KEGG ORTHOLOGY: K05858

ORTHOLOGY: K05858

Entry

K05858 KO

Name

PLCB

Definition

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko04020	Calcium signaling pathway
ko04062	Chemokine signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04270	Vascular smooth muscle contraction
ko04310	Wnt signaling pathway
ko04540	Gap junction
ko04713	Circadian entrainment
ko04720	Long-term potentiation
ko04723	Retrograde endocannabinoid signaling
ko04724	Glutamatergic synapse
ko04725	Cholinergic synapse
ko04726	Serotonergic synapse
ko04728	Dopaminergic synapse
ko04730	Long-term depression
ko04745	Phototransduction - fly
ko04911	Insulin secretion
ko04912	GnRH signaling pathway
ko04915	Estrogen signaling pathway
ko04916	Melanogenesis
ko04961	Endocrine and other factor-regulated calcium reabsorption
ko04970	Salivary secretion
ko04971	Gastric acid secretion
ko04972	Pancreatic secretion
ko05010	Alzheimer's disease
ko05016	Huntington's disease
ko05142	Chagas disease (American trypanosomiasis)
ko05143	African trypanosomiasis
ko05146	Amoebiasis

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Cellular Processes
  Cell communication
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Circulatory system
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Infectious diseases
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease (American trypanosomiasis)
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
KEGG pathway modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta

Other DBs

RN:

R03435

GO:

0004435

Genes

HSA:	23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR:	451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS:	100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO:	101129357(PLCB3) 101140350(PLCB2) 101153613 101154323(PLCB4)
PON:	100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
MCC:	701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MMU:	18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
RNO:	24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
CFA:	100856190 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
AML:	100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
FCA:	101090005(PLCB4) 101090942(PLCB2) 101092262(PLCB1) 101092961(PLCB3)
BTA:	281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
SSC:	100152679(PLCB1) 100157641(PLCB2) 100516581 100525148(PLCB3)
ECB:	100051485(PLCB4) 100051558 100055407(PLCB3) 100057315(PLCB2)
MDO:	100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR:	100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
OAA:	100078508
GGA:	416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
MGP:	100547667(PLCB4) 100548128 664713(PLCB2)
TGU:	100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
ACS:	100551754(plcb2) 100560758(plcb4) 100566853 100567752(plcb3)
XLA:	397692(plcb3)
XTR:	100125098(plcb4) 100487267 780394(plcb1)
DRE:	100001532(plcb3) 100537538
TRU:	101065367 101073102 101076025 101078708
OLA:	100049465(mfplc-beta2) 100049529(mfplc-beta3) 100049535(mfplc-beta4) 101172698
BFO:	BRAFLDRAFT_202613 BRAFLDRAFT_202677
CIN:	100182086 100186259(plcb4)
SPU:	100888919 587412(plcb4)
DME:	Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DPO:	Dpse_GA17564 Dpse_GA18269
DAN:	Dana_GF19456 Dana_GF20639
DER:	Dere_GG18703 Dere_GG24713
DPE:	Dper_GL14297 Dper_GL18869
DSE:	Dsec_GM12340 Dsec_GM16735
DSI:	Dsim_GD23017
DWI:	Dwil_GK15712 Dwil_GK23786
DYA:	Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C)
DGR:	Dgri_GH10584 Dgri_GH24286
DMO:	Dmoj_GI16411 Dmoj_GI23110
DVI:	Dvir_GJ17032 Dvir_GJ23620
AGA:	AgaP_AGAP001936 AgaP_AGAP009115
AAG:	AaeL_AAEL009380 AaeL_AAEL010124
CQU:	CpipJ_CPIJ000778 CpipJ_CPIJ008403
AME:	408791(Plc) 408996(norpA2)
NVI:	100115054(NV15983) 100120894(NV13419)
TCA:	659062 662602
API:	100162131 100166756
PHU:	Phum_PHUM231170 Phum_PHUM602870
ISC:	IscW_ISCW001177 IscW_ISCW001178
CEL:	CELE_B0348.4(egl-8)
CBR:	CBG06373(Cbr-egl-8)
BMY:	Bm1_51505
TSP:	Tsp_02482 Tsp_02544
SMM:	Smp_146330
NVE:	NEMVE_v1g101739 NEMVE_v1g174
HMG:	100200484
TAD:	TRIADDRAFT_61893 TRIADDRAFT_61894
AQU:	100641378
MBR:	MONBRDRAFT_21166

» show all

Reference

PMID:18593525

Authors

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Title

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Journal

BMB Rep 41:415-34 (2008)

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Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (116)   
   KEGG PATHWAY (60)   
   KEGG MODULE (56)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (231)   
   KEGG GENES (151)   
   KEGG DGENES (14)   
   KEGG EGENES (34)   
   KEGG MGENES (32)   
Protein sequence (84)   
   UniProt (84)   
Literature (1)   
   PubMed (1)   
All databases (442)   

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