KEGG   ORTHOLOGY: K06641Help
Entry
K06641                      KO                                     

Name
CHK2
Definition
serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
Pathway
Cell cycle
Cell cycle - yeast
p53 signaling pathway
HTLV-I infection
Module
M00691  
DNA damage-induced cell cycle checkpoints
Disease
H00881  
Li-Fraumeni syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06641  CHK2; serine/threonine-protein kinase Chk2
   04111 Cell cycle - yeast
    K06641  CHK2; serine/threonine-protein kinase Chk2
   04115 p53 signaling pathway
    K06641  CHK2; serine/threonine-protein kinase Chk2
 Human Diseases
  Infectious diseases
   05166 HTLV-I infection
    K06641  CHK2; serine/threonine-protein kinase Chk2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K06641  CHK2; serine/threonine-protein kinase Chk2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06641  CHK2; serine/threonine-protein kinase Chk2
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CAMK group
  RAD53 family
   K06641  CHK2; serine/threonine-protein kinase Chk2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K06641  CHK2; serine/threonine-protein kinase Chk2
BRITE hierarchy
Other DBs
COG: 
Genes
HSA: 
11200(CHEK2)
PTR: 
458733(CHEK2)
PPS: 
100987687(CHEK2)
GGO: 
PON: 
100461345(CHEK2)
NLE: 
100594542(CHEK2)
MCC: 
713668(CHEK2)
MCF: 
102122988(CHEK2)
CJC: 
100404949(CHEK2)
MMU: 
50883(Chek2)
RNO: 
114212(Chek2)
CGE: 
100769280(Chek2)
NGI: 
103750875(Chek2)
HGL: 
101721212(Chek2)
OCU: 
100339430(CHEK2)
TUP: 
102484993(CHEK2)
CFA: 
486338(CHEK2)
AML: 
100467146(CHEK2)
UMR: 
103659236(CHEK2)
FCA: 
101085665(CHEK2)
PTG: 
102960814(CHEK2)
BTA: 
518897(CHEK2)
BOM: 
102283552(CHEK2)
PHD: 
102320600(CHEK2)
CHX: 
102184180(CHEK2)
OAS: 
101105532(CHEK2)
SSC: 
100192447(CHEK2)
CFR: 
102508820(CHEK2)
BACU: 
103014798(CHEK2)
LVE: 
103076926(CHEK2)
ECB: 
100059288(CHEK2)
MYB: 
102250232(CHEK2)
MYD: 
102766522(CHEK2)
PALE: 
102882358(CHEK2)
MDO: 
100030584(CHEK2)
SHR: 
100932330(CHEK2)
OAA: 
100077482(CHEK2)
GGA: 
768913(CHEK2)
MGP: 
APLA: 
101802450(CHEK2)
TGU: 
100228558(CHEK2)
FAB: 
101811158(CHEK2)
PHI: 
102110514(CHEK2)
FPG: 
101911493(CHEK2)
FCH: 
102057640(CHEK2)
CLV: 
102090751(CHEK2)
ASN: 
102386466(CHEK2)
AMJ: 
102574431(CHEK2)
PSS: 
102461937(CHEK2)
CMY: 
102947582(CHEK2)
PBI: 
103066019(CHEK2)
XLA: 
398179(chek2)
XTR: 
100144952(chek2)
DRE: 
336998(chek2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362683(CHEK2)
CMK: 
103184008(chek2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
551949(lok)
NVI: 
TCA: 
BMOR: 
692482(Chk2)
API: 
PHU: 
CEL: 
CBR: 
CBG20512(Cbr-chk-2)
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
SCE: 
YDL101C(DUN1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B05910(NCAS0B05910)
NDI: 
NDAI_0B03190(NDAI0B03190)
TPF: 
TPHA_0C04570(TPHA0C04570)
TBL: 
TBLA_0B07330(TBLA0B07330)
TDL: 
TDEL_0G02820(TDEL0G02820)
KAF: 
KAFR_0K02450(KAFR0K02450)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1504014(AO090026000841)
ANG: 
ANI_1_520114(An13g00100)
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
DSQ: 
PCO: 
PSQ: 
ADL: 
FME: 
SCM: 
CPUT: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_05550(fhkA) DFA_07254(fhkD) DFA_10013(fhkC)
EHI: 
EHI_011510(90.t00001)
EDI: 
TPS: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
  Title
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
  Journal
Mol Cell Biol 28:5874-85 (2008)
  Sequence
[hsa:11200]
Reference
  Authors
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ
  Title
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
  Journal
Oncogene 27:3977-85 (2008)
  Sequence
[hsa:11200]
Reference
  Authors
Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H
  Title
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
  Journal
Nat Cell Biol 12:492-9 (2010)
  Sequence
[hsa:11200]

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