KEGG   ORTHOLOGY: K06641
Entry
K06641                      KO                                     
Symbol
CHEK2
Name
serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
Pathway
map04110  Cell cycle
map04111  Cell cycle - yeast
map04115  p53 signaling pathway
map04218  Cellular senescence
map05166  Human T-cell leukemia virus 1 infection
Disease
H00020  Colorectal cancer
H00036  Osteosarcoma
H00881  Li-Fraumeni syndrome
H02624  Tumor predisposition syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04111 Cell cycle - yeast
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04115 p53 signaling pathway
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04218 Cellular senescence
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06641  CHEK2; serine/threonine-protein kinase CHEK2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   K06641  CHEK2; serine/threonine-protein kinase CHEK2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Other DBs
COG: COG0515
Genes
HSA: 11200(CHEK2)
PTR: 458733(CHEK2)
PPS: 100987687(CHEK2)
GGO: 101124618(CHEK2)
PON: 100461345(CHEK2)
NLE: 100594542(CHEK2)
HMH: 116458592(CHEK2)
MCC: 713668(CHEK2)
MCF: 102122988(CHEK2)
MTHB: 126963968
MNI: 105487285(CHEK2)
CSAB: 103223122(CHEK2)
CATY: 105575682(CHEK2)
PANU: 101015280(CHEK2)
TGE: 112633701(CHEK2)
MLEU: 105550735(CHEK2)
RRO: 104658998(CHEK2)
RBB: 108517558(CHEK2)
TFN: 117096133(CHEK2)
PTEH: 111525354(CHEK2)
CANG: 105506620(CHEK2)
CJC: 100404949(CHEK2)
SBQ: 101051768(CHEK2)
CIMI: 108290013(CHEK2)
CSYR: 103261071(CHEK2)
MMUR: 105870892(CHEK2)
LCAT: 123625798(CHEK2)
PCOQ: 105810166(CHEK2)
OGA: 100959652(CHEK2)
MMU: 50883(Chek2)
MCAL: 110294527(Chek2)
MPAH: 110312870(Chek2)
RNO: 114212(Chek2)
MCOC: 116068143(Chek2)
ANU: 117697671(Chek2)
MUN: 110553166(Chek2)
CGE: 100769280(Chek2)
MAUA: 101829845(Chek2)
PROB: 127215931(Chek2)
PLEU: 114685972
MORG: 121446253(Chek2)
MFOT: 126488526
AAMP: 119825027(Chek2)
NGI: 103750875(Chek2)
HGL: 101721212(Chek2)
CPOC: 100727440(Chek2)
CCAN: 109690250(Chek2)
DORD: 105984170(Chek2)
DSP: 122097162(Chek2)
PLOP: 125348986(Chek2)
NCAR: 124991831
MMMA: 107154594(Chek2)
OCU: 100339430
OPI: 101527828(CHEK2)
TUP: 102484993(CHEK2)
GVR: 103598989(CHEK2)
CFA: 486338(CHEK2)
CLUD: 112676766(CHEK2)
VVP: 112906959(CHEK2)
VLG: 121475489(CHEK2)
NPO: 129507791(CHEK2)
AML: 100467146(CHEK2)
UMR: 103659236(CHEK2)
UAH: 113244997(CHEK2)
UAR: 123788135(CHEK2)
ELK: 111160086
LLV: 125081641
MPUF: 101690611(CHEK2)
MNP: 132023294(CHEK2)
MLK: 131811318(CHEK2)
NVS: 122903292(CHEK2)
ORO: 101386368(CHEK2)
EJU: 114225227(CHEK2)
ZCA: 113912998(CHEK2)
MLX: 118018616(CHEK2)
NSU: 110592495(CHEK2)
LWW: 102740114(CHEK2)
FCA: 101085665(CHEK2)
PYU: 121022574(CHEK2)
PCOO: 112870152(CHEK2)
PBG: 122470428(CHEK2)
PVIV: 125149108(CHEK2)
LRUF: 124518366
PTG: 102960814(CHEK2)
PPAD: 109253543(CHEK2)
PUC: 125914493
AJU: 106985461
HHV: 120227007(CHEK2)
BTA: 518897(CHEK2)
BOM: 102283552(CHEK2)
BIU: 109571019(CHEK2)
BBUB: 102409445(CHEK2)
BBIS: 104980115(CHEK2)
CHX: 102184180(CHEK2)
OAS: 101105532(CHEK2)
BTAX: 128062388(CHEK2) 128071171
ODA: 120871465(CHEK2)
CCAD: 122421545(CHEK2)
MBEZ: 129542403(CHEK2)
SSC: 100192447(CHEK2)
CFR: 102508820(CHEK2)
CBAI: 105066046(CHEK2)
CDK: 105099476(CHEK2)
VPC: 102528805(CHEK2)
BACU: 103014798(CHEK2)
BMUS: 118906782(CHEK2)
LVE: 103076926(CHEK2)
OOR: 101289528(CHEK2)
DLE: 111162720(CHEK2)
PCAD: 102986126(CHEK2)
PSIU: 116739234(CHEK2)
NASI: 112415141(CHEK2)
ECB: 100059288(CHEK2)
EPZ: 103554111(CHEK2)
EAI: 106827624(CHEK2)
MYB: 102250232(CHEK2)
MYD: 102766522(CHEK2)
MMYO: 118678212(CHEK2)
MLF: 111828035(CHEK2)
PKL: 118725344(CHEK2)
EFUS: 103287141(CHEK2)
MNA: 107526210(CHEK2)
DRO: 112310842(CHEK2)
SHON: 118991250(CHEK2)
AJM: 119055166(CHEK2)
PDIC: 114509918(CHEK2)
PHAS: 123810780(CHEK2)
MMF: 118639835(CHEK2)
PPAM: 129087453(CHEK2)
HAI: 109383036(CHEK2)
RFQ: 117017741(CHEK2)
PALE: 102882358(CHEK2)
PGIG: 120601945(CHEK2)
PVP: 105300942(CHEK2)
RAY: 107520494(CHEK2)
MJV: 108408453(CHEK2)
TOD: 119244807(CHEK2)
SARA: 101551593(CHEK2)
SETR: 126030601(CHEK2)
LAV: 100666208(CHEK2)
TMU: 101359759
ETF: 101654360(CHEK2)
DNM: 101433313(CHEK2)
MDO: 100030584(CHEK2)
GAS: 123256922(CHEK2)
SHR: 100932330(CHEK2)
AFZ: 127545635
PCW: 110215254(CHEK2)
OAA: 100077482(CHEK2)
GGA: 768913(CHEK2)
PCOC: 116228512(CHEK2)
MGP: 100543068(CHEK2)
CJO: 107321227(CHEK2)
TPAI: 128083884(CHEK2)
LMUT: 125701808(CHEK2)
NMEL: 110406189(CHEK2)
APLA: 119718547(CHEK2)
ACYG: 106043894(CHEK2)
CATA: 118257551(CHEK2)
AFUL: 116496237(CHEK2)
TGU: 100228558(CHEK2)
LSR: 110478117(CHEK2)
SCAN: 103818108(CHEK2)
PMOA: 120509791(CHEK2)
OTC: 121338890(CHEK2)
PRUF: 121364905(CHEK2)
GFR: 102038788(CHEK2)
FAB: 101811158(CHEK2)
OMA: 130259820(CHEK2)
PHI: 102110514(CHEK2)
PMAJ: 107211857(CHEK2)
CCAE: 111936476(CHEK2)
CCW: 104688640(CHEK2)
CBRC: 103615960(CHEK2)
ETL: 114061540(CHEK2)
ZAB: 102074783(CHEK2)
ACHL: 103807248(CHEK2)
SVG: 106852403(CHEK2)
MMEA: 130579619(CHEK2)
HRT: 120760510(CHEK2)
FPG: 101911493(CHEK2)
FCH: 102057640(CHEK2)
CLV: 102090751(CHEK2)
EGZ: 104122580(CHEK2)
NNI: 104015770(CHEK2)
PCRI: 104034884(CHEK2)
PLET: 104614156(CHEK2)
EHS: 104517007(CHEK2)
PCAO: 104040006(CHEK2)
ACUN: 113486115(CHEK2)
TALA: 104369204(CHEK2)
PADL: 103922582(CHEK2)
AFOR: 103901854(CHEK2)
ACHC: 115346208(CHEK2)
HALD: 104310710(CHEK2)
HLE: 104840813(CHEK2)
AGEN: 126040677
GCL: 127022946
CCRI: 104155061(CHEK2)
CSTI: 104550158(CHEK2)
CMAC: 104476199(CHEK2)
MUI: 104533845(CHEK2)
BREG: 104630198(CHEK2)
FGA: 104080965(CHEK2)
GSTE: 104250858(CHEK2)
LDI: 104339794(CHEK2)
MNB: 103778082(CHEK2)
OHA: 104327946(CHEK2)
NNT: 104400160(CHEK2)
SHAB: 115614786(CHEK2)
DPUB: 104309009(CHEK2)
PGUU: 104458250(CHEK2)
ACAR: 104520756(CHEK2)
CPEA: 104388023(CHEK2)
AVIT: 104273658(CHEK2)
CVF: 104289437(CHEK2)
RTD: 128917243(CHEK2)
CUCA: 104068451(CHEK2)
TEO: 104370071(CHEK2)
BRHI: 104487976(CHEK2)
AAM: 106492744(CHEK2)
AROW: 112968877(CHEK2)
NPD: 112945202(CHEK2)
TGT: 104566530(CHEK2)
DNE: 112990117(CHEK2)
SCAM: 104142411(CHEK2)
ASN: 102386466(CHEK2)
AMJ: 102574431(CHEK2)
CPOO: 109312584(CHEK2)
GGN: 109290633(CHEK2)
PSS: 102461937(CHEK2)
CMY: 102947582(CHEK2)
CCAY: 125622921(CHEK2)
DCC: 119843583(CHEK2)
CPIC: 101952469(CHEK2)
TST: 117887954(CHEK2)
CABI: 116816357(CHEK2)
MRV: 120386116(CHEK2)
ASAO: 132780926(CHEK2)
PVT: 110083425(CHEK2)
PBI: 103066019(CHEK2)
PMUR: 107287280(CHEK2)
CTIG: 120316802(CHEK2)
TSR: 106550569(CHEK2)
PGUT: 117672313(CHEK2)
APRI: 131185748(CHEK2)
PTEX: 113448613(CHEK2)
NSS: 113423945(CHEK2)
VKO: 123021468(CHEK2)
PMUA: 114587126(CHEK2)
PRAF: 128403965(CHEK2)
ZVI: 118076474(CHEK2)
HCG: 128338126(CHEK2)
GJA: 107123921(CHEK2)
STOW: 125442669(CHEK2)
EMC: 129341075(CHEK2)
XLA: 398179(chek2.L)
XTR: 100144952(chek2)
NPR: 108788045(CHEK2)
RTEM: 120937463(CHEK2)
BBUF: 120988812(CHEK2)
BGAR: 122924376(CHEK2)
MUO: 115479909(CHEK2)
GSH: 117365655(CHEK2)
DRE: 336998(chek2)
SRX: 107723314(chek2) 107751420
PTET: 122344848(chek2)
LROH: 127164710(chek2)
OMC: 131540908(chek2)
PPRM: 120469300(chek2)
RKG: 130088145(chek2)
MAMB: 125267298(chek2)
CIDE: 127513317
TROS: 130550715(chek2)
TDW: 130419886(chek2)
MANU: 129439657(chek2)
IPU: 108255821
PHYP: 113525110(chek2)
SMEO: 124380672(chek2)
TFD: 113648162(chek2)
TVC: 132855263(chek2)
AMEX: 103034962(chek2)
CMAO: 118827351(chek2)
EEE: 113572926(chek2)
CHAR: 105890008(chek2)
TRU: 101063164(chek2)
TFS: 130525893(chek2)
TBEN: 117469109(chek2)
GACU: 117562423(chek2)
EMAC: 134873996(chek2)
ELY: 117252154(chek2)
EFO: 125890878(chek2)
SLUC: 116058675(chek2)
PFLV: 114555216(chek2)
PPUG: 119225341(chek2)
AFB: 129100893(chek2)
PSWI: 130196775(chek2)
MSAM: 119891558(chek2)
SCHU: 122876018(chek2)
CUD: 121509236(chek2)
ALAT: 119019026(chek2)
MZE: 101485707(chek2)
ONL: 100708289(chek2)
OAU: 116311592(chek2)
OLA: 101170645(chek2)
OML: 112137749(chek2)
CSAI: 133451182(chek2)
XMA: 102224037
XCO: 114154787
XHE: 116730244(chek2)
PRET: 103460387(chek2)
PFOR: 103156298(chek2)
PLAI: 106940749(chek2)
PMEI: 106910148(chek2)
GAF: 122828618(chek2)
PPRL: 129366189(chek2)
CVG: 107105136
CTUL: 119777639(chek2)
GMU: 124877950(chek2)
NFU: 107386179(chek2)
KMR: 108248076(chek2)
ALIM: 106536288(chek2)
NWH: 119412971(chek2)
AOCE: 111573057(chek2)
MCEP: 125012658(chek2)
CSEM: 103397943(chek2)
POV: 109645723
SSEN: 122769258(chek2)
HSP: 118114701(chek2)
SMAU: 118314379(chek2)
LCF: 108894515
SDU: 111237444(chek2)
SLAL: 111649055(chek2)
XGL: 120787503(chek2)
HCQ: 109525295(chek2)
SSCV: 125993791
SBIA: 133499406(chek2)
PEE: 133399613(chek2)
PTAO: 133475665(chek2)
BPEC: 110169250(chek2)
MALB: 109957388
BSPL: 114861437(chek2)
SJO: 128364725(chek2)
OTW: 112248230 112263301(chek2)
OMY: 100286815(chek2) 110525341
OGO: 124034568 124036029(chek2)
OKI: 109876183 109895648(chek2)
OKE: 118358049(chek2) 118392920
ELS: 105014423(chek2)
SFM: 108927301(chek2)
PKI: 111852734(chek2)
AANG: 118206841(chek2)
LOC: 102691768(chek2)
PSPA: 121299476(chek2)
PSEX: 120539988(chek2)
LCM: 102362683(CHEK2)
CMK: 103184008(chek2)
RTP: 109911275(chek2)
CPLA: 122562547(chek2)
HOC: 132827286(chek2)
LERI: 129709207(chek2)
PMRN: 116942575(CHEK2)
LRJ: 133349183
BFO: 118426647
BBEL: 109464726
CIN: 100175326
SCLV: 120342829
LPIC: 129281450
APLC: 110976646
AJC: 117115738
SKO: 100372241
DME: Dmel_CG10895(lok)
DER: 6549116
DSE: 6614767
DSI: Dsimw501_GD24241(Dsim_GD24241)
DAN: 6497269
DPO: 4816397
DPE: 6596561
DMN: 108162747
DWI: 6646756
DGR: 6566473
DAZ: 108609925
DNV: 108650024
DHE: 111600369
DVI: 6634353
CCAT: 101453004
BOD: 106617276
BDR: 105223735
RZE: 108366280
AOQ: 129249122
TDA: 119689748
MDE: 101896859
SCAC: 106083079
LCQ: 111686974
LSQ: 119600412
ECOE: 129942159
CLON: 129618600
HIS: 119653022
AFUN: 125761963
AALI: 118459133
AAG: 5569344
CPII: 120428163
BCOO: 119085957
AME: 551949
ACER: 108001115
ALAB: 122710387
ADR: 102677249
AFLR: 100867678
BIM: 100745014
BBIF: 117206025
BVK: 117235533
BVAN: 117154104
BTER: 100649762
BAFF: 126916913
BPYO: 122565977
BPAS: 132905303
FVI: 122530057
CCAL: 108628555
OBB: 114871747
OLG: 117610987
MGEN: 117225470
NMEA: 116435205
CGIG: 122400706
MPHA: 105833500
AEC: 105151042
ACEP: 105619804
PBAR: 105422193
VEM: 105566545
HST: 105181538
DQU: 106746783
CFO: 105258386
FEX: 115244616
LHU: 105668387
PGC: 109861563
OBO: 105285139
PCF: 106793397
PFUC: 122524740
VPS: 122628186
VCRB: 124422489
VVE: 124947493
NVI: 100117742
CSOL: 105366519
TPRE: 106649768
LHT: 122512610
LBD: 127277477
MDL: 103568664
CGLO: 123266353
FAS: 105268457
DAM: 107037437
VCAN: 122415034
CCIN: 107268766
DSM: 124410278
NPT: 124220171
NFB: 124183354
NLO: 107220920
NVG: 124305199
AROA: 105687701
TCA: 661264
DPA: 109538347
SOY: 115884314
AGRG: 126746931
ATD: 109608704
CSET: 123316527
NVL: 108558766
APLN: 108732626
PPYR: 116177683
OTU: 111426617
BMOR: 692482(Chk2)
BMAN: 114252597
MSEX: 115456086
BANY: 112044455
MJU: 123872577
NIQ: 126773997
VCD: 124534033
MCIX: 123656406
PMAC: 106717857
PPOT: 106108458
PXU: 106115782
PRAP: 111003433
PBX: 123710233
PNAP: 125048953
ZCE: 119830996
CCRC: 123696391
LSIN: 126977390
AAGE: 121733143
HAW: 110374774
HZE: 124637262
TNL: 113498960
SLIU: 111364921
OFU: 114360681
PXY: 105381643
PGW: 126372026
CCRN: 123291965
API: 100163511
DNX: 107174043
AGS: 114123755
RMD: 113547984
DVT: 126902282
BTAB: 109031651
CLEC: 106664898
HHAL: 106678371
NLU: 111043225
MQU: 128998475
SGRE: 126326589
IEL: 124158614
DMK: 116919216
PVM: 113829798
PJA: 122256431
PCHN: 125038545
PMOO: 119597764
HAME: 121871072
PCLA: 123759711
CQD: 128695821
PTRU: 123510413
ESN: 127000315
HAZT: 108667675
EAF: 111701005
LSM: 121124457
TCF: 131889649
CSCU: 111617872
LPOL: 106465562
PMEO: 129585414
CEL: CELE_T08D2.7(chkr-1) CELE_Y60A3A.12(chk-2)
CBR: CBG_20512(Cbr-chk-2) CBG_24469
PVUL: 126825193
PCAN: 112561834
BGT: 106067930
HRF: 124147750
HRJ: 124286961
CRG: 105318723
CANU: 128187581
OED: 125655887
MYI: 110445255
PMAX: 117333091
MCAF: 127712666
MMER: 123533799
RPHI: 132758253
DPOL: 127852373
OBI: 106878443
OSN: 115226143
LAK: 106155701
SHX: MS3_00007174(CHEK2_2)
EGL: EGR_00376
NVE: 5516550
EPA: 110232754
ATEN: 116295913
ADF: 107341547
AMIL: 114959893
PDAM: 113686167
SPIS: 111336580
DGT: 114520644
XEN: 124434659
HMG: 100207948
SCE: YDL101C(DUN1)
SEUB: DI49_0969
ERC: Ecym_5624
KMX: KLMA_20647(DUN1)
NCS: NCAS_0B05910(NCAS0B05910)
NDI: NDAI_0B03190(NDAI0B03190)
TPF: TPHA_0C04570(TPHA0C04570)
TBL: TBLA_0B07330(TBLA0B07330)
TDL: TDEL_0G02820(TDEL0G02820)
KAF: KAFR_0K02450(KAFR0K02450)
KNG: KNAG_0A05670(KNAG0A05670)
CAL: CAALFM_C505100CA(DUN1)
NCR: NCU02814(prd-4)
NTE: NEUTE1DRAFT133979(NEUTE1DRAFT_133979)
PBEL: QC761_107860(DUN1)
PPSD: QC762_107860(DUN1)
PPSP: QC763_107860(DUN1)
PPSA: QC764_107860(DUN1)
MGR: MGG_01596
PGRI: PgNI_03902
SSCK: SPSK_05999
MAW: MAC_01056
MAJ: MAA_05678
CMT: CCM_01421
MBE: MBM_06218
ABE: ARB_00949
TVE: TRV_00735
PNO: SNOG_03701(SNOG_03700)
PTE: PTT_12246
MBR: MONBRDRAFT_15828(Cds1)
DDI: DDB_G0281567(fhkC)
DFA: DFA_05550(fhkA)
EHI: EHI_011510(90.t00001)
 » show all
Reference
  Authors
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
  Title
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
  Journal
Mol Cell Biol 28:5874-85 (2008)
DOI:10.1128/MCB.00821-08
  Sequence
[hsa:11200]
Reference
  Authors
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ
  Title
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
  Journal
Oncogene 27:3977-85 (2008)
DOI:10.1038/onc.2008.17
  Sequence
[hsa:11200]
Reference
PMID:9836640
  Authors
Matsuoka S, Huang M, Elledge SJ
  Title
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
  Journal
Science 282:1893-7 (1998)
DOI:10.1126/science.282.5395.1893
  Sequence
[hsa:11200]

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