KEGG   ORTHOLOGY: K06464Help
Entry
K06464                      KO                                     

Name
ITGB2
Definition
integrin beta 2
Pathway
Rap1 signaling pathway
Phagosome
Hippo signaling pathway
Cell adhesion molecules (CAMs)
Complement and coagulation cascades
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pertussis
Legionellosis
Leishmaniasis
Malaria
Amoebiasis
Staphylococcus aureus infection
Tuberculosis
HTLV-I infection
Rheumatoid arthritis
Viral myocarditis
Disease
H00099  
Leukocyte adhesion deficiency (LAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06464  ITGB2; integrin beta 2
   04390 Hippo signaling pathway
    K06464  ITGB2; integrin beta 2
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06464  ITGB2; integrin beta 2
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06464  ITGB2; integrin beta 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06464  ITGB2; integrin beta 2
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K06464  ITGB2; integrin beta 2
   04650 Natural killer cell mediated cytotoxicity
    K06464  ITGB2; integrin beta 2
   04670 Leukocyte transendothelial migration
    K06464  ITGB2; integrin beta 2
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    K06464  ITGB2; integrin beta 2
  Cardiovascular diseases
   05416 Viral myocarditis
    K06464  ITGB2; integrin beta 2
  Infectious diseases
   05133 Pertussis
    K06464  ITGB2; integrin beta 2
   05134 Legionellosis
    K06464  ITGB2; integrin beta 2
   05150 Staphylococcus aureus infection
    K06464  ITGB2; integrin beta 2
   05152 Tuberculosis
    K06464  ITGB2; integrin beta 2
   05166 HTLV-I infection
    K06464  ITGB2; integrin beta 2
   05146 Amoebiasis
    K06464  ITGB2; integrin beta 2
   05144 Malaria
    K06464  ITGB2; integrin beta 2
   05140 Leishmaniasis
    K06464  ITGB2; integrin beta 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06464  ITGB2; integrin beta 2
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   ICAM family
    ICAM1; intercellular adhesion molecule 1
     LFA-1
      K06464 ITGB2; integrin beta 2
     CR3, Mac-1
      K06464 ITGB2; integrin beta 2
    ICAM2; intercellular adhesion molecule 2
     LFA-1
      K06464 ITGB2; integrin beta 2
     CR3, Mac-1
      K06464 ITGB2; integrin beta 2
    ICAM3; intercellular adhesion molecule 3
     LFA-1
      K06464 ITGB2; integrin beta 2
     alpha D beta 2
      K06464 ITGB2; integrin beta 2
   Others
    CD226, DNAM1; CD226 antigen
     LFA-1
      K06464 ITGB2; integrin beta 2
  Neural system
   N/0 subfamily
    ICAM5, TLCN; intercellular adhesion molecule 5
     LFA-1
      K06464 ITGB2; integrin beta 2
    THY1, CD90; Thy-1 cell surface antigen
     CR3, Mac-1
      K06464 ITGB2; integrin beta 2
  Others
   VCAM1; vascular cell adhesion molecule 1
    CR3, Mac-1
     K06464 ITGB2; integrin beta 2
    alpha D beta 2
     K06464 ITGB2; integrin beta 2
   ICAM4; intercellular adhesion molecule 4
    LFA-1
     K06464 ITGB2; integrin beta 2
    CR3, Mac-1
     K06464 ITGB2; integrin beta 2
    p150/95
     K06464 ITGB2; integrin beta 2
   F11R, JAM1; junctional adhesion molecule 1
    LFA-1
     K06464 ITGB2; integrin beta 2
   JAM3; junctional adhesional molecule 3
    CR3, Mac-1
     K06464 ITGB2; integrin beta 2
 3. Selectin Family
  SELE; selectin, endothelial cell
   CR3, Mac-1
    K06464 ITGB2; integrin beta 2
 7. Others
  TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5
   CR3, Mac-1
    K06464 ITGB2; integrin beta 2
  CD209; CD209 antigen
   CR3, Mac-1
    K06464 ITGB2; integrin beta 2
Cellular antigens [BR:ko04090]
 Proteins
  K06464  CD18, ITGB2; integrin, beta 2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3689(ITGB2)
PTR: 
458607(ITGB2)
PPS: 
100985940(ITGB2)
GGO: 
101142773(ITGB2)
PON: 
100451938(ITGB2)
NLE: 
100600337(ITGB2)
MCC: 
710577(ITGB2)
MCF: 
101925124(ITGB2)
RRO: 
104659958(ITGB2)
CJC: 
100402685(ITGB2)
MMU: 
16414(Itgb2) 16415(Itgb2l)
RNO: 
309684(Itgb2)
CGE: 
100756135(Itgb2)
NGI: 
103739950(Itgb2)
HGL: 
101703921(Itgb2)
OCU: 
100339049(ITGB2)
TUP: 
CFA: 
403770(ITGB2)
AML: 
100484264(ITGB2)
UMR: 
103680739(ITGB2)
FCA: 
101087258(ITGB2)
PTG: 
102962262(ITGB2)
BTA: 
281877(ITGB2)
BOM: 
102285348(ITGB2)
PHD: 
102336279(ITGB2)
CHX: 
OAS: 
494433(ITGB2)
SSC: 
396943(ITGB2)
CFR: 
102512225(ITGB2)
BACU: 
103008120(ITGB2)
LVE: 
103079755(ITGB2)
ECB: 
100056128(ITGB2)
MYB: 
102248879(ITGB2)
MYD: 
102760033(ITGB2)
PALE: 
102896231(ITGB2)
MDO: 
100024596(ITGB2)
SHR: 
100925715(ITGB2) 100928650(ITGB2)
GGA: 
396181(ITGB2)
MGP: 
100543565(ITGB2)
CJO: 
107316393(ITGB2)
APLA: 
101796803(ITGB2)
TGU: 
100229042(ITGB2)
GFR: 
102035991(ITGB2)
FAB: 
101806243(ITGB2)
PHI: 
102111289(ITGB2)
CCW: 
104698247(ITGB2)
FPG: 
101919496(ITGB2)
FCH: 
102051822(ITGB2)
CLV: 
102087554(ITGB2)
AAM: 
106492316(ITGB2)
ASN: 
102383861(ITGB2)
AMJ: 
102563942(ITGB2)
PSS: 
102455278(ITGB2)
CMY: 
102947116(ITGB2)
ACS: 
100564287(itgb2)
PBI: 
103050081(ITGB2)
GJA: 
107117606(ITGB2)
XLA: 
379708(itgb2-b)
XTR: 
100492659(itgb2)
DRE: 
557797(itgb2)
TRU: 
101071641(itgb2)
MZE: 
101476106(itgb2)
OLA: 
XMA: 
LCM: 
102365824(ITGB2)
CMK: 
103176852(itgb2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3028646
  Authors
Kishimoto TK, O'Connor K, Lee A, Roberts TM, Springer TA
  Title
Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.
  Journal
Cell 48:681-90 (1987)
  Sequence
[hsa:3689]
Reference
  Authors
Xu J, Gao XP, Ramchandran R, Zhao YY, Vogel SM, Malik AB
  Title
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
  Journal
Nat Immunol 9:880-6 (2008)

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