KEGG   ORTHOLOGY: K06752Help
Entry
K06752                      KO                                     

Name
MHC2
Definition
major histocompatibility complex, class II
Pathway
Phagosome
Cell adhesion molecules (CAMs)
Antigen processing and presentation
Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
Intestinal immune network for IgA production
Type I diabetes mellitus
Leishmaniasis
Toxoplasmosis
Staphylococcus aureus infection
Tuberculosis
Influenza A
HTLV-I infection
Herpes simplex infection
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Disease
H00079  
Asthma
H00080  
Systemic lupus erythematosus
H00081  
Hashimoto's thyroiditis
H00082  
Graves' disease
H00083  
Allograft rejection
H00294  
Dilated cardiomyopathy (DCM)
H00295  
Viral myocarditis
H00342  
Tuberculosis
H00408  
Type I diabetes mellitus
H01362  
Dermatitis herpetiformis
H01468  
Eosinophilic granulomatosis with polyangiitis
H01490  
Multiple sclerosis
H01492  
Systemic sclerosis
H01502  
Sjogren's Syndrome
H01504  
Vogt-Koyanagi-Harada syndrome
H01516  
Adult onset Still's disease
H01698  
Giant cell arteritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06752  MHC2; major histocompatibility complex, class II
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06752  MHC2; major histocompatibility complex, class II
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06752  MHC2; major histocompatibility complex, class II
   04612 Antigen processing and presentation
    K06752  MHC2; major histocompatibility complex, class II
   04658 Th1 and Th2 cell differentiation
    K06752  MHC2; major histocompatibility complex, class II
   04659 Th17 cell differentiation
    K06752  MHC2; major histocompatibility complex, class II
   04672 Intestinal immune network for IgA production
    K06752  MHC2; major histocompatibility complex, class II
 Human Diseases
  Immune diseases
   05310 Asthma
    K06752  MHC2; major histocompatibility complex, class II
   05322 Systemic lupus erythematosus
    K06752  MHC2; major histocompatibility complex, class II
   05323 Rheumatoid arthritis
    K06752  MHC2; major histocompatibility complex, class II
   05320 Autoimmune thyroid disease
    K06752  MHC2; major histocompatibility complex, class II
   05321 Inflammatiory bowel disease (IBD)
    K06752  MHC2; major histocompatibility complex, class II
   05330 Allograft rejection
    K06752  MHC2; major histocompatibility complex, class II
   05332 Graft-versus-host disease
    K06752  MHC2; major histocompatibility complex, class II
  Cardiovascular diseases
   05416 Viral myocarditis
    K06752  MHC2; major histocompatibility complex, class II
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K06752  MHC2; major histocompatibility complex, class II
  Infectious diseases
   05150 Staphylococcus aureus infection
    K06752  MHC2; major histocompatibility complex, class II
   05152 Tuberculosis
    K06752  MHC2; major histocompatibility complex, class II
   05166 HTLV-I infection
    K06752  MHC2; major histocompatibility complex, class II
   05164 Influenza A
    K06752  MHC2; major histocompatibility complex, class II
   05168 Herpes simplex infection
    K06752  MHC2; major histocompatibility complex, class II
   05145 Toxoplasmosis
    K06752  MHC2; major histocompatibility complex, class II
   05140 Leishmaniasis
    K06752  MHC2; major histocompatibility complex, class II
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06752  MHC2; major histocompatibility complex, class II
  Exosomal proteins of epithelial cells
   K06752  MHC2; major histocompatibility complex, class II
  Exosomal proteins of breast milk
   K06752  MHC2; major histocompatibility complex, class II
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   Others
    CD4; CD4 antigen
     K06752 MHC2; major histocompatibility complex, class II
    LAG3; lymphocyte-activation gene 3 protein
     K06752 MHC2; major histocompatibility complex, class II
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3108(HLA-DMA) 3109(HLA-DMB) 3111(HLA-DOA) 3112(HLA-DOB) 3113(HLA-DPA1) 3115(HLA-DPB1) 3117(HLA-DQA1) 3118(HLA-DQA2) 3119(HLA-DQB1) 3122(HLA-DRA) 3123(HLA-DRB1) 3125(HLA-DRB3) 3126(HLA-DRB4) 3127(HLA-DRB5)
PTR: 
100608816(MAMU-DMA) 100616520(Patr-DQB1) 104006793(Patr-DRB) 449592(PATR-DMB) 462591(PATR-DRA) 462592(PATR-DRB5) 462594(PATR-DQB1) 462598(PATR-DPA1) 462599(PATR-DPB1) 471974(PATR-DQA1) 471976(PATR-DQA2) 471977(PATR-DOB) 471979
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
100187587(MAMU-DRA) 100428228(MAMU-DRB5) 100428435(DRB) 100429241(Mamu-DQB) 100429857(MAMU-DMB) 692100(MAMU-DRB1) 705588(Mamu-DRB) 716823(MAMU-DQB1) 717623(HLA-DQA1) 717702(MAMU-DOB) 717870(MAMU-DMA) 717947(MAMU-DOA) 717969(MAMU-DPB) 717992(MAMU-DPA) 720582(MAMU-DQA1)
MCF: 
102132662(Mafa-DQA) 102133044(DQB1) 102136468(DPB1) 102136862(Mafa-DPA) 102137481(Mafa-DOA) 102139994(Mafa-DMA) 102140649(Mafa-DMB) 102140782(Mafa-DRB) 102141176(Mafa-DQA) 102141582(Mafa-DRB) 102141962 102142740 102144039(DRA) 102144414(Mafa-DRB) 102144782(DQB1) 102145413(Mafa-DOB)
CSAB: 
103221682(MHC-DPB1) 103221683(MHC-DPA1) 103221684(MHC-DOA) 103221688(MHC-DMA) 103221689(MHC-DMB) 103221695(MHC-DOB) 103221696(MHC-DQB1) 103221698(MHC-DQA1) 103221700 103221702 103221704(MHC-DRA) 103247136 103247138 103247148
RRO: 
RBB: 
CJC: 
100385427(CAJA-DRA) 100386155(CAJA-DRB1) 100386508(HLA-DQA1) 100386865(Caja-DQB1) 100387227 100387854(HLA-DRB1) 100397732(caja-DRB) 100405222(Caja-DQB2) 100407771(CAJA-DMA) 100408132(CAJA-DOA) 100408503(CAJA-DPB1) 100410700(Caja-DRB) 100411388(Caja-DQA1) 100412691(CAJA-DMB) 100413648(CAJA-DPA1) 103792390 108591149(Caja-DQB1)
SBQ: 
MMU: 
100504404(H2-Ea-ps) 14960(H2-Aa) 14961(H2-Ab1) 14969(H2-Eb1) 14998(H2-DMa) 14999(H2-DMb1) 15000(H2-DMb2) 15001(H2-Oa) 15002(H2-Ob)
RNO: 
100911800 108348072 108348139 24984(RT1-DOa) 24986(RT1-Ha) 294269(RT1-Da) 294270(RT1-Db1) 294273(RT1-DMb) 294274(RT1-DMa) 309621(RT1-Ba) 309622(RT1-Bb) 365542(RT1-DOb) 688090(Bb)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
100328929(RLA-DR-ALPHA) 100341358 100343144(Orcu-DQA) 100348904(RLA-DRB1) 100349408 100349667 100350168(Orcu-DRB) 100350656(RLA-DRB1) 100351163(RLA-DQB) 100351416 100352415(RLA-DMA) 100352672 100352927 100355948(RLA-DMB)
TUP: 
CFA: 
100856137(DLA-DQB1) 474860(HLA-DRB1) 474861(DLA-DQA1) 474862(DLA-DQB1) 474869(DLA-DOA) 481731(DLA-DRA) 481732(DLA-DMA) 607786(DLA-DOB) 607827(DLA-DMB)
AML: 
100463634 100463773(Aime-DQA) 100463889 100464279(Aime-DRA) 100464393 100464636(HLA-DMA) 100464780(Aime-DRB1) 100477284(HLA-DMB) 100478290(HLA-DOB) 100478546 100484974(Aime-DQB)
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
100848815(BoLA-DQA) 101902890 282490(BOLA-DMA) 282491(BOLA-DMB) 282493(BOLA-DOB) 282494(BOLA-DQA5) 282495(BOLA-DQB) 282497(BOLA-DYA) 282498(BOLA-DYB) 282530(BOLA-DRB3) 282534(BOLA-DQA1) 282535(BOLA-DQA2) 282536(BOLA-DQA3) 506214(BOLA-DRA) 525727(BOLA-DOA) 538700(BOLA-DRB2) 539241(BLA-DQB) 618722(DSB) 790858(LA-DQB)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
100037921(SLA-DQB1) 100135040(SLA-DRA) 100135049(SLA-DOB) 100135050(SLA-DMB) 100153386(SLA-DRB1) 100153387(SLA-DQA1) 100157996(SLA-DOA) 106504372 445528(SLA-DMA)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
101747454(BLB2) 417050(DMA) 417051(DMB2) 425256(BLB3) 430189(BLA) 693256(BLB1)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PBI: 
GJA: 
XLA: 
XTR: 
100127727(hla-dqa1) 100145090 100145508 100495183 100495336(mhc2a) 100495492(hla-dra) 734125(hla-drb1)
NPR: 
DRE: 
100038779(zgc:158870) 30762(mhc2dab) 30763(mhc2dcb) 30764(mhc2deb) 30783(mhc2a) 335509(zgc:113912) 368614(si:busm1-48c11.3) 368615(si:busm1-194e12.12) 368816(si:busm1-194e12.8) 368877(si:busm1-266f07.1) 368878(si:busm1-266f07.2) 571282 654336(zgc:123077) 791723
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC
  Title
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.
  Journal
Genes Immun 11:99-112 (2010)
DOI:10.1038/gene.2009.83
Reference
PMID:8849454
  Authors
Weber DA, Evavold BD, Jensen PE
  Title
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
  Journal
Science 274:618-20 (1996)
DOI:10.1126/science.274.5287.618
  Sequence
[hsa:3109]

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