KEGG ORTHOLOGY: K07409

ORTHOLOGY: K07409

Entry

K07409                      KO

Symbol

CYP1A2

Name

cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]

Pathway

map00140

Steroid hormone biosynthesis

map00232

Caffeine metabolism

map00380

Tryptophan metabolism

map00591

Linoleic acid metabolism

map00830

Retinol metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map05204

Chemical carcinogenesis - DNA adducts

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R03408

R03629

melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase

R07000

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07001

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07021

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07022

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07055

R07056

R07098

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07099

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07939

caffeine:oxygen oxidoreductase (N3-demethylating)

R07943

R07945

R08293

R08294

R08392

R09405

R09407

R09408

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00591 Linoleic acid metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00982 Drug metabolism - cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05207 Chemical carcinogenesis - receptor activation
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05208 Chemical carcinogenesis - reactive oxygen species
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP1 family
   K07409  CYP1A2; cytochrome P450 family 1 subfamily A2

Genes

HSA:	1544(CYP1A2)

PTR:	735881(CYP1A2)

PPS:	100975837(CYP1A2)

GGO:

101130358

PON:	100172368(CYP1A2)

NLE:

100586622

HMH:

116481901

MCF:	102130662(CYP1A2)

MTHB:

126959999

MNI:

105490960

CSAB:

103245329(CYP1A2)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100392712(CYP1A2)

SBQ:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13077(Cyp1a2)

MCAL:

110301271

MPAH:

110328034

RNO:	24297(Cyp1a2)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

121445350 121445351 121445352

MFOT:

126507532 126507533 126507534

AAMP:

119808953 119808954 119808956

NGI:

103736875

CPOC:

100135513(Cyp1a2)

CCAN:

109695949

DORD:

105982353 105982354 105982355

DSP:	122098436 122098439

PLOP:

NCAR:

MMMA:

OCU:

TUP:

GVR:

CFA:	494010(CYP1A2)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	554345(CYP1A2)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	503552(CYP1A2)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	100152910(CYP1A2)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100062244(CYP1A2)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

HAI:

RFQ:

PGIG:

PVP:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:	101424165 101426385 101432104

MDO:

GAS:

SHR:

AFZ:

PCW:

TCF:

MMER:

HSY:

Reference

PMID:3755823

Authors

Jaiswal AK, Nebert DW, Gonzalez FJ

Title

Human P3(450): cDNA and complete amino acid sequence.

Journal

Nucleic Acids Res 14:6773-4 (1986)
DOI:10.1093/nar/14.16.6773

Sequence

[hsa:1544]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (24)   
   KEGG PATHWAY (24)   
Chemical reaction (34)   
   KEGG ENZYME (1)   
   KEGG REACTION (19)   
   KEGG RCLASS (14)   
Gene (177)   
   KEGG GENES (154)   
   KEGG MGENES (5)   
   RefGene (7)   
   OC (11)   
Literature (1)   
   PubMed (1)   
All databases (239)   

Download RDF

DBGET integrated database retrieval system