KEGG   ORTHOLOGY: K06752Help
Entry
K06752                      KO                                     

Name
MHC2
Definition
major histocompatibility complex, class II
Pathway
Phagosome
Cell adhesion molecules (CAMs)
Antigen processing and presentation
Intestinal immune network for IgA production
Type I diabetes mellitus
Leishmaniasis
Toxoplasmosis
Staphylococcus aureus infection
Tuberculosis
Influenza A
HTLV-I infection
Herpes simplex infection
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Disease
H00079  
Asthma
H00080  
Systemic lupus erythematosus
H00081  
Hashimoto's thyroiditis
H00082  
Graves' disease
H00083  
Allograft rejection
H00294  
Dilated cardiomyopathy (DCM)
H00295  
Viral myocarditis
H00342  
Tuberculosis
H00408  
Type I diabetes mellitus
H01362  
Dermatitis herpetiformis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06752  MHC2; major histocompatibility complex, class II
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06752  MHC2; major histocompatibility complex, class II
 Organismal Systems
  Immune system
   04612 Antigen processing and presentation
    K06752  MHC2; major histocompatibility complex, class II
   04672 Intestinal immune network for IgA production
    K06752  MHC2; major histocompatibility complex, class II
 Human Diseases
  Immune diseases
   05310 Asthma
    K06752  MHC2; major histocompatibility complex, class II
   05322 Systemic lupus erythematosus
    K06752  MHC2; major histocompatibility complex, class II
   05323 Rheumatoid arthritis
    K06752  MHC2; major histocompatibility complex, class II
   05320 Autoimmune thyroid disease
    K06752  MHC2; major histocompatibility complex, class II
   05321 Inflammatiory bowel disease (IBD)
    K06752  MHC2; major histocompatibility complex, class II
   05330 Allograft rejection
    K06752  MHC2; major histocompatibility complex, class II
   05332 Graft-versus-host disease
    K06752  MHC2; major histocompatibility complex, class II
  Cardiovascular diseases
   05416 Viral myocarditis
    K06752  MHC2; major histocompatibility complex, class II
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K06752  MHC2; major histocompatibility complex, class II
  Infectious diseases
   05150 Staphylococcus aureus infection
    K06752  MHC2; major histocompatibility complex, class II
   05152 Tuberculosis
    K06752  MHC2; major histocompatibility complex, class II
   05166 HTLV-I infection
    K06752  MHC2; major histocompatibility complex, class II
   05164 Influenza A
    K06752  MHC2; major histocompatibility complex, class II
   05168 Herpes simplex infection
    K06752  MHC2; major histocompatibility complex, class II
   05145 Toxoplasmosis
    K06752  MHC2; major histocompatibility complex, class II
   05140 Leishmaniasis
    K06752  MHC2; major histocompatibility complex, class II
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06752  MHC2; major histocompatibility complex, class II
  Exosomal proteins of epithelial cells
   K06752  MHC2; major histocompatibility complex, class II
  Exosomal proteins of breast milk
   K06752  MHC2; major histocompatibility complex, class II
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   Others
    CD4; CD4 antigen
     K06752 MHC2; major histocompatibility complex, class II
    LAG3; lymphocyte-activation gene 3 protein
     K06752 MHC2; major histocompatibility complex, class II
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
100509457 101060835 3108(HLA-DMA) 3109(HLA-DMB) 3111(HLA-DOA) 3112(HLA-DOB) 3113(HLA-DPA1) 3115(HLA-DPB1) 3117(HLA-DQA1) 3118(HLA-DQA2) 3119(HLA-DQB1) 3122(HLA-DRA) 3123(HLA-DRB1) 3125(HLA-DRB3) 3126(HLA-DRB4) 3127(HLA-DRB5)
PTR: 
100608816(MAMU-DMA) 100616520 449592(PATR-DMB) 462591(PATR-DRA) 462592(PATR-DRB5) 462594(PATR-DQB1) 462598(PATR-DPA1) 462599(PATR-DPB1) 471974(PATR-DQA1) 471976(PATR-DQA2) 471977(PATR-DOB) 471979
PPS: 
GGO: 
PON: 
MCC: 
100187587(MAMU-DRA) 100428228(MAMU-DRB5) 100429857(MAMU-DMB) 692100(MAMU-DRB1) 705588 716823(MAMU-DQB1) 717623(HLA-DQA1) 717702(MAMU-DOB) 717870(MAMU-DMA) 717947(MAMU-DOA) 717969(MAMU-DPB) 717992(MAMU-DPA) 720582(MAMU-DQA1)
MCF: 
102132662(Mafa-DQA) 102133044 102136468(Mafa-DPB) 102136862(Mafa-DPA) 102137481 102139994 102140649 102140782(Mafa-DRB) 102141176(Mafa-DQA) 102141582(Mafa-DRB) 102142353 102144039(Mafa-DRA) 102144414(Mafa-DRB) 102144782(Mafa-DQB) 102145413
MMU: 
100504404(H2-Ea-ps) 14960(H2-Aa) 14961(H2-Ab1) 14969(H2-Eb1) 14998(H2-DMa) 14999(H2-DMb1) 15000(H2-DMb2) 15001(H2-Oa) 15002(H2-Ob)
RNO: 
100909593 100909630 100911800 24984(RT1-DOa) 24986(RT1-Ha) 294269(RT1-Da) 294270(RT1-Db1) 294273(RT1-DMb) 294274(RT1-DMa) 309621(RT1-Ba) 309622(RT1-Bb) 365542(RT1-DOb) 688090(Bb)
CGE: 
HGL: 
TUP: 
CFA: 
100856137 474860(HLA-DRB1) 474861(DLA-DQA1) 474862(DLA-DQB1) 474869(DLA-DOA) 481731(DLA-DRA) 481732(DLA-DMA) 607786(DLA-DOB) 607827(DLA-DMB)
AML: 
FCA: 
PTG: 
BTA: 
100848815 101903005 282490(BOLA-DMA) 282491(BOLA-DMB) 282493(BOLA-DOB) 282494(BOLA-DQA5) 282495(BOLA-DQB) 282498(BOLA-DYB) 282530(BOLA-DRB3) 282534(BOLA-DQA1) 282535(BOLA-DQA2) 506214(BOLA-DRA) 525727(BOLA-DOA) 539241(BLA-DQB) 790858(LA-DQB)
BOM: 
PHD: 
CHX: 
SSC: 
100037921(SLA-DQB1) 100135040(SLA-DRA) 100135049(SLA-DOB) 100135050(SLA-DMB) 100153386(SLA-DRB1) 100153387(SLA-DQA1) 100157996(SLA-DOA) 445528(SLA-DMA)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
417050(BMA1) 417051(BMA2) 425256(BLB3) 430189(BLA) 693256(BLB2) 724083(BLB1)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379662(MGC69040) 399001(mhc2a) 495177(hla-dra) 495209 495464 733414
XTR: 
DRE: 
100038779 30762(mhc2dab) 30763(mhc2dcb) 30764(mhc2deb) 30783(mhc2a) 335509(a1) 368614(si:dz48c11.3) 368615(MHCII) 368816(MHCII) 368877(si:dz266f07.1) 368878(MHCII) 571282 654336 791723
TRU: 
MZE: 
OLA: 
101156150 101156161(Orla-DDA) 101156391(Orla-DCB) 101160212(Orla-DAB) 101160459(Orla-DAA) 101163459(Orla-DFA) 101163710 101170459(Orla-DEB) 101170703 101173053(Orla-DDB) 101173297
XMA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC
  Title
Regulation of major histocompatibility complex class II gene expression, genetic  variation and disease.
  Journal
Genes Immun 11:99-112 (2010)
Reference
PMID:8849454
  Authors
Weber DA, Evavold BD, Jensen PE
  Title
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
  Journal
Science 274:618-20 (1996)

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