KEGG ORTHOLOGY: K08588

ORTHOLOGY: K08588

Entry

K08588                      KO

Symbol

BAP1, UCHL2

Name

ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]

Pathway

map03083

Polycomb repressive complex

Disease

H02623

Kury-Isidor syndrome

H02624

Tumor predisposition syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
   03036 Chromosome and associated proteins
    K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C12: ubiquitin C-terminal hydrolase family
   K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
Ubiquitin system [BR:ko04121]
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UCH
    K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    PR-DUB complex
     K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1

Other DBs

GO:

0004843

Genes

HSA:	8314(BAP1)

PTR:	460426(BAP1)

PPS:	100985439(BAP1)

GGO:	101125045(BAP1)

PON:	100462322(BAP1)

NLE:	100580456(BAP1)

HMH:	116473400(BAP1)

MCC:	697221(BAP1)

MCF:	102117932(BAP1)

MTHB:

126948655

MNI:	105480544(BAP1)

CSAB:

103227728(BAP1)

CATY:

105585554(BAP1)

PANU:

101015649(BAP1)

TGE:	112618576(BAP1)

MLEU:

105544008(BAP1)

RRO:	104663707(BAP1)

RBB:	108522347(BAP1)

TFN:	117082750(BAP1)

PTEH:

111528764(BAP1)

CANG:

105523830(BAP1)

CJC:	100390086(BAP1)

SBQ:	101051638(BAP1)

CIMI:

108314012(BAP1)

CSYR:

103257234(BAP1)

MMUR:

105875045(BAP1)

LCAT:

123623194(BAP1)

PCOQ:

105827590(BAP1)

OGA:	100947137(BAP1)

MMU:	104416(Bap1)

MCAL:

110309469(Bap1)

MPAH:

110325384(Bap1)

RNO:	306257(Bap1)

MCOC:

116084131(Bap1)

ANU:	117706205(Bap1)

MUN:	110547591(Bap1)

CGE:	100765297(Bap1)

MAUA:

101823335(Bap1)

PROB:

127236860(Bap1)

PLEU:

114708169(Bap1)

MORG:

121455051(Bap1)

MFOT:

126511226

AAMP:

119827394(Bap1)

NGI:	103748997(Bap1)

HGL:	101703932(Bap1)

CPOC:

100731081(Bap1)

CCAN:

109692466(Bap1)

DORD:

105996609(Bap1)

DSP:	122107992(Bap1)

PLOP:

125358616(Bap1)

NCAR:

124968534

MMMA:

107149646(Bap1)

OCU:

100346021

OPI:	101519010(BAP1)

TUP:	102498644(BAP1)

GVR:	103590342(BAP1)

CFA:	484737(BAP1)

CLUD:

112665881(BAP1)

VVP:	112910553(BAP1)

VLG:	121495553(BAP1)

NPO:	129522479(BAP1)

AML:	100477897(BAP1)

UMR:	103675070(BAP1)

UAH:	113256949(BAP1)

UAR:	123798730(BAP1)

ELK:

111144240

LLV:

125079081

MPUF:

101678284(BAP1)

MNP:	132011396(BAP1)

MLK:	131824007(BAP1)

NVS:	122909360(BAP1)

ORO:	101368565(BAP1)

EJU:	114218557 114225109(BAP1)

ZCA:	113918460(BAP1) 113921958

MLX:	118005004(BAP1)

NSU:	110584768(BAP1)

LWW:	102726476(BAP1)

FCA:	101092671(BAP1)

PYU:	121016878(BAP1)

PCOO:

112852663(BAP1)

PBG:	122487305(BAP1)

PVIV:

125151998(BAP1)

LRUF:

124523914

PTG:	102959486(BAP1)

PPAD:

109247903(BAP1)

PUC:

125929444

AJU:

106987006

HHV:	120239424(BAP1)

BTA:	100124510(BAP1)

BOM:	102272096(BAP1)

BBUB:

102389364(BAP1)

BBIS:

104997139(BAP1)

CHX:	102183466(BAP1)

OAS:	101111666(BAP1) 101116449

BTAX:

128054041(BAP1) 128054600

ODA:	120868355(BAP1)

CCAD:

122424716(BAP1) 122453182

MBEZ:

129547906(BAP1)

SSC:	100154798(BAP1)

CFR:	102514794(BAP1)

CBAI:

105080182(BAP1)

CDK:	105093436(BAP1)

VPC:	102532553(BAP1)

BACU:

103013242(BAP1)

BMUS:

118903440(BAP1)

LVE:	103086992(BAP1)

OOR:	101269779(BAP1)

DLE:	111174309(BAP1)

PCAD:

102977608(BAP1)

PSIU:

116762629(BAP1)

NASI:

112400586(BAP1)

ECB:	100051934(BAP1)

EPZ:	103546494(BAP1)

EAI:	106821741(BAP1)

MYB:	102249893(BAP1)

MYD:	102768770(BAP1)

MMYO:

118668009(BAP1)

MLF:	102421577(BAP1)

PKL:	118715159(BAP1)

EFUS:

103295166(BAP1)

MNA:	107534696(BAP1)

DRO:	112301253(BAP1)

SHON:

118993369(BAP1)

AJM:	119041440(BAP1)

PDIC:

114501594(BAP1)

PHAS:

123814390(BAP1)

MMF:	118633286(BAP1) 118639718

PPAM:

129088530(BAP1)

HAI:	109373875(BAP1)

RFQ:	117037095(BAP1)

PALE:

102898027(BAP1)

PGIG:

120606333(BAP1)

PVP:	105300369(BAP1)

RAY:	107498568(BAP1)

MJV:	108404436(BAP1)

TOD:	119261078(BAP1)

SARA:

101551324(BAP1)

SETR:

126013569(BAP1)

LAV:	100661537(BAP1)

TMU:

101352931

ETF:	101640237 101648625(BAP1)

DNM:	101433333(BAP1)

MDO:	100030960(BAP1)

GAS:	123245329(BAP1)

SHR:	100931031(BAP1)

AFZ:

127553978

PCW:	110197566(BAP1)

OAA:	100073550(BAP1)

GGA:	415944(BAP1)

PCOC:

116241072(BAP1)

MGP:	100550251(BAP1)

CJO:	107319642(BAP1)

TPAI:

128078403(BAP1)

LMUT:

125698980(BAP1)

NMEL:

110405013(BAP1)

APLA:

101803525(BAP1)

ACYG:

106042812(BAP1)

CATA:

118248201(BAP1)

AFUL:

116493163(BAP1)

TGU:	100224993(BAP1)

LSR:	110472133(BAP1)

SCAN:

103824275(BAP1)

PMOA:

120514069(BAP1)

OTC:	121347343(BAP1)

PRUF:

121351605(BAP1)

GFR:	102033547(BAP1)

FAB:	101821997(BAP1)

OMA:	130258281(BAP1)

PHI:	102107539(BAP1)

PMAJ:

107210501(BAP1)

CCAE:

111935317(BAP1)

CCW:	104683444(BAP1)

CBRC:

103614276(BAP1)

ETL:	114058662(BAP1)

ZAB:	102068442(BAP1)

SVG:	106849187(BAP1)

MMEA:

130578583(BAP1)

HRT:	120758070(BAP1)

FPG:	101921900(BAP1)

FCH:	102058766(BAP1)

CLV:	102093813(BAP1)

EGZ:	104126671(BAP1)

NNI:	104008733(BAP1)

PCRI:

104027604(BAP1)

PLET:

104619343(BAP1)

EHS:	104508290(BAP1)

PCAO:

104046143(BAP1)

ACUN:

113484683(BAP1)

TALA:

104364570(BAP1)

PADL:

103915082(BAP1)

AFOR:

103895252(BAP1)

ACHC:

115353802(BAP1)

HALD:

104319811

HLE:	104835135(BAP1)

AGEN:

126049694

GCL:

127021598

CCRI:

104169409(BAP1)

CMAC:

104485081(BAP1)

MUI:	104542668(BAP1)

BREG:

104639411(BAP1)

FGA:	104077288(BAP1)

GSTE:

104256883(BAP1)

LDI:	104342568(BAP1)

MNB:	103767962(BAP1)

OHA:	104336645(BAP1)

NNT:	104407295(BAP1)

SHAB:

115614127(BAP1)

DPUB:

104305437(BAP1)

PGUU:

104465236(BAP1)

ACAR:

104532006(BAP1)

CPEA:

104387135(BAP1)

AVIT:

104273061(BAP1)

CVF:	104291964(BAP1)

RTD:	128915556(BAP1)

CUCA:

104066706(BAP1)

TEO:	104381636(BAP1)

BRHI:

104493788(BAP1)

AAM:	106487051(BAP1)

AROW:

112968845(BAP1)

NPD:	112953098(BAP1)

TGT:	104576640(BAP1)

DNE:	112986942(BAP1)

SCAM:

104139418(BAP1)

ASN:	102369399(BAP1)

AMJ:	102569589(BAP1)

CPOO:

109311430(BAP1)

GGN:	109292779(BAP1)

PSS:	106731683(BAP1)

CMY:	102938034(BAP1)

CCAY:

125639883(BAP1)

DCC:	119858300(BAP1)

CPIC:

101949440(BAP1)

TST:	117879735(BAP1)

CABI:

116831437(BAP1)

MRV:	120409213(BAP1)

ACS:	100557123(bap1)

ASAO:

132769166(BAP1)

PVT:	110084477(BAP1)

SUND:

121921575(BAP1)

PBI:	103061901(BAP1)

PMUR:

107291052(BAP1)

CTIG:

120307650(BAP1)

TSR:	106557150(BAP1)

PGUT:

117678507(BAP1)

APRI:

131190139(BAP1)

PTEX:

113453628(BAP1)

NSS:	113415723(BAP1)

VKO:	123034122(BAP1)

PMUA:

114591571(BAP1)

PRAF:

128408188(BAP1)

ZVI:	118080614(BAP1)

HCG:	128345805(BAP1)

GJA:	107106808(BAP1)

STOW:

125428092(BAP1)

EMC:	129328777(BAP1)

XLA:	108715839(bap1.S) 734438(bap1.L)

XTR:	493568(bap1)

NPR:	108793423(BAP1)

RTEM:

120944932(BAP1)

BBUF:

120978630(BAP1)

BGAR:

122943824(BAP1)

MUO:	115471631(BAP1)

GSH:	117351270(BAP1)

DRE:	558885(bap1)

SRX:	107731337(bap1) 107755981

SANH:

107695622 107704441

SGH:	107579198(bap1) 107586981

CCAR:

109083534

CAUA:

113040238 113064729 113079559

CGIB:

127943356 127987971

PTET:

122327320(bap1)

LROH:

127153836(bap1)

OMC:	131530269(bap1)

PPRM:

120492824(bap1)

RKG:	130077265(bap1)

MAMB:

125263631(bap1)

CIDE:

127521269

MASI:

127438554 127439097

TROS:

130548691(bap1)

TDW:	130430099(bap1)

MANU:

129452741(bap1)

IPU:

108254761

IFU:	128625033(bap1)

PHYP:

113539726(bap1)

SMEO:

124402447(bap1)

TFD:	113636997(bap1)

TVC:	132837794(bap1)

AMEX:

103034294(bap1)

CMAO:

118799773(bap1)

EEE:	113583822(bap1)

CHAR:

105903415(bap1)

TRU:	101071387(bap1)

TFS:	130524137(bap1)

TNG:	GSTEN00027401G001

LCO:	104925131(bap1)

NCC:	104967518(bap1)

TBEN:

117489827(bap1)

CGOB:

115007726(bap1)

PGEO:

117446919(bap1)

GACU:

117548223(bap1)

EMAC:

134883521(bap1)

ELY:	117257476(bap1)

EFO:	125894021(bap1)

PLEP:

121958618(bap1)

SLUC:

116041560(bap1)

ECRA:

117943781(bap1)

ESP:	116688219(bap1)

PFLV:

114553610(bap1)

GAT:	120835808(bap1)

PPUG:

119194049(bap1)

AFB:	129105312(bap1)

CLUM:

117730898(bap1)

PSWI:

130208224(bap1)

MSAM:

119886183(bap1)

SCHU:

122869640(bap1)

CUD:	121506906(bap1)

ALAT:

119021741(bap1)

MZE:	101468372(bap1)

ONL:	100695869(bap1)

OAU:	116313674(bap1)

OLA:	101162036(bap1)

OML:	112145576(bap1)

CSAI:

133448557(bap1)

XMA:	102226073(bap1)

XCO:	114135986(bap1)

XHE:	116710927(bap1)

PRET:

103465106(bap1)

PFOR:

103138034(bap1)

PLAI:

106945188(bap1)

PMEI:

106925233(bap1)

GAF:	122834455(bap1)

PPRL:

129358484(bap1)

CVG:	107094770(bap1)

CTUL:

119779985(bap1)

GMU:	124856136(bap1)

NFU:	107385131(bap1)

KMR:	108247371(bap1)

ALIM:

106533996(bap1)

NWH:	119412476(bap1)

AOCE:

111563221(bap1)

MCEP:

125007164(bap1)

CSEM:

103385804(bap1)

POV:	109638500(bap1)

SSEN:

122768553(bap1)

HHIP:

117761751(bap1)

HSP:	118105268(bap1)

SMAU:

118309768(bap1)

LCF:

108889387

SDU:	111222958(bap1)

SLAL:

111660860(bap1)

XGL:	120807151(bap1)

HCQ:	109522285(bap1)

SSCV:

125977100

SBIA:

133507052(bap1)

PEE:	133409218(bap1)

PTAO:

133483337(bap1)

BPEC:

110168639(bap1)

MALB:

109952395(bap1)

BSPL:

114855229(bap1)

SJO:	128355987(bap1)

SASA:

106565169 106583439

STRU:

115150231 115208228

OTW:	112214777 112254919(bap1)

OMY:	110494025(bap1) 110528439

OGO:	124003092 124027954

ONE:	115142728 115143108

OKI:	109891354 109892631

OKE:	118389054 118400527

SALP:

111970412 112070394

SNH:	120063723 120065369

CCLU:

121575486 121578065

ELS:	105028121(bap1)

SFM:	108931967(bap1)

PKI:	111833096(bap1)

AANG:

118208387(bap1)

LOC:	102695851(bap1)

PSPA:

121298272 121329165

ARUT:

117411763(bap1) 117963434

LCM:	102364413(BAP1)

CMK:	103176712(bap1)

CPLA:

122559155(bap1)

HOC:	132822401(bap1)

LERI:

129704575(bap1)

PMRN:

116949476(BAP1)

LRJ:	133342546(BAP1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918222 588864

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG8445(caly)

DER:

6548522

DSE:

6609392

DSI:	Dsimw501_GD25561(Dsim_GD25561)

DYA:	Dyak_GE14091

DAN:

DSR:

DPO:

DPE:

DMN:	108159446 117191489

DWI:

6643431

DGR:

6568805

DMO:	Dmoj_GI18963

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ001439

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206464

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110375892(calY)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:	100162983 100169168

DNX:	107165864 107168742

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:	111058754 120353971

HVI:

124359589

MQU:	128993519 128998195 129005684

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_54920

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

TSP:

HRO:	HELRODRAFT_188801

LGI:	LOTGIDRAFT_175432

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111106455 111110179

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_147920

OVI:	T265_10764

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_55363

AQU:

100639183

» show all

Reference

PMID:9528852

Authors

Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, Wilkinson KD, Maul GG, Barlev N, Berger SL, Prendergast GC, Rauscher FJ 3rd

Title

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.

Journal

Oncogene 16:1097-112 (1998)
DOI:10.1038/sj.onc.1201861

Sequence

[hsa:8314]

All links

Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1695)   
   KEGG GENES (662)   
   KEGG MGENES (185)   
   RefGene (846)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (1707)   

Download RDF

DBGET integrated database retrieval system