KEGG ORTHOLOGY: K07515

ORTHOLOGY: K07515

Entry

K07515 KO

Name

HADHA

Definition

enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]

Pathway

ko00062	Fatty acid elongation
ko00071	Fatty acid metabolism
ko00280	Valine, leucine and isoleucine degradation
ko00310	Lysine degradation
ko00362	Benzoate degradation
ko00380	Tryptophan metabolism
ko00410	beta-Alanine metabolism
ko00627	Aminobenzoate degradation
ko00640	Propanoate metabolism
ko00650	Butanoate metabolism
ko00930	Caprolactam degradation
ko01040	Biosynthesis of unsaturated fatty acids

Module

M00013	Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA
M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085	Fatty acid biosynthesis, elongation, mitochondria
M00087	beta-Oxidation

Disease

H00473	Mitochondrial respiratory chain deficiencies (MRCD)
H00525	Disorders of fatty-acid oxidation

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00640 Propanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00650 Butanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Lipid metabolism
   00062 Fatty acid elongation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   01040 Biosynthesis of unsaturated fatty acids
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00627 Aminobenzoate degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00930 Caprolactam degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
KEGG pathway modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Other carbohydrate metabolism
    M00013  Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   Fatty acid metabolism
    M00085  Fatty acid biosynthesis, elongation, mitochondria
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
    M00087  beta-Oxidation
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Nucleotide and amino acid metabolism
   Lysine metabolism
    M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.211  long-chain-3-hydroxyacyl-CoA dehydrogenase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase

Other DBs

RN:

R01778 R02685 R03026 R03045 R04137 R04170 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04743 R04744 R04745 R04746 R04748 R04749 R05595 R06942 R07935 R07936 R07951 R07952

GO:

0004300 0016509

Genes

HSA:	3030(HADHA)
PTR:	459079(HADHA)
PPS:	100978217(HADHA)
GGO:	101143053(HADHA)
PON:	100172963(HADHA)
MCC:	695975(HADHA)
MMU:	97212(Hadha)
RNO:	170670(Hadha)
CFA:	100856745
AML:	100469654(HADHA)
FCA:	101084701(HADHA)
BTA:	281810(HADHA)
SSC:	397012(HADHA)
ECB:	100071381(HADHA)
MDO:	100030776(HADHA)
SHR:	100928252(HADHA)
OAA:	100077524(HADHA)
GGA:	395929(HADHA)
MGP:	100548080(HADHA)
TGU:	100223290(HADHA)
ACS:	100553746(hadha)
XLA:	444044(hadha)
XTR:	394832(hadha)
DRE:	553401(hadhaa) 793834(hadhab)
TRU:	101073662
OLA:	101155646
BFO:	BRAFLDRAFT_115072
CIN:	100181980
SPU:	585357(hadha)
DME:	Dmel_CG4389(Mtpalpha)
DPO:	Dpse_GA18151
DAN:	Dana_GF21951
DER:	Dere_GG24022
DPE:	Dper_GL19219
DSE:	Dsec_GM12408
DSI:	Dsim_GD22351
DWI:	Dwil_GK23812
DYA:	Dyak_GE10479
DGR:	Dgri_GH11058
DMO:	Dmoj_GI17575
DVI:	Dvir_GJ17917
AGA:	AgaP_AGAP007784
AAG:	AaeL_AAEL010146 AaeL_AAEL015524
CQU:	CpipJ_CPIJ020263
AME:	410325
NVI:	100121740(NV11442)
TCA:	662336
API:	100165657
PHU:	Phum_PHUM238600
ISC:	IscW_ISCW005458
CEL:	CELE_C29F3.1(ech-1) CELE_T08B2.7(T08B2.7)
CBR:	CBG12562
BMY:	Bm1_51120
TSP:	Tsp_09991
NVE:	NEMVE_v1g195800
HMG:	100197152(hadha)
TAD:	TRIADDRAFT_58079
AQU:	100631983
MBR:	MONBRDRAFT_10361
PTI:	PHATRDRAFT_35240
TPS:	THAPSDRAFT_26365
PIF:	PITG_06693

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