KEGG ORTHOLOGY: K07436

KEGG

ORTHOLOGY: K07436

Entry

K07436                      KO

Symbol

CYP24A1

Name

vitamin D3 24-hydroxylase [EC:1.14.15.16]

Pathway

Steroid biosynthesis

Metabolic pathways

Parathyroid hormone synthesis, secretion and action

MicroRNAs in cancer

Reaction

calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating)

calcidiol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating)

Disease

Hypercalcemia infantile

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07436  CYP24A1; vitamin D3 24-hydroxylase
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K07436  CYP24A1; vitamin D3 24-hydroxylase
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07436  CYP24A1; vitamin D3 24-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07436  CYP24A1; vitamin D3 24-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.16  vitamin D3 24-hydroxylase
     K07436  CYP24A1; vitamin D3 24-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP24 family
   K07436  CYP24A1; vitamin D3 24-hydroxylase

Other DBs

GO:	0008403 0030342

Genes

HSA:	1591(CYP24A1)

PTR:	746729(CYP24A1)

PPS:	100971976(CYP24A1)

GGO:

PON:

NLE:

HMH:

MCC:

MCF:	102117231(CYP24A1)

MTHB:

MNI:

CSAB:

103243965(CYP24A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

SBQ:

CIMI:

108281352(CYP24A1)

CSYR:

MMUR:

105864362 105869419

LCAT:

PCOQ:

OGA:

MMU:	13081(Cyp24a1)

MCAL:

MPAH:

RNO:	25279(Cyp24a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	485935(CYP24A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101096141(CYP24A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	540080(CYP24A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:	100170323(CYP24)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	397145(CYP24A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100053452(CYP24A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	395827(CYP24A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102574966(CYP24A1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100555767 100564552

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108700906(cyp24a1.L) 108718538

XTR:	100496967 100497429(cyp24a1)

NPR:	108784249 108790437

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	100004700(cyp24a1)

SRX:

SANH:

107666154 107696435

SGH:	107560513 107587600

CCAR:

CAUA:

113050135 113078343 113104946 113105072

CGIB:

127959124 128016032

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

127446014 127449569

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00033861G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

106565076(CP24A) 106583685

STRU:

115150083 115208378

OTW:	112255537 112267058

OMY:	100136661 110493887

OGO:	124002353 124018524

ONE:	115125232 115142853

OKI:	109890306 109891209

OKE:	118373224 118388929

SALP:

111961723 111970527

SNH:	120064455 120065468

CCLU:

121575591 121577964

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

121297804 121319232

ARUT:

117418538 117433450

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

ACOO:

DVT:

HVI:

MQU:

HAME:

CQD:

RSAN:

RMP:

PMEO:

GAE:	121366250 121373112

HRF:	124134044 124135907

HRJ:	124282302 124283687 124289154

CANU:

OED:

HSY:

Reference

Authors

Chen KS, Prahl JM, DeLuca HF

Title

Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.

Journal

Proc Natl Acad Sci U S A 90:4543-7 (1993)
DOI:10.1073/pnas.90.10.4543

Sequence

[hsa:1591]

Reference

Authors

Prosser DE, Jones G

Title

Enzymes involved in the activation and inactivation of vitamin D.

Journal

Trends Biochem Sci 29:664-73 (2004)
DOI:10.1016/j.tibs.2004.10.005

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