KEGG ORTHOLOGY: K10263

ORTHOLOGY: K10263

Entry

K10263                      KO

Symbol

FBXW5

Name

F-box and WD-40 domain protein 5

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10263  FBXW5; F-box and WD-40 domain protein 5
   03036 Chromosome and associated proteins
    K10263  FBXW5; F-box and WD-40 domain protein 5
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     K10263  FBXW5; F-box and WD-40 domain protein 5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K10263  FBXW5; F-box and WD-40 domain protein 5

Genes

HSA:	54461(FBXW5)

PTR:	464877(FBXW5)

PPS:	100982419(FBXW5)

GGO:	101128872(FBXW5)

PON:	100458694(FBXW5)

NLE:	100591723(FBXW5)

HMH:	116475893(FBXW5)

MCC:	721653(FBXW5)

MCF:	102126305(FBXW5)

MTHB:

126936960

MNI:	105471954(FBXW5)

CSAB:

103239598(FBXW5)

CATY:

105580592(FBXW5)

PANU:

101020646(FBXW5)

TGE:	112607880(FBXW5)

MLEU:

105543269(FBXW5)

RRO:	104669648(FBXW5)

RBB:	108542879(FBXW5)

TFN:	117099133(FBXW5)

PTEH:

111553040(FBXW5)

CANG:

105522699(FBXW5)

CJC:	100401277(FBXW5)

SBQ:	101034492(FBXW5)

CIMI:

108287257(FBXW5)

MMUR:

105882281(FBXW5)

LCAT:

123645597(FBXW5)

PCOQ:

105818691(FBXW5)

OGA:	100966058(FBXW5)

MMU:	30839(Fbxw5)

MCAL:

110284729(Fbxw5)

MPAH:

110318149(Fbxw5)

RNO:	362081(Fbxw5)

MCOC:

116089824(Fbxw5)

ANU:	117710791(Fbxw5)

MUN:	110557017(Fbxw5)

CGE:	100762398(Fbxw5)

MAUA:

101823588(Fbxw5)

PROB:

127214704 127222601(Fbxw5)

PLEU:

114692792(Fbxw5)

MORG:

121463152(Fbxw5)

MFOT:

126509300

AAMP:

119818901(Fbxw5)

NGI:	103741186(Fbxw5)

HGL:	101701263(Fbxw5)

CPOC:

100732858(Fbxw5)

CCAN:

109699336(Fbxw5)

DORD:

105995662(Fbxw5)

DSP:	122099714(Fbxw5)

PLOP:

125351512(Fbxw5)

NCAR:

124964720

MMMA:

107159216(Fbxw5)

OPI:	101529807(FBXW5)

TUP:	102473515(FBXW5)

GVR:	103610989(FBXW5)

CFA:	491243(FBXW5)

CLUD:

112677466(FBXW5)

VVP:	112906896(FBXW5)

VLG:	121473807(FBXW5)

NPO:	129517346(FBXW5)

AML:	100474341(FBXW5)

UMR:	103675248(FBXW5)

UAH:	113248597 113248653

UAR:	123796333(FBXW5)

ELK:

111145801

LLV:

125083612

MPUF:

101689920(FBXW5)

MNP:	132024223(FBXW5)

MLK:	131813069(FBXW5)

NVS:	122917081(FBXW5)

ORO:	101372237(FBXW5)

EJU:	114201763(FBXW5)

ZCA:	113934583(FBXW5)

MLX:	118017500(FBXW5)

NSU:	110581225(FBXW5)

LWW:	102727926(FBXW5)

FCA:	101096616(FBXW5)

PYU:	121020259(FBXW5)

PBG:	122474993(FBXW5)

PVIV:

125150054(FBXW5)

LRUF:

124522348

PTG:	102967095(FBXW5)

PPAD:

109258780(FBXW5)

PUC:

125923537

AJU:

113596686

HHV:	120226447(FBXW5)

BTA:	517357(FBXW5)

BOM:	102280614(FBXW5)

BIU:	109566623(FBXW5)

BBUB:

102396191(FBXW5)

BBIS:

104983808(FBXW5)

CHX:	102179019(FBXW5)

OAS:	114113846(FBXW5)

BTAX:

128055502(FBXW5)

ODA:	120860779 120860781

CCAD:

122442421(FBXW5)

MBEZ:

129539172(FBXW5)

SSC:	100514029(FBXW5)

CFR:	102510469(FBXW5)

CBAI:

105068595(FBXW5)

CDK:	105106198(FBXW5)

VPC:	102537543(FBXW5)

BACU:

103019640(FBXW5)

BMUS:

118897216(FBXW5)

LVE:	103088468(FBXW5)

OOR:	101281057(FBXW5)

DLE:	111177007(FBXW5)

PCAD:

102979036(FBXW5)

PSIU:

116755973(FBXW5)

NASI:

112411505(FBXW5)

ECB:	100067988(FBXW5)

EPZ:	103567825(FBXW5)

EAI:	106845530(FBXW5)

MYB:	102263577(FBXW5)

MYD:	102772646(FBXW5)

MMYO:

118655262(FBXW5)

PKL:	118707014(FBXW5)

EFUS:

103295969(FBXW5)

MNA:	107536207(FBXW5)

DRO:	112306443(FBXW5)

SHON:

118980125(FBXW5)

AJM:	119036065(FBXW5)

PDIC:

114496853(FBXW5)

PHAS:

123823484(FBXW5)

MMF:	118630183(FBXW5)

PPAM:

129079152(FBXW5)

HAI:	109381686(FBXW5)

RFQ:	117031653(FBXW5)

PALE:

102889593(FBXW5)

PGIG:

120599773(FBXW5)

PVP:	105298570(FBXW5)

RAY:	107503116(FBXW5)

MJV:	108406837(FBXW5)

TOD:	119231257(FBXW5)

SARA:

101549743(FBXW5)

SETR:

126009246(FBXW5)

LAV:	100670110(FBXW5)

TMU:

101355169

DNM:	101410934(FBXW5)

MDO:	100022310(FBXW5)

GAS:	123235159(FBXW5)

SHR:	100935180(FBXW5)

AFZ:

127549119

PCW:	110205310(FBXW5)

OAA:	114808685(FBXW5)

GGA:	417289(FBXW5)

PCOC:

116234111(FBXW5)

MGP:	100545542(FBXW5)

CJO:	107321657(FBXW5)

TPAI:

128079772(FBXW5)

LMUT:

125702607(FBXW5)

NMEL:

110406783(FBXW5)

APLA:

101799660(FBXW5)

ACYG:

106037086(FBXW5)

CATA:

118260734(FBXW5)

AFUL:

116496884(FBXW5)

TGU:	100226264(FBXW5)

LSR:	110472192(FBXW5)

SCAN:

103819085(FBXW5)

PMOA:

120507353(FBXW5)

OTC:	121336900(FBXW5)

PRUF:

121357504(FBXW5)

GFR:	102039082(FBXW5)

FAB:	101807097(FBXW5)

OMA:	130260218(FBXW5)

PHI:	102106191(FBXW5)

PMAJ:

107212130(FBXW5)

CCAE:

111936894(FBXW5)

CCW:	104688417(FBXW5)

CBRC:

103615004(FBXW5)

ETL:	114064139(FBXW5)

ZAB:	102072669(FBXW5)

ACHL:

103805200(FBXW5)

SVG:	106856004(FBXW5)

MMEA:

130584585(FBXW5)

HRT:	120761815(FBXW5)

FPG:	101916505(FBXW5)

FCH:	102049773(FBXW5)

CLV:	102094444(FBXW5)

EGZ:	104123984(FBXW5)

NNI:	104018378(FBXW5)

PCRI:

104031732(FBXW5)

PLET:

104628510(FBXW5)

EHS:	104503265(FBXW5)

PCAO:

104043990(FBXW5)

ACUN:

113486362(FBXW5)

TALA:

104360189(FBXW5)

PADL:

103921146(FBXW5)

AFOR:

103908291(FBXW5)

ACHC:

115335374(FBXW5)

HALD:

104317255(FBXW5)

HLE:	104829985(FBXW5)

AGEN:

126052117

GCL:

127023792

CCRI:

104155584(FBXW5)

CSTI:

104556858(FBXW5)

CMAC:

104487615(FBXW5)

MUI:	104540076(FBXW5)

BREG:

104630272

FGA:	104083587(FBXW5)

GSTE:

104262626(FBXW5)

LDI:	104345003(FBXW5)

MNB:	103770015(FBXW5)

OHA:	104338200(FBXW5)

NNT:	104402073(FBXW5)

SHAB:

115616899(FBXW5)

DPUB:

104300176(FBXW5)

PGUU:

104465850(FBXW5)

ACAR:

104521686(FBXW5)

CPEA:

104397866(FBXW5)

CVF:	104291071(FBXW5)

RTD:	128917340(FBXW5)

CUCA:

104059099(FBXW5)

TEO:	104381572(FBXW5)

BRHI:

104494495(FBXW5)

AAM:	106494226(FBXW5)

AROW:

112969745(FBXW5)

NPD:	112955936(FBXW5)

TGT:	104573539(FBXW5)

DNE:	112986786(FBXW5)

SCAM:

104139803(FBXW5)

ASN:	102385103(FBXW5)

AMJ:	102564597(FBXW5)

CPOO:

109313782(FBXW5)

GGN:	109292830(FBXW5)

PSS:	102450209(FBXW5)

CMY:	102940848(FBXW5)

CCAY:

125623441(FBXW5)

DCC:	119844348(FBXW5)

CPIC:

101933802(FBXW5)

TST:	117867259(FBXW5)

CABI:

116832956(FBXW5)

MRV:	120386647(FBXW5)

ACS:	100561338(fbxw5)

ASAO:

132763632(FBXW5)

PVT:	110087463(FBXW5)

SUND:

121936586(FBXW5)

PBI:	103066285(FBXW5)

PMUR:

107302542(FBXW5)

CTIG:

120308628(FBXW5)

TSR:	106541962(FBXW5)

PGUT:

117676632(FBXW5)

APRI:

131186028(FBXW5)

PTEX:

113443862(FBXW5)

NSS:	113424252(FBXW5)

VKO:	123028385(FBXW5)

PMUA:

114607288(FBXW5)

PRAF:

128424015(FBXW5)

ZVI:	118092292(FBXW5)

HCG:	128338844(FBXW5)

GJA:	107115162(FBXW5)

STOW:

125441692(FBXW5)

EMC:	129341858(FBXW5)

XLA:	446791(fbxw5.S)

XTR:	493431(fbxw5)

NPR:	108787247(FBXW5)

RTEM:

120914051(FBXW5)

BBUF:

120977317(FBXW5)

BGAR:

122946431(FBXW5)

MUO:	115472611(FBXW5)

GSH:	117367750(FBXW5)

DRE:	406611(fbxw5)

SRX:	107730335(fbxw5) 107746474

SANH:

107684358(fbxw5) 107697984

SGH:	107567701 107595987

CCAR:

109064979 109088461

CAUA:

113083509(fbxw5)

CGIB:

127989204

PTET:

122345293(fbxw5)

LROH:

127165040(fbxw5)

OMC:	131540101(fbxw5)

PPRM:

120471950(fbxw5)

MAMB:

125267989(fbxw5)

CIDE:

127513414

MASI:

127428695 127433939

TROS:

130550408(fbxw5)

TDW:	130419590(fbxw5)

MANU:

129441175(fbxw5)

IPU:

108259927

IFU:	128603336(fbxw5)

PHYP:

113531645(fbxw5)

SMEO:

124378725(fbxw5)

TFD:	113641499(fbxw5)

TVC:	132840975(fbxw5)

AMEX:

103029837(fbxw5)

CMAO:

118814557(fbxw5)

EEE:	113588080(fbxw5)

CHAR:

105890531(fbxw5)

TRU:	101079136(fbxw5)

TFS:	130517729(fbxw5)

TNG:	GSTEN00017167G001 GSTEN00025342G001

LCO:	104925077(fbxw5)

NCC:	104953548(fbxw5)

TBEN:

117476521(fbxw5)

CGOB:

115016770(fbxw5)

PGEO:

117456135(fbxw5)

GACU:

117539185(fbxw5)

EMAC:

134868547(fbxw5)

ELY:	117270002(fbxw5)

EFO:	125906289(fbxw5)

PLEP:

121960182(fbxw5)

SLUC:

116035064(fbxw5)

ECRA:

117958913(fbxw5)

ESP:	116703983(fbxw5)

PFLV:

114571106(fbxw5)

GAT:	120831958(fbxw5)

PPUG:

119226958(fbxw5)

AFB:	129102854(fbxw5)

CLUM:

117740350(fbxw5)

PSWI:

130204859(fbxw5)

MSAM:

119914702(fbxw5)

SCHU:

122865631(fbxw5)

CUD:	121525629(fbxw5)

ALAT:

119030276(fbxw5)

MZE:	101466173(fbxw5)

ONL:	100710047(fbxw5)

OAU:	116331707(fbxw5)

OLA:	101159521(fbxw5)

OML:	112162879(fbxw5)

CSAI:

133455205(fbxw5)

XMA:	102219318(fbxw5)

XCO:	114149694(fbxw5)

XHE:	116724375(fbxw5)

PRET:

103473817(fbxw5)

PFOR:

103149829(fbxw5)

PLAI:

106950857(fbxw5)

PMEI:

106917431(fbxw5)

GAF:	122819461(fbxw5)

PPRL:

129366610(fbxw5)

CVG:	107096286(fbxw5)

CTUL:

119794716(fbxw5)

GMU:	124872762(fbxw5)

NFU:	107374335(fbxw5)

KMR:	108231101(fbxw5)

ALIM:

106522828(fbxw5)

NWH:	119425188(fbxw5)

AOCE:

111576856(fbxw5)

MCEP:

124996839(fbxw5)

CSEM:

103390225(fbxw5)

POV:	109626282(fbxw5)

SSEN:

122758408(fbxw5)

HHIP:

117771242(fbxw5)

HSP:	118125817(fbxw5)

SMAU:

118285228(fbxw5)

LCF:

108874452

SDU:	111239576(fbxw5)

SLAL:

111664830(fbxw5)

XGL:	120806198(fbxw5)

HCQ:	109520404(fbxw5)

SSCV:

125979940

SBIA:

133515265(fbxw5)

PEE:	133413578(fbxw5)

PTAO:

133490301(fbxw5)

BPEC:

110160546 110160659(fbxw5)

MALB:

109960678(fbxw5)

BSPL:

114866590(fbxw5)

SJO:	128379750(fbxw5)

SASA:

106563306 106566753(fbxw5)

STRU:

115204051(fbxw5)

OTW:

112230969

OMY:	110509778(fbxw5)

OGO:

124007133

ONE:	115101152(fbxw5)

OKI:

109873694

OKE:	118385318 118388094(fbxw5)

SALP:

111964002

SNH:

120021435

CCLU:

121541653 121582532

ELS:	105015037(fbxw5)

SFM:	108929970(fbxw5)

PKI:	111847459(fbxw5)

AANG:

118212451(fbxw5)

LOC:	102686984(fbxw5)

PSPA:

121310836(fbxw5)

ARUT:

117396689 117973886

PSEX:

120541998(fbxw5)

LCM:	102356055(FBXW5)

RTP:	109916782(fbxw5)

CPLA:

122564695(fbxw5)

HOC:	132825776(fbxw5)

LERI:

129711944(fbxw5)

PMRN:

116953113(FBXW5) 116953118

LRJ:	133354602 133354718 133354732

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG9144(Fbw5)

DER:

6543512

DSE:

6613580

DSI:	Dsimw501_GD22601(Dsim_GD22601)

DYA:	Dyak_GE18949

DAN:

6498215

DSR:

110185851

DPO:

4817915

DPE:	113565872 6589228

DMN:

108162954

DWI:

6642372

DGR:

6561548

DMO:	Dmoj_GI13488

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119688409 119688926

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ006276

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201911

PMAC:

PPOT:

PXU:

PRAP:

AAGE:

TNL:

OFU:

CFEL:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM136920

FOC:	113204773 113205394 113211077 113212134

TPAL:

117639503 117640402 117644956

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_197724

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111697668 111702304

LSM:

121117786

TCF:	131878421 131881632

PPOI:

ISC:

DSV:

RSAN:

RMP:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_K06A9.2(K06A9.2)

CBR:

CBG_16425

CRQ:	GCK72_022299

NAI:	NECAME_00646

BMY:	BM_BM9478(Bm9478)

LOA:	LOAG_08499

LGI:	LOTGIDRAFT_126606 LOTGIDRAFT_152090 LOTGIDRAFT_92511

PVUL:

126808482 126817589

PCAN:

112575089 112575200 112575203

BGT:

106067110

GAE:	121383410 121384716

HRF:	124145531 124150103

HRJ:	124255416 124257799

CRG:	105327008 105333306 105337234 105341009 105345311 105347553 109617363

CVN:	111122549 111128809 111130931

CANU:

128156372 128177738 128178011 128178436

OED:	125649363 125680984

MYI:	110441562 110441887 110445689 110460167

PMAX:

117321928 117334430 117334490 117334962

MMER:

123524702 123557020 123566554

RPHI:

132734437 132753258 132753259

DPOL:

127876437 127877655

OBI:

106875284

OSN:

115210973

LAK:	106170485 106180778

NVE:

5519346

EPA:

110248511

ATEN:

116291973

ADF:	107330802 107333011 107333012

AMIL:

PDAM:

SPIS:

Reference

PMID:18381890

Authors

Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y

Title

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

Journal

Genes Dev 22:866-71 (2008)
DOI:10.1101/gad.1624008

Sequence

[hsa:54461]

Reference

PMID:21725316

Authors

Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grunwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gonczy P, Malek NP

Title

The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.

Journal

Nat Cell Biol 13:1004-9 (2011)
DOI:10.1038/ncb2282

Sequence

[hsa:54461]

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Ontology (3)   
   KEGG BRITE (3)   
Gene (1665)   
   KEGG GENES (652)   
   KEGG MGENES (209)   
   RefGene (801)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (1670)   

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