KEGG   ORTHOLOGY: K05859Help
Entry
K05859                      KO                                     

Name
PLCG2
Definition
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
M00130  
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Organismal Systems
  Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Development
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Infectious diseases
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
5336(PLCG2)
PTR: 
454268(PLCG2)
PPS: 
100984694(PLCG2)
GGO: 
101133643(PLCG2)
PON: 
MCC: 
714173(PLCG2)
MCF: 
102117471(PLCG2)
MMU: 
234779(Plcg2)
RNO: 
29337(Plcg2)
CGE: 
100752475(Plcg2)
HGL: 
TUP: 
102483786(PLCG2)
CFA: 
489692(PLCG2)
AML: 
100481994(PLCG2)
FCA: 
101080675(PLCG2)
PTG: 
102963653(PLCG2)
BOM: 
102285300(PLCG2)
PHD: 
102318880(PLCG2)
CHX: 
102180337(PLCG2)
SSC: 
100518663(PLCG2)
CFR: 
102514470(PLCG2)
BACU: 
103014764(PLCG2)
LVE: 
103070997(PLCG2)
ECB: 
100055670(PLCG2)
MYB: 
102261553(PLCG2)
MYD: 
102773476(PLCG2)
PALE: 
102883128(PLCG2)
MDO: 
100027579(PLCG2)
SHR: 
100919206(PLCG2)
OAA: 
100076776(PLCG2)
GGA: 
415805(PLCG2)
MGP: 
100549684(PLCG2)
TGU: 
100219388(PLCG2)
FAB: 
101811465(PLCG2)
PHI: 
102103443(PLCG2)
APLA: 
101799246(PLCG2)
FPG: 
101914329(PLCG2)
FCH: 
102058636(PLCG2)
CLV: 
102095823(PLCG2)
ASN: 
102378303(PLCG2)
AMJ: 
102574067(PLCG2)
PSS: 
102454220(PLCG2)
CMY: 
102930635(PLCG2)
ACS: 
100566814(plcg2)
PBI: 
103052396(PLCG2)
XLA: 
398360(xplcg1a)
XTR: 
100496686(plcg2)
DRE: 
561747(plcg2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103175953(plcg2)
API: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)

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