KEGG   ORTHOLOGY: K08775Help
Entry
K08775                      KO                                     

Name
BRCA2, FANCD1
Definition
breast cancer 2 susceptibility protein
Pathway
Homologous recombination
Fanconi anemia pathway
Pathways in cancer
Pancreatic cancer
Disease
H00019  
Pancreatic cancer
H00027  
Ovarian cancer
H00031  
Breast cancer
H00238  
Fanconi anemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03440 Homologous recombination
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03460 Fanconi anemia pathway
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   05212 Pancreatic cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   BRCC complex
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
BRITE hierarchy
Genes
HSA: 
675(BRCA2)
PTR: 
452526(BRCA2)
PPS: 
100976403(BRCA2)
GGO: 
101126719(BRCA2)
PON: 
100435800(BRCA2)
MCC: 
721981(BRCA2)
MCF: 
102140332(BRCA2)
MMU: 
12190(Brca2)
RNO: 
360254(Brca2)
CGE: 
100689197(Brca2)
HGL: 
101698015(Brca2)
TUP: 
102491921(BRCA2)
CFA: 
474180(BRCA2)
AML: 
FCA: 
493878(BRCA2)
PTG: 
102965865(BRCA2)
BTA: 
507069(BRCA2)
BOM: 
102276437(BRCA2)
PHD: 
102315726(BRCA2)
CHX: 
102182417(BRCA2)
SSC: 
100153762(BRCA2)
CFR: 
102515425(BRCA2)
BACU: 
103017905(BRCA2)
LVE: 
103076579(BRCA2)
ECB: 
100064578(BRCA2)
MYB: 
102245665(BRCA2)
MYD: 
102773822(BRCA2)
PALE: 
102896802(BRCA2)
MDO: 
100049015(BRCA2)
SHR: 
100915673(BRCA2)
OAA: 
100079887(BRCA2)
GGA: 
374139(BRCA2)
MGP: 
TGU: 
100218603(BRCA2)
FAB: 
101819655(BRCA2)
PHI: 
102113036(BRCA2)
APLA: 
101799101(BRCA2)
FPG: 
101912402(BRCA2)
FCH: 
102052685(BRCA2)
CLV: 
102091608(BRCA2)
ASN: 
102383360(BRCA2)
AMJ: 
102560146(BRCA2)
PSS: 
102455975(BRCA2)
CMY: 
102945068(BRCA2)
ACS: 
PBI: 
103068142(BRCA2)
XTR: 
100038818(brca2)
DRE: 
566758(brca2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351607(BRCA2)
CMK: 
103177244(brca2)
SPU: 
584780(brca2)
AGA: 
AAG: 
CQU: 
AME: 
725687(GB17004)
BMOR: 
API: 
PHU: 
ISC: 
TSP: 
SMM: 
NVE: 
ATH: 
AT4G00020(BRCA2(IV)) AT5G01630(BRCA2B)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0014s19050g(POPTRDRAFT_573323)
VVI: 
SLY: 
SOT: 
OBR: 
BDI: 
SBI: 
SORBI_0013s007040(SORBIDRAFT_0013s007040)
SITA: 
ATR: 
s00023p00030650(AMTR_s00023p00030650)
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
CCI: 
SCM: 
UMA: 
PGR: 
DDI: 
DPP: 
DFA: 
ACAN: 
TPS: 
NGD: 
NGR: 
TVA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Holloman WK
  Title
Unraveling the mechanism of BRCA2 in homologous recombination.
  Journal
Nat Struct Mol Biol 18:748-54 (2011)
  Sequence
[hsa:675]
Reference
  Authors
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG
  Title
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
  Journal
Hum Mol Genet 13:1241-8 (2004)
  Sequence
[hsa:675]

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