
101806522(GNAI3) 101807650(GNAI2) 101818889(GNAI1)
PHI: 
102100320(GNAI3) 102105798(GNAI2) 102111212(GNAI1)
APLA: 
FPG: 
101917880(GNAI1) 101924920(GNAI2)
FCH: 
102051232(GNAI2) 102059982(GNAI1)
CLV: 
ASN: 
102377099(GNAI2) 102383800(GNAI1)
PSS: 
102452618(GNAI1) 102453613(GNAI3)
ACS: 
XLA: 
379236(gnai3) 380034(gnai1-a) 399463(gnai1-b) 779438(gnai2)
XTR: 
100038283(gnai1) 394861(gnai2) 496962(gnai3)
DRE: 
100006888(gnai3) 323509(gnaia) 327650(gnai2b) 336421(gnai2a) 393946(gnai1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
445618(gi1)
SPU: 
DME: 
Dmel_CG10060(G-ialpha65A)
DPO: 
DAN: 
DER: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411704(GB10966)
NVI: 
API: 
PHU: 
CEL: 
CBR: 
CBG13491(Cbr-gpa-4) CBG18548(Cbr-gpa-16)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
100192225(gnai4)
TAD: 
DDI: 
DPP: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)

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