KEGG ORTHOLOGY: K06854

ORTHOLOGY: K06854

Entry

K06854                      KO

Symbol

THPO

Name

thrombopoietin

Pathway

map04060

Cytokine-cytokine receptor interaction

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

Disease

H00227

Congenital amegakaryocytic thrombocytopenia

H00978

Thrombocytopenia (THC)

H01612

Essential thrombocythemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K06854  THPO; thrombopoietin
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K06854  THPO; thrombopoietin
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06854  THPO; thrombopoietin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K06854  THPO; thrombopoietin
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  CSF and other factors
   K06854  THPO; thrombopoietin

Genes

HSA:	7066(THPO)

PTR:	736549(THPO)

PPS:	100980796(THPO)

GGO:	101153569(THPO)

PON:	100452053(THPO)

NLE:	100582097(THPO)

HMH:	116479910(THPO)

MCC:	100428640(THPO)

MCF:	102144240(THPO)

MTHB:

126948437

MNI:	105480132(THPO)

CSAB:

103221127(THPO)

CATY:

105573967(THPO)

PANU:

101001830(THPO)

TGE:	112618287(THPO)

MLEU:

105541018(THPO)

RRO:	104664621(THPO)

RBB:	108525238(THPO)

TFN:	117083831(THPO)

PTEH:

111523151(THPO)

CANG:

105514483(THPO)

CJC:	103795045(THPO)

SBQ:	101047352(THPO)

CIMI:

108311082(THPO)

CSYR:

103265077(THPO)

MMUR:

105855760(THPO)

LCAT:

123630336(THPO)

PCOQ:

105807921(THPO)

OGA:	100951424(THPO)

MMU:	21832(Thpo)

MCAL:

110311636(Thpo)

MPAH:

110329913(Thpo)

RNO:	81811(Thpol1)

MCOC:

116085736(Thpo)

ANU:	117718059(Thpo)

MUN:	110549398(Thpo)

CGE:	100774906(Thpo)

MAUA:

101833329(Thpo)

PROB:

127226978(Thpo)

PLEU:

114683319(Thpo)

MORG:

121464925(Thpo)

MFOT:

126504255

AAMP:

119825722(Thpo)

NGI:	103732660(Thpo)

HGL:	101705058(Thpo)

CPOC:

100726592(Thpo)

CCAN:

109694098(Thpo)

DORD:

105998355(Thpo)

DSP:	122098733(Thpo)

PLOP:

125351151(Thpo)

NCAR:

124993061

MMMA:

107154328(Thpo)

OCU:

100357079

OPI:	101531307(THPO)

TUP:	102496781(THPO)

GVR:	103593913(THPO)

CFA:	100855822(THPO)

CLUD:

112662717(THPO)

VVP:	112926269(THPO)

VLG:	121477570(THPO)

NPO:	129498714(THPO)

AML:	100469915(THPO)

UMR:	103676077(THPO)

UAH:	113254294(THPO)

UAR:	123778956(THPO)

ELK:

111151805

LLV:

125101528

MPUF:

101683620(THPO)

MNP:	132010062(THPO)

MLK:	131824784(THPO)

NVS:	122910499(THPO)

ORO:	101363544(THPO)

EJU:	114207163(THPO)

ZCA:	113916931(THPO)

MLX:	118000347(THPO)

NSU:	110582516(THPO)

LWW:	102727719(THPO)

FCA:	100302539(THPO)

PYU:	121034084(THPO)

PCOO:

112850179(THPO)

PBG:	122491660(THPO)

PVIV:

125174575(THPO)

PTG:	102953221(THPO)

PPAD:

109275230(THPO)

PUC:

125921119

AJU:

106983813

HHV:	120238130(THPO)

BTA:	538672(THPO)

BOM:	102275287(THPO)

BIU:	109557333(THPO)

BBUB:

102409271(THPO)

BBIS:

105000030(THPO)

CHX:	102181435(THPO)

OAS:	101119601(THPO)

BTAX:

128050927(THPO)

ODA:	120872130(THPO)

CCAD:

122444854(THPO)

MBEZ:

129545151(THPO)

SSC:	100620258(THPO)

CFR:	102521318(THPO)

CBAI:

105072303(THPO)

CDK:	105085874(THPO)

VPC:	102537361(THPO)

BACU:

103007149

BMUS:

118894248(THPO)

LVE:	103089418(THPO)

OOR:	101275544(THPO)

DLE:	111173147(THPO)

PCAD:

102978432(THPO)

PSIU:

116752547(THPO)

NASI:

112415433(THPO)

ECB:	100059159(THPO)

EPZ:	103554738(THPO)

EAI:	106834515(THPO)

MYB:	102245928(THPO)

MYD:	102769651(THPO)

MMYO:

118677362(THPO)

MLF:	102441175(THPO)

PKL:	118724187(THPO)

EFUS:

103300654(THPO)

MNA:	107543119(THPO)

DRO:	112309408(THPO)

SHON:

118974245(THPO)

AJM:	119056464(THPO)

PDIC:

114490884(THPO)

PHAS:

123827187(THPO)

MMF:	118617476(THPO)

PPAM:

129077169(THPO)

HAI:	109371411(THPO)

RFQ:	117013523(THPO)

PALE:

102878621(THPO)

PGIG:

120592937(THPO)

PVP:	105306931(THPO)

RAY:	107504909(THPO)

MJV:	108395274(THPO)

TOD:	119257354(THPO)

SARA:

101545913(THPO)

SETR:

126012076(THPO)

LAV:	100663051(THPO)

TMU:

101356566

ETF:	101646517(THPO)

DNM:	101428927(THPO)

MDO:	100026113(THPO)

GAS:	123247571(THPO)

SHR:	105750562(THPO)

AFZ:

127563460

PCW:	110221303(THPO)

OAA:	100090972(THPO)

GGA:	414803(THPO)

PCOC:

116235407(THPO)

MGP:	100543941(THPO)

CJO:	107318257(THPO)

TPAI:

128081855(THPO)

NMEL:

110397883(THPO)

APLA:

119717719(THPO)

ACYG:

106032161

CATA:

118253201(THPO)

AFUL:

116492516(THPO)

LSR:	110478160(THPO)

SCAN:

103815603(THPO)

PMOA:

120504304(THPO)

OTC:	121336667(THPO)

PRUF:

121353865(THPO)

GFR:	102041268(THPO)

FAB:	101806443(THPO)

PHI:	102103618(THPO)

PMAJ:

107209005(THPO)

CCAE:

111933391(THPO)

CCW:	104687985(THPO)

CBRC:

103625184(THPO)

ETL:	114060825(THPO)

ZAB:	102064002(THPO)

ACHL:

103810310(THPO)

SVG:	106850414(THPO)

MMEA:

130574113(THPO)

HRT:	120756971(THPO)

FPG:	101917806(THPO)

FCH:

102051023

CLV:	102089501(THPO)

EGZ:	104122234(THPO)

NNI:	104015698(THPO)

PCRI:

104028101

PLET:

104622091(THPO)

EHS:	104503734(THPO)

ACUN:

113483431(THPO)

TALA:

104368408(THPO)

PADL:

103925631(THPO)

AFOR:

103906265(THPO)

ACHC:

115347807(THPO)

HALD:

104311248

HLE:	104835207(THPO)

AGEN:

126039583

CCRI:

104169516(THPO)

CSTI:

104560102

CMAC:

104474066(THPO)

MUI:	104535004(THPO)

BREG:

104630933(THPO)

FGA:	104072603(THPO)

GSTE:

104261381(THPO)

LDI:

104350012

OHA:	104336006(THPO)

NNT:	104402265(THPO)

SHAB:

115611954(THPO)

DPUB:

104303024(THPO)

PGUU:

104467762

ACAR:

104518627

CPEA:

104390900(THPO)

AVIT:

104275180

CVF:	104284993(THPO)

RTD:	128911742(THPO)

CUCA:

104057873(THPO)

TEO:

104375338

BRHI:

104490733(THPO)

AAM:	106494212(THPO)

AROW:

112968558(THPO)

NPD:	112952389(THPO)

DNE:	112980184(THPO)

SCAM:

104148846(THPO)

ASN:	102371526(THPO)

AMJ:	102558692(THPO)

CPOO:

109308488(THPO)

GGN:	109288042(THPO)

PSS:	102453725(THPO)

CMY:	102937299(THPO)

CCAY:

125643188(THPO)

DCC:	119861350(THPO)

CPIC:

101950073(THPO)

TST:	117883109(THPO)

CABI:

116838575(THPO)

MRV:	120372359(THPO)

ACS:	103280792(thpo)

ASAO:

132770457(THPO)

PVT:	110089823(THPO)

SUND:

121926502(THPO)

PBI:	112542478(THPO)

CTIG:

PGUT:

APRI:

PTEX:

VKO:	123025563(THPO)

PMUA:

114598050(THPO)

PRAF:

128414833(THPO)

ZVI:	118094072(THPO)

HCG:

128351073

STOW:

125438508(THPO)

EMC:	129332626(THPO)

XLA:	108716349(thpo.L) 108717570(thpo.S)

XTR:	100489048(thpo)

NPR:	108804690(THPO)

RTEM:

120936949(THPO)

BGAR:

122935019

MUO:

115478604

DRE:	100189608(thpo)

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122356081(thpo)

LROH:

127154069(thpo) 127177230

OMC:	131552356(thpo)

PPRM:

120478228 120481625(thpo)

RKG:	130094464(thpo)

MAMB:

125251557(thpo)

CIDE:

127505469

MASI:

127441412 127441882

TROS:

130553925(thpo)

TDW:	130417813(thpo)

MANU:

129442458(thpo)

IPU:	108280322(thpo)

IFU:	128624450(thpo)

SMEO:

124402894(thpo)

TFD:	125139915(thpo)

TVC:	132843868(thpo)

CMAO:

118797439(thpo)

EEE:

113590227

CHAR:

122128656(thpo)

TFS:	130539547(thpo)

TBEN:

117488960(thpo)

CGOB:

115022335(thpo)

PGEO:

117461851(thpo)

GACU:

117558322(thpo)

EMAC:

134865912(thpo)

ELY:	117263982(thpo)

PLEP:

121951754(thpo)

SLUC:

116046091(thpo)

ECRA:

117953853(thpo)

ESP:	116698645(thpo)

PFLV:

114565937

GAT:	120822224(thpo)

PPUG:

119209360(thpo)

AFB:	129089122(thpo)

CLUM:

117741715(thpo)

PSWI:

130211079(thpo)

MSAM:

119902099(thpo)

SCHU:

122886581(thpo)

CUD:	121520601(thpo)

ALAT:

119009370 119010523(thpo)

ONL:

100689976

OAU:	120434460(thpo)

OLA:

110016899

OML:	112147551(thpo)

CSAI:

133451958(thpo)

GAF:	122832397(thpo)

CTUL:

119775233(thpo)

GMU:	124884329(thpo)

NFU:

107383964

AOCE:

111578815(thpo)

MCEP:

125010437(thpO)

CSEM:

103396086

POV:	109640320(thpo)

SSEN:

122778901(thpo)

HSP:	118117185(thpo)

SMAU:

124850042(thpo)

LCF:

108883465

SDU:	111238992(thpo)

SLAL:

111653527(thpo)

XGL:	120791580 120799160(thpo)

HCQ:

109521182

SSCV:

125984558

SBIA:

133511210(thpo)

PTAO:

133489257(thpo)

BSPL:

114844748(thpo) 114868688

SJO:	128368924(thpo)

OMY:	110504093 110508802(thpo)

OGO:	124004731 124040958

OKI:

109872230

OKE:

118375251

CCLU:

121568332

SFM:	108932167(thpo)

AANG:

118209291 118229561(thpo)

ARUT:

117423252

» show all

Reference

PMID:11756417

Authors

Kirito K, Watanabe T, Sawada K, Endo H, Ozawa K, Komatsu N

Title

Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.

Journal

J Biol Chem 277:8329-37 (2002)
DOI:10.1074/jbc.M109824200

Sequence

[hsa:7066]

Reference

PMID:16380230

Authors

Chanprasert S, Geddis AE, Barroga C, Fox NE, Kaushansky K

Title

Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes.

Journal

Cell Signal 18:1212-8 (2006)
DOI:10.1016/j.cellsig.2005.09.010

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (352)   
   KEGG GENES (341)   
   KEGG MGENES (10)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (365)   

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