KEGG   ORTHOLOGY: K04632Help
Entry
K04632                      KO                                     
Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Gap junction
Circadian entrainment
Glutamatergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Estrogen signaling pathway
Melanogenesis
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Chagas disease (American trypanosomiasis)
Amoebiasis
Dilated cardiomyopathy
Disease
H00244  
Pseudohypoparathyroidism
H00441  
Progressive osseous heteroplasia (POH)
H00501  
Fibrous dysplasia, polyostotic
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Cellular Processes
  Cell communication
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian Steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Sensory system
   04742 Taste transduction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Human Diseases
  Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Infectious diseases
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
BRITE hierarchy
Genes
HSA: 
2778(GNAS)
PTR: 
469986(GNAS)
PPS: 
GGO: 
101132215(GNAS)
PON: 
100442753(GNAS)
MCC: 
694289(GNAS)
MMU: 
14683(Gnas)
RNO: 
24896(Gnas)
CFA: 
403943(GNAS)
AML: 
FCA: 
101098453(GNAS)
BTA: 
281793(GNAS)
SSC: 
100049657(GNAS)
MDO: 
100021523(GNAS) 100029582
SHR: 
100930666
OAA: 
100080392
GGA: 
419313(GNAS)
MGP: 
100550361
TGU: 
100232476
ACS: 
100558300
XLA: 
394414(gnas) 399059
XTR: 
407931(gnas)
DRE: 
557353(gnas)
TRU: 
101065996
OLA: 
101163657 101166373
BFO: 
BRAFLDRAFT_95909
SPU: 
414053
DME: 
Dmel_CG2835(G-salpha60A)
DPO: 
Dpse_GA15477
DAN: 
Dana_GF12878
DER: 
Dere_GG22906
DPE: 
Dper_GL11181
DSE: 
Dsec_GM16066
DSI: 
Dsim_GD11812
DWI: 
Dwil_GK15719
DYA: 
Dyak_GE14344
DGR: 
Dgri_GH21696
DMO: 
Dmoj_GI18851
DVI: 
Dvir_GJ21886
AGA: 
AgaP_AGAP012095(GNAS_ANOGA)
AAG: 
AaeL_AAEL003989
CQU: 
CpipJ_CPIJ006458
AME: 
411011
NVI: 
100122520(NV14972)
TCA: 
655613
API: 
100159067
PHU: 
Phum_PHUM550760
CEL: 
CELE_R06A10.2(gsa-1)
CBR: 
CBG22078(Cbr-gsa-1)
BMY: 
Bm1_48675
TSP: 
Tsp_05311
SMM: 
Smp_059340.1
NVE: 
NEMVE_v1g158666
HMG: 
100192291(gnal)
TAD: 
TRIADDRAFT_35829
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DBGET integrated database retrieval system