KEGG   ORTHOLOGY: K07515Help
Entry
K07515                      KO                                     

Name
HADHA
Definition
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Pathway
Fatty acid elongation
Fatty acid degradation
Valine, leucine and isoleucine degradation
Lysine degradation
Tryptophan metabolism
beta-Alanine metabolism
Aminobenzoate degradation
Propanoate metabolism
Butanoate metabolism
Caprolactam degradation
Biosynthesis of unsaturated fatty acids
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Carbon metabolism
Fatty acid metabolism
Module
M00013  
Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
M00032  
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  
Fatty acid biosynthesis, elongation, mitochondria
M00087  
beta-Oxidation
Disease
H00489  
LCHAD deficiency
H00525  
Disorders of fatty-acid oxidation
H01352  
Mitochondrial trifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00640 Propanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00650 Butanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Lipid metabolism
   00062 Fatty acid elongation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   01040 Biosynthesis of unsaturated fatty acids
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00930 Caprolactam degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Other carbohydrate metabolism
    M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   Fatty acid metabolism
    M00085  Fatty acid biosynthesis, elongation, mitochondria
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
    M00087  beta-Oxidation
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  Nucleotide and amino acid metabolism
   Lysine metabolism
    M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.211  long-chain-3-hydroxyacyl-CoA dehydrogenase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
Genes
HSA: 
3030(HADHA)
PTR: 
459079(HADHA)
PPS: 
GGO: 
101143053(HADHA)
PON: 
100172963(HADHA)
NLE: 
MCC: 
695975(HADHA)
MCF: 
102142372(HADHA)
CSAB: 
103220642(HADHA)
RRO: 
104677892(HADHA)
RBB: 
108532679(HADHA)
CJC: 
100390439(HADHA)
SBQ: 
101047074(HADHA)
MMU: 
97212(Hadha)
RNO: 
170670(Hadha)
CGE: 
100757947(Hadha)
NGI: 
103735655(Hadha)
HGL: 
101724137(Hadha)
CCAN: 
109685831(Hadha)
OCU: 
100355022(HADHA)
TUP: 
CFA: 
100856745(HADHA)
AML: 
100469654(HADHA)
UMR: 
103671672(HADHA)
ORO: 
101364854(HADHA)
FCA: 
101084701(HADHA)
PTG: 
102966470(HADHA)
AJU: 
106967830(HADHA)
BTA: 
281810(HADHA)
BOM: 
102287426(HADHA)
BIU: 
109566315(HADHA)
PHD: 
102332095(HADHA)
CHX: 
102189046(HADHA)
OAS: 
100192316(HADHA)
SSC: 
397012(HADHA)
CFR: 
102516648(HADHA)
CDK: 
105098509(HADHA)
BACU: 
103001885(HADHA)
LVE: 
103086620(HADHA)
ECB: 
100071381(HADHA)
EPZ: 
103546462(HADHA)
EAI: 
106840921(HADHA)
MYB: 
102263028(HADHA)
MYD: 
102751724(HADHA)
HAI: 
109383051(HADHA)
RSS: 
PALE: 
102889313(HADHA)
LAV: 
100675857(HADHA)
TMU: 
MDO: 
100030776(HADHA)
SHR: 
100928252(HADHA)
OAA: 
100077524(HADHA)
GGA: 
395929(HADHA)
MGP: 
100548080(HADHA)
CJO: 
107312378(HADHA)
APLA: 
101799809(HADHA)
ACYG: 
106048383(HADHA)
TGU: 
100223290(HADHA)
GFR: 
102032411(HADHA)
FAB: 
101815112(HADHA)
PHI: 
102103703(HADHA)
PMAJ: 
107198787(HADHA)
CCW: 
104683133(HADHA)
FPG: 
101918262(HADHA)
FCH: 
102045684(HADHA)
CLV: 
102093055(HADHA)
EGZ: 
104130955(HADHA)
AAM: 
106499621(HADHA)
ASN: 
102387874(HADHA)
AMJ: 
102559143(HADHA)
PSS: 
102461507(HADHA)
CMY: 
102938765(HADHA)
CPIC: 
101942783(HADHA)
ACS: 
100553746(hadha)
PVT: 
110090547(HADHA)
PBI: 
103053277(HADHA)
GJA: 
107113769(HADHA)
XLA: 
108717268(hadha.L) 444044(hadha.S)
XTR: 
394832(hadha)
NPR: 
108803249(HADHA)
DRE: 
553401(hadhaa) 793834(hadhab)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
101073662(hadha)
TNG: 
LCO: 
104929997(hadha)
NCC: 
104942173(hadha)
MZE: 
OLA: 
101155646(hadha)
XMA: 
102229661(hadha)
PRET: 
103458382(hadha)
NFU: 
107392010(hadha)
CSEM: 
103380450(hadha)
LCF: 
108874899(hadha)
HCQ: 
BPEC: 
SASA: 
ELS: 
105026863(hadha)
SFM: 
LCM: 
102350823(HADHA)
CMK: 
103183149(hadha)
BFO: 
CIN: 
SPU: 
585357(hadha)
APLC: 
SKO: 
DME: 
Dmel_CG4389(Mtpalpha)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD22351(Dsim_GD22351)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PMAC: 
PRAP: 
PXY: 
API: 
DNX: 
PHU: 
ZNE: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
CBR: 
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
OVI: 
NVE: 
EPA: 
ADF: 
HMG: 
100197152(hadha)
TAD: 
AQU: 
MBR: 
SRE: 
PTI: 
FCY: 
TPS: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
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