KEGG   ORTHOLOGY: K05031Help
Entry
K05031                      KO                                     

Name
CFTR
Definition
cystic fibrosis transmembrane conductance regulator [EC:3.6.3.49]
Pathway
ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Disease
H00218  
Cystic fibrosis (CF)
H00933  
Hereditary pancreatitis
H01033  
Congenital bilateral absence of vas deferens
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Membrane transport
   02010 ABC transporters
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
  Signal transduction
   04024 cAMP signaling pathway
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
   04152 AMPK signaling pathway
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
 Organismal Systems
  Digestive system
   04971 Gastric acid secretion
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
   04972 Pancreatic secretion
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
   04976 Bile secretion
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
 Human Diseases
  Infectious diseases
   05110 Vibrio cholerae infection
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.49  channel-conductance-controlling ATPase
     K05031  CFTR; cystic fibrosis transmembrane conductance regulator
Transporters [BR:ko02000]
 ABC Transporters, Eukaryotic Type
  ABCC (CFTR/MRP) subfamily
   Others
    K05031  CFTR; cystic fibrosis transmembrane conductance regulator
BRITE hierarchy
Other DBs
Genes
HSA: 
1080(CFTR)
PTR: 
463674(CFTR)
PPS: 
100989405(CFTR)
GGO: 
101132066(CFTR)
PON: 
100137035(CFTR)
NLE: 
100601480(CFTR)
MCC: 
574346(CFTR)
MCF: 
102130331(CFTR)
CJC: 
100415251(CFTR)
MMU: 
12638(Cftr)
RNO: 
24255(Cftr)
CGE: 
100754506(Cftr)
HGL: 
101709472(Cftr)
TUP: 
102490714(CFTR)
CFA: 
492302(CFTR)
AML: 
UMR: 
103676590(CFTR)
FCA: 
492308(CFTR)
PTG: 
102956215(CFTR)
BTA: 
281067(CFTR)
BOM: 
PHD: 
102332344(CFTR)
CHX: 
102179446(CFTR)
OAS: 
443347(CFTR)
SSC: 
403154(CFTR)
CFR: 
102505598(CFTR)
BACU: 
103004581(CFTR)
LVE: 
103088529(CFTR)
ECB: 
100071259(CFTR)
MYB: 
102257625(CFTR)
MYD: 
102773631(CFTR)
PALE: 
102884577(CFTR)
MDO: 
100014119(CFTR)
SHR: 
100919086(CFTR)
OAA: 
100078764(CFTR)
GGA: 
100049619(CFTR)
MGP: 
APLA: 
101803386(CFTR)
TGU: 
100222243(CFTR)
FAB: 
101809710(CFTR)
PHI: 
102114534(CFTR)
FPG: 
101921929(CFTR)
FCH: 
102050923(CFTR)
CLV: 
102089481(CFTR)
ASN: 
102369471(CFTR)
AMJ: 
102563163(CFTR)
PSS: 
102447829(CFTR)
CMY: 
102936252(CFTR)
ACS: 
100559531(cftr)
PBI: 
103057487(CFTR)
XTR: 
100486085(cftr)
DRE: 
559080(cftr)
TRU: 
492310(cftr)
MZE: 
OLA: 
XMA: 
LCM: 
102346483(CFTR)
CMK: 
103179362(cftr)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Riordan JR
  Title
CFTR function and prospects for therapy.
  Journal
Annu Rev Biochem 77:701-26 (2008)
Reference
  Authors
Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T
  Title
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.
  Journal
Xenobiotica 38:833-62 (2008)

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