KEGG ORTHOLOGY: K05406

ORTHOLOGY: K05406

Entry

K05406                      KO

Symbol

IL12A

Name

interleukin 12A

Pathway

map04060

Cytokine-cytokine receptor interaction

map04620

Toll-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04936

Alcoholic liver disease

map04940

Type I diabetes mellitus

map05133

Pertussis

map05134

Legionellosis

map05140

Leishmaniasis

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05321

Inflammatory bowel disease

map05330

Allograft rejection

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05406  IL12A; interleukin 12A
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05406  IL12A; interleukin 12A
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04622 RIG-I-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04625 C-type lectin receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04658 Th1 and Th2 cell differentiation
    K05406  IL12A; interleukin 12A
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05406  IL12A; interleukin 12A
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05406  IL12A; interleukin 12A
   05164 Influenza A
    K05406  IL12A; interleukin 12A
   05162 Measles
    K05406  IL12A; interleukin 12A
   05168 Herpes simplex virus 1 infection
    K05406  IL12A; interleukin 12A
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05406  IL12A; interleukin 12A
   05134 Legionellosis
    K05406  IL12A; interleukin 12A
   05152 Tuberculosis
    K05406  IL12A; interleukin 12A
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05406  IL12A; interleukin 12A
   05144 Malaria
    K05406  IL12A; interleukin 12A
   05145 Toxoplasmosis
    K05406  IL12A; interleukin 12A
   05140 Leishmaniasis
    K05406  IL12A; interleukin 12A
   05142 Chagas disease
    K05406  IL12A; interleukin 12A
   05143 African trypanosomiasis
    K05406  IL12A; interleukin 12A
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05406  IL12A; interleukin 12A
   05330 Allograft rejection
    K05406  IL12A; interleukin 12A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05406  IL12A; interleukin 12A
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05406  IL12A; interleukin 12A
   04936 Alcoholic liver disease
    K05406  IL12A; interleukin 12A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05406  IL12A; interleukin 12A
   00536 Glycosaminoglycan binding proteins
    K05406  IL12A; interleukin 12A
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05406  IL12A; interleukin 12A
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K05406  IL12A; interleukin 12A

Other DBs

GO:

0005143

Genes

HSA:	3592(IL12A)

PTR:	460816(IL12A)

PPS:	100979574(IL12A)

GGO:	101150677(IL12A)

PON:	100444807(IL12A)

NLE:	100603245(IL12A)

HMH:	116463392 116463424

MCC:	703205(IL12A)

MCF:	102115316(IL12A)

MTHB:

126949358

MNI:	105488536(IL12A)

CSAB:

103241402(IL12A)

CATY:

105598171(IL12A)

PANU:

100126719(IL12A)

TGE:	112619066(IL12A)

MLEU:

105552064(IL12A)

RRO:	104665012(IL12A)

RBB:	108514790(IL12A)

TFN:	117079203(IL12A)

PTEH:

111550126(IL12A)

CANG:

105523976(IL12A)

CJC:	100406669(IL12A)

SBQ:	101044358(IL12A)

CIMI:

108284144(IL12A)

CSYR:

103258245(IL12A)

MMUR:

105881187(IL12A)

LCAT:

123646097(IL12A)

PCOQ:

105809128(IL12A)

OGA:	100959043(IL12A)

MMU:	16159(Il12a)

MCAL:

110291699(Il12a)

MPAH:

110320680(Il12a)

RNO:	84405(Il12a)

MCOC:

116094048(Il12a)

ANU:	117707571(Il12a)

MUN:	110557307(Il12a)

CGE:	100760602(Il12a)

MAUA:

101844248(Il12a)

PROB:

127232891(Il12a)

PLEU:

114691738(Il12a)

MORG:

121452968(Il12a)

MFOT:

126504946

AAMP:

119826750(Il12a)

NGI:	103745345(Il12a)

HGL:	101701392(Il12a)

CPOC:

100379543(Il12a)

CCAN:

109692199(Il12a)

DORD:

105985549(Il12a)

DSP:	122112737(Il12a)

PLOP:

125351136(Il12a)

NCAR:

124993138

MMMA:

107143551(Il12a)

OCU:

100349007

OPI:	101518190(IL12A)

TUP:	102493627(IL12A)

GVR:	103605130(IL12A)

CFA:	403977(IL12A)

CLUD:

112645861(IL12A)

VVP:	112933314(IL12A)

VLG:	121477529(IL12A)

NPO:	129498700(IL12A)

AML:	100470471(IL12A)

UMR:	103681335(IL12A)

UAH:	113254130(IL12A)

UAR:	123801580(IL12A)

ELK:

111150468

LLV:

125099687

MPUF:

101689314(IL12A)

MNP:	132012091(IL12A)

MLK:	131824928(IL12A)

NVS:	122910459(IL12A)

ORO:	101367178(IL12A)

EJU:	114209150(IL12A)

ZCA:	113916510(IL12A)

MLX:	118005789(IL12A)

NSU:	110591738(IL12A)

LWW:	102738603(IL12A)

FCA:	493741(IL12A)

PYU:	121033922(IL12A)

PCOO:

112849717(IL12A)

PBG:	122491789(IL12A)

PVIV:

125175189(IL12A)

LRUF:

124526682

PTG:	102971802(IL12A)

PPAD:

109262066(IL12A)

PUC:

125921200

AJU:

106969467

HHV:	120238298(IL12A)

BTA:	281856(IL12A)

BOM:	102276398(IL12A)

BIU:	109564477(IL12A)

BBUB:

102406980(IL12A)

BBIS:

104988502(IL12A)

CHX:	100861293(IL12A)

OAS:	443064(IL12A)

BTAX:

128050368(IL12A)

ODA:	120881582(IL12A)

CCAD:

122444988(IL12A)

MBEZ:

129551055(IL12A)

SSC:	397053(IL12A)

CFR:	102507202(IL12A)

CBAI:

105066646(IL12A)

CDK:	105094260(IL12A)

VPC:	102530946(IL12A)

BACU:

103003516(IL12A)

BMUS:

118894377(IL12A)

LVE:	103079299(IL12A)

OOR:	101279088(IL12A)

DLE:	111174517(IL12A)

PCAD:

102982335(IL12A)

PSIU:

116753024(IL12A)

NASI:

112406240(IL12A)

ECB:	100034215(IL12A)

EPZ:	103562911(IL12A)

EAI:	106824114(IL12A)

MYB:	102251395(IL12A)

MYD:	102753538(IL12A)

MMYO:

118675787(IL12A)

MLF:	102431058(IL12A)

PKL:	118722291(IL12A)

EFUS:

103286786(IL12A)

MNA:	107539273(IL12A)

DRO:	112304655(IL12A)

SHON:

118987454(IL12A)

PDIC:

114491057(IL12A)

PHAS:

123827188(IL12A)

MMF:	118617678(IL12A)

PPAM:

129073129(IL12A)

HAI:	109373148(IL12A)

RFQ:	117036506(IL12A)

PALE:

102887571(IL12A)

PGIG:

120598918(IL12A)

PVP:	105305876(IL12A)

RAY:	107512954(IL12A)

MJV:	108409113(IL12A)

TOD:	119256979(IL12A)

SARA:

101539403(IL12A)

SETR:

126026256(IL12A)

LAV:	100665137(IL12A)

TMU:

101353752

ETF:	101641618(IL12A)

DNM:	101425226(IL12A)

MDO:	100018516(IL12A)

GAS:	123242043(IL12A)

SHR:	100914201(IL12A)

AFZ:

127557721

PCW:	110210080(IL12A)

OAA:	100086041(IL12A)

GGA:	407090(IL12A)

PCOC:

116235488(IL12A)

MGP:	100542954(IL12A)

CJO:	107318422(IL12A)

TPAI:

128082460(IL12A)

LMUT:

125697669(IL12A)

NMEL:

110397416(IL12A)

APLA:

113844483(IL12A)

ACYG:

106043510(IL12A)

CATA:

118258017(IL12A)

AFUL:

116492528(IL12A)

LSR:	110476606(IL12A)

OTC:

121336701

PRUF:

121353830

FAB:	101809609(IL12A)

OMA:	130256960(IL12A)

CCW:	104688158(IL12A)

CBRC:

103615719(IL12A)

ETL:	114062930(IL12A)

ACHL:

103802304(IL12A)

FPG:	101915475(IL12A)

FCH:	102047690(IL12A)

CLV:	102091031(IL12A)

EGZ:	104122263(IL12A)

NNI:	104011599(IL12A)

PCRI:

104026598(IL12A)

PLET:

104622095(IL12A)

EHS:	104505612(IL12A)

PCAO:

104042903(IL12A)

ACUN:

113483415(IL12A)

TALA:

104361192(IL12A)

PADL:

103925294(IL12A)

AFOR:

103899051(IL12A)

ACHC:

115347215(IL12A)

HALD:

104312900(IL12A)

HLE:	104842575(IL12A)

AGEN:

126039801

GCL:

127020209

CCRI:

104157671(IL12A)

CSTI:

104552433(IL12A)

BREG:

104635022(IL12A)

FGA:	104082263(IL12A)

LDI:	104341792(IL12A)

MNB:	103777763(IL12A)

OHA:	104334437(IL12A)

NNT:	104412611(IL12A)

SHAB:

115612199(IL12A)

DPUB:

104301678(IL12A)

PGUU:

104471462(IL12A)

CPEA:

104387039(IL12A)

AVIT:

104275833(IL12A)

CVF:	104285963(IL12A)

RTD:	128911046(IL12A)

CUCA:

104062802(IL12A)

TEO:	104372701(IL12A)

BRHI:

104497158(IL12A)

AAM:	106495099(IL12A)

AROW:

112961972(IL12A)

NPD:	112952373(IL12A)

TGT:	104581103(IL12A)

DNE:	112981307(IL12A)

SCAM:

104140049(IL12A)

ASN:	102368752(IL12A)

AMJ:	102576541(IL12A)

GGN:	109287816(IL12A)

PSS:	102457029(IL12A)

CMY:	102945506(IL12A)

CCAY:

125642736(IL12A)

DCC:	119861806(IL12A)

CPIC:

101945519(IL12A)

TST:	117882372(IL12A)

CABI:

116815969(IL12A)

MRV:	120372381(IL12A)

HCG:	128352498(IL12A)

XTR:

101734580

DRE:	100004358(zmp:0000001127) 445410(il12a)

SRX:	107720418 107747527 107750094

SANH:

107701302 107703011

SGH:

107551286

CCAR:

109063918 109063941 109094392

CAUA:

113046466 113115444

PTET:

122326874 122358897(il12a)

LROH:

127152832 127177348(il12a)

OMC:	131520808(il12a) 131521563

PPRM:

120464476 120464488 120470279

RKG:	130101545(zmp:0000001127) 130102084(il12a)

MAMB:

125249020(il12a) 125251788

CIDE:

127496131 127523638

MASI:

127421788 127429820

TROS:

130554909 130565029(il12a)

TDW:	130418244 130428341(il12a)

MANU:

129437567(il12a) 129442597

IPU:	108267859(zmp:0000001127) 108280274(il12a)

IFU:	128609727 128624558(il12a)

PHYP:

113540201 113543055

SMEO:

124387956(zmp:0000001127) 124403349(il12a)

TFD:	113646835(il12a) 113649170(zmp:0000001127)

TVC:	132840637(il12a) 132847843(zmp:0000001127)

AMEX:

103025849 107197652

CMAO:

118797489(il12a) 118825427

EEE:

113588304

TRU:	101061955 115247888 446069(il12a)

TFS:	130534565(il12a) 130539546(zmp:0000001127)

LCO:

104936631

NCC:	104951464 104954280

TBEN:

117470545(il12a) 117488965

CGOB:

115018081

PGEO:

117456860(il12a) 117461720

GACU:

117538330 117554846(il12a)

EMAC:

134865471(zmp:0000001127) 134880048(il12a)

ELY:	117260285(il12a)

EFO:	125888559(il12a)

PLEP:

121943813(il12a)

SLUC:

116037408 116050803(il12a)

ECRA:

117942332(il12a) 117954544

ESP:	116682505 116699462

PFLV:

114553224 114565169(il12a)

GAT:	120816383 120824284(il12a)

PPUG:

119215541(il12a)

AFB:	129089316 129096969(il12a)

CLUM:

117741747(il12a) 117746853

PSWI:

130198075(zmp:0000001127) 130210467(il12a)

MSAM:

119883275(il12a) 119902142

SCHU:

122878743(il12a)

CUD:	121520201 121526300(il12a)

ALAT:

119008508(il12a) 119011350

MZE:	101467238 101469522

ONL:	100693748 100701404

OAU:	116323590(il12a) 116332858

OLA:	101156757 101158636

OML:	112139606 112149667(il12a)

CSAI:

133442533(il12a)

XMA:

111612051

XCO:

114161440

XHE:	116721905 116737328

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122832580(il12a) 122840819

PPRL:

129362234 129369906(il12a)

CVG:

107081893

CTUL:

119786140 119797295(il12a)

GMU:	124869262(zmp:0000001127) 124884050(il12a)

NFU:

107380562

KMR:	108239606 108240891(il12a)

NWH:	119410891(il12a)

AOCE:

111572772

MCEP:

125011367 125013840(il12a)

CSEM:

103378499

POV:	109630380 109638746

SSEN:

122763998 122773547(il12a)

HHIP:

117772855(il12a) 117777965

HSP:	118106541(il12a) 118117381

SMAU:

118299177(il12a) 118311396(zmp:0000001127)

LCF:

108883223

SDU:	111229125 111239818

SLAL:

111654387 111654424

XGL:	120792403(il12a) 120799320

HCQ:

109518416

SSCV:

125971856

SBIA:

133504974(il12a)

PEE:	133405317(il12a)

PTAO:

133482325(il12a)

BPEC:

110159295

MALB:

109957731

BSPL:

114844910(zmp:0000001127) 114867871(il12a)

SJO:	128359922 128369638

SASA:

106580951

STRU:

115162812 115169258

OTW:	112244633 112267572

OMY:	110503453 110507263 110508876

OGO:	123992739 124004815 124040981

ONE:	115101587 115137632 115142156

OKI:	109872245 109905179 109909301

OKE:	118394530 118395174 118396950

SALP:

111949782 111979755

SNH:	120018486(il12a) 120019809 120028377

CCLU:

121568492 121581688

ELS:

109616205

PKI:	111841504(il12a) 111847694

AANG:

118210312(il12a) 118229324

LOC:	107079109(il12a)

PSPA:

121326368

ARUT:

117416699 117423220

CMK:	103176349(il12a)

CPLA:

122556360(zmp:0000001127)

HOC:	132821556(zmp:0000001127)

LERI:

129703696(il12a)

» show all

Reference

PMID:1673147

Authors

Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, et al.

Title

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

Journal

J Immunol 146:3074-81 (1991)

Sequence

[hsa:3592]

Reference

PMID:20843320

Authors

Klinke DJ 2nd

Title

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.

Journal

Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (50)   
   KEGG PATHWAY (50)   
Drug (4)   
   KEGG DRUG (4)   
Gene (432)   
   KEGG GENES (428)   
   KEGG MGENES (3)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (492)   

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