KEGG   ORTHOLOGY: K07198Help
Entry
K07198                      KO                                     

Name
PRKAA, AMPK
Definition
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Pathway
FoxO signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Apelin signaling pathway
Tight junction
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04068 FoxO signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04151 PI3K-Akt signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04152 AMPK signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04150 mTOR signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Cellular community - eukaryotes
   04530 Tight junction
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04922 Glucagon signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04920 Adipocytokine signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04921 Oxytocin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04213 Longevity regulating pathway - multiple species
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   05410 Hypertrophic cardiomyopathy (HCM)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04931 Insulin resistance
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CAMK group
  CAMKL family
   K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   Others
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Mitophagy factors
   Other mitophagy factors
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
BRITE hierarchy
Genes
HSA: 
5562(PRKAA1) 5563(PRKAA2)
PTR: 
471564(PRKAA1) 741802(PRKAA2)
PPS: 
100975618(PRKAA1) 100991417(PRKAA2)
GGO: 
101137882(PRKAA2) 101152987(PRKAA1)
PON: 
100172060(PRKAA2) 100174304(PRKAA1)
NLE: 
100582042(PRKAA2) 100595096(PRKAA1)
MCC: 
695558(PRKAA1) 717703(PRKAA2)
MCF: 
102143726(PRKAA2) 102144683(PRKAA1)
CSAB: 
103215177(PRKAA1) 103224740(PRKAA2)
RRO: 
104664292(PRKAA2) 104676941(PRKAA1)
RBB: 
108532936(PRKAA2) 108544746(PRKAA1)
CJC: 
100385413(PRKAA1) 100396565(PRKAA2)
SBQ: 
101030830(PRKAA1) 101033212(PRKAA2)
MMU: 
105787(Prkaa1) 108079(Prkaa2)
RNO: 
65248(Prkaa1) 78975(Prkaa2)
CGE: 
100767909(Prkaa2) 100769574(Prkaa1)
NGI: 
103734094(Prkaa2) 103741338(Prkaa1)
HGL: 
101698482(Prkaa2) 101722998(Prkaa1)
CCAN: 
109687258(Prkaa2) 109695664(Prkaa1)
OCU: 
100340670(PRKAA2) 100358166(PRKAA1)
TUP: 
102491119(PRKAA2) 106735707(PRKAA1)
CFA: 
479351(PRKAA1) 489571(PRKAA2)
AML: 
100470115(PRKAA1) 100481376(PRKAA2)
UMR: 
103664677(PRKAA1) 103670673(PRKAA2)
ORO: 
101372712(PRKAA1) 101379000(PRKAA2)
FCA: 
101095885(PRKAA1) 101096000(PRKAA2)
PTG: 
102956343(PRKAA1) 102970831(PRKAA2)
AJU: 
106970910(PRKAA1) 106974988(PRKAA2)
BTA: 
538954(PRKAA2) 540404(PRKAA1)
BOM: 
102265959(PRKAA1) 102270414(PRKAA2)
BIU: 
PHD: 
102316046(PRKAA1) 102325193(PRKAA2)
CHX: 
102171295(PRKAA2) 102181338(PRKAA1)
OAS: 
100127210(PRKAA2) 101103425(PRKAA1)
SSC: 
100145903(PRKAA1) 397504(PRKAA2)
CFR: 
102510276(PRKAA1) 102523424(PRKAA2)
CDK: 
105092817(PRKAA2) 105106940(PRKAA1)
BACU: 
103018222(PRKAA2) 103019090(PRKAA1)
LVE: 
103069202(PRKAA2) 103074848(PRKAA1)
ECB: 
100009710(PRKAA1) 100034159(PRKAA2)
EPZ: 
EAI: 
106824750(PRKAA1) 106833475(PRKAA2)
MYB: 
102241697(PRKAA2) 102248668(PRKAA1)
MYD: 
102759339(PRKAA1) 102774877(PRKAA2)
HAI: 
109374016(PRKAA2) 109376169(PRKAA1)
RSS: 
PALE: 
102884524(PRKAA2) 102886520(PRKAA1)
LAV: 
100659413(PRKAA1) 100671280(PRKAA2)
TMU: 
MDO: 
100013711(PRKAA1) 100019066(PRKAA2)
SHR: 
100926139(PRKAA2) 100928944(PRKAA1)
OAA: 
100075352(PRKAA1)
GGA: 
427185(PRKAA1) 429110(PRKAA2)
MGP: 
100034740(PRKAA1) 780945(PRKAA2)
CJO: 
107305860(PRKAA1) 107317703(PRKAA2)
APLA: 
101799561(PRKAA2) 101801595(PRKAA1)
ACYG: 
106033088(PRKAA2) 106036363(PRKAA1)
TGU: 
100217569(PRKAA1) 100224153(PRKAA2)
GFR: 
102031783(PRKAA2) 102038682(PRKAA1) 102044941
FAB: 
101809698(PRKAA1) 101811154(PRKAA2)
PHI: 
102111333(PRKAA2) 102111653(PRKAA1)
PMAJ: 
107208272(PRKAA2) 107216196(PRKAA1)
CCW: 
104686759(PRKAA1) 104695510(PRKAA2)
FPG: 
101913786(PRKAA1) 101919295(PRKAA2)
FCH: 
102049360(PRKAA2) 102050598(PRKAA1)
CLV: 
102087954(PRKAA1) 102088108(PRKAA2)
EGZ: 
104123889(PRKAA2) 104133929(PRKAA1)
AAM: 
106498958(PRKAA2) 106499548(PRKAA1) 106499832
ASN: 
102374152(PRKAA2) 102375567(PRKAA1)
AMJ: 
102570371(PRKAA1) 102576605(PRKAA2)
PSS: 
102444277(PRKAA1) 102459596(PRKAA2)
CMY: 
102940952(PRKAA2) 102944011(PRKAA1)
CPIC: 
101941141(PRKAA1) 101948919(PRKAA2)
ACS: 
100551935(prkaa2) 100567445(prkaa1)
PVT: 
110073913(PRKAA1) 110077130(PRKAA2)
PBI: 
103057294(PRKAA1) 103064935(PRKAA2)
GJA: 
107108814(PRKAA1) 107118038(PRKAA2)
XLA: 
108714249 108715541 399172(prkaa2.S) 495290(prkaa1.L)
XTR: 
100145520(prkaa1) 100216099(prkaa2)
NPR: 
108788157(PRKAA2) 108790816(PRKAA1)
DRE: 
100001198(prkaa1) 572074(prkaa2)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
103022500(prkaa1) 103028619(prkaa2)
TRU: 
101065197(prkaa1) 101076074(prkaa2)
TNG: 
LCO: 
104919125(prkaa2) 104924922(prkaa1)
NCC: 
104959371(prkaa1) 104959556(prkaa2)
MZE: 
101471464(prkaa1) 101487955(prkaa2)
OLA: 
101162057(prkaa1) 101173851(prkaa2)
XMA: 
102231393(prkaa2) 102237231(prkaa1)
PRET: 
103463785(prkaa2) 103473399(prkaa1)
NFU: 
107374929(prkaa1) 107393439(prkaa2)
CSEM: 
103376655(prkaa2) 103390073(prkaa1)
LCF: 
108874097(prkaa1) 108879064(prkaa2)
HCQ: 
109517709(prkaa1) 109532068(prkaa2)
BPEC: 
110154939(prkaa2) 110157325(prkaa1)
SASA: 
ELS: 
105011784(prkaa2) 105015246(prkaa1)
SFM: 
108923517(prkaa2) 108924948(prkaa1)
LCM: 
102349521(PRKAA1) 102365637(PRKAA2)
CMK: 
103172450(prkaa1) 103185288(prkaa2)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
100313552(Prkaa2)
DME: 
Dmel_CG3051(AMPKalpha)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD16554(Dsim_GD16554)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409577(SNF1A)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
663357(Snf1a)
DPA: 
NVL: 
BMOR: 
DPL: 
PMAC: 
PRAP: 
PXY: 
API: 
DNX: 
PHU: 
ZNE: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG06916(Cbr-aak-1) CBG16249(Cbr-aak-2)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
EPA: 
ADF: 
HMG: 
101238049(prkaa2)
TAD: 
AQU: 
ATH: 
AT3G01090(KIN10) AT3G29160(KIN11) AT5G39440(SnRK1.3)
ALY: 
CRB: 
CSAT: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CPAP: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0072749.1(Lj0g3v0072749.1) Lj0g3v0093489.2(Lj0g3v0093489.2) Lj0g3v0267379.1(Lj0g3v0267379.1) Lj0g3v0267379.2(Lj0g3v0267379.2) Lj0g3v0278259.1(Lj0g3v0278259.1) Lj1g3v2449150.1(Lj1g3v2449150.1) Lj2g3v1068760.1(Lj2g3v1068760.1) Lj3g3v1411750.1(Lj3g3v1411750.1) Lj3g3v2118210.1(Lj3g3v2118210.1) Lj5g3v1813880.1(Lj5g3v1813880.1) Lj5g3v1813880.2(Lj5g3v1813880.2) Lj5g3v1813880.3(Lj5g3v1813880.3) Lj6g3v1984590.1(Lj6g3v1984590.1)
LANG: 
FVE: 
PPER: 
PMUM: 
PAVI: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
MCHA: 
RCU: 
JCU: 
HBR: 
POP: 
POPTR_0003s18030g(POPTRDRAFT_1074512) POPTR_0004s11500g(POPTRDRAFT_818055) POPTR_0010s00490g(POPTRDRAFT_821684) POPTR_0011s07230g POPTR_0013s09420g(POPTRDRAFT_895706) POPTR_0016s14100g(POPTRDRAFT_254300) POPTR_0017s12380g(POPTRDRAFT_577688) POPTR_0018s02460g(POPTRDRAFT_825779)
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
NSY: 
NTO: 
INI: 
SIND: 
HAN: 
BVG: 
SOE: 
NNU: 
OSA: 
DOSA: 
Os01t0292200-01(Os01g0292200) Os01t0824600-01(Os01g0824600) Os02t0178000-01(Os02g0178000) Os03t0289100-01(Os03g0289100) Os05t0136200-01(Os05g0136200) Os05t0332300-01(Os05g0332300) Os05t0476350-00(Os05g0476350) Os05t0476466-00(Os05g0476466) Os05t0530500-01(Os05g0530500) Os06t0543400-01(Os06g0543400) Os07t0687000-00(Os07g0687000) Os08t0484600-01(Os08g0484600) Os11t0113700-01(Os11g0113700) Os12t0113500-01(Os12g0113500)
OBR: 
BDI: 
ATS: 
109735326(LOC109735326) 109740446(LOC109740446) 109753963(LOC109753963) 109763841(LOC109763841) 109768849(LOC109768849) 109768972(LOC109768972) 109770353(LOC109770353) 109772576(LOC109772576) 109776637(LOC109776637) 109777741(LOC109777741) 109778022(LOC109778022) 109781333(LOC109781333) 109786308(LOC109786308) 109786686(LOC109786686)
SBI: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
MNG: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
FGR: 
PSQ: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_01354(snfA)
ACAN: 
TAN: 
TPV: 
TOT: 
BEQ: 
BBO: 
BBOV_III009120(17.m07797)
TET: 
PTM: 
SMIN: 
v1.2.001779.t1(symbB.v1.2.001779.t1) v1.2.012456.t2(symbB.v1.2.012456.t2) v1.2.020616.t1(symbB.v1.2.020616.t1) v1.2.020700.t1(symbB.v1.2.020700.t1)
PTI: 
FCY: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB
  Title
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
  Journal
Mol Cell 18:283-93 (2005)
DOI:10.1016/j.molcel.2005.03.027
Reference
PMID:8557660
  Authors
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
  Title
Mammalian AMP-activated protein kinase subfamily.
  Journal
J Biol Chem 271:611-4 (1996)
DOI:10.1074/jbc.271.2.611
  Sequence
[hsa:5562]

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