KEGG ORTHOLOGY: K08893

ORTHOLOGY: K08893

Entry

K08893                      KO

Symbol

HCK

Name

hemopoietic cell kinase [EC:2.7.10.2]

Pathway

map04062

Chemokine signaling pathway

map04666

Fc gamma R-mediated phagocytosis

map05167

Kaposi sarcoma-associated herpesvirus infection

Disease

H02660

Autoinflammation with pulmonary and cutaneous vasculitis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K08893  HCK; hemopoietic cell kinase
   04062 Chemokine signaling pathway
    K08893  HCK; hemopoietic cell kinase
09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K08893  HCK; hemopoietic cell kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08893  HCK; hemopoietic cell kinase
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08893  HCK; hemopoietic cell kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08893  HCK; hemopoietic cell kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SRC family
   K08893  HCK; hemopoietic cell kinase
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08893  HCK; hemopoietic cell kinase

Other DBs

GO:

0004715

Genes

HSA:

3055(HCK)

PTR:	458163(HCK)

PPS:	100975763(HCK)

GGO:	101149280(HCK)

PON:	100455620(HCK)

NLE:	100587780(HCK)

HMH:	116461143(HCK)

MCC:	715723(HCK)

MCF:	102115729(HCK)

MTHB:

126964221

MNI:	105496179(HCK)

CSAB:

103248155(HCK)

CATY:

105582249(HCK)

PANU:

101016095(HCK)

TGE:	112632946(HCK)

MLEU:

105539484(HCK)

RRO:	104653712(HCK)

RBB:	108524139(HCK)

TFN:	117068628(HCK)

PTEH:

111548133(HCK)

CANG:

105524623(HCK)

CJC:	100389637(HCK)

SBQ:	101032860(HCK)

CIMI:

108291185(HCK)

CSYR:

103255160(HCK)

MMUR:

105865943(HCK)

LCAT:

123622835(HCK)

PCOQ:

105804972(HCK)

OGA:	100954296(HCK)

MMU:	15162(Hck)

MCAL:

110309091(Hck)

MPAH:

110317518(Hck)

RNO:	25734(Hck)

MCOC:

116091190(Hck)

ANU:	117704369(Hck)

MUN:	110550096(Hck)

CGE:	100773315(Hck)

MAUA:

101836672(Hck)

PROB:

127228521(Hck)

PLEU:

114705554(Hck)

MORG:

121460158(Hck)

MFOT:

126507069

AAMP:

119814087(Hck)

NGI:	103731073(Hck)

HGL:	101709222(Hck)

CPOC:

100714976(Hck)

CCAN:

109691761(Hck)

DORD:

105981479(Hck)

DSP:	122120233(Hck)

PLOP:

125353363(Hck)

NCAR:

124977986

MMMA:

107138980(Hck)

OCU:

100343961

OPI:	101519769(HCK)

TUP:	102491330(HCK)

GVR:	103594006(HCK)

CFA:	485828(HCK)

CLUD:

112673783(HCK)

VVP:	112909929(HCK)

VLG:	121477700(HCK)

NPO:	129495206(HCK)

AML:	100468494(HCK)

UMR:	103674340(HCK)

UAH:	113258471(HCK)

UAR:	123798585(HCK)

ELK:

111141509

LLV:

125109120

MPUF:

101670407(HCK)

MNP:	132021825(HCK)

MLK:	131807874(HCK)

NVS:	122916170(HCK)

ORO:	101383723(HCK)

EJU:	114220725(HCK)

ZCA:	113938080(HCK)

MLX:	118011341(HCK)

NSU:	110579337(HCK)

LWW:	102739741(HCK)

FCA:	101101207(HCK)

PYU:	121012328(HCK)

PCOO:

112869543(HCK)

PBG:	122496394(HCK)

PVIV:

125161726(HCK)

LRUF:

124503311

PTG:	102953452(HCK)

PPAD:

109272582(HCK)

PUC:

125936126

AJU:

106974647

HHV:	120235421(HCK)

BTA:	280814(HCK)

BOM:	102274987(HCK)

BIU:	109567352(HCK)

BBUB:

102410643(HCK)

BBIS:

104989906(HCK)

CHX:	102183977(HCK)

OAS:	101113167(HCK)

BTAX:

128058279(HCK)

ODA:	120868750(HCK)

CCAD:

122448276(HCK)

MBEZ:

129562253(HCK)

SSC:	100526085(HCK)

CFR:	102507677(HCK)

CBAI:

105073576(HCK)

CDK:	105100829(HCK)

VPC:	102528858(HCK)

BACU:

103015546(HCK)

BMUS:

118882005(HCK)

LVE:	103078130(HCK)

OOR:	101288667(HCK)

DLE:	111184309(HCK) 111184310

PCAD:

102977689(HCK)

PSIU:

116740009(HCK)

NASI:

112398513(HCK)

ECB:	100068557(HCK)

EPZ:	103554273(HCK)

EAI:	106833726(HCK)

MYB:	102256952(HCK)

MYD:	102756136(HCK)

MMYO:

118663803(HCK)

MLF:	102418447(HCK)

PKL:	118708178(HCK)

EFUS:

103285800(HCK)

MNA:	107527783(HCK)

DRO:	112303915(HCK)

SHON:

118985350(HCK)

AJM:	119047732(HCK)

PDIC:

114506945(HCK)

PHAS:

123814888(HCK)

MMF:	118618187(HCK)

PPAM:

129070785(HCK)

HAI:	109384426(HCK)

RFQ:	117015950(HCK)

PALE:

102890019(HCK)

PGIG:

120603531(HCK)

PVP:	105305509(HCK)

RAY:	107512878(HCK)

MJV:	108397287(HCK)

TOD:	119234305(HCK)

SARA:

101556901(HCK)

SETR:

126017360(HCK)

LAV:	100660288(HCK)

TMU:

101344005

ETF:	101646312(HCK)

DNM:	101436877(HCK)

MDO:	100010539(HCK)

GAS:	123235427(HCK)

SHR:	100913992(HCK)

AFZ:

127550442

PCW:	110211423(HCK)

OAA:	100085668(HCK)

GGA:	419280(HCK)

PCOC:

116225952(HCK)

MGP:	100543739(HCK)

CJO:	107323072(HCK)

TPAI:

128080951(HCK)

LMUT:

125701152(HCK)

NMEL:

110408000(HCK)

APLA:

101792612(HCK)

ACYG:

106047123(HCK)

CATA:

118258329(HCK)

AFUL:

116495852(HCK)

TGU:	100220059(HCK)

LSR:	110469018(HCK)

SCAN:

103818665(HCK)

PMOA:

120507022(HCK)

OTC:	121331606(HCK)

PRUF:

121348635(HCK)

GFR:	102036877(HCK)

FAB:	101812195(HCK)

OMA:	130261414(HCK)

PHI:	102101716(HCK)

PMAJ:

107213469(HCK)

CCAE:

111943147(HCK)

CCW:	104687710(HCK)

CBRC:

103616038(HCK)

ETL:	114063045(HCK)

ZAB:	102067552(HCK)

ACHL:

103802604(HCK)

SVG:	106861614(HCK)

MMEA:

130573537(HCK)

HRT:	120760001(HCK)

FPG:	101910593(HCK)

FCH:	102055899(HCK)

CLV:	102096776(HCK)

EGZ:	104127632(HCK)

NNI:	104018316(HCK)

PCAO:

104047975

ACUN:

113487683(HCK)

TALA:

116964001(HCK)

PADL:

103912489(HCK)

AFOR:

103899157(HCK)

ACHC:

115339158(HCK)

HLE:	104832964(HCK)

AGEN:

GCL:

CSTI:

MUI:

BREG:

MNB:

OHA:	104326489(LCK)

NNT:

104402536

SHAB:

115615189(HCK)

DPUB:

104301445(HCK)

CPEA:

104385534(HCK)

CVF:	104293860(HCK)

RTD:	128916756(HCK)

CUCA:

104060798(HCK)

AAM:	106497371(HCK)

AROW:

112961963(HCK)

NPD:	112949614(HCK)

DNE:	112987294(HCK)

ASN:	102368801(HCK)

AMJ:	106737579(HCK)

CPOO:

109313085(HCK)

GGN:	109292514(HCK)

PSS:	106732490(HCK)

CMY:	102941333(HCK)

CCAY:

125621983(HCK)

DCC:	119841906(HCK)

CPIC:

101948814(HCK)

TST:	117885820(HCK)

CABI:

116816783(HCK)

MRV:	120380306(HCK)

ACS:	100557519(hck)

ASAO:

132772977(HCK)

PVT:	110086725(HCK)

SUND:

121928438(HCK)

PBI:	103054220(HCK)

PMUR:

107299503(HCK)

CTIG:

120296871(HCK)

PGUT:

117658938

APRI:

131194111(HCK)

PTEX:

113451379(HCK)

NSS:

113428839

VKO:	123036314(HCK)

PMUA:

114599837(HCK)

PRAF:

128416665(HCK)

ZVI:	118089194(HCK)

HCG:	128324743(HCK)

GJA:	107123021(HCK)

STOW:

125433774(HCK)

EMC:	129331352(HCK)

XLA:	373700(hck.L)

XTR:	548439(hck)

NPR:	108786954(HCK)

RTEM:

120919363(HCK)

BBUF:

121003346(HCK)

BGAR:

122940304(HCK)

DRE:	101885596(hck)

SRX:	107707747 107747493

SANH:

107681869 107690859

SGH:	107558239(hck) 107559464

CCAR:

109048064 109066820

CAUA:

113041145 113078068

CGIB:

127944748 128011780

LROH:

127154760(hck)

OMC:	131532434(hck)

PPRM:

120463238(hck)

RKG:	130077499(hck)

MAMB:

125259890(hck)

CIDE:

127504938

MASI:

127419047 127420385

TROS:

130545341(hck)

TDW:	130409248(hck)

MANU:

129431031(hck)

IPU:

108275896

IFU:	128619664(hck)

PHYP:

113530620(hck)

SMEO:

124398777(hck)

TFD:	113641889(hck)

TVC:	132861872(hck)

AMEX:

103036768(hck)

CMAO:

118822535(hck)

EEE:	113575473(hck)

CHAR:

105898956(hck)

TRU:	101067815(hck)

TFS:	130519911(hck)

TNG:	GSTEN00003489G001

LCO:	104933734(hck)

TBEN:

117492629(hck)

CGOB:

115010682(hck)

PGEO:

117442834(hck)

GACU:

117539034(hck)

EMAC:

134872372(hck)

ELY:	117257637(hck)

EFO:	125891249(hck)

PLEP:

121947517(hck)

SLUC:

116040767(hck)

ECRA:

117948366(hck)

ESP:	116693216(hck)

PFLV:

114558466(hck)

GAT:	120828828(hck)

PPUG:

119200291(hck) 119223429

AFB:	129100415(hck)

CLUM:

117733005(hck)

PSWI:

130199315(hck)

MSAM:

119905779(hck)

SCHU:

122882906(hck)

CUD:	121517388(hck)

ALAT:

119022948(hck)

MZE:	101483358(hck)

ONL:	100699435(hck)

OAU:	116315560(hck)

OLA:	101163900(hck)

OML:	112159674(hck)

CSAI:

133457530(hck)

XMA:	102216930(hck)

XCO:	114145598(hck)

XHE:	116724078(hck)

PRET:

103466927(hck)

PFOR:

103150214(hck)

PLAI:

106939342

PMEI:

106908045

GAF:	122830438(hck)

PPRL:

129371700(hck)

CVG:

107098932

CTUL:

119787601(hck)

GMU:	124875239(hck)

NFU:

107386929

KMR:	108246117(hck)

ALIM:

106523041(hck)

NWH:	119417202(hck)

AOCE:

111570488(hck)

MCEP:

125006698(hck)

CSEM:

103384757(hck)

POV:	109630933(hck)

SSEN:

122777515(hck)

HHIP:

117764119(hck)

HSP:	118111169(hck)

SMAU:

118316439(hck)

LCF:

108885037

SDU:	111237026(hck)

SLAL:

111651844

XGL:	120803647(hck)

HCQ:	109511820(hck)

SSCV:

125989058

SBIA:

133490674(hck)

PEE:	133400095(hck)

PTAO:

133475285(hck)

BPEC:

110169150(hck)

MALB:

109969986(hck)

BSPL:

114858678(hck)

SJO:	128357771(hck)

SASA:

100136375(hck) 106572127

STRU:

115166008 115168643

OTW:	112215985(hck) 112221354

OMY:	110492657 110532244

OGO:	124031908 124045508

ONE:	115122634 115132122

OKI:	109880577 109907963

OKE:	118361063 118376471

SALP:

111976955(hck) 112068453

SNH:	120058931 120061488(hck)

CCLU:

121538305 121546120

ELS:

105013770

SFM:	108925655(hck) 108926451

PKI:	111839877 111858947

AANG:

118207244(hck) 118211520

LOC:	102689082(hck)

PSPA:

121297688 121319271

ARUT:

117421328 117430462 117963906

PSEX:

120514189(hck)

LCM:

102352014

CMK:

103172176

RTP:	109911600(hck) 125485490

CPLA:

122559930 122560162

HOC:	132822857 132822957

LERI:

129707536(hck)

PMRN:

116942512 116946671 116955526

LRJ:	133347747 133349194 133352966

CQD:

128704027

PVUL:

126817723

RPHI:

132725543

OVI:	T265_04412

» show all

Reference

PMID:9407116

Authors

Warmuth M, Bergmann M, Priess A, Hauslmann K, Emmerich B, Hallek M

Title

The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

Journal

J Biol Chem 272:33260-70 (1997)
DOI:10.1074/jbc.272.52.33260

Reference

PMID:3496523

Authors

Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD

Title

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

Journal

Mol Cell Biol 7:2267-75 (1987)
DOI:10.1128/MCB.7.6.2267

Sequence

[hsa:3055]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (688)   
   KEGG GENES (406)   
   KEGG MGENES (109)   
   RefGene (168)   
   OC (5)   
Literature (2)   
   PubMed (2)   
All databases (703)   

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