KEGG   ORTHOLOGY: K04674Help
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
Cellular senescence
TGF-beta signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Th17 cell differentiation
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Hepatocellular carcinoma
Gastric cancer
Module
M00680  
TGF-beta signaling
Disease
H00018  
Gastric cancer
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04371 Apelin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Cell growth and death
   04218 Cellular senescence
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Cellular community - eukaryotes
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Endocrine system
   04926 Relaxin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Development
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05225 Hepatocellular carcinoma
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05226 Gastric cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Infectious diseases
   05166 HTLV-I infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05142 Chagas disease (American trypanosomiasis)
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzyme-linked receptors [BR:ko01020]
 Receptor serine/threonine kinases
  Type I TGF-beta receptor
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Cytokine receptors [BR:ko04050]
 TGF-beta receptors
  Type I TGF-beta receptor
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7046(TGFBR1)
PTR: 
472992(TGFBR1)
PPS: 
100984463(TGFBR1)
GGO: 
101128510(TGFBR1)
PON: 
100450864(TGFBR1)
NLE: 
100592854(TGFBR1)
MCC: 
714952(TGFBR1)
MCF: 
102115287(TGFBR1)
CSAB: 
103219139(TGFBR1)
RRO: 
104657765(TGFBR1)
RBB: 
108512466(TGFBR1)
CJC: 
100389596(TGFBR1)
SBQ: 
101030583(TGFBR1)
MMU: 
21812(Tgfbr1)
RNO: 
29591(Tgfbr1)
CGE: 
100772727(Tgfbr1)
NGI: 
103744902(Tgfbr1)
HGL: 
101718090(Tgfbr1)
CCAN: 
109691424(Tgfbr1)
OCU: 
100345812(TGFBR1)
TUP: 
102476700(TGFBR1)
CFA: 
481628(TGFBR1)
AML: 
100475698(TGFBR1)
UMR: 
103678627(TGFBR1)
FCA: 
101094057(TGFBR1)
PTG: 
102950020(TGFBR1)
AJU: 
106972043(TGFBR1)
BTA: 
282382(TGFBR1)
BOM: 
102283685(TGFBR1)
BIU: 
109563078(TGFBR1)
PHD: 
102324779(TGFBR1)
CHX: 
102187767(TGFBR1)
OAS: 
554326(TGFBR1)
SSC: 
396665(TGFBR1)
CFR: 
102522485(TGFBR1)
CDK: 
105086891(TGFBR1)
BACU: 
102999446(TGFBR1)
LVE: 
103071954(TGFBR1)
ECB: 
100034117(TGFBR1)
EPZ: 
103555266(TGFBR1)
EAI: 
106842924(TGFBR1)
MYB: 
102241353(TGFBR1)
MYD: 
102765185(TGFBR1)
HAI: 
109386421(TGFBR1)
RSS: 
109446110(TGFBR1)
PALE: 
102880759(TGFBR1)
LAV: 
100656286(TGFBR1)
MDO: 
100011507(TGFBR1)
SHR: 
100913844(TGFBR1)
OAA: 
100092358(TGFBR1)
GGA: 
374094(TGFBR1)
MGP: 
100543917(TGFBR1)
CJO: 
107309773(TGFBR1)
APLA: 
101805328(TGFBR1)
ACYG: 
106038346(TGFBR1)
TGU: 
100230911(TGFBR1)
GFR: 
102037879(TGFBR1)
FAB: 
101809241(TGFBR1)
PHI: 
102113190(TGFBR1)
PMAJ: 
107200568(TGFBR1)
CCW: 
104688870(TGFBR1)
FPG: 
101922518(TGFBR1)
FCH: 
102055038(TGFBR1)
CLV: 
102095465(TGFBR1)
AAM: 
106491015(TGFBR1)
ASN: 
102370778(TGFBR1)
AMJ: 
102568992(TGFBR1)
CMY: 
102942001(TGFBR1)
CPIC: 
101944287(TGFBR1)
ACS: 
100566944(tgfbr1)
PVT: 
110086076(TGFBR1)
PBI: 
GJA: 
107109116(TGFBR1)
XLA: 
108719029 399295(tgfbr1.S)
XTR: 
548715(tgfbr1)
NPR: 
108799247(TGFBR1)
DRE: 
560578(tgfbr1a) 792928(tgfbr1b)
SRX: 
SANH: 
SGH: 
IPU: 
108271704(tgfbr1)
AMEX: 
TRU: 
TNG: 
LCO: 
104920074(acvr1c) 104931778(tgfbr1)
NCC: 
MZE: 
101479229(tgfbr1)
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102350402(TGFBR1)
CMK: 
CIN: 
445775(tgfbr-ic)
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10620(Dsim_GD10620)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
CQU: 
AME: 
550930(babo)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
659969(babo)
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
EPA: 
ADF: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8242743
  Authors
Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K
  Title
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
  Journal
Cell 75:681-92 (1993)
DOI:10.1016/0092-8674(93)90489-D
  Sequence
[hsa:7046]

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