KEGG ORTHOLOGY: K04936

ORTHOLOGY: K04936

Entry

K04936                      KO

Symbol

KCNMA1, KCA1.1

Name

potassium large conductance calcium-activated channel subfamily M alpha member 1

Pathway

map04022

cGMP-PKG signaling pathway

map04270

Vascular smooth muscle contraction

map04911

Insulin secretion

map04924

Renin secretion

map04970

Salivary secretion

map04972

Pancreatic secretion

Disease

H00808

Idiopathic generalized epilepsies

H01258

Generalized epilepsy and paroxysmal dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
   04924 Renin secretion
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
  09154 Digestive system
   04970 Salivary secretion
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
   04972 Pancreatic secretion
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   K04936  KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1

Other DBs

GO:

0015269

TC:	1.A.1.3.1 1.A.1.3.2 1.A.1.3.3

Genes

HSA:	3778(KCNMA1)

PTR:	466115(KCNMA1)

PPS:	100978771(KCNMA1)

GGO:	101153410(KCNMA1)

NLE:	100589545(KCNMA1)

HMH:	116459993(KCNMA1)

MCC:	574103(KCNMA1)

MCF:	102139202(KCNMA1)

MTHB:

126962412

MNI:	105465975(KCNMA1)

CSAB:

103215949(KCNMA1)

CATY:

105597466(KCNMA1)

TGE:	112631183(KCNMA1)

MLEU:

105535686(KCNMA1)

RRO:	104662238(KCNMA1)

RBB:	108529255(KCNMA1)

TFN:	117082813(KCNMA1)

PTEH:

111537811(KCNMA1)

CANG:

105502272(KCNMA1)

CJC:	100402638(KCNMA1)

SBQ:	101035009(KCNMA1)

CSYR:

103261382(KCNMA1)

LCAT:

123650054(KCNMA1)

PCOQ:

105825508(KCNMA1)

OGA:	100966844(KCNMA1)

MMU:	16531(Kcnma1)

MCAL:

110309908(Kcnma1)

MPAH:

110325018(Kcnma1)

RNO:	83731(Kcnma1)

MCOC:

116084252(Kcnma1)

MUN:	110562795(Kcnma1)

CGE:	100764731(Kcnma1)

MAUA:

101843799(Kcnma1)

PROB:

127214364(Kcnma1)

PLEU:

114700183(Kcnma1)

MORG:

121434854(Kcnma1)

MFOT:

126491556

AAMP:

119800438(Kcnma1)

NGI:	103747438(Kcnma1)

HGL:	101726007(Kcnma1)

CPOC:

100728344(Kcnma1)

CCAN:

109684792

DORD:

105992679(Kcnma1)

DSP:	122116532(Kcnma1)

PLOP:

125346504(Kcnma1)

NCAR:

124984496

MMMA:

107158118(Kcnma1)

OCU:	100008745(KCNMA1)

OPI:	101521547(KCNMA1)

TUP:	102471296(KCNMA1)

GVR:	103596161(KCNMA1)

CFA:	403984(KCNMA1)

CLUD:

112651925(KCNMA1)

VVP:	112924709(KCNMA1)

VLG:	121487239(KCNMA1)

NPO:	129509862(KCNMA1)

AML:	100473263(KCNMA1)

UMR:	103668030(KCNMA1)

UAH:	113259211(KCNMA1)

UAR:	123782863(KCNMA1)

ELK:

111144685

LLV:

125084505

MPUF:

101692757(KCNMA1)

MNP:	132016538(KCNMA1)

MLK:	131828787(KCNMA1)

NVS:	122900823(KCNMA1)

ORO:	101374985(KCNMA1)

EJU:	114214133(KCNMA1)

ZCA:	113923402(KCNMA1)

MLX:	118022052(KCNMA1)

NSU:	110589197(KCNMA1)

FCA:	101099080(KCNMA1)

PYU:	121036835(KCNMA1)

PCOO:

112854602(KCNMA1)

PBG:	122492894(KCNMA1)

PVIV:

125147913(KCNMA1)

LRUF:

124506931

PTG:	102949074(KCNMA1)

PPAD:

109264456(KCNMA1)

PUC:

125933120

AJU:

106969710

HHV:	120233744 120237306

BTA:	282573(KCNMA1)

BOM:	102270859(KCNMA1)

BIU:	109553636(KCNMA1)

BBUB:

102397404(KCNMA1)

BBIS:

104984462(KCNMA1)

CHX:	102186276(KCNMA1)

OAS:	100270685(KCNMA1)

BTAX:

128047934(KCNMA1)

ODA:	120865253(KCNMA1)

CCAD:

122446347(KCNMA1)

MBEZ:

129555678(KCNMA1)

SSC:	397434(KCNMA1)

CFR:	102509654(KCNMA1)

CBAI:

105075342(KCNMA1)

CDK:	105092432(KCNMA1)

VPC:	102546173(KCNMA1)

BACU:

103020151(KCNMA1)

BMUS:

118882984(KCNMA1)

LVE:

103072349

OOR:	101271854(KCNMA1)

DLE:	111183580(KCNMA1)

PCAD:

102986016(KCNMA1)

PSIU:

116741577(KCNMA1)

NASI:

112396490(KCNMA1)

ECB:	100064366(KCNMA1)

EPZ:	103550311(KCNMA1)

EAI:	106828419(KCNMA1)

MYB:	102242737(KCNMA1)

MYD:	102763054(KCNMA1)

MMYO:

118670184(KCNMA1)

MLF:	102422084(KCNMA1)

PKL:	118719103(KCNMA1)

EFUS:

103289441(KCNMA1)

MNA:	107545799(KCNMA1)

DRO:	112305509(KCNMA1)

SHON:

118993855(KCNMA1)

AJM:	119038124(KCNMA1)

PDIC:

114497318(KCNMA1)

PHAS:

123820868(KCNMA1)

PPAM:

129069848(KCNMA1)

HAI:	109390493(KCNMA1)

RFQ:	117035928(KCNMA1)

PALE:

102894757(KCNMA1)

PGIG:

120609569(KCNMA1)

PVP:	105288884(KCNMA1)

RAY:	107518064(KCNMA1)

MJV:	108402086(KCNMA1)

TOD:	119234626(KCNMA1)

SARA:

101540412(KCNMA1)

SETR:

126031353(KCNMA1)

LAV:	100656201(KCNMA1)

TMU:

101341595

ETF:	101650522(KCNMA1)

DNM:	101436114(KCNMA1)

MDO:	100013395(KCNMA1)

GAS:	123232932(KCNMA1)

SHR:	100922504(KCNMA1)

AFZ:

127551880

PCW:	110221426(KCNMA1)

OAA:	100079144(KCNMA1)

GGA:	374065(KCNMA1)

PCOC:

116235069(KCNMA1)

MGP:	100550498(KCNMA1)

CJO:	107315852(KCNMA1)

TPAI:

128077496(KCNMA1)

LMUT:

125693975(KCNMA1)

NMEL:

110399692(KCNMA1)

APLA:

101792241(KCNMA1)

ACYG:

106032783(KCNMA1)

CATA:

118246746(KCNMA1)

AFUL:

116491480(KCNMA1)

TGU:	100227091(KCNMA1)

LSR:	110471744(KCNMA1)

SCAN:

103814013(KCNMA1)

PMOA:

120510966(KCNMA1)

OTC:	121336176(KCNMA1)

PRUF:

121357945(KCNMA1)

GFR:	102039116(KCNMA1)

FAB:	101808418(KCNMA1)

OMA:	130254767(KCNMA1)

PHI:	102099683(KCNMA1)

PMAJ:

107199677(KCNMA1)

CCAE:

111931041(KCNMA1)

CCW:	104697623(KCNMA1)

CBRC:

103623694(KCNMA1)

ETL:

114055902

ZAB:	102061365(KCNMA1)

SVG:	106859436(KCNMA1)

MMEA:

130573044(KCNMA1)

HRT:	120756145(KCNMA1)

FPG:	101915596(KCNMA1)

FCH:	102050777(KCNMA1)

CLV:	102089237(KCNMA1)

EGZ:	104129096(KCNMA1)

NNI:	104015238(KCNMA1)

EHS:	104511321(KCNMA1)

ACUN:

113481413(KCNMA1)

TALA:

104368567(KCNMA1)

PADL:

103920867(KCNMA1)

AFOR:

103897576(KCNMA1)

ACHC:

115348165(KCNMA1)

HALD:

104323496(KCNMA1)

HLE:	104831920(KCNMA1)

AGEN:

126042636

GCL:

127017722

CMAC:

104476156(KCNMA1)

MUI:	104537166(KCNMA1)

LDI:

104346251

OHA:	104333626(KCNMA1)

SHAB:

115607893(KCNMA1)

DPUB:

104297654(KCNMA1)

PGUU:

104468096(KCNMA1)

CPEA:

104391449(KCNMA1)

AVIT:

104279402

CVF:	104289663(KCNMA1)

RTD:	128910792(KCNMA1)

CUCA:

104067993(KCNMA1)

TEO:

104373747

BRHI:

104490944

AAM:	106498905(KCNMA1)

AROW:

112961142(KCNMA1)

NPD:	112951450(KCNMA1)

TGT:	104568611(KCNMA1)

DNE:	112993320(KCNMA1)

SCAM:

104142450(KCNMA1)

ASN:	102383994(KCNMA1)

AMJ:	106736888(KCNMA1)

CPOO:

109323868(KCNMA1)

GGN:	109287362(KCNMA1)

PSS:	102443545(KCNMA1)

CMY:	102943582(KCNMA1)

CCAY:

125639405(KCNMA1)

DCC:	119858512(KCNMA1)

CPIC:

101935665(KCNMA1)

TST:	117880990(KCNMA1)

CABI:

116817576(KCNMA1)

MRV:	120369293(KCNMA1)

ACS:	100553783(kcnma1)

ASAO:

132771289(KCNMA1)

PVT:	110080331(KCNMA1)

SUND:

121924977(KCNMA1)

PBI:	103067321(KCNMA1)

PMUR:

107294560

CTIG:

120310651

TSR:

106543426

PGUT:

117669488(KCNMA1)

PTEX:

113443035(KCNMA1)

NSS:	113419122(KCNMA1)

VKO:	123018319(KCNMA1)

PRAF:

128413725(KCNMA1)

ZVI:	118096077(KCNMA1)

HCG:	128348851(KCNMA1)

GJA:	107114736(KCNMA1)

STOW:

125437088(KCNMA1)

EMC:	129331904(KCNMA1)

XLA:	373712(kcnma1.L)

XTR:	100491898(kcnma1)

NPR:	108788403(KCNMA1)

RTEM:

120909031(KCNMA1)

BBUF:

121006158(KCNMA1)

BGAR:

122941637(KCNMA1)

MUO:	115470236(KCNMA1)

GSH:	117358932(KCNMA1)

DRE:	568554(kcnma1a) 798583(kcnma1b)

SRX:	107708442 107718678 107747466 107748344

SANH:

107659644 107676421 107678532 107698159

SGH:	107582501 107589535 107595209 107597763

CCAR:

109077134 109096456 109101175 109101176(kcnma1)

CAUA:

113055774 113057177 113111377 113112952

CGIB:

127968803 127970003 128025546 128026419

PTET:

122333525 122356634 122356635

LROH:

127173793 127174964(kcnma1a)

OMC:	131550869 131552754(kcnma1a)

PPRM:

120462114 120479328(kcnma1a)

RKG:	130078461 130083119(kcnma1a)

MAMB:

125254972 125276641(kcnma1a)

CIDE:

127523192

MASI:

127412089 127413832 127423501 127426643

TROS:

130559212(kcnma1a) 130569511

TDW:	130431394(kcnma1a) 130439152

MANU:

129416484(kcnma1a) 129420586

IPU:	108263740(kcnma1a) 108273798

IFU:	128605546(kcnma1a) 128616844

PHYP:

113524874 113541005

SMEO:

124375341(kcnma1a) 124388457

TFD:	113634796 113639837(kcnma1a)

TVC:	132847248(kcnma1a) 132861367

AMEX:

103038321 103039470(kcnma1) 111197389

CMAO:

118809003 118810346(kcnma1a) 118827632

EEE:	113576346 113576347 113576349 113576350 113578927 113582898 113582905 113589032

CHAR:

105889881 105909674(kcnma1a) 105912905

TRU:	101064381 101078302(kcnma1)

TFS:	130534143(kcnma1a) 130535860

TNG:	GSTEN00016416G001 GSTEN00024660G001

LCO:	104930360 104930626

NCC:	104955367 104967399

TBEN:

117473796 117499515

CGOB:

115020475 115025038

PGEO:

117459588 117464534

GACU:

117543371 117560771(kcnma1a)

EMAC:

134858772(kcnma1a) 134871237

ELY:	117247532 117248230

EFO:	125881277 125903104(kcnma1a)

PLEP:

121954844(kcnma1a) 121959156

SLUC:

116054775(kcnma1a) 116060962

ECRA:

117937096 117960548(kcnma1a)

ESP:	116671648 116705702

PFLV:

114548337 114571764

GAT:	100462705(kcnma1a) 100462713

PPUG:

119213001 119214165(kcnma1a)

AFB:	129091718 129092818(kcnma1a)

CLUM:

117743876(kcnma1a) 117748667

PSWI:

130203158 130206922

MSAM:

119916055 119916898(kcnma1a)

SCHU:

122867222 122884388(kcnma1a)

CUD:	121511455(kcnma1a) 121528074

ALAT:

119009716 119033173(kcnma1a)

MZE:	101474300 101488046

ONL:	100692364(kcnma1) 100703246

OAU:	116309897(kcnma1a) 116327464

OLA:	101155390(kcnma1) 101174692

OML:	112154175 112161478(kcnma1a)

CSAI:

133419317 133463728(kcnma1a)

XMA:	102216920 102225404

XCO:	114137551 114151845

XHE:	116713775 116727519

PRET:

103476821 103481816(kcnma1)

PFOR:

103133502 103142316

PLAI:

106944667 106949528

PMEI:

106917953 106919544

GAF:	122823516 122842999(kcnma1a)

PPRL:

129359963(kcnma1a) 129367878

CVG:	107089490 107092828

CTUL:

119774917 119788566(kcnma1a)

GMU:	124859519(kcnma1a) 124875148

NFU:	107376042 107387848(kcnma1)

KMR:	108243866(kcnma1a) 108247925

ALIM:

106515337(kcnma1) 106517014

NWH:	119413082(kcnma1a) 119424021

AOCE:

111574789 111587260(kcnma1)

MCEP:

125018773(kcnma1a) 125022175

CSEM:

103381911(kcnma1) 103386992

POV:	109626875 109634297

SSEN:

122759084 122781676

HHIP:

117752546 117775033(kcnma1a)

HSP:	118100200 118118810(kcnma1a)

SMAU:

118284031(kcnma1a) 118287080

LCF:	108897232(kcnma1a) 108899034

SDU:	111219727 111235220

SLAL:

111657121 111670059

XGL:	120794835 120796280(kcnma1a)

HCQ:	109512391(kcnma1)

SSCV:

125978999 125991087

SBIA:

133495445 133510019(kcnma1a)

PEE:	133409623(kcnma1a) 133417562

PTAO:

133469744 133486117(kcnma1a)

BPEC:

110163239 110173610

MALB:

109961943 109963052

BSPL:

114845677 114870627

SJO:	128373149(kcnma1a) 128380949

SASA:

106577193 106585114 106589905 106611671 106613356

STRU:

115153363 115153540 115164286 115193575 115201715

OTW:	112224696 112248660 112251626 112256167(kcnma1a) 112258082

OMY:	100301648 100301649 100301650 110503104(kcnma1a) 110525875

OGO:	124034157 124038361 124038495 124040425 124041120

ONE:	115111781 115113835 115113856 115119800

OKI:	109882135 109890060 109899813 109899946

OKE:	118357681 118369425 118371387 118379065 118393401

SALP:

111951745 111951890 111974981 111977944 111978374 112069277

SNH:	120017966 120029580 120045928 120046735 120051458

CCLU:

121547750 121553222 121574320 121576253 121585032

ELS:	105010141 105010599

SFM:	108920903 108939557(kcnma1)

PKI:	111839611 111841957

AANG:

118217910(kcnma1a) 118219574

LOC:	102687607 102695720(kcnma1)

PSPA:

121303021 121321825 121325589

ARUT:

117397775 117415708 117418354 117966086

PSEX:

120541439(kcnma1a)

LCM:	102354999(KCNMA1)

CMK:	103181796(kcnma1a)

CPLA:

122541861(kcnma1a) 122542962

HOC:	132834900(kcnma1a) 132836919

LERI:

129712918(kcnma1a) 129713289

PMRN:

116940353 116945031

LRJ:	133341908 133350524(KCNMA1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG10693(slo)

DER:

6554692

DSE:

6607786

DSI:	Dsimw501_GD21120(Dsim_GD21120)

DYA:	Dyak_GE23506

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24019(Dmoj_slo)

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108359571 108379453 108380248

AOQ:

129236084

TDA:

119680541

MDE:	101896394 131806527

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005769

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100122182(Slo)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200122

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:	128990621 128990690

PHU:	Phum_PHUM221720

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_313756

DMK:

116931518

DPZ:

124349241

PVM:	113802902 113807409

PJA:	122242435 122249360

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111699332 111700206 111710629 111713653

LSM:	121113620 121127049

TCF:	131891459 131892409

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:	124497120 124499799

CSCU:

111630243 111633310

PTEP:

107437872 107441522

ABRU:

129962640 129967157

UDV:	129216255 129221512

SDM:	118179995 118194290

LPOL:

106459536 106460285 106478146 106478382

PMEO:

129583521 129584554 129584598 129584700 129584727 129585174 129586757 129587381 129591389 129593433 129593721 129597593 129597647 129598352 129600564 129602083

CEL:	CELE_Y51A2D.19(slo-1)

CBR:	CBG_12923(Cbr-slo-1)

CRQ:	GCK72_022034

NAI:	NECAME_08093

TSP:	Tsp_10880 Tsp_10882

HRO:	HELRODRAFT_64618

LGI:	LOTGIDRAFT_111687

PVUL:

126809837

PCAN:

112576630

BGT:	106056525 106056545

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_166620 Smp_166910

SHX:	MS3_00003037

OVI:	T265_03018 T265_13931

EGL:	EGR_03683 EGR_06404 EGR_07380

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	101236626 105848876

HSY:	130647627 130647632

TAD:	TRIADDRAFT_23687

AQU:

105314193

PPP:	112278454 112285717 112289293

DDI:	DDB_G0269896(kcnma1)

DPP:	DICPUDRAFT_98532

DFA:	DFA_05869(kcnma1)

SMIN:

v1.2.029291.t1(symbB.v1.2.029291.t1)

PSOJ:

PHYSODRAFT_535373

SPAR:

SPRG_03227

NGR:	NAEGRDRAFT_62424

» show all

Reference

PMID:11880485

Authors

Wang YW, Ding JP, Xia XM, Lingle CJ

Title

Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.

Journal

J Neurosci 22:1550-61 (2002)
DOI:10.1523/JNEUROSCI.22-05-01550.2002

Sequence

[hsa:3778]

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Ontology (6)   
   KEGG BRITE (2)   
   GO (1)   
   TC (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (7373)   
   KEGG GENES (851)   
   KEGG MGENES (807)   
   RefGene (5705)   
   OC (10)   
Literature (1)   
   PubMed (1)   
All databases (7394)   

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