KEGG ORTHOLOGY: K08775

ORTHOLOGY: K08775

Entry

K08775                      KO

Symbol

BRCA2, FANCD1

Name

breast cancer 2 susceptibility protein

Pathway

map03440

Homologous recombination

map03460

Fanconi anemia pathway

map05200

Pathways in cancer

map05212

Pancreatic cancer

map05224

Breast cancer

Disease

H00019

Pancreatic cancer

H00027

Ovarian cancer

H00031

Breast cancer

H00042

Glioma

H00238

Fanconi anemia

H01554

Fallopian tube cancer

H02301

Nephroblastoma

H02531

Familial breast-ovarian cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03460 Fanconi anemia pathway
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   05224 Breast cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03036 Chromosome and associated proteins
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03400 DNA repair and recombination proteins
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   BRCC complex
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA complex
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein

Genes

HSA:	675(BRCA2)

PTR:	452526(BRCA2)

PPS:	100976403(BRCA2)

GGO:	101126719(BRCA2)

PON:	100435800(BRCA2)

NLE:	100601625(BRCA2)

HMH:	116467095(BRCA2)

MCC:	721981(BRCA2)

MCF:	102140332(BRCA2)

MTHB:

126940709

MNI:	105485994(BRCA2)

CSAB:

103214248(BRCA2)

CATY:

105587897(BRCA2)

PANU:

101020669(BRCA2)

TGE:	112610610(BRCA2)

MLEU:

105552218(BRCA2)

RRO:	104665294(BRCA2)

RBB:	108517532 108524798(BRCA2)

TFN:	117097609(BRCA2)

PTEH:

111540474(BRCA2)

CANG:

105515183(BRCA2)

CJC:	100397509(BRCA2)

SBQ:

101048321

CIMI:

108310783(BRCA2)

CSYR:

103267329(BRCA2)

MMUR:

105864328(BRCA2)

LCAT:

123648995(BRCA2)

PCOQ:

105808475(BRCA2)

OGA:	100952650(BRCA2)

MMU:	12190(Brca2)

MCAL:

110294557(Brca2)

MPAH:

110312957(Brca2)

RNO:	360254(Brca2)

MCOC:

116068815(Brca2)

ANU:	117697744(Brca2)

CGE:	100689197(Brca2)

MAUA:

101844060(Brca2)

PROB:

127237107(Brca2)

PLEU:

114699159(Brca2)

MORG:

121464668(Brca2)

MFOT:

126513498

AAMP:

119825089(Brca2)

NGI:	103727209(Brca2)

HGL:	101698015(Brca2)

CPOC:

100713136(Brca2)

CCAN:

109674121 109694719

DORD:

105993896(Brca2)

DSP:	122112751(Brca2)

PLOP:

125348364(Brca2)

NCAR:

124984516

MMMA:

107140779(Brca2)

OCU:

100355331

OPI:	101531225(BRCA2)

TUP:	102491921(BRCA2)

GVR:	103595849(BRCA2)

CFA:	474180(BRCA2)

CLUD:

112669432(BRCA2)

VVP:	112918664(BRCA2)

VLG:	121497024(BRCA2)

NPO:	129504631(BRCA2)

AML:	100472854(BRCA2)

UMR:	103664352(BRCA2)

UAH:	113251242(BRCA2)

UAR:	123791929(BRCA2)

ELK:

111158584

LLV:

125096287

MPUF:

101687876(BRCA2)

MNP:	132002834(BRCA2)

MLK:	131813490(BRCA2)

NVS:	122907005(BRCA2)

ORO:	101364023(BRCA2)

EJU:	114211112(BRCA2)

ZCA:	113920052(BRCA2)

MLX:	118009525(BRCA2)

NSU:	110570289(BRCA2)

LWW:	102738635(BRCA2)

FCA:	493878(BRCA2)

PYU:	121012828(BRCA2)

PCOO:

112860373(BRCA2)

PBG:	122481231(BRCA2)

PVIV:

125162678(BRCA2)

LRUF:

124511444

PTG:	102965865(BRCA2)

PPAD:

109266065(BRCA2)

PUC:

125933696

AJU:

106973859

HHV:	120236814(BRCA2)

BTA:	507069(BRCA2)

BOM:	102276437(BRCA2)

BIU:	109566792(BRCA2)

BBUB:

102398645(BRCA2)

BBIS:

104985665(BRCA2)

CHX:	102182417(BRCA2)

OAS:	101109980(BRCA2)

BTAX:

128057667(BRCA2)

ODA:	120883138(BRCA2)

CCAD:

122447096(BRCA2)

MBEZ:

129556342(BRCA2)

SSC:	100624979(BRCA2)

CFR:	102515425(BRCA2)

CBAI:

105066311(BRCA2)

CDK:	105101018(BRCA2)

VPC:	102528275(BRCA2)

BACU:

103017905(BRCA2)

BMUS:

118883983(BRCA2)

LVE:	103076579(BRCA2)

OOR:	101286498(BRCA2)

DLE:	111175212(BRCA2)

PCAD:

102995983(BRCA2)

PSIU:

116743061(BRCA2)

NASI:

112406530(BRCA2)

ECB:	100064578(BRCA2)

EPZ:	103543936(BRCA2)

EAI:	106835608(BRCA2)

MYB:	102245665(BRCA2)

MYD:	102773822(BRCA2)

MMYO:

118651699(BRCA2)

MLF:	102430585(BRCA2)

PKL:	118728968(BRCA2)

EFUS:

103301241(BRCA2)

MNA:	107529959(BRCA2)

DRO:	112323192(BRCA2)

SHON:

118980526(BRCA2)

AJM:	119041294(BRCA2)

PDIC:

114513136(BRCA2)

PHAS:

123822747(BRCA2)

MMF:	118623597(BRCA2)

PPAM:

129073786(BRCA2)

HAI:	109388018(BRCA2)

RFQ:	117021051(BRCA2)

PALE:

102896802(BRCA2)

PGIG:

120610664(BRCA2)

PVP:	105302449(BRCA2)

RAY:	107504798(BRCA2)

MJV:	108406123(BRCA2)

TOD:	119258825(BRCA2)

SARA:

101541067(BRCA2)

SETR:

126015929(BRCA2)

LAV:	100669658(BRCA2)

TMU:	101352659 111818977

DNM:	101446376(BRCA2)

MDO:	100049015(BRCA2)

GAS:	123238851(BRCA2)

SHR:	100915673(BRCA2)

AFZ:

127554686

PCW:	110215556(BRCA2)

OAA:	100079887(BRCA2)

GGA:	374139(BRCA2)

PCOC:

116244248(BRCA2)

MGP:	100542730(BRCA2)

CJO:	107308262(BRCA2)

TPAI:

128074855(BRCA2)

LMUT:

125688447(BRCA2)

NMEL:

110388671(BRCA2)

APLA:

101799101(BRCA2)

ACYG:

106041121(BRCA2)

CATA:

118245859(BRCA2)

AFUL:

116499758(BRCA2)

TGU:	100218603(BRCA2)

LSR:	110476707(BRCA2)

SCAN:

103827353(BRCA2)

PMOA:

120506731(BRCA2)

OTC:	121342040(BRCA2)

PRUF:

121364223(BRCA2)

GFR:	102044477(BRCA2)

FAB:	101819655(BRCA2)

OMA:	130252184(BRCA2)

PHI:	102113036(BRCA2)

PMAJ:

107202642(BRCA2)

CCAE:

111922973(BRCA2)

CCW:	104689910(BRCA2)

CBRC:

103613659(BRCA2)

ETL:	114064874(BRCA2)

ZAB:	102066240(BRCA2)

ACHL:

103805036(BRCA2)

SVG:	106861406(BRCA2)

MMEA:

130586536(BRCA2)

HRT:	120749443(BRCA2)

FPG:	101912402(BRCA2)

FCH:	102052685(BRCA2)

CLV:	102091608(BRCA2)

EGZ:	104131391(BRCA2)

NNI:	104023078(BRCA2)

PCRI:

104032718(BRCA2)

PLET:

104613614

EHS:	104502866(BRCA2)

PCAO:

104052539(BRCA2)

ACUN:

113481451(BRCA2)

TALA:

104368632(BRCA2)

PADL:

103920079(BRCA2)

AFOR:

103907942(BRCA2)

ACHC:

115353502(BRCA2)

HALD:

104322710(BRCA2)

HLE:	104834989(BRCA2)

AGEN:

126048214

GCL:

127025535

CCRI:

104154648(BRCA2)

CSTI:

104555117(BRCA2)

CMAC:

104487441

MUI:	104540672(BRCA2)

BREG:

104633408(BRCA2)

FGA:	104072484(BRCA2)

GSTE:

104263742(BRCA2)

LDI:

104347132

MNB:	103777641(BRCA2)

OHA:	104332725(BRCA2)

NNT:	104399347(BRCA2)

SHAB:

115603615(BRCA2)

DPUB:

104306123(BRCA2)

PGUU:

104469832(BRCA2)

ACAR:

104531823(BRCA2)

CPEA:

104389365(BRCA2)

AVIT:

104267545(BRCA2)

CVF:	104289466(BRCA2)

RTD:	128910077(BRCA2)

CUCA:

104064239(BRCA2)

TEO:	104369785(BRCA2)

BRHI:

104500883(BRCA2)

AAM:	106500375(BRCA2)

AROW:

112976488(BRCA2)

NPD:	112956321(BRCA2)

TGT:	104578740(BRCA2)

DNE:	112988365(BRCA2)

SCAM:

104151572(BRCA2)

ASN:	102383360(BRCA2)

AMJ:	102560146(BRCA2)

CPOO:

109305525(BRCA2)

GGN:	109302750(BRCA2)

PSS:	102455975(BRCA2)

CMY:	102945068(BRCA2)

CCAY:

125635457(BRCA2)

DCC:	119857112(BRCA2)

CPIC:

101936312(BRCA2)

TST:	117871054(BRCA2)

CABI:

116834095(BRCA2)

MRV:	120372195(BRCA2)

ACS:	100554942(brca2)

ASAO:

132772096(BRCA2)

PVT:	110076433(BRCA2)

SUND:

121925402(BRCA2)

PBI:	103068142(BRCA2)

PMUR:

107286819(BRCA2)

CTIG:

120299116(BRCA2)

TSR:	106550252(BRCA2)

PGUT:

117661907(BRCA2)

APRI:

131200167(BRCA2)

VKO:	123029080(BRCA2)

PMUA:

114589974 114595785(BRCA2)

PRAF:

128412724(BRCA2)

ZVI:	118084983(BRCA2)

GJA:	107121297(BRCA2)

STOW:

125430602(BRCA2)

EMC:	129326287(BRCA2)

XLA:	108708691(brca2.L)

XTR:	100038818(brca2)

NPR:	108785046(BRCA2)

RTEM:

120929172(BRCA2)

BBUF:

120993980(BRCA2)

BGAR:

122930548(BRCA2)

MUO:	115469609(BRCA2)

GSH:	117362281(BRCA2)

DRE:	566758(brca2)

SRX:	107752535 107756265

SANH:

107682889 107704788(brca2)

SGH:	107559013 107587266(brca2)

CCAR:

109103614 109104097

CAUA:

113114797

CGIB:

127972863

PTET:

122359442(brca2)

LROH:

127177612(brca2)

OMC:	131520506(brca2)

PPRM:

120478925(brca2)

RKG:	130105782(brca2)

MAMB:

125248529(brca2)

CIDE:

127495795

MASI:

127422162 127429461

TROS:

130565172(brca2)

TDW:	130429000(brca2)

MANU:

129438238(brca2)

IPU:

108278342

IFU:	128621790(brca2)

PHYP:

113539295(brca2)

SMEO:

124394738(brca2)

TFD:	113649412(brca2)

TVC:	132858206(brca2)

AMEX:

103047230(brca2)

CMAO:

118804629(brca2)

EEE:

113582267

CHAR:

105899805(brca2)

TRU:	101079601(brca2)

TFS:	130535217(brca2)

TNG:	GSTEN00030170G001

LCO:

109139185

NCC:	104967210(brca2)

TBEN:

117468847(brca2)

CGOB:

115017602(brca2)

PGEO:

117457229(brca2)

GACU:

117540448(brca2)

EMAC:

134880407(brca2)

ELY:	117259595(brca2)

EFO:	125889063(brca2)

PLEP:

121943074(brca2)

SLUC:

116048345(brca2)

ECRA:

117941048(brca2)

ESP:	116671031(brca2)

PFLV:

114552461(brca2)

GAT:	120825482(brca2)

PPUG:

119216444(brca2)

AFB:	129092793(brca2)

CLUM:

117741230(brca2)

PSWI:

130210935(brca2)

MSAM:

119883039(brca2)

SCHU:

122879014(brca2)

CUD:	121520353(brca2)

ALAT:

119008890(brca2)

MZE:	101485201(brca2)

ONL:	100534447(brca2)

OAU:	116310866(brca2)

OLA:	101156345(brca2)

OML:	112149564(brca2)

CSAI:

133442568(brca2)

XMA:	102225954(brca2)

XCO:	114161835(brca2)

XHE:	116737613(brca2)

PRET:

103474967(brca2)

PFOR:

103140692(brca2)

PLAI:

106950190(brca2)

PMEI:

106921054(brca2)

GAF:	122832403(brca2)

PPRL:

129358924(brca2)

CVG:	107092105(brca2)

CTUL:

119789504(brca2)

GMU:	124884417(brca2)

NFU:	107380244(brca2)

KMR:	108235962(brca2)

ALIM:

106521498(brca2)

NWH:	119411340(brca2)

AOCE:

111563668(brca2)

MCEP:

125014143(brca2)

CSEM:

103378186(brca2)

POV:	109630257(brca2)

SSEN:

122773327(brca2)

HHIP:

117772701(brca2)

HSP:	118106715(n4bp2l2)

SMAU:

118299074(brca2)

LCF:

108876019

SDU:

111224419

SLAL:

111653091

XGL:	120791707(brca2)

HCQ:	109507836(brca2)

SBIA:

133504391(brca2)

PEE:	133405608(brca2)

PTAO:

133482260

BPEC:

110162211(brca2)

MALB:

109967492(brca2)

BSPL:

114867537(brca2)

SJO:	128359863(brca2)

SASA:

106612363(brca2)

STRU:

115205809(brca2)

OTW:	112216675(brca2)

OMY:	110490044(brca2)

OGO:	123994837(brca2)

ONE:

115107213

OKI:	109864480(brca2)

OKE:	118366004(brca2)

SALP:

111960628(brca2)

SNH:	120028573(brca2)

CCLU:

121567292(brca2)

ELS:	105007503(brca2)

SFM:	108941845(brca2)

PKI:	111851369(brca2)

AANG:

118209152(brca2)

LOC:	102688640(brca2)

PSPA:

121302850(brca2)

ARUT:

117406128 117407181

LCM:	102351607(BRCA2)

RTP:	109928012(brca2)

CPLA:

122551063(brca2)

HOC:	132816952(brca2)

BFO:

BBEL:

SPU:

APLC:

AJC:

SKO:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ012893

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214401

BANY:

PMAC:

PPOT:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:

DNX:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM580760

FOC:

TPAL:

ZNE:

CSEC:

DPX:	DAPPUDRAFT_303344

DMK:

PVM:

PJA:

PCHN:

HAME:

PCLA:

LSM:

DSV:

RMP:

CSCU:

TSP:

HRO:	HELRODRAFT_192253

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:	106166803 106173426

SMM:	Smp_160680

NVE:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

ATH:	AT4G00020(BRCA2(IV)) AT5G01630(BRCA2B)

ALY:

9306979

CRB:

17882096

CSAT:

104710001 104734139 104768297

EUS:	EUTSA_v10012491mg EUTSA_v10027627mg

BRP:	103855405 103868332

BNA:	106391934 106398396 106427200 106433819

BOE:	106297065 106334586

RSZ:	108819090 108845743 130506466

THJ:	104798645 104816179

CPAP:

110822814

CIT:

102628548

CIC:	CICLE_v10013403mg

TCC:

18597460

GRA:

105780797

GHI:	107899592 107948956

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_006G005800g

VRA:

VAR:

VUN:

VUM:

CCAJ:

MTR:	11435666 25480600 25495886

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj0g3v0001919.1(Lj0g3v0001919.1) Lj0g3v0089779.1(Lj0g3v0089779.1)

ADU:

107482461

AIP:

107635814

AHF:	112740860 112795580

LANG:

109344405

PCIN:

129316881

QSA:	O6P43_016544

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:	105118053 105125913

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107804563 107807912

NSY:	104225995 104235790

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110710775 110733881

ATRI:

MOF:

NNU:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119267072 119267143 119274900 119274983

TAES:

123060317 123068835 123077330

TUA:

125542836

LPER:

127341280

LRD:	124661677 124665383

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:

DCT:

PEQ:

AOF:

MSIN:

ATR:

MNG:	MNEG_12354

OLU:	OSTLU_26389

OTA:	OT_ostta11g00630

MIS:	MICPUN_62958(BRCA2)

MPP:	MICPUCDRAFT_62866(JGI:MicpuC2_62866)

GSL:	Gasu_21050

CCP:	CHC_T00003194001

CNE:

CNG03110

CNB:

CNBG1640

CGI:	CGB_G2270W

CDEU:

CNBG_2331

PPL:	POSPLDRAFT_105553 POSPLDRAFT_91017

TVS:	TRAVEDRAFT_109911

DSQ:	DICSQDRAFT_142816

PCO:	PHACADRAFT_248310

SHS:	STEHIDRAFT_62664

HIR:	HETIRDRAFT_468984

PSQ:	PUNSTDRAFT_117563

ADL:	AURDEDRAFT_61787

FME:	FOMMEDRAFT_128955

LBC:	LACBIDRAFT_159274

CCI:	CC1G_06567

ABP:	AGABI1DRAFT104048(AGABI1DRAFT_104048)

ABV:	AGABI2DRAFT113908(AGABI2DRAFT_113908)

MPR:	MPER_04450

MRR:	Moror_15975

SCM:	SCHCO_064762(SCHCODRAFT_064762)

SLA:	SERLADRAFT_412477

WSE:	WALSEDRAFT_37947

UMA:	UMAG_03200

SGRA:

EX895_005860

MGL:

MGL_2937

MRT:

MRET_3539

PGR:	PGTG_20647

PTRC:

PtA15_1A579

MLR:	MELLADRAFT_76689

DDI:	DDB_G0293414

DPP:	DICPUDRAFT_75690

ACAN:

ACA1_110350

FCY:	FRACYDRAFT_183976(BRCA2a)

TPS:	THAPS_263089(BRAC2)

NGR:	NAEGRDRAFT_45350

» show all

Reference

PMID:21731065

Authors

Holloman WK

Title

Unraveling the mechanism of BRCA2 in homologous recombination.

Journal

Nat Struct Mol Biol 18:748-54 (2011)
DOI:10.1038/nsmb.2096

Sequence

[hsa:675]

Reference

PMID:15115758

Authors

Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG

Title

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.

Journal

Hum Mol Genet 13:1241-8 (2004)
DOI:10.1093/hmg/ddh135

Sequence

[hsa:675]

Reference

PMID:8524414

Authors

Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G

Title

Identification of the breast cancer susceptibility gene BRCA2.

Journal

Nature 378:789-92 (1995)
DOI:10.1038/378789a0

Sequence

[hsa:675]

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