KEGG   ORTHOLOGY: K07198Help
Entry
K07198                      KO                                     

Name
PRKAA, AMPK
Definition
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Pathway
FoxO signaling pathway
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04151 PI3K-Akt signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04152 AMPK signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04150 mTOR signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Cellular Processes
  Transport and catabolism
   04140 Regulation of autophagy
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04922 Glucagon signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04920 Adipocytokine signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04921 Oxytocin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04213 Longevity regulating pathway - multiple species
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04931 Insulin resistance
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CAMK group
  CAMKL family
   K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Mitophagy factors
   Other mitophagy factors
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
BRITE hierarchy
Genes
HSA: 
5562(PRKAA1) 5563(PRKAA2)
PTR: 
471564(PRKAA1) 741802(PRKAA2)
PPS: 
100975618(PRKAA1) 100991417(PRKAA2)
GGO: 
101137882(PRKAA2) 101152987(PRKAA1)
PON: 
100172060(PRKAA2) 100174304(PRKAA1)
NLE: 
100582042(PRKAA2) 100595096(PRKAA1)
MCC: 
695558(PRKAA1) 717703(PRKAA2)
MCF: 
102143726(PRKAA2) 102144683(PRKAA1)
RRO: 
104664292(PRKAA2) 104676941(PRKAA1)
CJC: 
100385413(PRKAA1) 100396565(PRKAA2)
MMU: 
105787(Prkaa1) 108079(Prkaa2)
RNO: 
65248(Prkaa1) 78975(Prkaa2)
CGE: 
100767909(Prkaa2) 100769574(Prkaa1)
NGI: 
103734094(Prkaa2) 103741338(Prkaa1)
HGL: 
101698482(Prkaa2) 101722998(Prkaa1)
OCU: 
100340670(PRKAA2) 100358166(PRKAA1)
TUP: 
102491119(PRKAA2) 106735707(PRKAA1)
CFA: 
479351(PRKAA1) 489571(PRKAA2)
AML: 
100470115(PRKAA1) 100481376(PRKAA2)
UMR: 
103664677(PRKAA1) 103670673(PRKAA2)
FCA: 
101095885(PRKAA1) 101096000(PRKAA2)
PTG: 
102956343(PRKAA1) 102970831(PRKAA2)
BTA: 
538954(PRKAA2) 540404(PRKAA1)
BOM: 
102265959(PRKAA1) 102270414(PRKAA2)
PHD: 
102316046(PRKAA1) 102325193(PRKAA2)
CHX: 
102171295(PRKAA2) 102181338(PRKAA1)
OAS: 
100127210(PRKAA2) 101103425(PRKAA1)
SSC: 
100145903(PRKAA1) 397504(PRKAA2)
CFR: 
102510276(PRKAA1) 102523424(PRKAA2)
BACU: 
103018222(PRKAA2) 103019090(PRKAA1)
LVE: 
103069202(PRKAA2) 103074848(PRKAA1)
ECB: 
100009710(PRKAA1) 100034159(PRKAA2)
MYB: 
102241697(PRKAA2) 102248668(PRKAA1)
MYD: 
102759339(PRKAA1) 102774877(PRKAA2)
PALE: 
102884524(PRKAA2) 102886520(PRKAA1)
MDO: 
100013711(PRKAA1) 100019066(PRKAA2)
SHR: 
100926139(PRKAA2) 100928944(PRKAA1)
OAA: 
100075352(PRKAA1)
GGA: 
427185(PRKAA1) 429110(PRKAA2)
MGP: 
100034740(PRKAA1) 780945(PRKAA2)
APLA: 
101799561(PRKAA2) 101801595(PRKAA1)
TGU: 
100217569(PRKAA1) 100224153(PRKAA2)
GFR: 
102031783(PRKAA2) 102038682(PRKAA1) 102044941
FAB: 
101809698(PRKAA1) 101811154(PRKAA2)
PHI: 
102111333(PRKAA2) 102111653(PRKAA1)
CCW: 
104686759(PRKAA1) 104695510(PRKAA2)
FPG: 
101913786(PRKAA1) 101919295(PRKAA2)
FCH: 
102049360(PRKAA2) 102050598(PRKAA1)
CLV: 
102087954(PRKAA1) 102088108(PRKAA2)
ASN: 
102374152(PRKAA2) 102375567(PRKAA1)
AMJ: 
102570371(PRKAA1) 102576605(PRKAA2)
PSS: 
102444277(PRKAA1) 102459596(PRKAA2)
CMY: 
102940952(PRKAA2) 102944011(PRKAA1)
ACS: 
100551935(prkaa2) 100567445(prkaa1)
PBI: 
103057294(PRKAA1) 103064935(PRKAA2)
XLA: 
399172(prkaa2) 495290(prkaa1)
XTR: 
100145520(prkaa1) 100216099(prkaa2)
DRE: 
100001198(prkaa1) 572074(prkaa2)
TRU: 
101065197(prkaa1) 101076074(prkaa2)
MZE: 
101471464(prkaa1) 101487955(prkaa2)
OLA: 
101162057(prkaa1) 101173851(prkaa2)
XMA: 
102231393(prkaa2) 102237231(prkaa1)
LCM: 
102349521(PRKAA1) 102365637(PRKAA2)
CMK: 
103172450(prkaa1) 103185288(prkaa2)
BFO: 
CIN: 
SPU: 
SKO: 
100313552(Prkaa2)
DME: 
Dmel_CG3051(AMPKalpha)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
Dyak_GE16684(dyak_GLEANR_18082)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409577(SNF1A)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
663357(Snf1a)
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06916(Cbr-aak-1) CBG16249(Cbr-aak-2)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
101238049(prkaa2)
TAD: 
AQU: 
ATH: 
AT3G01090(KIN10) AT3G29160(KIN11) AT5G39440(SnRK1.3)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0003s18030g(POPTRDRAFT_1074512) POPTR_0004s11500g(POPTRDRAFT_818055) POPTR_0010s00490g(POPTRDRAFT_821684) POPTR_0010s08950g(POPTRDRAFT_566160) POPTR_0011s07230g POPTR_0013s09420g(POPTRDRAFT_895706) POPTR_0016s14100g(POPTRDRAFT_254300) POPTR_0017s12380g(POPTRDRAFT_577688) POPTR_0018s02460g(POPTRDRAFT_825779)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4325161(CIPK1) 4332495(OSK35) 4339410(OSK1) 4345873(OSK24)
DOSA: 
Os01t0292200-01(Os01g0292200) Os01t0759400-02(Os01g0759400) Os01t0824600-01(Os01g0824600) Os02t0178000-01(Os02g0178000) Os03t0289100-01(Os03g0289100) Os05t0136200-01(Os05g0136200) Os05t0332300-01(Os05g0332300) Os05t0476350-00(Os05g0476350) Os05t0476466-00(Os05g0476466) Os05t0530500-01(Os05g0530500) Os06t0543400-01(Os06g0543400) Os07t0687000-00(Os07g0687000) Os08t0484600-01(Os08g0484600) Os11t0113700-01(Os11g0113700) Os12t0113500-01(Os12g0113500)
OBR: 
BDI: 
SBI: 
SORBI_01g036020(SORBIDRAFT_01g036020) SORBI_02g040580(SORBIDRAFT_02g040580) SORBI_03g002340(SORBIDRAFT_03g002340) SORBI_03g011880(SORBIDRAFT_03g011880) SORBI_03g033530(SORBIDRAFT_03g033530) SORBI_03g035160(SORBIDRAFT_03g035160) SORBI_03g035170(SORBIDRAFT_03g035170) SORBI_03g038380(SORBIDRAFT_03g038380) SORBI_04g004230(SORBIDRAFT_04g004230) SORBI_05g001050(SORBIDRAFT_05g001050) SORBI_08g002740(SORBIDRAFT_08g002740) SORBI_09g002900(SORBIDRAFT_09g002900) SORBI_09g013580(SORBIDRAFT_09g013580) SORBI_09g025420(SORBIDRAFT_09g025420) SORBI_09g026450(SORBIDRAFT_09g026450) SORBI_10g021570(SORBIDRAFT_10g021570)
ZMA: 
100037796 100141385 100192108 100193471 100274837(GRMZM2G099002) 100280494(cl63836_1) 100280653(GRMZM2G176519) 100281326(GRMZM2G075002) 100281661(GRMZM2G316136) 100283368(pco122768) 100284454(GRMZM2G129018) 100383557 100383954(GRMZM2G409658) 100384241(gpm299b) 103634395(GRMZM2G062651) 103635843(GRMZM2G096115) 103636630(GRMZM2G136410) 103636631(GRMZM2G136400) 103639865(GRMZM2G067408) 103639989 103647175(GRMZM2G180704) 103647773 103653911 541785(pk4) 542687(SnrK1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
FGR: 
PSQ: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_01354(snfA)
ACAN: 
TAN: 
TPV: 
TOT: 
BEQ: 
BBO: 
BBOV_III009120(17.m07797)
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
GLA: 
VG: 
6804836(FeldSpV_gp053) 920776(ORF111)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB
  Title
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
  Journal
Mol Cell 18:283-93 (2005)
  Sequence
[hsa:5562]
Reference
PMID:8557660
  Authors
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
  Title
Mammalian AMP-activated protein kinase subfamily.
  Journal
J Biol Chem 271:611-4 (1996)
  Sequence
[hsa:5562]

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