KEGG   ORTHOLOGY: K05717Help
Entry
K05717                      KO                                     

Name
FN1
Definition
fibronectin 1
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Amoebiasis
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Disease
H01260  
Glomerulopathy with fibronectin deposits (GFND)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K05717  FN1; fibronectin 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05717  FN1; fibronectin 1
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05717  FN1; fibronectin 1
  Cell communication
   04510 Focal adhesion
    K05717  FN1; fibronectin 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05717  FN1; fibronectin 1
   05205 Proteoglycans in cancer
    K05717  FN1; fibronectin 1
   05222 Small cell lung cancer
    K05717  FN1; fibronectin 1
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K05717  FN1; fibronectin 1
   05146 Amoebiasis
    K05717  FN1; fibronectin 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   K05717  FN1; fibronectin 1
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   CXADR, CAR; coxsackievirus and adenovirus receptor
    K05717 FN1; fibronectin 1
 2. Integrin Family
  Beta1 integrins
   VLA-4
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   VLA-5
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   VLA-8
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   alpha V beta 1
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K05717 FN1; fibronectin 1
   VNR
    ITGB3; integrin beta 3
     K05717 FN1; fibronectin 1
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K05717 FN1; fibronectin 1
  Beta7 integrins
   alpha 4 beta 7
    ITGB7; integrin beta 7
     K05717 FN1; fibronectin 1
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K05717 FN1; fibronectin 1
 4. Link Protein Family
  CD44; CD44 antigen
   K05717 FN1; fibronectin 1
 7. Others
  SDC1; syndecan 1
   K05717 FN1; fibronectin 1
  SDC4; syndecan 4
   K05717 FN1; fibronectin 1
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Extracellular matrix molecules
  K05717  FN1; fibronectin 1
BRITE hierarchy
Genes
HSA: 
2335(FN1)
PTR: 
459926(FN1)
PPS: 
GGO: 
PON: 
MCC: 
613269(FN1)
MCF: 
MMU: 
14268(Fn1)
RNO: 
25661(Fn1)
CGE: 
HGL: 
TUP: 
CFA: 
403845(FN1)
AML: 
FCA: 
PTG: 
BTA: 
280794(FN1)
BOM: 
PHD: 
CHX: 
SSC: 
397620(FN1)
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
GGA: 
396133(FN1)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
397744(fn1)
XTR: 
595087(fn1)
DRE: 
100005469(fn1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yi M, Ruoslahti E
  Title
A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis.
  Journal
Proc Natl Acad Sci U S A 98:620-4 (2001)
Reference
  Authors
Ambesi A, Klein RM, Pumiglia KM, McKeown-Longo PJ
  Title
Anastellin, a fragment of the first type III repeat of fibronectin, inhibits extracellular signal-regulated kinase and causes G(1) arrest in human microvessel endothelial cells.
  Journal
Cancer Res 65:148-56 (2005)

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