KEGG ORTHOLOGY: K08047

ORTHOLOGY: K08047

Entry

K08047                      KO

Symbol

ADCY7

Name

adenylate cyclase 7 [EC:4.6.1.1]

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

map01522

Endocrine resistance

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04114

Oocyte meiosis

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04371

Apelin signaling pathway

map04540

Gap junction

map04611

Platelet activation

map04713

Circadian entrainment

map04714

Thermogenesis

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04727

GABAergic synapse

map04750

Inflammatory mediator regulation of TRP channels

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04913

Ovarian steroidogenesis

map04914

Progesterone-mediated oocyte maturation

map04915

Estrogen signaling pathway

map04916

Melanogenesis

map04918

Thyroid hormone synthesis

map04921

Oxytocin signaling pathway

map04923

Regulation of lipolysis in adipocytes

map04925

Aldosterone synthesis and secretion

map04926

Relaxin signaling pathway

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map04970

Salivary secretion

map04971

Gastric acid secretion

map04972

Pancreatic secretion

map04976

Bile secretion

map05032

Morphine addiction

map05163

Human cytomegalovirus infection

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05414

Dilated cardiomyopathy

Reaction

R00089

ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)

R00434

GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08047  ADCY7; adenylate cyclase 7
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04371 Apelin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04020 Calcium signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04072 Phospholipase D signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04024 cAMP signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04022 cGMP-PKG signaling pathway
    K08047  ADCY7; adenylate cyclase 7
09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08047  ADCY7; adenylate cyclase 7
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08047  ADCY7; adenylate cyclase 7
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08047  ADCY7; adenylate cyclase 7
   04062 Chemokine signaling pathway
    K08047  ADCY7; adenylate cyclase 7
  09152 Endocrine system
   04911 Insulin secretion
    K08047  ADCY7; adenylate cyclase 7
   04923 Regulation of lipolysis in adipocytes
    K08047  ADCY7; adenylate cyclase 7
   04912 GnRH signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04913 Ovarian steroidogenesis
    K08047  ADCY7; adenylate cyclase 7
   04915 Estrogen signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04914 Progesterone-mediated oocyte maturation
    K08047  ADCY7; adenylate cyclase 7
   04921 Oxytocin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04926 Relaxin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04935 Growth hormone synthesis, secretion and action
    K08047  ADCY7; adenylate cyclase 7
   04918 Thyroid hormone synthesis
    K08047  ADCY7; adenylate cyclase 7
   04928 Parathyroid hormone synthesis, secretion and action
    K08047  ADCY7; adenylate cyclase 7
   04916 Melanogenesis
    K08047  ADCY7; adenylate cyclase 7
   04925 Aldosterone synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
   04927 Cortisol synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08047  ADCY7; adenylate cyclase 7
   04270 Vascular smooth muscle contraction
    K08047  ADCY7; adenylate cyclase 7
  09154 Digestive system
   04970 Salivary secretion
    K08047  ADCY7; adenylate cyclase 7
   04971 Gastric acid secretion
    K08047  ADCY7; adenylate cyclase 7
   04972 Pancreatic secretion
    K08047  ADCY7; adenylate cyclase 7
   04976 Bile secretion
    K08047  ADCY7; adenylate cyclase 7
  09156 Nervous system
   04724 Glutamatergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04727 GABAergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04725 Cholinergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04723 Retrograde endocannabinoid signaling
    K08047  ADCY7; adenylate cyclase 7
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08047  ADCY7; adenylate cyclase 7
  09149 Aging
   04211 Longevity regulating pathway
    K08047  ADCY7; adenylate cyclase 7
   04213 Longevity regulating pathway - multiple species
    K08047  ADCY7; adenylate cyclase 7
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08047  ADCY7; adenylate cyclase 7
   04714 Thermogenesis
    K08047  ADCY7; adenylate cyclase 7
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08047  ADCY7; adenylate cyclase 7
   05207 Chemical carcinogenesis - receptor activation
    K08047  ADCY7; adenylate cyclase 7
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08047  ADCY7; adenylate cyclase 7
   05163 Human cytomegalovirus infection
    K08047  ADCY7; adenylate cyclase 7
  09165 Substance dependence
   05032 Morphine addiction
    K08047  ADCY7; adenylate cyclase 7
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08047  ADCY7; adenylate cyclase 7
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08047  ADCY7; adenylate cyclase 7
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08047  ADCY7; adenylate cyclase 7
Enzymes [BR:ko01000]
4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08047  ADCY7; adenylate cyclase 7

Other DBs

GO:

0004016

Genes

HSA:	113(ADCY7)

PTR:	473278(ADCY7)

PPS:	100984225(ADCY7)

GGO:	101126268(ADCY7)

PON:	100436577(ADCY7)

NLE:	100587036(ADCY7)

HMH:	116471246(ADCY7)

MCC:	694730(ADCY7)

MCF:	102125718(ADCY7)

MTHB:

126944901

MNI:	105492251(ADCY7)

CSAB:

103232667(ADCY7)

CATY:

105588901(ADCY7)

PANU:

101000833(ADCY7)

TGE:	112613998(ADCY7)

MLEU:

105545643(ADCY7)

RRO:	104672569(ADCY7)

RBB:	108522948(ADCY7)

TFN:	117087765(ADCY7)

PTEH:

111541238(ADCY7)

CANG:

105514953(ADCY7)

CJC:	100404620(ADCY7)

SBQ:	101032672(ADCY7)

CIMI:

108305477(ADCY7)

CSYR:

103259338(ADCY7)

MMUR:

105884745(ADCY7)

LCAT:

123625466(ADCY7)

PCOQ:

105808848(ADCY7)

OGA:	100956925(ADCY7)

MMU:	11513(Adcy7)

MCAL:

110299719(Adcy7)

MPAH:

110337453(Adcy7)

RNO:	84420(Adcy7)

MCOC:

116069817(Adcy7)

ANU:	117723273(Adcy7)

MUN:	110560723(Adcy7)

CGE:	100756132(Adcy7)

MAUA:

101839314(Adcy7)

PROB:

127229980(Adcy7)

PLEU:

114708501(Adcy7)

MORG:

121446853(Adcy7)

MFOT:

126487138

AAMP:

119801694(Adcy7)

NGI:	103730120(Adcy7)

HGL:	101712483(Adcy7)

CPOC:

100726699(Adcy7)

CCAN:

109698373(Adcy7)

DORD:

105994440(Adcy7)

DSP:	122119361(Adcy7)

PLOP:

125358478(Adcy7)

NCAR:

124966834

MMMA:

107144878(Adcy7)

OCU:

100357357

OPI:	101519430(ADCY7)

TUP:	102496578(ADCY7)

GVR:	103583204 103594947(ADCY7)

CFA:	487289(ADCY7)

CLUD:

112660528(ADCY7)

VVP:	112929565(ADCY7)

VLG:	121497930(ADCY7)

NPO:	129513386(ADCY7)

AML:	100466965(ADCY7)

UMR:	103673916(ADCY7)

UAH:	113252223(ADCY7)

UAR:	123798393(ADCY7)

ELK:

111157326

LLV:

125088705

MPUF:

101684190(ADCY7)

MNP:	132005324(ADCY7)

MLK:	131818734(ADCY7)

NVS:	122911463(ADCY7)

ORO:	101377421(ADCY7)

EJU:	114202960 114202963

ZCA:	113935770(ADCY7)

MLX:	118023800(ADCY7)

NSU:	110593510(ADCY7)

LWW:	102732736(ADCY7)

FCA:	101094148(ADCY7)

PYU:	121045271(ADCY7)

PCOO:

112857348(ADCY7)

PBG:	122494184(ADCY7)

PVIV:

125153013(ADCY7)

LRUF:

124511307

PTG:	102972917(ADCY7)

PPAD:

109270953(ADCY7)

PUC:

125915408

AJU:

106985835

HHV:	120238226(ADCY7)

BTA:	281603(ADCY7)

BOM:	102266966(ADCY7)

BIU:	109572478(ADCY7)

BBUB:

102410456(ADCY7)

BBIS:

104999563(ADCY7)

CHX:	102185858(ADCY7)

OAS:	101112667(ADCY7)

BTAX:

128063240(ADCY7)

ODA:	120872811(ADCY7)

CCAD:

122421548(ADCY7)

MBEZ:

129547117(ADCY7)

SSC:	100620994(ADCY7)

CFR:	102524614(ADCY7)

CBAI:

105074271(ADCY7)

CDK:	105097528(ADCY7)

VPC:	102529498(ADCY7)

BACU:

102997912(ADCY7)

BMUS:

118884739(ADCY7)

LVE:	103078677(ADCY7)

OOR:	101273592(ADCY7)

DLE:	111164991(ADCY7)

PCAD:

102985075(ADCY7)

PSIU:

116744731(ADCY7)

NASI:

112401228(ADCY7)

ECB:	100058891(ADCY7)

EPZ:	103556685(ADCY7)

EAI:	106824126(ADCY7)

MYB:	102253549(ADCY7)

MYD:	102764043(ADCY7)

MMYO:

118674005(ADCY7)

PKL:	118720641(ADCY7)

EFUS:

103295862(ADCY7)

MNA:	107531029(ADCY7)

DRO:	112296774(ADCY7)

SHON:

119001137(ADCY7)

AJM:	119046468(ADCY7)

PDIC:

114488191(ADCY7)

PHAS:

123805699(ADCY7)

MMF:	118639510(ADCY7)

PPAM:

129068161(ADCY7)

HAI:	109383261(ADCY7)

RFQ:	117034378(ADCY7)

PALE:

102881535(ADCY7)

PGIG:

120617254(ADCY7)

PVP:	105292087(ADCY7)

RAY:	107512248(ADCY7)

MJV:	108407296(ADCY7)

TOD:	119249160(ADCY7)

SARA:

101543858(ADCY7)

SETR:

126027080(ADCY7)

LAV:	100653771(ADCY7)

TMU:

101341715

ETF:	101640587(ADCY7)

DNM:	101427927(ADCY7)

MDO:	100013823(ADCY7)

GAS:	123233664(ADCY7)

SHR:	100929278(ADCY7)

AFZ:

127550695

PCW:	110207473(ADCY7)

OAA:	100076221(ADCY7)

GGA:	415732(ADCY7)

PCOC:

116243930(ADCY7)

MGP:

100548914

CJO:	107319017(ADCY7)

TPAI:

128082547(ADCY7)

LMUT:

125699136(ADCY7)

NMEL:

110404374(ADCY7)

APLA:

101794076(ADCY7)

ACYG:

106039584(ADCY7)

CATA:

118246350(ADCY7)

AFUL:

116494191(ADCY7)

TGU:	100225700(ADCY7)

LSR:	110473537(ADCY7)

SCAN:

103816806(ADCY7)

PMOA:

120507978(ADCY7)

OTC:	121333986(ADCY7)

PRUF:

121348916(ADCY7)

GFR:	102043194(ADCY7)

FAB:	101816007(ADCY7)

OMA:	130257686(ADCY7)

PHI:	102106688(ADCY7)

PMAJ:

107209841(ADCY7)

CCAE:

111934618(ADCY7)

CCW:	104687454(ADCY7)

CBRC:

103620194(ADCY7)

ETL:	114055552(ADCY7)

ZAB:	102073757(ADCY7)

ACHL:

103800785(ADCY7)

SVG:	106856945(ADCY7)

MMEA:

130579119(ADCY7)

HRT:	120757744(ADCY7)

FPG:	101914615(ADCY7)

FCH:	102052224(ADCY7)

CLV:	102090470(ADCY7)

EGZ:	104125176(ADCY7)

NNI:	104011289(ADCY7)

PCRI:

104031527(ADCY7)

PLET:

104617349(ADCY7)

EHS:	104509139(ADCY7)

PCAO:

104042414(ADCY7)

ACUN:

113484440(ADCY7)

TALA:

104368104(ADCY7)

PADL:

103913801(ADCY7)

AFOR:

103896863(ADCY7)

ACHC:

115345521(ADCY7)

HALD:

104320370(ADCY7)

HLE:	104842584(ADCY7)

AGEN:

126041284

GCL:

127021006

CCRI:

104157350(ADCY7)

CSTI:

104553421

CMAC:

104479655(ADCY7)

MUI:	104533950(ADCY7)

BREG:

104638310(ADCY7)

FGA:	104077549(ADCY7)

GSTE:

104256338(ADCY7)

LDI:	104345595(ADCY7)

MNB:	103770738(ADCY7)

OHA:	104338983(ADCY7)

NNT:	104406202(ADCY7)

SHAB:

115601291(ADCY7)

DPUB:

104303154(ADCY7)

PGUU:

104464269(ADCY7)

ACAR:

104532959(ADCY7)

CPEA:

104388571(ADCY7)

AVIT:

104269827

CVF:	104286482(ADCY7)

RTD:	128908370(ADCY7)

CUCA:

104068389(ADCY7)

TEO:	104371518(ADCY7)

AAM:	106483289(ADCY7)

AROW:

112967538(ADCY7)

NPD:	112944957(ADCY7)

TGT:	104566596(ADCY7)

DNE:	112984414(ADCY7)

SCAM:

104146325(ADCY7)

ASN:	102368976(ADCY7)

AMJ:	102566330(ADCY7)

CPOO:

109310532(ADCY7)

GGN:	109289593(ADCY7)

PSS:	102449192(ADCY7)

CMY:	102946407(ADCY7)

CCAY:

125645349(ADCY7)

DCC:	119841199(ADCY7)

CPIC:

101938536(ADCY7)

TST:	117886819(ADCY7)

CABI:

116826976(ADCY7)

MRV:	120384768(ADCY7)

ACS:	100558751(adcy7)

ASAO:

132783079(ADCY7)

PVT:	110086573(ADCY7)

SUND:

121914489(ADCY7)

PBI:	103060035(ADCY7)

PMUR:

107290046(ADCY7)

CTIG:

120312119(ADCY7)

TSR:	106554339(ADCY7)

PGUT:

117670935(ADCY7)

APRI:

131184024(ADCY7)

PTEX:

113444984(ADCY7)

NSS:	113417526(ADCY7)

VKO:	123022135(ADCY7)

PMUA:

114602227(ADCY7)

PRAF:

128419465(ADCY7)

ZVI:	118085993(ADCY7)

HCG:	128334274(ADCY7)

GJA:	107117185(ADCY7)

STOW:

125443684(ADCY7)

EMC:	129344146(ADCY7)

XLA:	399055(adcy7.L)

XTR:	100127741(adcy7)

NPR:	108794932(ADCY7)

RTEM:

120917430(ADCY7)

BBUF:

120981193(ADCY7)

BGAR:

122920478(ADCY7)

MUO:	115470804(ADCY7)

GSH:	117359545(ADCY7)

DRE:	568726(adcy7)

SRX:	107742778 107750233

SANH:

107657123 107696709

SGH:	107551487 107554606

CCAR:

109080760 109091999

CAUA:

113051418 113106060

CGIB:

127961582 128016846

PTET:

122349408(adcy7)

LROH:

127167860(adcy7)

OMC:	131544254(adcy7)

PPRM:

120468737(adcy7)

RKG:	130069752(adcy7)

MAMB:

125265058(adcy7)

CIDE:

127515179

MASI:

127444080 127453675

TROS:

130557119(adcy7)

TDW:	130418420(adcy7)

MANU:

129444859(adcy7)

IPU:

108259218

IFU:	128602846(adcy7)

PHYP:

113540899(adcy7)

SMEO:

124379641(adcy7)

TFD:	113648472(adcy7)

TVC:	132838932(adcy7)

AMEX:

103025161(adcy7)

CMAO:

118817411(adcy7)

EEE:

113581231

CHAR:

105899759(adcy7)

TRU:	101066272(adcy7)

TFS:	130521879(adcy7)

LCO:	104940647(adcy7)

TBEN:

117496670(adcy7)

CGOB:

115005259(adcy7)

PGEO:

117441125(adcy7)

GACU:

117549142(adcy7)

EMAC:

134863119(adcy7)

ELY:	117253092(adcy7)

EFO:	125878880(adcy7)

PLEP:

121939187(adcy7)

SLUC:

116037616(adcy7)

ECRA:

117949494(adcy7)

ESP:	116693865(adcy7)

PFLV:

114555545(adcy7)

GAT:	120811617(adcy7)

PPUG:

119226484(adcy7)

AFB:	129105651(adcy7)

CLUM:

117726078(adcy7)

PSWI:

130192880(adcy7)

MSAM:

119889811(adcy7)

SCHU:

122863875(adcy7)

CUD:	121509307(adcy7)

ALAT:

119018820(adcy7)

MZE:	101480238(adcy7)

ONL:	100703488(adcy7)

OAU:	116325574(adcy7)

OLA:	101164967(adcy7)

OML:	112160437(adcy7)

CSAI:

133463928(adcy7)

XMA:	102223009(adcy7)

XCO:	114142861(adcy7)

XHE:	116718405(adcy7)

PRET:

103462645(adcy7)

PFOR:

103138067(adcy7)

PLAI:

106957719

PMEI:

106927339

GAF:	122825208(adcy7)

PPRL:

129364417(adcy7)

CVG:	107088499(adcy7)

CTUL:

119781951(adcy7)

GMU:	124867163(adcy7)

NFU:	107381237(adcy7)

KMR:	108243337(adcy7)

ALIM:

106527041

NWH:	119426404(adcy7)

AOCE:

111572244(adcy7)

MCEP:

125005160(adcy7)

CSEM:

103398552

POV:	109625125(adcy7)

SSEN:

122772187(adcy7)

HHIP:

117759592(adcy7)

HSP:	118106353(adcy7)

SMAU:

118302966(adcy7)

LCF:

108876970

SDU:	111217971(adcy7)

SLAL:

111672304(adcy7)

XGL:	120789257(adcy7)

HCQ:	109513976(adcy7)

SSCV:

125967608

SBIA:

133498167(adcy7)

PEE:	133397769(adcy7)

PTAO:

133474155(adcy7)

BPEC:

110175272(adcy7)

MALB:

109955816(adcy7)

BSPL:

114852640(adcy7)

SJO:	128358809(adcy7)

SASA:

106562384 106587576

STRU:

115167552 115203287

OTW:	112249333 112249354

OMY:	110506731 110526596

OGO:	124033586 124035566

ONE:	115112487 115113769

OKI:	109881364 109881656

OKE:	118362652 118365705

SALP:

111974474

SNH:	120024860 120048037

CCLU:

121534524 121562328

ELS:	105025700(adcy7)

SFM:

108932972

PKI:	111832687 111848207

AANG:

118215074(adcy7) 118227441

LOC:	102689559(adcy7)

PSPA:

121296167 121325516

ARUT:

117424464(adcy7) 117425878

PSEX:

120535204(adcy7)

LCM:	102351065(ADCY7)

CMK:	103176081(adcy7)

CPLA:

122558411(adcy7)

HOC:	132823957(adcy7)

DMK:

DFR:

UDV:

Reference

PMID:7961850

Authors

Watson PA, Krupinski J, Kempinski AM, Frankenfield CD

Title

Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.

Journal

J Biol Chem 269:28893-8 (1994)

Sequence

[hsa:113]

Reference

PMID:22264442

Authors

Joeyen-Waldorf J, Nikolova YS, Edgar N, Walsh C, Kota R, Lewis DA, Ferrell R, Manuck SB, Hariri AR, Sibille E

Title

Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.

Journal

Biol Psychiatry 71:627-32 (2012)
DOI:10.1016/j.biopsych.2011.11.029

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