KEGG   ORTHOLOGY: K05858Help
Entry
K05858                      KO                                     

Name
PLCB
Definition
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Pathway
Inositol phosphate metabolism
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
NOD-like receptor signaling pathway
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Phototransduction - fly
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
M00130  
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00606  
Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04072 Phospholipase D signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04071 Sphingolipid signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04022 cGMP - PKG signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Organismal Systems
  Immune system
   04611 Platelet activation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04621 NOD-like receptor signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04922 Glucagon signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04921 Oxytocin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04918 Thyroid hormone synthesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04919 Thyroid hormone signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04924 Renin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04925 Aldosterone synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04750 Inflammatory mediator regulation of TRP channels
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Infectious diseases
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease (American trypanosomiasis)
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
BRITE hierarchy
Other DBs
Genes
HSA: 
23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR: 
451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS: 
100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO: 
PON: 
100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
NLE: 
100597115(PLCB1) 100600507(PLCB4) 100600865(PLCB3) 100606558(PLCB2)
MCC: 
701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF: 
101925220(PLCB4) 102123165(PLCB3) 102136896(PLCB2) 102140615(PLCB1)
CSAB: 
103233299(PLCB3) 103245842(PLCB2) 103246591(PLCB4) 103246657(PLCB1)
RRO: 
104655777(PLCB4) 104659669(PLCB2) 104668296(PLCB1) 104673127(PLCB3)
CJC: 
100386921(PLCB2) 100400803(PLCB3) 100409716(PLCB1) 100410075(PLCB4)
SBQ: 
101029401(PLCB3) 101046851(PLCB4) 101047168(PLCB1) 101052271(PLCB2)
MMU: 
18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
RNO: 
24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
CGE: 
100751979(Plcb1) 100760134(Plcb3) 100760731(Plcb2) 100770957(Plcb4)
NGI: 
103728414 103735195(Plcb1) 103738797(Plcb3) 103741502(Plcb2)
HGL: 
101696454(Plcb4) 101697744(Plcb3) 101708380(Plcb2) 101725860(Plcb1)
OCU: 
100341512(PLCB1) 100348672(PLCB2) 100350395(PLCB4) 103347536
TUP: 
102472532(PLCB3) 102476196(PLCB4) 102477438(PLCB1) 102492903(PLCB2)
CFA: 
100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
AML: 
100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
UMR: 
103673552(PLCB2) 103674425(PLCB1) 103674426(PLCB4) 103679549(PLCB3)
FCA: 
101090005(PLCB4) 101090942(PLCB2) 101092262(PLCB1) 101092961(PLCB3) 102899339(PLCB2)
PTG: 
102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3)
BTA: 
281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
BOM: 
102264989(PLCB4) 102273347(PLCB1) 102276260(PLCB3) 102278948(PLCB2)
PHD: 
102318466(PLCB4) 102333745(PLCB2) 102337250(PLCB3) 102342417(PLCB1)
CHX: 
102169966(PLCB2) 102180505(PLCB4) 102188148(PLCB1) 102189653(PLCB3)
OAS: 
101103585(PLCB1) 101106864(PLCB4) 101113074(PLCB2) 101116105(PLCB3)
SSC: 
100152679(PLCB1) 100157641(PLCB2) 100516581(PLCB4) 100525148(PLCB3)
CFR: 
102505338(PLCB3) 102509058(PLCB2) 102513431(PLCB4) 102513996(PLCB1)
BACU: 
102997432(PLCB4) 103006361(PLCB3) 103007077(PLCB2) 103020805(PLCB1)
LVE: 
103078639(PLCB4) 103079287(PLCB1) 103083884(PLCB3) 103086280(PLCB2)
ECB: 
100051485(PLCB4) 100051558(PLCB1) 100055407(PLCB3) 100057315(PLCB2)
MYB: 
102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102254054(PLCB2)
MYD: 
102751685(PLCB1) 102751959(PLCB4) 102755123(PLCB3) 102760520(PLCB2)
PALE: 
102879238(PLCB3) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2)
LAV: 
100663829(PLCB3) 100668575(PLCB2) 100670617(PLCB4) 100672435(PLCB1)
MDO: 
100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR: 
100922938(PLCB3) 100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
OAA: 
GGA: 
416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
MGP: 
100547667(PLCB4) 100548128 664713(PLCB2)
CJO: 
107307599 107310934(PLCB4) 107310953(PLCB1) 107314230(PLCB2)
APLA: 
101790966(PLCB1) 101804447(PLCB2) 101805172(PLCB4)
TGU: 
100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
GFR: 
102031336(PLCB4) 102037268(PLCB1) 102045029(PLCB2)
FAB: 
101806047(PLCB2) 101812094(PLCB4) 101816169(PLCB1)
PHI: 
CCW: 
104691519(PLCB1) 104691520(PLCB4) 104692980(PLCB2)
FPG: 
101912415(PLCB2) 101916711(PLCB4) 101922366(PLCB1)
FCH: 
102048018(PLCB2) 102048448(PLCB1) 102054421(PLCB4)
CLV: 
102096635(PLCB2) 102097554(PLCB4) 102098150(PLCB1)
AAM: 
106486714(PLCB2) 106490470(PLCB4) 106490480(PLCB1)
ASN: 
102371353(PLCB3) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1)
AMJ: 
102560430(PLCB4) 102566880(PLCB1) 102572359(PLCB2) 102576994(PLCB3)
PSS: 
102449462(PLCB3) 102455767(PLCB4) 102460883(PLCB1) 102461092(PLCB2)
CMY: 
102931046(PLCB2) 102932254(PLCB3) 102942020(PLCB1) 102942246(PLCB4)
ACS: 
100551754(plcb2) 100560758(plcb4) 100566853(plcb1) 100567752(plcb3)
PBI: 
GJA: 
107106753(PLCB1) 107115177(PLCB3) 107119642(PLCB2) 107123869 107123894(PLCB4)
XLA: 
397692(plcb3.L)
XTR: 
100125098(plcb4) 100487267(plcb3) 101734935(plcb2) 780394(plcb1)
DRE: 
100001532(plcb3) 100537538(plcb4) 407700(plcb4) 569376(plcb2)
TRU: 
101065367(plcb1) 101069591 101073102(plcb3) 101076025(plcb2) 101078708(plcb4)
TNG: 
MZE: 
101464832(plcb4) 101465812(plcb1) 101474135(plcb3) 101475994(plcb2) 101478971
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD16687(Dsim_GD16687) Dsimw501_GD23017(Dsim_GD23017)
DWI: 
DYA: 
Dyak_GE16341(dyak_GLEANR_17772) Dyak_GE16747(Dyak_Plc21C)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408791(Plc) 408996(norpA2)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
100329153(PLCb1) 100329154(PLCb4)
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG06373(Cbr-egl-8)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
MBR: 
SRE: 
EHX: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC
  Title
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).
  Journal
Biochim Biophys Acta 1517:63-72 (2000)
  Sequence
[hsa:23236]
Reference
PMID:1644792
  Authors
Park D, Jhon DY, Kriz R, Knopf J, Rhee SG
  Title
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
  Journal
J Biol Chem 267:16048-55 (1992)
  Sequence
[hsa:5330]
Reference
PMID:1333955
  Authors
Carozzi AJ, Kriz RW, Webster C, Parker PJ
  Title
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.
  Journal
Eur J Biochem 210:521-9 (1992)
  Sequence
[hsa:5331]
Reference
PMID:8530101
  Authors
Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W
  Title
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).
  Journal
Genomics 29:53-61 (1995)
  Sequence
[hsa:5332]

DBGET integrated database retrieval system