KEGG   ORTHOLOGY: K05858Help
Entry
K05858                      KO                                     

Name
PLCB
Definition
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Pathway
Inositol phosphate metabolism
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Phototransduction - fly
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
M00130  
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00606  
Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04022 cGMP - PKG signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Organismal Systems
  Immune system
   04611 Platelet activation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04921 Oxytocin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04918 Thyroid hormone synthesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04919 Thyroid hormone signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04750 Inflammatory mediator regulation of TRP channels
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Infectious diseases
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease (American trypanosomiasis)
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR: 
451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS: 
100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO: 
PON: 
100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
MCC: 
701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF: 
101925220 102123165(PLCB3) 102136896(PLCB2) 102140615(PLCB1)
MMU: 
18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
RNO: 
24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
CGE: 
100751979(Plcb1) 100760134(Plcb3) 100760731(Plcb2) 100770957(Plcb4)
HGL: 
101696454(Plcb4) 101697744(Plcb3) 101708380(Plcb2) 101725860(Plcb1)
TUP: 
102472532(PLCB3) 102476196(PLCB4) 102477438(PLCB1) 102492903(PLCB2)
CFA: 
100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
AML: 
100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
FCA: 
101090005(PLCB4) 101090942(PLCB2) 101092262(PLCB1) 101092961(PLCB3)
PTG: 
102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3)
BTA: 
281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
BOM: 
102264989(PLCB4) 102273347 102276260(PLCB3) 102278948(PLCB2)
PHD: 
102318466(PLCB4) 102333745(PLCB2) 102337250(PLCB3) 102342417(PLCB1)
CHX: 
102169966(PLCB2) 102180505(PLCB4) 102188148(PLCB1) 102189653(PLCB3)
SSC: 
100152679(PLCB1) 100157641(PLCB2) 100516581(PLCB4) 100525148(PLCB3)
CFR: 
102505338(PLCB3) 102509058(PLCB2) 102513431(PLCB4) 102513996(PLCB1)
BACU: 
102997432(PLCB4) 103006361(PLCB3) 103007077(PLCB2) 103020805(PLCB1)
LVE: 
103078639(PLCB4) 103079287(PLCB1) 103083884(PLCB3) 103086280(PLCB2)
ECB: 
100051485(PLCB4) 100051558(PLCB1) 100055407(PLCB3) 100057315(PLCB2)
MYB: 
102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102254054(PLCB2)
MYD: 
102751685(PLCB1) 102751959(PLCB4) 102755123(PLCB3) 102760520(PLCB2)
PALE: 
102879238(PLCB3) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2)
MDO: 
100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR: 
100922938(PLCB3) 100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
OAA: 
100078508(PLCB1)
GGA: 
416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
MGP: 
100547667(PLCB4) 100548128 664713(PLCB2)
TGU: 
100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
FAB: 
101806047(PLCB2) 101812094(PLCB4) 101816169(PLCB1)
PHI: 
102100609(PLCB4) 102105081(PLCB2) 102113003(PLCB1)
APLA: 
101790966(PLCB1) 101804447(PLCB2) 101805172(PLCB4)
FPG: 
101912415(PLCB2) 101916711(PLCB4) 101922366(PLCB1)
FCH: 
102048018(PLCB2) 102048448(PLCB1) 102054421(PLCB4)
CLV: 
102096635(PLCB2) 102097554(PLCB4) 102098150(PLCB1)
ASN: 
102371353(PLCB3) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1)
AMJ: 
102560430(PLCB4) 102566880 102572359(PLCB2) 102576994(PLCB3)
PSS: 
102449462(PLCB3) 102455767(PLCB4) 102460883(PLCB1) 102461092(PLCB2)
CMY: 
102931046(PLCB2) 102932254(PLCB3) 102942020(PLCB1) 102942246(PLCB4)
ACS: 
100551754(plcb2) 100560758(plcb4) 100566853 100567752(plcb3)
PBI: 
XLA: 
397692(plcb3)
XTR: 
100125098(plcb4) 100487267(plcb3) 101734935(plcb2) 780394(plcb1)
DRE: 
TRU: 
MZE: 
OLA: 
100049465(mfplc-beta2) 100049529(mfplc-beta3) 100049535(mfplc-beta4) 101166030 101172698 101175365
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408791(Plc) 408996(norpA2)
NVI: 
TCA: 
BMOR: 
100329153(PLCb1) 100329154(PLCb4)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06373(Cbr-egl-8)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
EHX: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)

DBGET integrated database retrieval system