KEGG   ORTHOLOGY: K06269Help
Entry
K06269                      KO                                     

Name
PPP1C
Definition
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Pathway
mRNA surveillance pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Meiosis - yeast
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Hippo signaling pathway
Focal adhesion
Platelet activation
Long-term potentiation
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Oxytocin signaling pathway
Amphetamine addiction
Alcoholism
Herpes simplex infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04024 cAMP signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04022 cGMP - PKG signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Cell growth and death
   04113 Meiosis - yeast
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04114 Oocyte meiosis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Cellular commiunity
   04510 Focal adhesion
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 Organismal Systems
  Immune system
   04611 Platelet activation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Endocrine system
   04910 Insulin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04921 Oxytocin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04270 Vascular smooth muscle contraction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Nervous system
   04728 Dopaminergic synapse
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04720 Long-term potentiation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Substance dependence
   05031 Amphetamine addiction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   05034 Alcoholism
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  Infectious diseases
   05168 Herpes simplex infection
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Spliceosome [BR:ko03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
BRITE hierarchy
Other DBs
COG: 
GO: 
Genes
HSA: 
5499(PPP1CA) 5500(PPP1CB) 5501(PPP1CC)
PTR: 
459118(PPP1CB) 462795(PPP1CC) 743656(PPP1CC) 745709(PPP1CA)
PPS: 
100974889(PPP1CC) 100978326(PPP1CB) 100992486(PPP1CA)
GGO: 
101129953(PPP1CB) 101135243(PPP1CA) 101143438(PPP1CC)
PON: 
100173410(PPP1CB) 100458223(PPP1CC) 100459799(PPP1CA)
NLE: 
100587142(PPP1CB) 100603005(PPP1CA) 100605408(PPP1CC)
MCC: 
703302(PPP1CB) 709935(PPP1CC) 721735(PPP1CA)
MCF: 
101925057 102133300(PPP1CB) 102138402(PPP1CA)
CJC: 
MMU: 
19045(Ppp1ca) 19046(Ppp1cb) 19047(Ppp1cc) 434233(Gm5601)
RNO: 
24668(Ppp1ca) 24669(Ppp1cc) 25594(Ppp1cb)
CGE: 
100760810(Ppp1ca) 100761524(Ppp1cb) 100774547(Ppp1cc)
NGI: 
103725581(Ppp1ca) 103730228(Ppp1cb) 103739088(Ppp1cc)
HGL: 
101698044(Ppp1cb) 101704720 101705408(Ppp1ca) 101714468(Ppp1cc)
OCU: 
100009298(PPP1CA) 100009587(PPP1CB) 100353054(PPP1CC)
TUP: 
102476316(PPP1CC) 102477186(PPP1CA) 102496931(PPP1CB)
CFA: 
403557(PPP1CC) 403558(PPP1CB) 403609(PPP1CA)
AML: 
UMR: 
103661277(PPP1CC) 103671909(PPP1CB) 103679611(PPP1CA)
FCA: 
101080405(PPP1CA) 101092932(PPP1CB) 101100922(PPP1CC)
PTG: 
102948702(PPP1CC) 102970154(PPP1CB)
BTA: 
282318(PPP1CC) 516175(PPP1CA) 538829(PPP1CB)
BOM: 
102266876(PPP1CB) 102270793(PPP1CA) 102275429(PPP1CC) 102281385
PHD: 
102315478(PPP1CC) 102323423(PPP1CB) 102332733 102340215(PPP1CA)
CHX: 
OAS: 
SSC: 
CFR: 
102505354 102520782(PPP1CB) 102522874(PPP1CC)
BACU: 
103000500(PPP1CB) 103008250 103008309(PPP1CA) 103017316(PPP1CC)
LVE: 
103072994(PPP1CC) 103074387(PPP1CA) 103080471(PPP1CB) 103086084
ECB: 
100058160(PPP1CC) 100059233(PPP1CA) 100071067(PPP1CB)
MYB: 
MYD: 
102753893(PPP1CC) 102760260(PPP1CB) 102762734 102764391(PPP1CA)
PALE: 
102881448(PPP1CB) 102887827(PPP1CC) 102892254(PPP1CA)
MDO: 
SHR: 
100915116(PPP1CA) 100920526 100930570(PPP1CB)
OAA: 
100074395(PPP1CC) 100078635(PPP1CB)
GGA: 
396019(PPP1CB) 416872(PPP1CC)
MGP: 
APLA: 
101792735(PPP1CC) 101798783(PPP1CB) 101800204
TGU: 
FAB: 
101810420(PPP1CA) 101813100(PPP1CB)
PHI: 
FPG: 
101913968(PPP1CA) 101916649(PPP1CB) 101924787
FCH: 
102053170(PPP1CA) 102054093 102058478(PPP1CB)
CLV: 
102083732(PPP1CB) 102086082 102096027(PPP1CA)
ASN: 
102373171(PPP1CA) 102375415(PPP1CC) 102383008(PPP1CB)
AMJ: 
PSS: 
102449920 102450584(PPP1CC) 102463695(PPP1CA) 102463789(PPP1CB)
CMY: 
ACS: 
100552053(ppp1cb) 100558590(ppp1ca) 100565990(ppp1cc)
PBI: 
103056218(PPP1CC) 103057409(PPP1CA) 103062218(PPP1CB)
XLA: 
379914(ppp1ca) 380598(ppp1cc) 397767(ppp1cc) 443852(ppp1cb)
XTR: 
100145598(ppp1ca) 407879(ppp1cc) 496958(ppp1cb)
DRE: 
100003223(ppp1cb) 327301(ppp1cab) 334597(ppp1cbl) 407980(ppp1caa) 571753(ppp1cc)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103184322(ppp1cc) 103189617(ppp1cb)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG10138(PpD5) Dmel_CG2096(flw) Dmel_CG3245(PpN58A) Dmel_CG41534(Pp1-Y1) Dmel_CG5650(Pp1-87B) Dmel_CG6593(Pp1alpha-96A) Dmel_CG8822(PpD6) Dmel_CG9156(Pp1-13C)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409430(GB18815) 409804(GB17612)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG00598(Cbr-gsp-2) CBG09676(Cbr-gsp-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G64040(TOPP3) AT2G29400(TOPP1) AT2G39840(TOPP4) AT3G05580 AT3G46820(TOPP5) AT4G11240(TOPP7) AT5G27840(TOPP8) AT5G43380(TOPP6) AT5G59160(TOPP2)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0001s09930g(POPTRDRAFT_709256) POPTR_0001s25260g(POPTRDRAFT_641133) POPTR_0005s02390g POPTR_0006s11380g POPTR_0008s06110g(POPTRDRAFT_832567) POPTR_0008s16630g POPTR_0009s04250g(POPTRDRAFT_723198) POPTR_0010s20510g(POPTRDRAFT_724597) POPTR_0013s01620g(POPTRDRAFT_894563) POPTR_0013s04310g(POPTRDRAFT_895535) POPTR_0016s14930g(POPTRDRAFT_808800) POPTR_0019s03470g(POPTRDRAFT_1107637) POPTR_1376s00200g
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0349400-01(Os01g0349400) Os02t0820000-01(Os02g0820000) Os03t0268000-01(Os03g0268000) Os06t0164100-02(Os06g0164100) Os08t0455600-01(Os08g0455600)
OBR: 
BDI: 
SBI: 
SORBI_01g000357(SORBIDRAFT_01g000357) SORBI_01g039930(SORBIDRAFT_01g039930) SORBI_03g013800(SORBIDRAFT_03g013800) SORBI_07g022270(SORBIDRAFT_07g022270) SORBI_09g004260(SORBIDRAFT_09g004260) SORBI_10g004490(SORBIDRAFT_10g004490)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00009p00134520(AMTR_s00009p00134520) s00077p00182860(AMTR_s00077p00182860) s00097p00117970(AMTR_s00097p00117970) s00165p00079470(AMTR_s00165p00079470)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YDR436W(PPZ2) YER133W(GLC7) YML016C(PPZ1) YPL179W(PPQ1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B04450(NCAS0B04450) NCAS_0H01100(NCAS0H01100) NCAS_0H02660(NCAS0H02660)
NDI: 
NDAI_0B01900(NDAI0B01900) NDAI_0C00960(NDAI0C00960) NDAI_0F02190(NDAI0F02190)
TPF: 
TPHA_0D02470(TPHA0D02470) TPHA_0H00280(TPHA0H00280) TPHA_0K00420(TPHA0K00420) TPHA_0N01200(TPHA0N01200)
TBL: 
TBLA_0A06980(TBLA0A06980) TBLA_0A08840(TBLA0A08840) TBLA_0B05260(TBLA0B05260) TBLA_0D01510(TBLA0D01510)
TDL: 
TDEL_0A04110(TDEL0A04110) TDEL_0B04530(TDEL0B04530) TDEL_0F01790(TDEL0F01790)
KAF: 
KAFR_0B02190(KAFR0B02190) KAFR_0C05490(KAFR0C05490) KAFR_0G03660(KAFR0G03660)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.13181(PPQ1) CaO19.13664(GLC7) CaO19.5758(PPQ1) CaO19.6285(GLC7) CaO19.726(PPZ1) CaO19.8345(PPZ1)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1490154 AOR_1_2644174(AO090005001522) AOR_1_650114(AO090701000351)
ANG: 
ANI_1_1062064(An07g08600)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT117366(AGABI1DRAFT_117366) AGABI1DRAFT86604(AGABI1DRAFT_86604)
ABV: 
AGABI2DRAFT147675(AGABI2DRAFT_147675) AGABI2DRAFT152533(AGABI2DRAFT_152533)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_09009(pppB)
EHI: 
EHI_176170(156.t00006)
EDI: 
ACAN: 
PFA: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_III006130(17.m07543)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
NGD: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
MMAZ: 
MEL: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bollen M
  Title
Combinatorial control of protein phosphatase-1.
  Journal
Trends Biochem Sci 26:426-31 (2001)
Reference
  Authors
Lee JH, You J, Dobrota E, Skalnik DG
  Title
Identification and characterization of a novel human PP1 phosphatase complex.
  Journal
J Biol Chem 285:24466-76 (2010)
  Sequence
[hsa:5500 5501]

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