KEGG   ORTHOLOGY: K04674Help
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Disease
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Cellular commiunity
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Organismal Systems
  Development
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Infectious diseases
   05166 HTLV-I infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05142 Chagas disease (American trypanosomiasis)
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzyme-linked receptors [BR:ko01020]
 Receptor serine/threonine kinases
  Type I TGF-beta receptor
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Cytokine receptors [BR:ko04050]
 TGF-beta receptors
  Type I TGF-beta receptor
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7046(TGFBR1)
PTR: 
472992(TGFBR1)
PPS: 
100984463(TGFBR1)
GGO: 
101128510(TGFBR1)
PON: 
100450864(TGFBR1)
MCC: 
714952(TGFBR1)
MCF: 
102115287(TGFBR1)
MMU: 
21812(Tgfbr1)
RNO: 
29591(Tgfbr1)
CGE: 
100772727(Tgfbr1)
HGL: 
101718090(Tgfbr1)
TUP: 
102476700(TGFBR1)
CFA: 
481628(TGFBR1)
AML: 
FCA: 
101094057(TGFBR1)
PTG: 
102950020(TGFBR1)
BTA: 
282382(TGFBR1)
BOM: 
102283685(TGFBR1)
PHD: 
102324779(TGFBR1)
CHX: 
102187767(TGFBR1)
SSC: 
CFR: 
102522485(TGFBR1)
BACU: 
102999446(TGFBR1)
LVE: 
103071954(TGFBR1)
ECB: 
100034117(ALK5)
MYB: 
102241353(TGFBR1)
MYD: 
PALE: 
102880759(TGFBR1)
MDO: 
100011507(TGFBR1)
SHR: 
100913844(TGFBR1)
OAA: 
100092358(TGFBR1)
GGA: 
374094(TGFBR1)
MGP: 
TGU: 
FAB: 
101809241(TGFBR1)
PHI: 
102113190(TGFBR1)
APLA: 
101805328(TGFBR1)
FPG: 
101922518(TGFBR1)
FCH: 
102055038(TGFBR1)
CLV: 
102095465(TGFBR1)
ASN: 
102370778(TGFBR1)
AMJ: 
102560440(TGFBR1)
CMY: 
102942001(TGFBR1)
ACS: 
PBI: 
XLA: 
399295(tgfbr1)
XTR: 
548715(tgfbr1)
DRE: 
560578(tgfbr1a) 792928(tgfbr1b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
550930(babo)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
SMM: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
  Authors
Lutz M, Knaus P
  Title
Integration of the TGF-beta pathway into the cellular signalling network.
  Journal
Cell Signal 14:977-88 (2002)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)

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