KEGG ORTHOLOGY: K05744

ORTHOLOGY: K05744

Entry

K05744                      KO

Symbol

LIMK2

Name

LIM domain kinase 2 [EC:2.7.11.1]

Pathway

map04360

Axon guidance

map04666

Fc gamma R-mediated phagocytosis

map04810

Regulation of actin cytoskeleton

map05170

Human immunodeficiency virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05744  LIMK2; LIM domain kinase 2
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05744  LIMK2; LIM domain kinase 2
  09158 Development and regeneration
   04360 Axon guidance
    K05744  LIMK2; LIM domain kinase 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05744  LIMK2; LIM domain kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05744  LIMK2; LIM domain kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05744  LIMK2; LIM domain kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  LISK family [OT]
   K05744  LIMK2; LIM domain kinase 2

Genes

HSA:	3985(LIMK2)

PTR:	458970(LIMK2)

PPS:	100978324(LIMK2)

GGO:	101133437(LIMK2)

PON:	100460494(LIMK2)

NLE:	100586214(LIMK2)

HMH:	116458826(LIMK2)

MCC:	716614(LIMK2)

MCF:	102136171(LIMK2)

MTHB:

126963929

MNI:	105487207(LIMK2)

CSAB:

103223186(LIMK2)

CATY:

105575749(LIMK2)

PANU:

101017879(LIMK2)

TGE:	112632978(LIMK2)

MLEU:

105538964(LIMK2)

RRO:	104660353(LIMK2)

RBB:	108527615(LIMK2)

TFN:	117096217(LIMK2)

PTEH:

111521834(LIMK2)

CANG:

105509193(LIMK2)

CJC:	100396965(LIMK2)

SBQ:	101031302(LIMK2)

CIMI:

108283288(LIMK2)

CSYR:

103258527(LIMK2)

MMUR:

105870954(LIMK2)

LCAT:

123625862(LIMK2)

PCOQ:

105821289(LIMK2)

OGA:	100944489(LIMK2)

MMU:	16886(Limk2)

MCAL:

110304738(Limk2)

MPAH:

110330408(Limk2)

RNO:	29524(Limk2)

MCOC:

116069764(Limk2)

ANU:	117713026(Limk2)

MUN:	110557623(Limk2)

CGE:	100760910(Limk2)

MAUA:

101830855(Limk2)

PROB:

127233784(Limk2)

PLEU:

114694032(Limk2)

MORG:

121436566 121459809

MFOT:

126500782

AAMP:

119826815(Limk2)

NGI:	103740428(Limk2)

HGL:	101698063(Limk2)

CPOC:

100720658(Limk2)

CCAN:

109696918(Limk2)

DORD:

105984318(Limk2)

DSP:	122095919(Limk2)

PLOP:

125349299(Limk2)

NCAR:

124990701

MMMA:

107158475

OCU:

100356835

OPI:	101532959(LIMK2)

TUP:	102477125(LIMK2)

GVR:	103605064(LIMK2)

CFA:	486363(LIMK2)

CLUD:

112676829(LIMK2)

VVP:	112909819(LIMK2)

VLG:	121475393(LIMK2)

NPO:	129507902(LIMK2)

AML:	100478557(LIMK2)

UMR:	103681084(LIMK2)

UAH:	113245055(LIMK2)

UAR:	123788184(LIMK2)

ELK:

111160080

LLV:

125082483

MPUF:

101684485(LIMK2)

MNP:	132023348(LIMK2)

MLK:	131811804(LIMK2)

NVS:	122903242(LIMK2)

ORO:	101365602(LIMK2)

EJU:	114225180(LIMK2)

ZCA:	113912331(LIMK2)

MLX:	118018669(LIMK2)

NSU:	110592506(LIMK2)

LWW:	102738570(LIMK2)

FCA:	101096766(LIMK2)

PYU:	121022669(LIMK2)

PCOO:

112870101(LIMK2)

PBG:	122470961(LIMK2)

PVIV:

125148861(LIMK2)

LRUF:

124518218

PTG:	102952158(LIMK2)

PPAD:

109253609(LIMK2)

PUC:

125913971

AJU:

106983306

HHV:	120227439(LIMK2)

BTA:	513539(LIMK2)

BOM:	102282980(LIMK2)

BIU:	109571147(LIMK2)

BBUB:

102406228(LIMK2)

BBIS:

104980159(LIMK2)

CHX:	102171364(LIMK2)

OAS:	101114815(LIMK2)

BTAX:

128062055(LIMK2)

ODA:	120871257(LIMK2)

CCAD:

122420691(LIMK2)

MBEZ:

129542806(LIMK2)

SSC:	100156359(LIMK2)

CFR:	102512622(LIMK2)

CBAI:

105066098(LIMK2)

CDK:	105099426(LIMK2)

VPC:	102531440(LIMK2)

BACU:

103015530(LIMK2)

BMUS:

118906797

LVE:	103087898(LIMK2)

OOR:

101273335

DLE:

111162707

PCAD:

102990180(LIMK2)

PSIU:

116765143

NASI:

112415112

ECB:	100058419(LIMK2)

EPZ:	103565974(LIMK2)

EAI:	106826900(LIMK2)

MYB:	102240139(LIMK2)

MYD:	102753215(LIMK2)

MMYO:

118678110(LIMK2)

MLF:	102437257(LIMK2)

PKL:	118725653(LIMK2)

EFUS:

103286833(LIMK2)

MNA:	107526171(LIMK2)

DRO:	112310817(LIMK2)

SHON:

118991309(LIMK2)

AJM:	119064893(LIMK2)

PDIC:

114509199(LIMK2)

PHAS:

123810960(LIMK2)

MMF:	118640005(LIMK2)

PPAM:

129087429(LIMK2)

HAI:	109383094(LIMK2)

RFQ:	117017518(LIMK2)

PALE:

102896062(LIMK2)

PGIG:

120602015(LIMK2)

PVP:	105308348(LIMK2)

RAY:	107521058(LIMK2)

MJV:	108386414(LIMK2)

TOD:	119244857(LIMK2)

SARA:

101538827(LIMK2)

SETR:

126030738(LIMK2)

LAV:	100656340(LIMK2)

TMU:

101345292

ETF:	101646862(LIMK2)

DNM:	101418223(LIMK2)

MDO:	100028612(LIMK2)

GAS:	123245448(LIMK2)

SHR:	100929464(LIMK2)

AFZ:

127545704

PCW:	110215131(LIMK2)

OAA:	100074515(LIMK2)

GGA:	396010(LIMK2)

PCOC:

116228441(LIMK2)

MGP:	100548509(LIMK2)

CJO:	107321328(LIMK2)

TPAI:

128083911(LIMK2)

LMUT:

125701696(LIMK2)

NMEL:

110406552(LIMK2)

APLA:

101794154(LIMK2)

ACYG:

106031338(LIMK2)

CATA:

118252848(LIMK2)

AFUL:

116496228(LIMK2)

TGU:	100223808(LIMK2)

LSR:	110481380(LIMK2)

SCAN:

103818028(LIMK2)

PMOA:

120510251(LIMK2)

OTC:	121344518(LIMK2)

PRUF:

121364886(LIMK2)

GFR:	102032107(LIMK2)

FAB:	101818799(LIMK2)

OMA:	130259795(LIMK2)

PHI:	102113067(LIMK2)

PMAJ:

107211532(LIMK2)

CCAE:

111936608

CCW:	104688553(LIMK2)

CBRC:

103614182(LIMK2)

ETL:	114056632(LIMK2)

ZAB:	102063683(LIMK2)

ACHL:

103809119(LIMK2)

SVG:	106864916(LIMK2)

MMEA:

130578017(LIMK2)

HRT:	120760370(LIMK2)

FPG:	101921786(LIMK2)

FCH:	102054991(LIMK2)

CLV:	102088187(LIMK2)

EGZ:	104129846(LIMK2)

NNI:	104011454(LIMK2)

PCRI:

104032678(LIMK2)

PLET:

104627172(LIMK2)

EHS:	104504070(LIMK2)

PCAO:

104044069(LIMK2)

ACUN:

113486061(LIMK2)

TALA:

104366914(LIMK2)

PADL:

103922685(LIMK2)

AFOR:

103899542(LIMK2)

ACHC:

115346159(LIMK2)

HALD:

104315834(LIMK2)

HLE:

104836302

AGEN:

126040482

GCL:

127022953

CCRI:

104157821(LIMK2)

CSTI:

104558803(LIMK2)

CMAC:

104480013(LIMK2)

MUI:

104538280

BREG:

104635433(LIMK2)

FGA:

104080904

GSTE:

104264909(LIMK2)

LDI:	104346063(LIMK2)

MNB:	103769404(LIMK2)

OHA:	104331418(LIMK2)

NNT:	104408266(LIMK2)

SHAB:

115614103(LIMK2)

DPUB:

104309627(LIMK2)

PGUU:

104466912

ACAR:

104524095(LIMK2)

CPEA:

104395142(LIMK2)

AVIT:

104276702

CVF:	104289616(LIMK2)

RTD:	128917067(LIMK2)

CUCA:

104068429(LIMK2)

TEO:	104381469(LIMK2)

BRHI:

104497039(LIMK2)

AAM:	106486256(LIMK2)

AROW:

112970575(LIMK2)

NPD:	112946011(LIMK2)

TGT:	104581131(LIMK2)

DNE:	112994626(LIMK2)

SCAM:

104152201(LIMK2)

ASN:	102373879(LIMK2)

AMJ:	102576616(LIMK2)

CPOO:

109312857(LIMK2)

GGN:	109290360(LIMK2)

PSS:	102445206(LIMK2)

CMY:	102932658(LIMK2)

CCAY:

125623142(LIMK2)

DCC:	119843478(LIMK2)

CPIC:

101931739(LIMK2)

TST:	117888082(LIMK2)

CABI:

116820930

MRV:	120386282(LIMK2)

ASAO:

132781186(LIMK2)

PVT:	110081951(LIMK2)

PBI:	103053548(LIMK2)

PMUR:

107293502(LIMK2)

CTIG:

120297939(LIMK2)

TSR:	106549718(LIMK2)

PGUT:

117677918(LIMK2)

APRI:

131185547(LIMK2)

PTEX:

113447054(LIMK2)

NSS:	113422164(LIMK2)

VKO:	123030452(LIMK2)

PMUA:

114586085(LIMK2)

PRAF:

128403999(LIMK2)

ZVI:	118075674(LIMK2)

HCG:	128338204(LIMK2)

GJA:	107126094(LIMK2)

STOW:

125442784(LIMK2)

EMC:	129341225(LIMK2)

XLA:	108705108(limk2.S) 398298(limk2.L)

XTR:	100216249(limk2)

NPR:	108787789(LIMK2)

RTEM:

120937001(LIMK2)

BBUF:

120988774(LIMK2)

BGAR:

122924405(LIMK2)

MUO:	115480228(LIMK2)

GSH:	117365331(LIMK2)

DRE:	436924(limk2)

SRX:	107741211 107743341

SANH:

107654635 107696070

SGH:	107595948 107597272(limk2)

CCAR:

109074613 109098917

CAUA:

113048881 113075265 113098770

CGIB:

128012702

PTET:

122344885(limk2)

LROH:

127165434(limk2)

OMC:	131541285(limk2)

PPRM:

120469903(limk2)

RKG:	130097102(limk2)

MAMB:

125266455(limk2)

CIDE:

127513235

MASI:

127419720 127439632

TROS:

130549798(limk2)

TDW:	130419225(limk2)

MANU:

129439874(limk2)

IPU:

108255496

IFU:	128625421(limk2)

PHYP:

113536929(limk2)

SMEO:

124380440(limk2)

TFD:	113653403(limk2)

TVC:	132854708(limk2)

AMEX:

103041870(limk2)

CMAO:

118827577(limk2)

EEE:	113572921(limk2)

TRU:	101073253(limk2)

TFS:	130525594(limk2)

TNG:	GSTEN00029494G001

LCO:	104920331(limk2)

NCC:	104950170(limk2)

TBEN:

117496752(limk2)

CGOB:

115014117(limk2)

PGEO:

117452723(limk2)

GACU:

117561025(limk2)

EMAC:

134873430(limk2)

ELY:	117253123(limk2)

EFO:	125890478(limk2)

PLEP:

121944693(limk2)

SLUC:

116056884(limk2)

ECRA:

117944358(limk2)

ESP:	116688935(limk2)

PFLV:

114556178(limk2)

GAT:	120830253(limk2)

PPUG:

119225365(limk2)

AFB:	129101089(limk2)

CLUM:

117736373(limk2)

PSWI:

130196452(limk2)

MSAM:

119891278(limk2)

SCHU:

122875875(limk2)

CUD:	121510333(limk2)

ALAT:

119020304(limk2)

MZE:	101466306(limk2)

ONL:	100704902(limk2)

OAU:	116332444(limk2)

OLA:	101164484(limk2)

OML:	112148589(limk2)

CSAI:

133450489(limk2)

XMA:	102223521(limk2)

XCO:	114154564(limk2)

XHE:	116729775(limk2)

PRET:

103470304(limk2)

PFOR:

103142854(limk2)

PLAI:

106937175(limk2)

PMEI:

106918102(limk2)

GAF:	122828366(limk2)

PPRL:

129372093(limk2)

CVG:	107091247(limk2)

CTUL:

119790146(limk2)

GMU:	124878025(limk2)

NFU:	107394200(limk2)

KMR:	108234561(limk2)

ALIM:

106521677(limk2)

NWH:	119413367(limk2)

AOCE:

111575831(limk2)

MCEP:

125012141(limk2)

CSEM:

103397254 103398611

POV:	109638189(limk2)

SSEN:

122769907(limk2)

HHIP:

117768245(limk2)

HSP:	118114621(limk2)

SMAU:

118313470(limk2)

LCF:

108878643

SDU:	111226455(limk2)

SLAL:

111660256(limk2)

XGL:	120804925(limk2)

HCQ:	109511502(limk2)

SSCV:

125965829

SBIA:

133499043(limk2)

PEE:	133399770(limk2)

PTAO:

133475483(limk2)

BPEC:

110169779(limk2)

MALB:

109956918(limk2)

BSPL:

114862181(limk2)

SJO:	128365199(limk2)

SASA:

106580321 106584981

STRU:

115164436 115200202

OTW:	112248520 112248521

OMY:	110525730 110536102

OGO:	124034261 124036370

ONE:	115111661 115140111

OKI:	109880552 109894911

OKE:	118358399 118393269

SALP:

111957923 111974246

SNH:	120025885 120063014

CCLU:

121530971 121584904

ELS:	105025609(limk2)

SFM:	108932592(limk2)

PKI:	111839994(limk2)

AANG:

118237555(limk2)

LOC:	102690924 102697124(limk2)

PSPA:

121297129 121299650

ARUT:

117427742 117963060

PSEX:

120540790(limk2)

LCM:	102347674(LIMK2)

CMK:	103190700(limk2)

CRG:

CANU:

MMER:

RPHI:

DPOL:

ATEN:

HSY:

Reference

PMID:10436159

Authors

Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S

Title

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

Journal

Science 285:895-8 (1999)
DOI:10.1126/science.285.5429.895

Reference

PMID:8537403

Authors

Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K

Title

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.

Journal

J Biol Chem 270:31321-30 (1995)
DOI:10.1074/jbc.270.52.31321

Sequence

[hsa:3985]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (898)   
   KEGG GENES (412)   
   KEGG MGENES (217)   
   RefGene (266)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (912)   

Download RDF

DBGET integrated database retrieval system