Entry |
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Symbol |
NSDHL, ERG26
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Name |
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC: 1.1.1.170]
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Pathway |
map01110 | Biosynthesis of secondary metabolites |
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Module |
M00101 | Cholesterol biosynthesis, FPP => cholesterol |
M00102 | Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol |
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Reaction |
R12404 | 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ 3-oxidoreductase (decarboxylating) |
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Disease |
H00496 | Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
K07748 NSDHL, ERG26; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
K07748 NSDHL, ERG26; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Brady DR, Crowder RD, Hayes WJ |
Title |
Mixed function oxidases in sterol metabolism. Source of reducing equivalents. |
Journal |
J Biol Chem 255:10624-9 (1980) |
Reference |
|
Authors |
Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M |
Title |
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. |
Journal |
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Sequence |
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