KEGG ORTHOLOGY: K06450

ORTHOLOGY: K06450

Entry

K06450                      KO

Symbol

CD3D

Name

T-cell surface glycoprotein CD3 delta chain

Pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04660 T cell receptor signaling pathway
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04658 Th1 and Th2 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04659 Th17 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05170 Human immunodeficiency virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05162 Measles
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05169 Epstein-Barr virus infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
CD molecules [BR:ko04090]
Proteins
  K06450  CD3d; CD3D antigen, delta polypeptide (TiT3 complex)

Genes

HSA:

915(CD3D)

PTR:	451584(CD3D)

PPS:	100979946(CD3D)

GGO:	101150395(CD3D)

PON:	100440740(CD3D)

NLE:	100603907(CD3D)

HMH:

116477008

MCC:	699582(CD3D)

MCF:	102133701(CD3D)

MTHB:

126936070

MNI:	105476413(CD3D)

CSAB:

103248585(CD3D)

CATY:

105582471(CD3D)

PANU:

101017443(CD3D)

TGE:	112606384(CD3D)

MLEU:

105528217(CD3D)

RRO:	104665574(CD3D)

RBB:	108536385(CD3D)

TFN:	117080882(CD3D)

PTEH:

111540206(CD3D)

CANG:

105501093(CD3D)

CJC:	100404313(CD3D)

SBQ:	101029738(CD3D)

CIMI:

108300597(CD3D)

CSYR:

103252246(CD3D)

MMUR:

105876053(CD3D)

LCAT:

123641520(CD3D)

PCOQ:

105819245(CD3D)

OGA:	100966280(CD3D)

MMU:	12500(Cd3d)

MCAL:

110302262(Cd3d)

MPAH:

110328514(Cd3d)

RNO:	25710(Cd3d)

MCOC:

116072408(Cd3d)

ANU:	117699353(Cd3d)

MUN:

110549118

CGE:	100756906(Cd3d)

MAUA:

101836347(Cd3d)

PROB:

127231639

PLEU:

114691294(Cd3d)

MORG:

121438266(Cd3d)

MFOT:

126510037

AAMP:

119809864(Cd3d)

NGI:	103748303(Cd3d)

HGL:	101712534(Cd3d)

CPOC:

100727506(Cd3d)

CCAN:

109699106(Cd3d)

DORD:

105980551(Cd3d)

DSP:	122110306(Cd3d)

PLOP:

NCAR:

MMMA:

OCU:

OPI:	101529860(CD3D)

TUP:	102498607(CD3D)

GVR:	103592269(CD3D)

CFA:	479419(CD3D)

CLUD:

112671248

VVP:	112920226(CD3D)

VLG:	121500522(CD3D)

NPO:

129497002

AML:	100484718(CD3D)

UMR:	103662337(CD3D)

UAH:	113260002(CD3D)

UAR:	123792618(CD3D)

ELK:

111153823

LLV:

125080069

MPUF:

101676392(CD3D)

MNP:

132027468

MLK:

131836621

NVS:	122912335(CD3D)

ORO:	101385969(CD3D)

EJU:	114211431(CD3D)

ZCA:	113914770(CD3D)

MLX:	118013287(CD3D)

NSU:	110586281(CD3D)

LWW:	102729861(CD3D)

FCA:	101083107(CD3D)

PYU:	121035465(CD3D)

PCOO:

112865955(CD3D)

PBG:	122483025(CD3D)

PVIV:

125176525

LRUF:

124504775

PTG:	102969057(CD3D)

PPAD:

109278564(CD3D)

PUC:

125909406

AJU:

106966153

HHV:	120229959(CD3D)

BTA:	281053(CD3D)

BOM:	102272573(CD3D)

BIU:	109569960(CD3D)

BBUB:

102390133(CD3D)

BBIS:

104981365(CD3D)

CHX:	102191154(CD3D)

OAS:	443397(CD3D)

BTAX:

128060506

ODA:	120876320(CD3D)

CCAD:

122450232(CD3D)

MBEZ:

129553778

SSC:	396661(CD3D)

CFR:	102505672(CD3D)

CBAI:

105067818(CD3D)

CDK:	105090171(CD3D)

VPC:	102533755(CD3D)

BACU:

103003761(CD3D)

BMUS:

118899710(CD3D)

LVE:	103069825(CD3D)

OOR:

101279567

DLE:	111166923(CD3D)

PCAD:

102979567

PSIU:

116758073(CD3D)

NASI:

112404016(CD3D)

ECB:	100062931(CD3D)

EPZ:	103546675(CD3D)

EAI:	106840277(CD3D)

MYB:	102240563(CD3D)

MYD:	102753304(CD3D)

MMYO:

118664240(CD3D)

MLF:	102436834(CD3D)

PKL:	118710562(CD3D)

EFUS:

103293741

MNA:	107530792(CD3D)

DRO:	112314228(CD3D)

SHON:

118994764(CD3D)

AJM:	119050808(CD3D)

PDIC:

114500133(CD3D)

PHAS:

123819998(CD3D)

MMF:	118628139(CD3D)

PPAM:

129086044

HAI:	109385283(CD3D)

RFQ:	117029810(CD3D)

PALE:

102894486(CD3D)

PGIG:

120622049(CD3D)

PVP:	105310192(CD3D)

RAY:	107516062(CD3D)

MJV:	108385099(CD3D)

TOD:

119239888

SARA:

101545654(CD3D)

SETR:

126015814

LAV:	100661471(CD3D)

TMU:

101353008

ETF:	101663960(CD3D)

DNM:	101413471(CD3D)

MDO:	100031472(CD3D)

GAS:	123242099(CD3D)

SHR:

100925080

PCW:	110207189(CD3D)

OAA:

100090811

GGA:	396518(CD3D)

PCOC:

116233175(CD3D)

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

120508489(CD3D)

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:	114056275 114056276

ZAB:

102070969

ACHL:

103806926(CD3D)

SVG:

106858161

MMEA:

130583264

HRT:

120762651

FPG:	101916542(CD3D)

FCH:	102052093(CD3D)

CLV:	102092403(CD3D)

EGZ:

104124562

NNI:	104019039(CD3D)

PCRI:

104037975(CD3D)

PLET:

104623866(CD3D)

EHS:

104504374

PCAO:

104041595(CD3D)

ACUN:

113488514

TALA:

104362679

PADL:

103921538(CD3D)

AFOR:

103894943(CD3D)

ACHC:

115344581(CD3D)

HALD:

104311029(CD3D)

HLE:	104836397(CD3D)

AGEN:

126038202

GCL:

127025805

CCRI:

104154784(CD3D)

CSTI:

104549896

CMAC:

104485277

MUI:	104533869(CD3D)

BREG:

104629353

FGA:	104073434(CD3D)

GSTE:

104260227(CD3D)

LDI:

104354396

MNB:	103774581(CD3D)

OHA:	104332056(CD3D)

NNT:

104408027

SHAB:

115616378

DPUB:

104301766

PGUU:

104462628(CD3D)

ACAR:

104521634

CPEA:

104398739

AVIT:

104270071(CD3D)

CVF:	104295032(CD3D)

RTD:

128918575

CUCA:

104068850(CD3D)

TEO:

104373115

BRHI:

104497096(CD3D)

AAM:	106491545(CD3D)

AROW:

112962044(CD3D)

NPD:	112948068(CD3D)

DNE:	112991715(CD3D)

ASN:	102382203(CD3D)

AMJ:	102572479(CD3D)

CPOO:

109315403(CD3D)

GGN:	109293913(CD3D)

CMY:	102940831(CD3G)

CCAY:

125625339

DCC:	119846672(CD3G)

CPIC:

101940477

TST:

117868715

CABI:

116822944(CD3G)

MRV:

ACS:

ASAO:

SUND:

NSS:	113420886(CD3G)

VKO:

PRAF:

ZVI:

HCG:

GJA:	107112603(CD3G)

STOW:

EMC:

SRX:

SGH:

CAUA:

TDW:

IPU:

TVC:

TRU:	654302(cd3g/d)

TNG:	GSTEN00012261G001

MSAM:

119883393

MZE:	101473769(cd3g)

XMA:

111611912

XCO:

114133423

CVG:	107080968 107102634

NFU:

ALIM:

CSEM:

SDU:

XGL:

SASA:

100136515 100137057 106580890

OTW:

112266839

OMY:

110503669

SALP:

111957658

LOC:	107075658(cd3d)

ARUT:

CPLA:

HOC:

LERI:

Reference

PMID:3488209

Authors

Tunnacliffe A, Sims JE, Rabbitts TH

Title

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

Journal

EMBO J 5:1245-52 (1986)
DOI:10.1002/j.1460-2075.1986.tb04353.x

Sequence

[hsa:915]

Reference

PMID:15546002

Authors

de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F

Title

Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

Journal

J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (9)   
   KEGG DRUG (9)   
Gene (286)   
   KEGG GENES (278)   
   KEGG MGENES (5)   
   RefGene (2)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (322)   

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