KEGG   ORTHOLOGY: K05427Help
Entry
K05427                      KO                                     

Name
CSF2, GMCSF
Definition
granulocyte-macrophage colony-stimulating factor
Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Salmonella infection
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04668 TNF signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04650 Natural killer cell mediated cytotoxicity
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04660 T cell receptor signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04664 Fc epsilon RI signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  Immune diseases
   05323 Rheumatoid arthritis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  Infectious diseases
   05132 Salmonella infection
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   05166 HTLV-I infection
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   05146 Amoebiasis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Cytokines [BR:ko04052]
 Class I cytokines (hematopoietin family)
  IL-3 receptor family
   K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Cytokines
  K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
BRITE hierarchy
Genes
HSA: 
1437(CSF2)
PTR: 
471627(CSF2)
PPS: 
100995954(CSF2)
GGO: 
101133274(CSF2)
PON: 
100447424(CSF2)
MCC: 
574371(CSF2)
MCF: 
102118747(CSF2)
MMU: 
12981(Csf2)
RNO: 
116630(Csf2)
CGE: 
100765221(Csf2)
HGL: 
101724943(Csf2)
TUP: 
102498758(CSF2)
CFA: 
403923(CSF2)
AML: 
FCA: 
101094153(CSF2) 493805(CSF2)
PTG: 
102966574(CSF2)
BTA: 
281095(CSF2)
BOM: 
102275474(CSF2)
PHD: 
102339456(CSF2)
CHX: 
100861208(GM-CSF)
OAS: 
443400(CSF2)
SSC: 
397208(CSF2)
CFR: 
102523249(CSF2)
BACU: 
103005117(CSF2)
LVE: 
103089107(CSF2)
ECB: 
100033981(GM-CSF)
MYB: 
102242138(CSF2)
MYD: 
102768422(CSF2)
PALE: 
102893042(CSF2)
MDO: 
103094208(CSF2)
GGA: 
416325(CSF2)
MGP: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Barreda DR, Hanington PC, Belosevic M
  Title
Regulation of myeloid development and function by colony stimulating factors.
  Journal
Dev Comp Immunol 28:509-54 (2004)
Reference
PMID:3488815
  Authors
Shaw G, Kamen R
  Title
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
  Journal
Cell 46:659-67 (1986)
Reference
  Authors
Fjell CD, Thair S, Hsu JL, Walley KR, Russell JA, Boyd J
  Title
Cytokines and signaling molecules predict clinical outcomes in sepsis.
  Journal
PLoS One 8:e79207 (2013)
  Sequence
[hsa:1437]

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