KEGG   ORTHOLOGY: K07198Help
Entry
K07198                      KO                                     

Name
PRKAA, AMPK
Definition
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Pathway
ko04068  FoxO signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04371  Apelin signaling pathway
ko04530  Tight junction
ko04710  Circadian rhythm
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04068 FoxO signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04151 PI3K-Akt signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04152 AMPK signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04150 mTOR signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Cellular community - eukaryotes
   04530 Tight junction
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04922 Glucagon signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04920 Adipocytokine signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04921 Oxytocin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04213 Longevity regulating pathway - multiple species
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04714 Thermogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   05410 Hypertrophic cardiomyopathy (HCM)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04931 Insulin resistance
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   Others
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Mitophagy factors
   Other mitophagy factors
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
BRITE hierarchy
Genes
HSA: 5562(PRKAA1) 5563(PRKAA2)
PTR: 471564(PRKAA1) 741802(PRKAA2)
PPS: 100975618(PRKAA1) 100991417(PRKAA2)
GGO: 101137882(PRKAA2) 101152987(PRKAA1)
PON: 100172060(PRKAA2) 100174304(PRKAA1)
NLE: 100582042(PRKAA2) 100595096(PRKAA1)
MCC: 695558(PRKAA1) 717703(PRKAA2)
MCF: 102143726(PRKAA2) 102144683(PRKAA1)
CSAB: 103215177(PRKAA1) 103224740(PRKAA2)
RRO: 104664292(PRKAA2) 104676941(PRKAA1)
RBB: 108532936(PRKAA2) 108544746(PRKAA1)
CJC: 100385413(PRKAA1) 100396565(PRKAA2)
SBQ: 101030830(PRKAA1) 101033212(PRKAA2)
MMU: 105787(Prkaa1) 108079(Prkaa2)
RNO: 65248(Prkaa1) 78975(Prkaa2)
CGE: 100767909(Prkaa2) 100769574(Prkaa1)
NGI: 103734094(Prkaa2) 103741338(Prkaa1)
HGL: 101698482(Prkaa2) 101722998(Prkaa1)
CCAN: 109687258(Prkaa2) 109695664(Prkaa1)
OCU: 100340670(PRKAA2) 100358166(PRKAA1)
TUP: 102491119(PRKAA2) 106735707(PRKAA1)
CFA: 479351(PRKAA1) 489571(PRKAA2)
AML: 100470115(PRKAA1) 100481376(PRKAA2)
UMR: 103664677(PRKAA1) 103670673(PRKAA2)
ORO: 101372712(PRKAA1) 101379000(PRKAA2)
FCA: 101095885(PRKAA1) 101096000(PRKAA2)
PTG: 102956343(PRKAA1) 102970831(PRKAA2)
AJU: 106970910(PRKAA1) 106974988(PRKAA2)
BTA: 538954(PRKAA2) 540404(PRKAA1)
BOM: 102265959(PRKAA1) 102270414(PRKAA2)
PHD: 102316046(PRKAA1) 102325193(PRKAA2)
CHX: 102171295(PRKAA2) 102181338(PRKAA1)
OAS: 100127210(PRKAA2) 101103425(PRKAA1)
SSC: 100145903(PRKAA1) 397504(PRKAA2)
CFR: 102510276(PRKAA1) 102523424(PRKAA2)
CDK: 105092817(PRKAA2) 105106940(PRKAA1)
BACU: 103018222(PRKAA2) 103019090(PRKAA1)
LVE: 103069202(PRKAA2) 103074848(PRKAA1)
OOR: 101287451(PRKAA1) 101290391(PRKAA2)
ECB: 100009710(PRKAA1) 100034159(PRKAA2)
EAI: 106824750(PRKAA1) 106833475(PRKAA2)
MYB: 102241697(PRKAA2) 102248668(PRKAA1)
MYD: 102759339(PRKAA1) 102774877(PRKAA2)
HAI: 109374016(PRKAA2) 109376169(PRKAA1)
RSS: 109440607 109441921 109450192(PRKAA1) 109453062(PRKAA2)
PALE: 102884524(PRKAA2) 102886520(PRKAA1)
LAV: 100659413(PRKAA1) 100671280(PRKAA2)
MDO: 100013711(PRKAA1) 100019066(PRKAA2)
SHR: 100926139(PRKAA2) 100928944(PRKAA1)
OAA: 100075352(PRKAA1)
GGA: 427185(PRKAA1) 429110(PRKAA2)
MGP: 100034740(PRKAA1) 780945(PRKAA2)
CJO: 107305860(PRKAA1) 107317703(PRKAA2)
APLA: 101799561(PRKAA2) 101801595(PRKAA1)
ACYG: 106033088(PRKAA2) 106036363(PRKAA1)
TGU: 100217569(PRKAA1) 100224153(PRKAA2)
GFR: 102031783(PRKAA2) 102038682(PRKAA1) 102044941
FAB: 101809698(PRKAA1) 101811154(PRKAA2)
PHI: 102111333(PRKAA2) 102111653(PRKAA1)
PMAJ: 107208272(PRKAA2) 107216196(PRKAA1)
CCW: 104686759(PRKAA1) 104695510(PRKAA2)
FPG: 101913786(PRKAA1) 101919295(PRKAA2)
FCH: 102049360(PRKAA2) 102050598(PRKAA1)
CLV: 102087954(PRKAA1) 102088108(PRKAA2)
EGZ: 104123889(PRKAA2) 104133929(PRKAA1)
AAM: 106498958(PRKAA2) 106499548(PRKAA1) 106499832
ASN: 102374152(PRKAA2) 102375567(PRKAA1)
AMJ: 102570371(PRKAA1) 102576605(PRKAA2)
PSS: 102444277(PRKAA1) 102459596(PRKAA2)
CMY: 102940952(PRKAA2) 102944011(PRKAA1)
CPIC: 101941141(PRKAA1) 101948919(PRKAA2)
ACS: 100551935(prkaa2) 100567445(prkaa1)
PVT: 110073913(PRKAA1) 110077130(PRKAA2)
PBI: 103057294(PRKAA1) 103064935(PRKAA2)
GJA: 107108814(PRKAA1) 107118038(PRKAA2)
XLA: 108714249 108715541 399172(prkaa2.S) 495290(prkaa1.L)
XTR: 100145520(prkaa1) 100216099(prkaa2)
NPR: 108788157(PRKAA2) 108790816(PRKAA1)
DRE: 100001198(prkaa1) 572074(prkaa2)
IPU: 108258037(prkaa2) 108260283
AMEX: 103022500(prkaa1) 103028619(prkaa2)
TRU: 101065197(prkaa1) 101076074(prkaa2)
LCO: 104919125(prkaa2) 104924922(prkaa1)
NCC: 104959371(prkaa1) 104959556(prkaa2)
MZE: 101471464(prkaa1) 101487955(prkaa2)
OLA: 101162057(prkaa1) 101173851(prkaa2)
XMA: 102231393(prkaa2) 102237231(prkaa1)
PRET: 103463785(prkaa2) 103473399(prkaa1)
NFU: 107374929(prkaa1) 107393439(prkaa2)
CSEM: 103376655(prkaa2) 103390073(prkaa1)
LCF: 108874097(prkaa1) 108879064(prkaa2)
HCQ: 109517709(prkaa1) 109532068(prkaa2)
BPEC: 110154939(prkaa2) 110157325(prkaa1)
SASA: 106560227 106562970(prkaa1) 106568674 106584208(prkaa2)
ELS: 105011784(prkaa2) 105015246(prkaa1)
SFM: 108923517(prkaa2) 108924948(prkaa1)
LCM: 102349521(PRKAA1) 102365637(PRKAA2)
CMK: 103172450(prkaa1) 103185288(prkaa2)
CIN: 100184788
SPU: 100888004
APLC: 110977481
SKO: 100313552(Prkaa2)
DME: Dmel_CG3051(AMPKalpha)
DSI: Dsimw501_GD16554(Dsim_GD16554)
MDE: 101899168
AAG: 5568845
AME: 409577(SNF1A)
BIM: 100744469
BTER: 100643177
SOC: 105201163
AEC: 105146359
ACEP: 105627819
PBAR: 105426255
HST: 105190214
CFO: 105252990
LHU: 105671278
PGC: 109855776
NVI: 100120450
TCA: 663357(Snf1a)
DPA: 109545112
NVL: 108557505
BMOR: 100101222
PMAC: 106711118
PRAP: 110991484
PXY: 105386201
API: 103309639
DNX: 107165577
ZNE: 110828230
CEL: CELE_PAR2.3(aak-1) CELE_T01C8.1(aak-2)
CBR: CBG06916(Cbr-aak-1) CBG16249(Cbr-aak-2)
BMY: Bm1_50100
CRG: 105341321
MYI: 110449031
OBI: 106875312
EPA: 110241483
ADF: 107338938
HMG: 101238049(prkaa2)
AQU: 100642122
ATH: AT3G01090(KIN10) AT3G29160(KIN11) AT5G39440(SnRK1.3)
LJA: Lj0g3v0072749.1(Lj0g3v0072749.1) Lj0g3v0093489.2(Lj0g3v0093489.2) Lj0g3v0267379.1(Lj0g3v0267379.1) Lj0g3v0267379.2(Lj0g3v0267379.2) Lj0g3v0278259.1(Lj0g3v0278259.1) Lj1g3v2449150.1(Lj1g3v2449150.1) Lj2g3v1068760.1(Lj2g3v1068760.1) Lj3g3v1411750.1(Lj3g3v1411750.1) Lj3g3v2118210.1(Lj3g3v2118210.1) Lj4g3v2249030.1(Lj4g3v2249030.1) Lj4g3v2249030.2(Lj4g3v2249030.2) Lj5g3v1813880.1(Lj5g3v1813880.1) Lj5g3v1813880.2(Lj5g3v1813880.2) Lj5g3v1813880.3(Lj5g3v1813880.3) Lj6g3v1984590.1(Lj6g3v1984590.1)
MDM: 103404469 103408873 103408874(CIPK14) 103413365 103416244(CIPK30) 103423097(CIPK23) 103429042 103433741(CIPK10) 103434891 103437872(CIPK01) 103441969(CIPK03) 103442725 103446313(CIPK20) 103452612(CIPK26) 103452734(CIPK27)
VVI: 100241678(CIPK13) 100243154 100244972(CIPK11) 100254223 100255067 100258329(CIPK16) 100259621(CIPK19)
DOSA: Os01t0292200-01(Os01g0292200) Os01t0824600-01(Os01g0824600) Os02t0178000-01(Os02g0178000) Os03t0289100-01(Os03g0289100) Os05t0136200-01(Os05g0136200) Os05t0332300-01(Os05g0332300) Os05t0476350-00(Os05g0476350) Os05t0476466-00(Os05g0476466) Os05t0530500-01(Os05g0530500) Os06t0543400-01(Os06g0543400) Os07t0637000-01(Os07g0637000) Os07t0687000-00(Os07g0687000) Os08t0484600-01(Os08g0484600) Os11t0113700-01(Os11g0113700) Os12t0113500-01(Os12g0113500)
ATS: 109735301(LOC109735301) 109735326(LOC109735326) 109740446(LOC109740446) 109753963(LOC109753963) 109763841(LOC109763841) 109768849(LOC109768849) 109768972(LOC109768972) 109770353(LOC109770353) 109772576(LOC109772576) 109776637(LOC109776637) 109777741(LOC109777741) 109778022(LOC109778022) 109781333(LOC109781333) 109786308(LOC109786308) 109786686(LOC109786686)
DDI: DDB_G0277905(snfA)
DFA: DFA_01354(snfA)
TAN: TA09820
TPV: TP04_0818
BBO: BBOV_III009120(17.m07797)
SMIN: v1.2.001779.t1(symbB.v1.2.001779.t1) v1.2.012456.t2(symbB.v1.2.012456.t2) v1.2.020616.t1(symbB.v1.2.020616.t1) v1.2.020700.t1(symbB.v1.2.020700.t1)
PTI: PHATRDRAFT_8773(MARK3)
TPS: THAPSDRAFT_26536(SNF1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB
  Title
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
  Journal
Mol Cell 18:283-93 (2005)
DOI:10.1016/j.molcel.2005.03.027
Reference
PMID:8557660
  Authors
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
  Title
Mammalian AMP-activated protein kinase subfamily.
  Journal
J Biol Chem 271:611-4 (1996)
DOI:10.1074/jbc.271.2.611
  Sequence
[hsa:5562]

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