KEGG   ORTHOLOGY: K06642Help
Entry
K06642                      KO                                     

Name
PRKDC
Definition
DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
Pathway
ko03450  Non-homologous end-joining
ko04110  Cell cycle
Module
M00297  DNA-PK complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03450 Non-homologous end-joining
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Repair system
    M00297  DNA-PK complex
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Termination Factors
   Other telomere regulation proteins
    Others
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    DNA-PK complex
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
BRITE hierarchy
Other DBs
GO: 0004677
Genes
HSA: 5591(PRKDC)
PTR: 464165(PRKDC)
PPS: 100981342(PRKDC)
GGO: 101128261(PRKDC)
PON: 100460398(PRKDC)
NLE: 100586225(PRKDC) 100596520
MCC: 708029(PRKDC)
MCF: 102119406(PRKDC)
CSAB: 103236758(PRKDC)
RRO: 104657634(PRKDC)
RBB: 108535350(PRKDC)
CJC: 100399020(PRKDC)
SBQ: 101053589(PRKDC)
MMU: 19090(Prkdc)
RNO: 360748(Prkdc)
CGE: 100770748(Prkdc)
HGL: 101722248(Prkdc)
CCAN: 109688672(Prkdc) 109688676
OCU: 100125348(PRKDC)
TUP: 102497296(PRKDC)
CFA: 474176(PRKDC)
AML: 100472045(PRKDC)
UMR: 103677407(PRKDC)
ORO: 101380166(PRKDC)
FCA: 101088389(PRKDC)
PTG: 102960352(PRKDC)
AJU: 106982122(PRKDC)
BTA: 512740(PRKDC)
BOM: 102285992(PRKDC)
BIU: 109568449(PRKDC)
CHX: 102171625(PRKDC)
OAS: 101111377(PRKDC)
SSC: 100156379(PRKDC)
CFR: 102519846(PRKDC)
CDK: 105095923 105095924(PRKDC)
BACU: 103019606(PRKDC)
LVE: 103090600(PRKDC)
OOR: 101286290(PRKDC)
ECB: 791233(PRKDC)
EAI: 106833571 106848336(PRKDC)
MYD: 102770810(PRKDC)
HAI: 109392680(PRKDC)
RSS: 109437505 109437515(PRKDC)
PALE: 102895801(PRKDC)
LAV: 100667300(PRKDC)
TMU: 101346733
MDO: 100030684(PRKDC)
SHR: 100915132(PRKDC)
OAA: 100084470(PRKDC)
GGA: 395376(PRKDC)
MGP: 100546550(PRKDC)
CJO: 107310139(PRKDC)
APLA: 101804792(PRKDC)
ACYG: 106038417(PRKDC)
TGU: 100224961(PRKDC)
GFR: 102042450(PRKDC)
FAB: 101819416(PRKDC)
PHI: 102108488(PRKDC)
PMAJ: 107200430(PRKDC)
CCW: 104690434(PRKDC)
FPG: 101914535(PRKDC)
FCH: 102045681(PRKDC)
CLV: 102084031 102099053(PRKDC)
EGZ: 104126877 104127679(PRKDC)
AAM: 106494392(PRKDC)
ASN: 102387673(PRKDC)
AMJ: 102575311(PRKDC)
PSS: 102454928(PRKDC)
CMY: 102937565(PRKDC)
CPIC: 101936824(PRKDC)
ACS: 100562493(prkdc)
PVT: 110077653(PRKDC)
PBI: 103059879(PRKDC) 103061618
GJA: 107122359(PRKDC)
XLA: 373602(prkdc.L)
XTR: 100488663(prkdc)
NPR: 108792226(PRKDC)
DRE: 562283(prkdc)
SANH: 107659432 107684509(prkdc)
SGH: 107591017(prkdc)
IPU: 108268160(prkdc)
AMEX: 103028565(prkdc)
TRU: 101073073(prkdc)
LCO: 104928964(prkdc)
NCC: 104943222(prkdc)
MZE: 101484851(prkdc)
OLA: 101171206(prkdc)
XMA: 102221760(prkdc)
PRET: 103482327(prkdc)
NFU: 107382641(prkdc)
CSEM: 103377075(prkdc)
LCF: 108898307(prkdc)
HCQ: 109507813(prkdc)
BPEC: 110165311(prkdc)
SASA: 106579558(prkdc)
ELS: 105019560(prkdc)
SFM: 108919710(prkdc)
LCM: 102352949(PRKDC)
CMK: 103175370(prkdc)
CIN: 100185020(prkdc)
SPU: 576405
APLC: 110990343
AAG: 5570160
AME: 552548(GB11176)
BIM: 100744526
BTER: 100644482
SOC: 105207712
AEC: 105148426
ACEP: 105619089
PBAR: 105433388
HST: 105182659
CFO: 105258805
LHU: 105673241
PGC: 109854737
NVI: 100123782
TCA: 659348
DPA: 109546518
NVL: 108562010
ZNE: 110836224
MYI: 110461426
OBI: 106874950
HMG: 100210864(prkdc)
AQU: 100633457
PPP: 112286712
DDI: DDB_G0281167(dnapkcs)
DFA: DFA_11411(dnapkcs)
SPAR: SPRG_12566
TCR: 507681.30
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Soubeyrand S, Pope L, Pakuts B, Hache RJ
  Title
Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.
  Journal
Cancer Res 63:1198-201 (2003)
  Sequence
[hsa:5591]

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