KEGG   ORTHOLOGY: K04959
Entry
K04959                      KO                                     
Symbol
ITPR2
Name
inositol 1,4,5-triphosphate receptor type 2
Pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04070  Phosphatidylinositol signaling system
map04114  Oocyte meiosis
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04380  Osteoclast differentiation
map04540  Gap junction
map04611  Platelet activation
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04750  Inflammatory mediator regulation of TRP channels
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map05010  Alzheimer disease
map05012  Parkinson disease
map05017  Spinocerebellar ataxia
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05205  Proteoglycans in cancer
Disease
H02281  Isolated anhidrosis with normal sweat glands
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04020 Calcium signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04070 Phosphatidylinositol signaling system
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04022 cGMP-PKG signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04210 Apoptosis
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04218 Cellular senescence
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04621 NOD-like receptor signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04625 C-type lectin receptor signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04929 GnRH secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04912 GnRH signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04915 Estrogen signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04921 Oxytocin signaling pathway
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04935 Growth hormone synthesis, secretion and action
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04918 Thyroid hormone synthesis
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04928 Parathyroid hormone synthesis, secretion and action
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04924 Renin secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04925 Aldosterone synthesis and secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04927 Cortisol synthesis and secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09154 Digestive system
   04970 Salivary secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04971 Gastric acid secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04972 Pancreatic secretion
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09156 Nervous system
   04724 Glutamatergic synapse
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04725 Cholinergic synapse
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04728 Dopaminergic synapse
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04726 Serotonergic synapse
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04720 Long-term potentiation
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04730 Long-term depression
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   04723 Retrograde endocannabinoid signaling
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05163 Human cytomegalovirus infection
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05012 Parkinson disease
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05017 Spinocerebellar ataxia
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05020 Prion disease
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
Ion channels [BR:ko04040]
 Ligand-gated channels
  IP3 receptor
   K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
Other DBs
GO: 0005220
TC: 1.A.3.2
Genes
HSA: 3709(ITPR2)
PTR: 473389(ITPR2)
PPS: 100980378(ITPR2)
GGO: 101151502(ITPR2)
PON: 100434318(ITPR2)
NLE: 100599135(ITPR2)
HMH: 116472793(ITPR2)
MCC: 708714(ITPR2)
MCF: 102115744(ITPR2)
MTHB: 126930046
MNI: 105492154(ITPR2)
CSAB: 103218776(ITPR2)
CATY: 105601409(ITPR2)
PANU: 101023200(ITPR2)
TGE: 112634518(ITPR2)
MLEU: 105555461(ITPR2)
RRO: 104675331(ITPR2)
RBB: 108523739(ITPR2)
TFN: 117090367(ITPR2)
PTEH: 111540617(ITPR2)
CANG: 105515211(ITPR2)
CJC: 118144170(ITPR2)
SBQ: 101049881(ITPR2)
CIMI: 108288162(ITPR2)
CSYR: 103261167(ITPR2)
MMUR: 105857276(ITPR2)
LCAT: 123639915(ITPR2)
PCOQ: 105807599(ITPR2)
OGA: 100954512(ITPR2)
MMU: 16439(Itpr2)
MCAL: 110295833(Itpr2)
MPAH: 110317251(Itpr2)
RNO: 81678(Itpr2)
MCOC: 116099798(Itpr2)
ANU: 117714743(Itpr2)
MUN: 110558908(Itpr2)
CGE: 100758965(Itpr2)
MAUA: 101835945(Itpr2)
PROB: 127213143(Itpr2)
PLEU: 114708393(Itpr2)
MORG: 121433763(Itpr2)
MFOT: 126515231
AAMP: 119806213(Itpr2)
HGL: 101716022(Itpr2)
CPOC: 100717278(Itpr2)
CCAN: 109674831 109687056
DORD: 106001099(Itpr2)
DSP: 122100994(Itpr2)
PLOP: 125342841(Itpr2)
NCAR: 124983533
MMMA: 107152732(Itpr2)
OCU: 100356806
OPI: 101526097(ITPR2)
TUP: 102482868(ITPR2)
CFA: 486628(ITPR2)
CLUD: 112665544(ITPR2)
VVP: 112917203(ITPR2)
VLG: 121479635(ITPR2)
NPO: 129505465(ITPR2)
AML: 100477888(ITPR2)
UMR: 103665275(ITPR2)
UAH: 113257782(ITPR2)
UAR: 123801684(ITPR2)
ELK: 111159979
LLV: 125107116
MPUF: 101684131(ITPR2)
MNP: 132019550(ITPR2)
MLK: 131838936(ITPR2)
NVS: 122891087(ITPR2)
ORO: 101377380(ITPR2)
EJU: 114216613(ITPR2)
ZCA: 113921922(ITPR2)
MLX: 118025560(ITPR2)
NSU: 110580957(ITPR2)
LWW: 102735685(ITPR2)
FCA: 101101230(ITPR2)
PYU: 121038795(ITPR2)
PCOO: 112867360(ITPR2)
PBG: 122472170(ITPR2)
PVIV: 125169550(ITPR2)
LRUF: 124501326
PTG: 102971840(ITPR2)
PPAD: 109268756(ITPR2)
PUC: 125920161
AJU: 106968786
HHV: 120237482(ITPR2)
BTA: 281878(ITPR2)
BOM: 102269013(ITPR2)
BIU: 109558547(ITPR2)
BBUB: 102401062(ITPR2)
BBIS: 105000232(ITPR2)
CHX: 102170858(ITPR2)
OAS: 101113317(ITPR2)
BTAX: 128048527(ITPR2)
ODA: 120858499(ITPR2)
CCAD: 122423671(ITPR2)
MBEZ: 129536224(ITPR2)
SSC: 100517279(ITPR2)
CFR: 102517295(ITPR2)
CBAI: 105062304(ITPR2)
CDK: 105102013(ITPR2)
VPC: 102529461(ITPR2)
BACU: 103018280(ITPR2)
BMUS: 118901583(ITPR2)
LVE: 103078697(ITPR2)
OOR: 101281155(ITPR2)
DLE: 111176861(ITPR2)
PCAD: 102984842(ITPR2)
PSIU: 116760890(ITPR2)
NASI: 112391770(ITPR2)
ECB: 100064557(ITPR2)
EPZ: 103546630(ITPR2) 103548182
EAI: 106834887(ITPR2)
MYB: 102256216(ITPR2)
MMYO: 118652119(ITPR2)
MLF: 102422734(ITPR2)
PKL: 118730836(ITPR2)
EFUS: 103285158(ITPR2)
MNA: 107525255(ITPR2)
DRO: 112318382(ITPR2)
SHON: 118978442(ITPR2)
AJM: 119048995(ITPR2)
PDIC: 114513086(ITPR2)
PHAS: 123812354(ITPR2)
MMF: 118623451(ITPR2)
PPAM: 129084965(ITPR2)
HAI: 109372316
RFQ: 117028439(ITPR2)
PALE: 102896356(ITPR2)
PGIG: 120618337(ITPR2)
PVP: 105294112(ITPR2)
RAY: 107497427(ITPR2)
MJV: 108403293(ITPR2)
TOD: 119247621(ITPR2)
SARA: 101556630(ITPR2)
SETR: 126022840(ITPR2)
LAV: 100667845(ITPR2)
TMU: 101356404
ETF: 101638553(ITPR2)
DNM: 101423325(ITPR2)
MDO: 100010212(ITPR2)
GAS: 123250011(ITPR2)
SHR: 100921270(ITPR2)
AFZ: 127539174
PCW: 110193334(ITPR2)
OAA: 103164954(ITPR2)
GGA: 418212(ITPR2)
PCOC: 116231423(ITPR2)
MGP: 100551445(ITPR2)
CJO: 107316928(ITPR2)
TPAI: 128084490(ITPR2)
LMUT: 125688029(ITPR2)
NMEL: 110396437(ITPR2)
APLA: 101791934(ITPR2)
ACYG: 106038242
CATA: 118245143(ITPR2)
AFUL: 116488562(ITPR2)
TGU: 100230706(ITPR2)
LSR: 110474888(ITPR2)
SCAN: 103819592(ITPR2)
PMOA: 120501588(ITPR2)
OTC: 121332088(ITPR2)
PRUF: 121354266(ITPR2)
GFR: 102036319(ITPR2)
FAB: 101811180(ITPR2)
OMA: 130265231(ITPR2)
PHI: 102112318(ITPR2)
PMAJ: 107204618(ITPR2)
CCAE: 111930014(ITPR2)
CCW: 104696157(ITPR2)
CBRC: 103623356(ITPR2)
ETL: 114064981(ITPR2)
ZAB: 102062691(ITPR2)
ACHL: 103805612
SVG: 106860950(ITPR2)
MMEA: 130576119(ITPR2)
HRT: 120751508(ITPR2)
FPG: 101920370
FCH: 102052635(ITPR2)
CLV: 102096683(ITPR2)
EGZ: 104135140(ITPR2)
NNI: 104012694(ITPR2)
PCRI: 104029680
PCAO: 104053012
ACUN: 113489114(ITPR2)
TALA: 104360363(ITPR2)
PADL: 103924320(ITPR2)
AFOR: 103898700(ITPR2)
ACHC: 115352454(ITPR2)
HALD: 104315324(ITPR2)
HLE: 104836698(ITPR2)
AGEN: 126047976
GCL: 127029777
CMAC: 104481042
MUI: 104547733(ITPR2)
BREG: 104641733(ITPR2)
GSTE: 104257964(ITPR2)
OHA: 104335261(ITPR2)
NNT: 104401715
SHAB: 115604669(ITPR2)
DPUB: 104305160(ITPR2)
PGUU: 104469213
CPEA: 104394556(ITPR2)
CVF: 104281650(ITPR2)
RTD: 128904284(ITPR2)
CUCA: 104067151(ITPR2)
TEO: 104374801
AAM: 106488657
AROW: 112966593(ITPR2)
NPD: 112950663(ITPR2)
DNE: 112991504(ITPR2)
SCAM: 104154123(ITPR2)
ASN: 102379727
AMJ: 102570264(ITPR2)
CPOO: 109316376(ITPR2)
GGN: 109296316(ITPR2)
PSS: 102453428(ITPR2)
CMY: 102942754(ITPR2)
CCAY: 125624778(ITPR2)
DCC: 119850635(ITPR2)
CPIC: 101931123(ITPR2)
TST: 117883546(ITPR2)
CABI: 116817304(ITPR2)
MRV: 120407194(ITPR2)
ACS: 100567982(itpr2)
ASAO: 132776516(ITPR2)
PVT: 110081241(ITPR2)
SUND: 121932190(ITPR2)
PBI: 103058322
PMUR: 107296465(ITPR2)
CTIG: 120314459(ITPR2)
PGUT: 117668319(ITPR2)
APRI: 131201668(ITPR2)
PTEX: 113436405(ITPR2)
NSS: 113412319(ITPR2)
VKO: 123019935(ITPR2)
PMUA: 114604922(ITPR2)
PRAF: 128421863(ITPR2)
ZVI: 118091007(ITPR2)
HCG: 128326332(ITPR2)
GJA: 107125949(ITPR2)
STOW: 125434869(ITPR2)
EMC: 129335399(ITPR2)
XLA: 108710178
XTR: 100124748(itpr2)
NPR: 108786728(ITPR2)
RTEM: 120932834(ITPR2)
BBUF: 121003741(ITPR2)
BGAR: 122928526(ITPR2)
MUO: 115477466
GSH: 117363742(ITPR2)
DRE: 562585(itpr2)
SRX: 107730567(itpr2) 107740421
SANH: 107672258 107686324
SGH: 107553933(itpr2) 107583890
CCAR: 109045995 109051794
CAUA: 113061517 113118284(itpr2)
CGIB: 127934719 127976986
PTET: 122362645
LROH: 127180437(itpr2)
OMC: 131524125(itpr2)
PPRM: 120462004(itpr2)
RKG: 130094764(itpr2)
MAMB: 125254454(itpr2)
CIDE: 127499474
MASI: 127417299 127456513
TROS: 130562404(itpr2)
TDW: 130435226(itpr2)
MANU: 129418804(itpr2)
IPU: 108264307
IFU: 128606629(itpr2)
PHYP: 113534384(itpr2)
SMEO: 124396223(itpr2)
TFD: 113652405(itpr2)
TVC: 132851296(itpr2)
AMEX: 103025600
CMAO: 118818001(itpr2)
EEE: 113590571
CHAR: 105898040(itpr2)
TRU: 101063873(itpr2)
TFS: 130536793(itpr2)
TNG: GSTEN00022806G001
LCO: 104924371(itpr2)
NCC: 104954420
TBEN: 117491304(itpr2)
CGOB: 115009269(itpr2)
PGEO: 117447615(itpr2)
GACU: 117545674(itpr2)
EMAC: 134876492(itpr2)
ELY: 117261747(itpr2)
EFO: 125887046(itpr2)
PLEP: 121950593(itpr2)
SLUC: 116062267(itpr2)
ECRA: 117949271(itpr2)
ESP: 116694480(itpr2)
PFLV: 114559590(itpr2)
GAT: 120808946(itpr2) 120812471
PPUG: 119196688(itpr2)
AFB: 129108800(itpr2)
CLUM: 117732901(itpr2)
PSWI: 130194653(itpr2)
MSAM: 119893420(itpr2)
SCHU: 122875567(itpr2)
CUD: 121514503(itpr2)
ALAT: 119024134(itpr2)
MZE: 101466928(itpr2)
ONL: 100690527(itpr2)
OAU: 116335542(itpr2)
OLA: 101155191(itpr2)
OML: 112152271(itpr2)
CSAI: 133444381(itpr2)
XMA: 102220160(itpr2)
XCO: 114157038(itpr2)
XHE: 116733729(itpr2) 116736269
PRET: 103466096(itpr2)
PFOR: 103133680(itpr2)
PLAI: 106950914(itpr2)
PMEI: 106916046(itpr2)
GAF: 122835154(itpr2)
PPRL: 129364907(itpr2)
CVG: 107104059(itpr2)
CTUL: 119792990(itpr2)
GMU: 124858594(itpr2)
NFU: 107388954(itpr2)
KMR: 108239960(itpr2)
ALIM: 106515612(itpr2)
NWH: 119416249(itpr2)
AOCE: 111568340(itpr2)
MCEP: 125015051(itpr2)
CSEM: 103380150(itpr2)
POV: 109624047(itpr2)
SSEN: 122775623(itpr2)
HHIP: 117763343(itpr2)
HSP: 118109898(itpr2)
SMAU: 118315934(itpr2)
LCF: 108875355
SDU: 111228375(itpr2)
SLAL: 111655344(itpr2)
XGL: 120792799(itpr2)
HCQ: 109530334(itpr2)
SSCV: 125971286
SBIA: 133501753(itpr2)
PEE: 133403056(itpr2)
PTAO: 133477708(itpr2)
BPEC: 110165611
MALB: 109970756(itpr2)
BSPL: 114857939(itpr2)
SJO: 128358534(itpr2)
SASA: 100196824(itpr2) 106573309
STRU: 115152168 115197365
OTW: 112218717 112232084
OMY: 110497694 110522681
OGO: 124002508 124035132
ONE: 115109547 115134115
OKI: 109866991 109889517
OKE: 118395799 118401101
SALP: 111952558 111960994
SNH: 120054057(itpr2) 120065919
CCLU: 121532247 121577003
ELS: 105022141(itpr2)
SFM: 108942564(itpr2)
PKI: 111845672(itpr2)
AANG: 118219247(itpr2)
LOC: 102683319(itpr2)
PSPA: 121318388 121319707
ARUT: 117415087 117419457
PSEX: 120534185(itpr2)
LCM: 102359880(ITPR2)
CMK: 103188869(itpr2)
CPLA: 122561564(itpr2)
HOC: 132826793(itpr2)
LERI: 129707658(itpr2)
 » show all
Reference
PMID:15632133
  Authors
Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, Mikoshiba K
  Title
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.
  Journal
J Biol Chem 280:10305-17 (2005)
DOI:10.1074/jbc.M413824200
  Sequence
[mmu:16439]

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Ontology (4)   
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