KEGG ORTHOLOGY: K08734

ORTHOLOGY: K08734

Entry

K08734 KO

Name

MLH1

Definition

DNA mismatch repair protein MLH1

Pathway

ko03430	Mismatch repair
ko03460	Fanconi anemia pathway
ko05200	Pathways in cancer
ko05210	Colorectal cancer
ko05213	Endometrial cancer

Module

M00295

BRCA1-associated genome surveillance complex (BASC)

Disease

H00020	Colorectal cancer
H00026	Endometrial Cancer
H00027	Ovarian cancer
H00876	Mismatch repair deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
Genetic Information Processing
  Replication and repair
   03430 Mismatch repair
    K08734  MLH1; DNA mismatch repair protein MLH1
   03460 Fanconi anemia pathway
    K08734  MLH1; DNA mismatch repair protein MLH1
Human Diseases
  Cancers
   05200 Pathways in cancer
    K08734  MLH1; DNA mismatch repair protein MLH1
   05210 Colorectal cancer
    K08734  MLH1; DNA mismatch repair protein MLH1
   05213 Endometrial cancer
    K08734  MLH1; DNA mismatch repair protein MLH1
KEGG pathway modules [BR:ko00002]
Structural complex
  Genetic information processing
   Repair system
    M00295  BRCA1-associated genome surveillance complex (BASC) [BR:ko03400]
     K08734  MLH1; DNA mismatch repair protein MLH1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic Type
  SSBR (single strand breaks repair)
   MMR (mismatch exicision repair)
    MutL homologs
     K08734  MLH1; DNA mismatch repair protein MLH1

Genes

HSA:	4292(MLH1)
PTR:	747104(MLH1)
PPS:	100971752(MLH1)
GGO:	101134891(MLH1)
PON:	100436876(MLH1)
MCC:	698782(MLH1) 712565
MMU:	17350(Mlh1)
RNO:	81685(Mlh1)
CFA:	477019(MLH1)
AML:	100476536(MLH1)
FCA:	101089037(MLH1)
BTA:	533652(MLH1)
SSC:	100337665(MLH1)
ECB:	100050351(MLH1)
MDO:	100011682(MLH1)
SHR:	100931562(MLH1)
OAA:	100073765
GGA:	420729(MLH1)
MGP:	100547634
TGU:	100232198(MLH1)
ACS:	100555611(mlh1)
XLA:	100036779(mlh1)
XTR:	100170640(mlh1)
DRE:	393632(mlh1)
TRU:	101074999
BFO:	BRAFLDRAFT_91042
CIN:	100182748
SPU:	588545(MLH1)
DME:	Dmel_CG11482(Mlh1)
DPO:	Dpse_GA11026
DAN:	Dana_GF13669
DER:	Dere_GG23342
DPE:	Dper_GL11208
DSE:	Dsec_GM21014
DSI:	Dsim_GD10548
DWI:	Dwil_GK15817
DYA:	Dyak_GE19183
DGR:	Dgri_GH21079
DMO:	Dmoj_GI18680
DVI:	Dvir_GJ21695
AGA:	AgaP_AGAP012192
AAG:	AaeL_AAEL005858
CQU:	CpipJ_CPIJ019829
AME:	724296(MLH1)
NVI:	100118334(Mlh1l) 100124199(Mlh1)
TCA:	661655
API:	100161532
PHU:	Phum_PHUM178580
ISC:	IscW_ISCW007938
CEL:	CELE_T28A8.7(mlh-1)
CBR:	CBG15306(Cbr-mlh-1)
BMY:	Bm1_19980
TSP:	Tsp_09579
SMM:	Smp_009550
NVE:	NEMVE_v1g167864
HMG:	100198136
TAD:	TRIADDRAFT_50100
AQU:	100641464(Mlh1)
ATH:	AT4G09140(MLH1)
ALY:	ARALYDRAFT_911184
GMX:	100794788
MTR:	MTR_3g005810
CSV:	101211816
RCU:	RCOM_1331420
POP:	POPTR_913572
VVI:	100854779
OSA:	4325393
DOSA:	Os01t0958900-01(Os01g0958900)
BDI:	100845473
SBI:	SORBI_03g046470(SORBIDRAFT_03g046470)
SMO:	SELMODRAFT_408722 SELMODRAFT_421150
PPP:	PHYPADRAFT_126125
CRE:	CHLREDRAFT_146633(MLH1)
VCN:	VOLCADRAFT_94705
OLU:	OSTLU_51248
OTA:	Ot13g02400
CME:	CMQ290C
SCE:	YMR167W(MLH1)
AGO:	AGOS_AFL199C
ERC:	Ecym_3383
KLA:	KLLA0D09955g
LTH:	KLTH0F09724g
PPA:	PAS_chr2-1_0165
VPO:	Kpol_1043p22
ZRO:	ZYRO0A07282g
CGR:	CAGL0F07733g
NCS:	NCAS_0D00900(NCAS0D00900)
NDI:	NDAI_0H03230(NDAI0H03230)
TPF:	TPHA_0C03640(TPHA0C03640)
TBL:	TBLA_0B09360(TBLA0B09360)
TDL:	TDEL_0G02710(TDEL0G02710)
KAF:	KAFR_0B04840(KAFR0B04840)
DHA:	DEHA2G22022g
PIC:	PICST_89086
PGU:	PGUG_02502
LEL:	LELG_04255
CAL:	CaO19.11638(MLH1) CaO19.4162(MLH1)
CTP:	CTRG_00069
CDU:	CD36_40840
COT:	CORT_0E01190
YLI:	YALI0C10032g
CLU:	CLUG_01772
NCR:	NCU08309
SMP:	SMAC_00910(mlh1)
PAN:	PODANSg7237
TTT:	THITE_2128823
MTM:	MYCTH_2086451
MGR:	MGG_07121
FGR:	FG09728.1
NHE:	NECHADRAFT_103428
VAL:	VDBG_08287
SSL:	SS1G_08608
BFU:	BC1G_03221
ANI:	AN0126.2
NFI:	NFIA_075580
AFM:	AFUA_5G11700
AOR:	AOR_1_500094(AO090120000288)
ANG:	ANI_1_376164(An18g03030)
AFV:	AFLA_092710
ACT:	ACLA_014760
PCS:	Pc21g06790
CIM:	CIMG_09173
CPW:	CPC735_015910
PBL:	PAAG_02412
URE:	UREG_05222
ABE:	ARB_03111
TVE:	TRV_01743
PNO:	SNOG_08751
PTE:	PTT_16542
ZTR:	MYCGRDRAFT_75629
TML:	GSTUM_00003139001
SPO:	SPBC1703.04(mlh1)
CNE:	CNE04630
CNB:	CNBE4630
CGI:	CGB_E6200C
PPL:	POSPLDRAFT_93080
LBC:	LACBIDRAFT_234236
MPR:	MPER_10039
CCI:	CC1G_05322
SCM:	SCHCODRAFT_59880
UMA:	UM05208.1
MGL:	MGL_1681
PGR:	PGTG_03468
ECU:	ECU05_0300
EIN:	Eint_050280
EHE:	EHEL_050340
NCE:	NCER_100082
MBR:	MONBRDRAFT_25323
NGR:	NAEGRDRAFT_81389
DDI:	DDB_G0287393(mlh1)
DPP:	DICPUDRAFT_55923
EHI:	EHI_129950(146.t00025)
EDI:	EDI_002010
PFA:	PF11_0184
PFD:	PFDG_00641
PFH:	PFHG_01926
PYO:	PY05214
PCB:	PC000677.03.0 PC000722.03.0 PC000800.01.0
PBE:	PB000037.02.0
PKN:	PKH_091520
PVX:	PVX_091525
PCY:	PCYB_092390
TAN:	TA06860
TPV:	TP01_0756
BBO:	BBOV_IV010910(23.m06225)
CPV:	cgd5_2560
CHO:	Chro.50122
TGO:	TGME49_066390
TET:	TTHERM_00127000
PTM:	GSPATT00010239001
TBR:	Tb927.8.6840(Tb08.30K1.770)
TCR:	504035.140 507991.60
LMA:	LMJF_24_1420
LIF:	LINJ_24_1460
LDO:	LDBPK_241460
LMI:	LMXM_24_1420
LBZ:	LBRM_24_1460
GLA:	GL50803_16149
TVA:	TVAG_226330
PTI:	PHATRDRAFT_54331(Mlh1)
TPS:	THAPSDRAFT_263509
PIF:	PITG_01204

» show all

Reference

PMID:17581638

Authors

Peng M, Litman R, Xie J, Sharma S, Brosh RM Jr, Cantor SB

Title

The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.

Journal

EMBO J 26:3238-49 (2007)

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (31)   
   KEGG PATHWAY (10)   
   KEGG MODULE (21)   
Disease (4)   
   KEGG DISEASE (4)   
Gene (423)   
   KEGG GENES (189)   
   KEGG DGENES (19)   
   KEGG EGENES (90)   
   KEGG MGENES (125)   
Protein sequence (163)   
   UniProt (163)   
Literature (1)   
   PubMed (1)   
All databases (626)   

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