KEGG   ORTHOLOGY: K04632Help
Entry
K04632                      KO                                     

Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Gap junction
Platelet activation
Circadian entrainment
Glutamatergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Chagas disease (American trypanosomiasis)
Amoebiasis
Pathways in cancer
Dilated cardiomyopathy
Module
M00695  
cAMP signaling
Disease
H00244  
Pseudohypoparathyroidism
H00441  
Progressive osseous heteroplasia (POH)
H00501  
Fibrous dysplasia, polyostotic
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04024 cAMP signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian Steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04921 Oxytocin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04918 Thyroid hormone synthesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Sensory system
   04742 Taste transduction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04750 Inflammatory mediator regulation of TRP channels
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Infectious diseases
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of colorectal cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of bladder cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
BRITE hierarchy
Genes
HSA: 
2778(GNAS)
PTR: 
469986(GNAS)
PPS: 
GGO: 
101132215(GNAS)
PON: 
100442753(GNAS)
NLE: 
MCC: 
694289(GNAS)
MCF: 
102145630(GNAS)
CJC: 
100408515(GNAS)
MMU: 
14683(Gnas)
RNO: 
24896(Gnas)
CGE: 
NGI: 
HGL: 
OCU: 
100008904(GNAS)
TUP: 
CFA: 
403943(GNAS)
AML: 
UMR: 
FCA: 
101098453(GNAS)
PTG: 
102964541(GNAS)
BTA: 
281793(GNAS)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100049657(GNAS)
CFR: 
102513869(GNAS)
BACU: 
103004432(GNAS)
LVE: 
103089051(GNAS)
ECB: 
MYB: 
MYD: 
PALE: 
102889764(GNAS)
MDO: 
SHR: 
OAA: 
100080392(GNAS)
GGA: 
419313(GNAS)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
DRE: 
557353(gnas)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352483(GNAS)
CMK: 
103171631(gnas)
BFO: 
SPU: 
DME: 
Dmel_CG2835(Galphas)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AgaP_AGAP012095(GNAS_ANOGA)
AAG: 
CQU: 
AME: 
411011(GB11944)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CBR: 
CBG22078(Cbr-gsa-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
100192291(gnal)
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)

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