KEGG   ORTHOLOGY: K04692Help
Entry
K04692                      KO                                     

Name
STAT3
Definition
signal transducer and activator of transcription 3
Pathway
EGFR tyrosine kinase inhibitor resistance
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Necroptosis
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Th17 cell differentiation
Prolactin signaling pathway
Adipocytokine signaling pathway
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Toxoplasmosis
Hepatitis C
Hepatitis B
Measles
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Acute myeloid leukemia
Non-small cell lung cancer
Inflammatory bowel disease (IBD)
Module
M00684  
JAK-STAT signaling
Disease
H00016  
Oral cancer
H00107  
Other well-defined immunodeficiency syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04066 HIF-1 signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04068 FoxO signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    K04692  STAT3; signal transducer and activator of transcription 3
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04692  STAT3; signal transducer and activator of transcription 3
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04692  STAT3; signal transducer and activator of transcription 3
   04062 Chemokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
  Endocrine system
   04920 Adipocytokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04917 Prolactin signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05206 MicroRNAs in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05205 Proteoglycans in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05203 Viral carcinogenesis
    K04692  STAT3; signal transducer and activator of transcription 3
   05212 Pancreatic cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05221 Acute myeloid leukemia
    K04692  STAT3; signal transducer and activator of transcription 3
   05223 Non-small cell lung cancer
    K04692  STAT3; signal transducer and activator of transcription 3
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K04692  STAT3; signal transducer and activator of transcription 3
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K04692  STAT3; signal transducer and activator of transcription 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04692  STAT3; signal transducer and activator of transcription 3
  Infectious diseases
   05162 Measles
    K04692  STAT3; signal transducer and activator of transcription 3
   05161 Hepatitis B
    K04692  STAT3; signal transducer and activator of transcription 3
   05160 Hepatitis C
    K04692  STAT3; signal transducer and activator of transcription 3
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05169 Epstein-Barr virus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05145 Toxoplasmosis
    K04692  STAT3; signal transducer and activator of transcription 3
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04692  STAT3; signal transducer and activator of transcription 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04692  STAT3; signal transducer and activator of transcription 3
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   STAT
    K04692  STAT3; signal transducer and activator of transcription 3
BRITE hierarchy
Genes
HSA: 
6774(STAT3)
PTR: 
454682(STAT3)
PPS: 
100987766(STAT3)
GGO: 
101135038(STAT3)
PON: 
100171541(STAT3)
NLE: 
100598877(STAT3)
MCC: 
574128(STAT3)
MCF: 
102118402(STAT3)
CSAB: 
103243410(STAT3)
RRO: 
104680286(STAT3)
RBB: 
108518318(STAT3)
CJC: 
100389282(STAT3)
SBQ: 
101049662(STAT3)
MMU: 
20848(Stat3)
RNO: 
25125(Stat3)
CGE: 
100755865(Stat3)
NGI: 
103735896(Stat3)
HGL: 
101721899(Stat3)
CCAN: 
109687324(Stat3)
OCU: 
100348778(STAT3)
TUP: 
102492738(STAT3)
CFA: 
490967(STAT3)
AML: 
100469938(STAT3)
UMR: 
103672573(STAT3)
FCA: 
101095698(STAT3)
PTG: 
102957987(STAT3)
AJU: 
106972608(STAT3)
BTA: 
508541(STAT3)
BOM: 
102282282(STAT3)
BIU: 
109573817(STAT3)
PHD: 
102339359(STAT3)
CHX: 
102186154(STAT3)
OAS: 
100294659(STAT3)
SSC: 
733648(STAT3)
CFR: 
102520228(STAT3)
CDK: 
105090458(STAT3)
BACU: 
LVE: 
103086495(STAT3)
ECB: 
100034011(STAT3)
EPZ: 
103550364(STAT3)
EAI: 
106826327(STAT3)
MYB: 
102239853(STAT3)
MYD: 
102752037(STAT3)
HAI: 
109395763(STAT3)
RSS: 
109455843(STAT3)
PALE: 
102884374(STAT3)
LAV: 
100669583(STAT3)
MDO: 
100011382(STAT3)
SHR: 
100933581(STAT3)
GGA: 
420027(STAT3)
MGP: 
100547142(STAT3)
CJO: 
107325206(STAT3)
APLA: 
101790010(STAT3)
ACYG: 
106048026(STAT3)
TGU: 
100219856(STAT3)
GFR: 
102036392(STAT3)
FAB: 
101809631(STAT3)
PHI: 
102101801(STAT3)
PMAJ: 
107215123(STAT3)
CCW: 
104697761(STAT3)
FPG: 
101917971(STAT3)
FCH: 
102053408(STAT3)
CLV: 
102090191(STAT3)
AAM: 
106491102(STAT3)
ASN: 
102381312(STAT3)
AMJ: 
102575901(STAT3)
PSS: 
102460388(STAT3)
CMY: 
102932633(STAT3)
CPIC: 
101952372(STAT3)
ACS: 
100566559(stat3)
PVT: 
110074829(STAT3)
PBI: 
103059982(STAT3)
GJA: 
107111493(STAT3)
XLA: 
108702168 108702458 379264(stat3.2.L) 779100(stat3.1.L)
XTR: 
100498278(stat3.1) 100498547(stat3.2)
NPR: 
108792989(STAT3)
DRE: 
30767(stat3)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
103033344(stat3)
TRU: 
101070968(stat3)
LCO: 
104925957(stat3)
NCC: 
MZE: 
101479682(stat2) 101480689(stat3)
OLA: 
100049477(stat3)
XMA: 
102226045(stat3) 102236235(stat2)
CSEM: 
LCF: 
108901193(stat3)
HCQ: 
109513792(stat3)
BPEC: 
110159498(stat3)
SASA: 
ELS: 
105013350(stat3)
SFM: 
LCM: 
102365345(STAT3)
CMK: 
103189176(stat3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, Shih HM, Kung HJ, Chen RH
  Title
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
  Journal
Mol Cell Biol 20:2043-54 (2000)
DOI:10.1128/MCB.20.6.2043-2054.2000
  Sequence
[hsa:6774]
Reference
PMID:7512451
  Authors
Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T
  Title
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
  Journal
Cell 77:63-71 (1994)
DOI:10.1016/0092-8674(94)90235-6
  Sequence
[hsa:6774]

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