KEGG ORTHOLOGY: K07827

ORTHOLOGY: K07827

Entry

K07827 KO

Name

KRAS, KRAS2

Definition

GTPase KRas

Pathway

ko04010	MAPK signaling pathway
ko04012	ErbB signaling pathway
ko04013	MAPK signaling pathway - fly
ko04062	Chemokine signaling pathway
ko04151	PI3K-Akt signaling pathway
ko04320	Dorso-ventral axis formation
ko04360	Axon guidance
ko04370	VEGF signaling pathway
ko04530	Tight junction
ko04540	Gap junction
ko04650	Natural killer cell mediated cytotoxicity
ko04660	T cell receptor signaling pathway
ko04662	B cell receptor signaling pathway
ko04664	Fc epsilon RI signaling pathway
ko04720	Long-term potentiation
ko04722	Neurotrophin signaling pathway
ko04725	Cholinergic synapse
ko04726	Serotonergic synapse
ko04730	Long-term depression
ko04810	Regulation of actin cytoskeleton
ko04910	Insulin signaling pathway
ko04912	GnRH signaling pathway
ko04914	Progesterone-mediated oocyte maturation
ko04915	Estrogen signaling pathway
ko04916	Melanogenesis
ko04960	Aldosterone-regulated sodium reabsorption
ko05034	Alcoholism
ko05160	Hepatitis C
ko05161	Hepatitis B
ko05166	HTLV-I infection
ko05200	Pathways in cancer
ko05203	Viral carcinogenesis
ko05205	Proteoglycans in cancer
ko05210	Colorectal cancer
ko05211	Renal cell carcinoma
ko05212	Pancreatic cancer
ko05213	Endometrial cancer
ko05214	Glioma
ko05215	Prostate cancer
ko05216	Thyroid cancer
ko05218	Melanoma
ko05219	Bladder cancer
ko05220	Chronic myeloid leukemia
ko05221	Acute myeloid leukemia
ko05223	Non-small cell lung cancer

Disease

H00003	Acute myeloid leukemia (AML)
H00010	Multiple myeloma
H00014	Non-small cell lung cancer
H00016	Oral cancer
H00018	Gastric cancer
H00019	Pancreatic cancer
H00020	Colorectal cancer
H00026	Endometrial Cancer
H00027	Ovarian cancer
H00030	Cervical cancer
H00032	Thyroid cancer
H00040	Squamous cell carcinoma
H00041	Kaposi's sarcoma
H00046	Cholangiocarcinoma
H00047	Gallbladder cancer
H00048	Hepatocellular carcinoma
H00458	Craniosynostosis
H00523	Noonan syndrome and related disorders

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04013 MAPK signaling pathway - fly
    K07827  KRAS, KRAS2; GTPase KRas
   04012 ErbB signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04370 VEGF signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04151 PI3K-Akt signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K07827  KRAS, KRAS2; GTPase KRas
  Cell communication
   04530 Tight junction
    K07827  KRAS, KRAS2; GTPase KRas
   04540 Gap junction
    K07827  KRAS, KRAS2; GTPase KRas
Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07827  KRAS, KRAS2; GTPase KRas
   04660 T cell receptor signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04662 B cell receptor signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04664 Fc epsilon RI signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04062 Chemokine signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
  Endocrine system
   04910 Insulin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04912 GnRH signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04915 Estrogen signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04914 Progesterone-mediated oocyte maturation
    K07827  KRAS, KRAS2; GTPase KRas
   04916 Melanogenesis
    K07827  KRAS, KRAS2; GTPase KRas
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K07827  KRAS, KRAS2; GTPase KRas
  Nervous system
   04725 Cholinergic synapse
    K07827  KRAS, KRAS2; GTPase KRas
   04726 Serotonergic synapse
    K07827  KRAS, KRAS2; GTPase KRas
   04720 Long-term potentiation
    K07827  KRAS, KRAS2; GTPase KRas
   04730 Long-term depression
    K07827  KRAS, KRAS2; GTPase KRas
   04722 Neurotrophin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
  Development
   04320 Dorso-ventral axis formation
    K07827  KRAS, KRAS2; GTPase KRas
   04360 Axon guidance
    K07827  KRAS, KRAS2; GTPase KRas
Human Diseases
  Cancers
   05200 Pathways in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05205 Proteoglycans in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05203 Viral carcinogenesis
    K07827  KRAS, KRAS2; GTPase KRas
   05210 Colorectal cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05212 Pancreatic cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05214 Glioma
    K07827  KRAS, KRAS2; GTPase KRas
   05216 Thyroid cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05221 Acute myeloid leukemia
    K07827  KRAS, KRAS2; GTPase KRas
   05220 Chronic myeloid leukemia
    K07827  KRAS, KRAS2; GTPase KRas
   05218 Melanoma
    K07827  KRAS, KRAS2; GTPase KRas
   05211 Renal cell carcinoma
    K07827  KRAS, KRAS2; GTPase KRas
   05219 Bladder cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05215 Prostate cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05213 Endometrial cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05223 Non-small cell lung cancer
    K07827  KRAS, KRAS2; GTPase KRas
  Substance dependence
   05034 Alcoholism
    K07827  KRAS, KRAS2; GTPase KRas
  Infectious diseases
   05166 HTLV-I infection
    K07827  KRAS, KRAS2; GTPase KRas
   05161 Hepatitis B
    K07827  KRAS, KRAS2; GTPase KRas
   05160 Hepatitis C
    K07827  KRAS, KRAS2; GTPase KRas
GTP-binding proteins [BR:ko04031]
Small (Monomeric) G-proteins
  Ras Family
   Ras
    K07827  KRAS, KRAS2; GTPase KRas

Genes

HSA:	3845(KRAS)
PTR:	473387(KRAS)
PPS:	100990801(KRAS)
GGO:	101144039(KRAS)
PON:	100462513
MCC:	707977(KRAS)
MMU:	16653(Kras)
RNO:	24525(Kras)
CFA:	403871(KRAS)
AML:	100483919
FCA:	751104(K-RAS)
BTA:	541140(KRAS)
SSC:	100518251
ECB:	100051785
MDO:	100009992 554186(KRAS)
SHR:	100915526(KRAS)
OAA:	100085430
GGA:	418207(KRAS)
MGP:	100151750(KRAS)
TGU:	100227892(KRAS)
ACS:	100559807 100563575
XLA:	100505423 373672(kras-a) 397771(kras-b) 399470(ralb)
XTR:	100485959 493396(kras)
DRE:	445289(kras)
TRU:	101077708
OLA:	100049322(c-Ki-ras-1) 101154954
BFO:	BRAFLDRAFT_61057
SPU:	578859
DME:	Dmel_CG9375(Ras85D)
DPO:	Dpse_GA21740
DAN:	Dana_GF16057
DER:	Dere_GG17366
DPE:	Dper_GL22227
DSE:	Dsec_GM26252
DSI:	Dsim_GD20791(Dsim_Ras85D)
DWI:	Dwil_GK13838
DYA:	Dyak_GE24771
DGR:	Dgri_GH19394
DMO:	Dmoj_GI22599
DVI:	Dvir_GJ23844(Dvir_Ras1)
AGA:	AgaP_AGAP002219
AAG:	AaeL_AAEL012071
CQU:	CpipJ_CPIJ006054
AME:	410812
NVI:	100114262(NV12723)
TCA:	663464
API:	100159403
PHU:	Phum_PHUM380970
CEL:	CELE_ZK792.6(let-60)
CBR:	CBG06092(Cbr-let-60)
BMY:	Bm1_37960
TSP:	Tsp_07908
SMM:	Smp_179910
NVE:	NEMVE_v1g247341
HMG:	100209445
TAD:	TRIADDRAFT_29518
AQU:	100637745
NGR:	NAEGRDRAFT_60817
DDI:	DDB_G0293434(rasG)
DPP:	DICPUDRAFT_92731(rasG)

» show all

Reference

PMID:15367757

Authors

Colicelli J

Title

Human RAS superfamily proteins and related GTPases.

Journal

Sci STKE 2004:RE13 (2004)

Reference

PMID:11752674

Authors

Wolfman A

Title

Ras isoform-specific signaling: location, location, location.

Journal

Sci STKE 2001:pe2 (2001)

Reference

PMID:10723799

Authors

Olson MF, Marais R

Title

Ras protein signalling.

Journal

Semin Immunol 12:63-73 (2000)

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (90)   
   KEGG PATHWAY (90)   
Disease (18)   
   KEGG DISEASE (18)   
Gene (94)   
   KEGG GENES (67)   
   KEGG DGENES (5)   
   KEGG EGENES (20)   
   KEGG MGENES (2)   
Protein sequence (60)   
   UniProt (60)   
Literature (3)   
   PubMed (3)   
All databases (268)   

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