KEGG   ORTHOLOGY: K06621Help
Entry
K06621                      KO                                     

Name
CDKN2A, P16, INK4A
Definition
cyclin-dependent kinase inhibitor 2A
Pathway
Cell cycle
p53 signaling pathway
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
MicroRNAs in cancer
Pancreatic cancer
Glioma
Melanoma
Bladder cancer
Chronic myeloid leukemia
Non-small cell lung cancer
Disease
H00004  
Chronic myeloid leukemia (CML)
H00008  
Burkitt lymphoma
H00009  
Adult T-cell leukemia
H00014  
Non-small cell lung cancer
H00015  
Malignant pleural mesothelioma
H00016  
Oral cancer
H00017  
Esophageal cancer
H00019  
Pancreatic cancer
H00022  
Bladder cancer
H00025  
Penile cancer
H00036  
Osteosarcoma
H00038  
Malignant melanoma
H00040  
Squamous cell carcinoma
H00042  
Glioma
H00045  
Malignant islet cell carcinoma
H00046  
Cholangiocarcinoma
H00047  
Gallbladder cancer
H00048  
Hepatocellular carcinoma
H00054  
Nasopharyngeal cancer
H00055  
Laryngeal cancer
H00409  
Type II diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   04115 p53 signaling pathway
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05206 MicroRNAs in cancer
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05203 Viral carcinogenesis
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05212 Pancreatic cancer
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05214 Glioma
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05220 Chronic myeloid leukemia
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05218 Melanoma
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05219 Bladder cancer
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
   05223 Non-small cell lung cancer
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
  Infectious diseases
   05166 HTLV-I infection
    K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1029(CDKN2A)
PTR: 
465021(CDKN2A)
PPS: 
GGO: 
101145463(CDKN2A)
PON: 
MCC: 
MCF: 
102135474(CDKN2A)
MMU: 
12578(Cdkn2a)
RNO: 
25163(Cdkn2a)
CGE: 
CFA: 
100271861(CDKN2A)
AML: 
FCA: 
101089220(CDKN2A)
BTA: 
616369(CDKN2A)
BOM: 
102284461(CDKN2A)
LVE: 
103072667(CDKN2A)
ECB: 
100146270(CDKN2A)
OAA: 
ACS: 
100562668(cdkn2b)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9724636
  Authors
Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, Peters G
  Title
The alternative product from the human CDKN2A locus, p14(ARF), participates in a  regulatory feedback loop with p53 and MDM2.
  Journal
EMBO J 17:5001-14 (1998)
  Sequence
[hsa:1029]

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