KEGG ORTHOLOGY: K09187

ORTHOLOGY: K09187

Entry

K09187                      KO

Symbol

MLL2, ALR

Name

[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04934

Cushing syndrome

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00570

Kabuki syndrome

H01613

Follicular lymphoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
   HMT complexes
    MLL-HCF complex
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2

Other DBs

GO:

0042800

Genes

HSA:	8085(KMT2D)

PTR:	100610362(KMT2D)

PPS:	100995808(KMT2D)

GGO:	101144774(KMT2D)

PON:	100441715(KMT2D)

NLE:	100586637(KMT2D)

HMH:	116461666(KMT2D)

MCC:	710795(KMT2D)

MCF:	102123773(KMT2D)

MTHB:

126930146

MNI:	105492887(KMT2D)

CSAB:

103238253(KMT2D)

CATY:

105580395(KMT2D)

PANU:

101013975(KMT2D)

TGE:	112634043(KMT2D)

MLEU:

105544907(KMT2D)

RRO:	104679726(KMT2D)

RBB:	108543918(KMT2D)

TFN:	117090180(KMT2D)

PTEH:

111542040(KMT2D)

CANG:

105507638(KMT2D)

CJC:	100408425(KMT2D)

SBQ:	101037539(KMT2D)

CIMI:

108316029(KMT2D)

CSYR:

103273452(KMT2D)

MMUR:

105869278(KMT2D)

LCAT:

123640430(KMT2D)

PCOQ:

105817625(KMT2D)

OGA:	100944849(KMT2D)

MMU:	381022(Kmt2d)

MCAL:

110310214(Kmt2d)

MPAH:

110334561(Kmt2d)

RNO:	100362634(Kmt2d)

MCOC:

116079206(Kmt2d)

ANU:	117719408(Kmt2d)

MUN:	110547438(Kmt2d)

CGE:	100765465(Kmt2d)

MAUA:

101839981(Kmt2d)

PROB:

127226039(Kmt2d)

PLEU:

114708576(Kmt2d)

MORG:

121441441(Kmt2d)

MFOT:

126493757

AAMP:

119824034(Kmt2d)

NGI:	103750570(Kmt2d)

HGL:	101718411(Kmt2d)

CPOC:

100728357(Kmt2d)

CCAN:

109694824(Kmt2d)

DORD:

105987518(Kmt2d)

DSP:	122106312(Kmt2d)

PLOP:

125365227(Kmt2d)

NCAR:

124984039

MMMA:

107148596(Kmt2d)

OCU:

100357052

OPI:	101525881(KMT2D)

TUP:	102480722(KMT2D)

GVR:	103588851(KMT2D)

CFA:	486558(KMT2D)

CLUD:

112678280(KMT2D)

VVP:	112921101(KMT2D)

VLG:	121480058(KMT2D)

NPO:	129517321(KMT2D)

AML:	100479447(KMT2D)

UMR:	103675622(KMT2D)

UAH:	113257661(KMT2D)

UAR:	123794786(KMT2D)

ELK:

111157787

LLV:

125107080

MPUF:

101672336(KMT2D)

MNP:	132019637(KMT2D)

MLK:	131838809(KMT2D)

NVS:	122891630(KMT2D)

ORO:	101369213(KMT2D)

EJU:	114225810(KMT2D)

ZCA:	113921953(KMT2D)

MLX:	118008878(KMT2D)

NSU:	110593565(KMT2D)

LWW:	102742632(KMT2D)

FCA:	101095268(KMT2D)

PYU:	121038633(KMT2D)

PCOO:

112867498(KMT2D)

PBG:	122472347(KMT2D)

PVIV:

125169640(KMT2D)

LRUF:

124501541

PTG:	102962859(KMT2D)

PPAD:

109249058(KMT2D)

PUC:

125919016

AJU:

106969329

HHV:	120223002(KMT2D)

BTA:	506805(KMT2D)

BOM:	102268887(KMT2D)

BIU:	109559148(KMT2D)

BBUB:

102401706(KMT2D)

BBIS:

105001687(KMT2D)

CHX:	102168698(KMT2D)

OAS:	101120741(KMT2D)

BTAX:

128048807(KMT2D)

ODA:	120858214 120861279

CCAD:

122427655(KMT2D)

MBEZ:

129536737(KMT2D)

SSC:	110260656(KMT2D)

CFR:	102515223(KMT2D)

CBAI:

105076349(KMT2D)

CDK:	105103813(KMT2D)

VPC:	102536075(KMT2D)

BACU:

103004413(KMT2D)

BMUS:

118902460(KMT2D)

LVE:	103082116(KMT2D)

OOR:	101269640(KMT2D)

DLE:	111174034(KMT2D)

PCAD:

102981848(KMT2D)

PSIU:

116760790(KMT2D)

NASI:

112394312(KMT2D)

ECB:	100058932(KMT2D)

EPZ:	103552202(KMT2D)

EAI:	106836860(KMT2D)

MYB:	102244965(KMT2D)

MYD:	102762410(KMT2D)

MMYO:

118650974(KMT2D)

MLF:	102434400(KMT2D)

PKL:	118730318(KMT2D)

EFUS:

129149802(KMT2D)

MNA:	107528109(KMT2D)

DRO:	112318232(KMT2D)

SHON:

118976513(KMT2D)

AJM:	119042258(KMT2D)

PDIC:

114512768(KMT2D)

PHAS:

123813126(KMT2D)

MMF:	118624157(KMT2D)

PPAM:

129084875(KMT2D)

HAI:	109393224(KMT2D)

RFQ:	117028056(KMT2D)

PALE:

102888593(KMT2D)

PGIG:

120618206(KMT2D)

PVP:	105297532(KMT2D)

RAY:	107514237(KMT2D)

MJV:	108383409(KMT2D)

TOD:	119247884(KMT2D)

SARA:

101556381(KMT2D)

SETR:

126022449(KMT2D)

LAV:	100670013(KMT2D)

TMU:

101353099

ETF:	101652640(KMT2D)

DNM:	101443835(KMT2D)

MDO:	103099827(KMT2D)

GAS:	123250244(KMT2D)

SHR:	100928575(KMT2D)

AFZ:

127538052

PCW:	110194047(KMT2D)

GGA:	425846(KMT2D)

PCOC:

116239278(KMT2D)

MGP:

104915798

CJO:	107325738(KMT2D)

TPAI:

128074181(KMT2D)

LMUT:

125685519(KMT2D)

NMEL:

110389135(KMT2D)

APLA:

119715282(KMT2D)

ACYG:

106047718(KMT2D)

CATA:

118261349(KMT2D)

AFUL:

116499959(KMT2D)

TGU:	100226907(KMT2D)

LSR:	110480395(KMT2D)

SCAN:

103824625(KMT2D)

PMOA:

120499503(KMT2D)

OTC:	121334290(KMT2D)

PRUF:

121356323(KMT2D)

FAB:	101818086(KMT2D)

OMA:	130265671(KMT2D)

PHI:	102100454(KMT2D)

PMAJ:

107198594(KMT2D)

CBRC:

103611912(KMT2D)

SVG:	106862663(KMT2D)

MMEA:

130584132(KMT2D)

HRT:	120764441(KMT2D)

TALA:

116963045(KMT2D)

ACHC:

115350939(KMT2D)

HLE:	104831179(KMT2D)

AGEN:

126046316

SHAB:

115618585(KMT2D)

CVF:	104284814(KMT2D)

RTD:	128901209(KMT2D)

CUCA:

104055021(KMT2D)

AROW:

112960842(KMT2D)

NPD:	112954231(KMT2D)

DNE:	112996078(KMT2D)

ASN:	102373099(KMT2D)

CPOO:

109323545(KMT2D)

GGN:	109305426(KMT2D)

CMY:	102944171(KMT2D)

CCAY:

125627479(KMT2D)

DCC:	119845758(KMT2D)

CPIC:

101934288(KMT2D)

TST:	117888986(KMT2D)

CABI:

116827822(KMT2D)

MRV:	120390931(KMT2D)

ACS:	100554175(kmt2d)

ASAO:

132768219(KMT2D)

PVT:	110075080(KMT2D)

SUND:

121922468(KMT2D)

PMUR:

107286389(KMT2D)

CTIG:

120306148(KMT2D)

PGUT:

117662873(KMT2D)

APRI:

131189511(KMT2D)

VKO:	123033085(KMT2D)

PMUA:

114587663

PRAF:

128407190

ZVI:	118079598(KMT2D)

HCG:	128342849(KMT2D)

GJA:	107105838(KMT2D)

STOW:

125428034(KMT2D)

EMC:	129346200(KMT2D)

XLA:	108708548(kmt2d.L) 108708990(kmt2d.S)

XTR:	100494109(kmt2d)

NPR:	108791395(KMT2D)

RTEM:

120929576(KMT2D)

BBUF:

120995961(KMT2D)

BGAR:

122930564(KMT2D)

MUO:	115465933(KMT2D)

GSH:

117357250

DRE:	100536523(kmt2d)

SRX:	107708781(kmt2d) 107716211

SANH:

107681934 107695802

SGH:	107563643 107570495(kmt2d)

CAUA:

113065480 113070551

CGIB:

127945167 128011063

PTET:

122328571 122329050(kmt2d)

LROH:

127154390(kmt2d)

OMC:	131531604(kmt2d)

PPRM:

120463585(kmt2d)

RKG:	130073522(kmt2d)

MAMB:

125259813(kmt2d)

MASI:

127418716 127419740

TROS:

130545175(kmt2d)

TDW:	130409817(kmt2d)

MANU:

129430804(kmt2d)

IPU:	108275851(kmt2d)

IFU:	128619792(kmt2d)

PHYP:

113530648(kmt2d)

TFD:	113658175(kmt2d)

TVC:	132861885(kmt2d)

AMEX:

103042576(kmt2d)

CMAO:

118822997(kmt2d)

EEE:	113584431(kmt2d)

CHAR:

105897331(kmt2d)

TRU:	101062458(kmt2d)

TFS:	130529879(kmt2d)

TNG:	GSTEN00028083G001

LCO:	104932523(kmt2d)

NCC:	104956939(kmt2d)

TBEN:

117494251(kmt2d)

CGOB:

115010606(kmt2d)

PGEO:

117449483(kmt2d)

GACU:

117542045(kmt2d)

EMAC:

134870678(kmt2d)

ELY:	117258597(kmt2d)

EFO:	125891096(kmt2d)

PLEP:

121946657(kmt2d)

SLUC:

116038913(kmt2d)

ECRA:

117947742(kmt2d)

ESP:	116692906(kmt2d)

PFLV:

114559193(kmt2d)

GAT:	120829072(kmt2d)

PPUG:

119206538

AFB:	129100258(kmt2d)

CLUM:

117733633(kmt2d)

PSWI:

130199076(kmt2d)

MSAM:

119887711 119919297(kmt2d)

SCHU:

122883461(kmt2d)

CUD:	121517403(kmt2d)

ALAT:

119023106(kmt2d)

MZE:	101486529(kmt2d)

ONL:	100706752(kmt2d)

OAU:	116325808(kmt2d)

OLA:	101172242(kmt2d)

OML:	112159276(kmt2d)

CSAI:

133457186(kmt2d)

XMA:	102237866(kmt2d)

XCO:	114140852(kmt2d)

XHE:	116727224(kmt2d)

PRET:

103467355(kmt2d)

PFOR:

103141131(kmt2d)

PLAI:

106959285(kmt2d)

PMEI:

106921544(kmt2d)

GAF:	122828614(kmt2d)

PPRL:

129372510(kmt2d)

CVG:	107086766(kmt2d)

CTUL:

119781989(kmt2d)

GMU:	124866846(kmt2d)

NFU:	107390885(kmt2d)

KMR:	108235223(kmt2d)

ALIM:

106524867(kmt2d)

NWH:	119417622(kmt2d)

AOCE:

111577439(kmt2d)

MCEP:

125019949(kmt2d)

CSEM:

103385102(kmt2d)

POV:	109630747(kmt2d)

SSEN:

122777068(kmt2d)

HHIP:

117764077(kmt2d)

HSP:	118110520(kmt2d)

SMAU:

118316365(kmt2d)

LCF:

108876442

SDU:	111219023(kmt2d)

SLAL:

111668971(kmt2d)

XGL:	120804417(kmt2d)

HCQ:	109531346(kmt2d)

SSCV:

125989448

SBIA:

133505432(kmt2d)

PEE:	133402236(kmt2d)

PTAO:

133478443(kmt2d)

BPEC:

110164958(kmt2d)

MALB:

109968659(kmt2d)

BSPL:

114858181(kmt2d)

SJO:	128356814(kmt2d)

SASA:

106567046(kmt2d) 106572669

STRU:

115165500 115167836(kmt2d)

OTW:	112221704(kmt2d) 112247360

OMY:	110491964(kmt2d) 110532701

OGO:	124032266 124046095(kmt2d)

ONE:	115102572(kmt2d) 115132488

OKI:	109869140(kmt2d) 109878425

OKE:	118360113(kmt2d) 118360673

SALP:

111966806 111976311

SNH:	120059601 120061017

CCLU:

121537893 121546498

ELS:	105013562(kmt2d)

SFM:

108939256

PKI:

111860624

AANG:

118207247(kmt2d) 118211876

LOC:	102683854(kmt2d)

PSPA:

121308967(kmt2d)

ARUT:

117401082 117967100

LCM:	102354014(KMT2D)

HOC:	132805781(kmt2d)

LERI:

129714725(kmt2d)

TAD:	TRIADDRAFT_62004

» show all

Reference

PMID:20808952

Authors

Andreu-Vieyra CV, Chen R, Agno JE, Glaser S, Anastassiadis K, Stewart AF, Matzuk MM

Title

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

Journal

PLoS Biol 8:e1000453 (2010)
DOI:10.1371/journal.pbio.1000453

Sequence

[hsa:8085] [mmu:381022]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:9247308

Authors

Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E

Title

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Journal

Oncogene 15:549-60 (1997)
DOI:10.1038/sj.onc.1201211

Sequence

[hsa:8085]

DBGET integrated database retrieval system