KEGG   ORTHOLOGY: K05860Help
Entry
K05860                      KO                                     

Name
PLCE
Definition
phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Pathway
Inositol phosphate metabolism
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Phosphatidylinositol signaling system
Thyroid hormone signaling pathway
Proteoglycans in cancer
Module
M00130  
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00626  
Nephrotic syndrome and focal segmental glomerulosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04015 Rap1 signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04020 Calcium signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04070 Phosphatidylinositol signaling system
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
51196(PLCE1)
PTR: 
450620(PLCE1)
PPS: 
100992707(PLCE1)
GGO: 
101125007(PLCE1)
PON: 
100444145(PLCE1)
MCC: 
701758(PLCE1)
MCF: 
102142941(PLCE1)
MMU: 
74055(Plce1)
RNO: 
114633(Plce1)
CGE: 
100754217(Plce1)
HGL: 
101706315(Plce1)
TUP: 
102499439(PLCE1)
CFA: 
486808(PLCE1)
AML: 
100479318(PLCE1)
FCA: 
101088695(PLCE1)
BTA: 
519037(PLCE1)
BOM: 
102268410(PLCE1)
PHD: 
102328398(PLCE1)
CHX: 
102178972(PLCE1)
SSC: 
100157745(PLCE1)
CFR: 
102519191(PLCE1)
ECB: 
100061676(PLCE1)
MYB: 
102241624(PLCE1)
MDO: 
100023487(PLCE1)
SHR: 
100917022(PLCE1)
GGA: 
MGP: 
100540174(PLCE1)
TGU: 
100222852(PLCE1)
FAB: 
101810240(PLCE1)
PHI: 
102113055(PLCE1)
APLA: 
101794187(PLCE1)
FPG: 
101913673(PLCE1)
FCH: 
102055055(PLCE1)
CLV: 
102086659(PLCE1)
ASN: 
102373514(PLCE1)
PSS: 
ACS: 
100552081(plce1)
XTR: 
100495530(plce1)
DRE: 
568288(plce1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345110(PLCE1)
AGA: 
AAG: 
CQU: 
AME: 
408804(Fucta)
NVI: 
TCA: 
BMOR: 
API: 
ISC: 
CEL: 
CBR: 
CBG17587(Cbr-plc-1)
BMY: 
LOA: 
TSP: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)

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