KEGG   ORTHOLOGY: K09186Help
Entry
K09186                      KO                                     

Name
MLL1
Definition
histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Disease
H00001  
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
H00002  
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Zinc finger
   Cys4 Trithorax
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
BRITE hierarchy
Other DBs
Genes
HSA: 
4297(KMT2A)
PTR: 
451587(MLL)
PPS: 
GGO: 
PON: 
MCC: 
705511(MLL)
MCF: 
MMU: 
214162(Kmt2a)
RNO: 
315606(Kmt2a)
CGE: 
100760424(Mll1)
HGL: 
101716671(Kmt2a)
TUP: 
102473382(KMT2A)
CFA: 
479417(KMT2A)
AML: 
FCA: 
BTA: 
508330(KMT2A)
BOM: 
102280025(KMT2A)
PHD: 
102332319(KMT2A)
CHX: 
102169033(KMT2A)
SSC: 
100623006(KMT2A)
CFR: 
102517824(KMT2A)
ECB: 
100071238(KMT2A)
MYB: 
102246785(KMT2A)
MDO: 
SHR: 
GGA: 
414897(MLL)
MGP: 
TGU: 
FAB: 
101813917(KMT2A)
PHI: 
102103515(KMT2A)
APLA: 
FPG: 
101922729(KMT2A)
FCH: 
102059401(KMT2A)
CLV: 
102084453(KMT2A)
ASN: 
102385246(KMT2A)
PSS: 
102463628(KMT2A)
ACS: 
XTR: 
100135006(kmt2a)
DRE: 
557048(kmt2a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357046(KMT2A)
BFO: 
CIN: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
Dvir_GJ22599(Dvir_trx)
AGA: 
AAG: 
CQU: 
AME: 
408716(trx)
TCA: 
BMOR: 
PHU: 
ISC: 
NVE: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF
  Title
Structural and biochemical insights into MLL1 core complex assembly.
  Journal
Structure 19:101-8 (2011)
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)

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