KEGG ORTHOLOGY: K10351

ORTHOLOGY: K10351

Entry

K10351                      KO

Symbol

MYL2

Name

myosin regulatory light chain 2

Pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04371

Apelin signaling pathway

map04510

Focal adhesion

map04520

Adherens junction

map04530

Tight junction

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map04814

Motor proteins

map04820

Cytoskeleton in muscle cells

map05131

Shigellosis

map05132

Salmonella infection

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00292

Hypertrophic cardiomyopathy

H00595

Myofibrillar myopathies

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K10351  MYL2; myosin regulatory light chain 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K10351  MYL2; myosin regulatory light chain 2
   04520 Adherens junction
    K10351  MYL2; myosin regulatory light chain 2
   04530 Tight junction
    K10351  MYL2; myosin regulatory light chain 2
  09142 Cell motility
   04814 Motor proteins
    K10351  MYL2; myosin regulatory light chain 2
   04820 Cytoskeleton in muscle cells
    K10351  MYL2; myosin regulatory light chain 2
   04810 Regulation of actin cytoskeleton
    K10351  MYL2; myosin regulatory light chain 2
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K10351  MYL2; myosin regulatory light chain 2
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K10351  MYL2; myosin regulatory light chain 2
   04261 Adrenergic signaling in cardiomyocytes
    K10351  MYL2; myosin regulatory light chain 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K10351  MYL2; myosin regulatory light chain 2
   05131 Shigellosis
    K10351  MYL2; myosin regulatory light chain 2
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K10351  MYL2; myosin regulatory light chain 2
   05414 Dilated cardiomyopathy
    K10351  MYL2; myosin regulatory light chain 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10351  MYL2; myosin regulatory light chain 2
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     K10351  MYL2; myosin regulatory light chain 2

Genes

HSA:	4633(MYL2)

PTR:	452243(MYL2)

PPS:	100973169(MYL2)

GGO:	101146701(MYL2)

PON:	100462280(MYL2)

NLE:	100590389(MYL2)

HMH:	116477929(MYL2)

MCC:	711937(MYL2)

MCF:	102147025(MYL2)

MNI:	105493412(MYL2)

CSAB:

103239122(MYL2)

CATY:

105573192(MYL2)

PANU:

100997019(MYL2)

RRO:	104674641(MYL2)

RBB:	108512247(MYL2)

CJC:	100408790(MYL2)

SBQ:	101050353(MYL2)

CIMI:

108313731(MYL2)

CSYR:

103258791(MYL2)

MMUR:

105880933(MYL2)

LCAT:

123626055(MYL2)

PCOQ:

105825660(MYL2)

OGA:	100954524(MYL2)

MMU:	17906(Myl2)

MCAL:

110294798(Myl2)

MPAH:

110312960(Myl2)

RNO:	363925(Myl2)

MCOC:

116070897(Myl2)

ANU:	117698422(Myl2)

MUN:	110545344(Myl2)

CGE:	100773969(Myl2)

MAUA:

101831072(Myl2)

PROB:

127216106(Myl2)

PLEU:

114704572

MORG:

121446255(Myl2)

MFOT:

126511699

AAMP:

119825182(Myl2)

NGI:	103745580(Myl2)

HGL:	101713909(Myl2) 101714346

CPOC:

100719658(Myl2)

CCAN:

109685543

DORD:

105990664(Myl2)

DSP:	122098548(Myl2)

PLOP:

125347983(Myl2)

NCAR:

124990741

MMMA:

107156437(Myl2)

OCU:

100353304

OPI:	101533043(MYL2)

TUP:	102502505(MYL2)

GVR:	103605741(MYL2)

CFA:	403614(MYL2)

CLUD:

112676544(MYL2)

VVP:	112935243(MYL2)

VLG:	121475789(MYL2) 121493338

NPO:	129508394(MYL2)

AML:	100483724(MYL2)

UMR:	103661279(MYL2)

UAH:	113267112(MYL2)

UAR:	123779111(MYL2)

ELK:

111156317

LLV:

125082476

MPUF:

101670913(MYL2)

MNP:	132023807(MYL2)

MLK:	131811692(MYL2)

NVS:	122902064(MYL2)

ORO:	101385566(MYL2)

EJU:	114219061(MYL2)

ZCA:	113912842(MYL2)

MLX:	118018471(MYL2)

NSU:	110588228(MYL2)

LWW:	102744743(MYL2)

FCA:	101101169(MYL2)

PYU:	121010339(MYL2)

PCOO:

112870159(MYL2)

PBG:	122470218(MYL2)

PVIV:

125149299(MYL2)

LRUF:

124518424

PTG:	102954811(MYL2)

PPAD:

109277655(MYL2)

PUC:

125914180

AJU:

106967527

HHV:	120247408(MYL2)

BTA:	505519(MYL2)

BOM:	102275987(MYL2)

BIU:	109571417(MYL2)

BBUB:

102393988(MYL2)

BBIS:

104989639(MYL2)

CHX:	102179873(MYL2)

OAS:	100196904(MYL2)

BTAX:

128062159(MYL2)

ODA:	120871092(MYL2)

CCAD:

122423562(MYL2)

MBEZ:

129542695(MYL2)

SSC:	396690(MYL2)

CFR:	102509636(MYL2)

CBAI:

105080603(MYL2)

CDK:	105102482(MYL2)

VPC:	102533574(MYL2)

BACU:

103016555(MYL2)

BMUS:

118880239(MYL2)

LVE:	103077775(MYL2)

OOR:	101287240(MYL2)

DLE:	111187002(MYL2)

PCAD:

102983557(MYL2)

PSIU:

116738885(MYL2)

NASI:

112408795(MYL2)

ECB:	100147688(MYL2)

EPZ:

103544050

EAI:	106842271(MYL2)

MYB:	102258260(MYL2)

MYD:	102754925(MYL2)

MMYO:

118678476(MYL2)

MLF:	102438342(MYL2)

PKL:	118725474(MYL2)

EFUS:

103287051(MYL2)

MNA:	107529566(MYL2)

DRO:	112310679 112310708

SHON:

118991347(MYL2)

AJM:	119040469(MYL2)

PDIC:

114509831(MYL2)

PHAS:

123823427(MYL2)

MMF:	118640015(MYL2)

PPAM:

129087184(MYL2)

HAI:	109386121 109386122

RFQ:	117017564(MYL2)

PALE:

102888244(MYL2)

PGIG:

120616125(MYL2)

PVP:	105289221(MYL2)

RAY:	107513248(MYL2)

MJV:	108400560(MYL2)

TOD:	119245327(MYL2)

SARA:

101537119(MYL2)

SETR:

126031105(MYL2)

TMU:

101351770

ETF:	101663637(MYL2)

DNM:	101441500(MYL2)

MDO:	100019715(MYL2)

GAS:	123232356(MYL2)

SHR:	100917142(MYL2)

AFZ:

127545470

PCW:	110196868(MYL2)

OAA:	100074559(MYL2)

GGA:	416874(MYL2)

PCOC:

116228589(MYL2)

MGP:	100547128(MYL2)

CJO:	107321507(MYL2)

TPAI:

128084726(MYL2)

LMUT:

125701687(MYL2)

NMEL:

110406487(MYL2)

APLA:

119718633(MYL2)

ACYG:

106031114(MYL2)

CATA:

118257545(MYL2)

AFUL:

116496258(MYL2)

TGU:	100223766(MYL2)

LSR:	110478104(MYL2)

SCAN:

103818146(MYL2)

PMOA:

120509775(MYL2)

OTC:	121338965(MYL2)

PRUF:

121365012(MYL2)

GFR:	102032391(MYL2)

FAB:	101808099(MYL2)

OMA:	130259779(MYL2)

PHI:	102101963(MYL2)

PMAJ:

107211518(MYL2)

CCAE:

111936417(MYL2)

CCW:	104688679(MYL2)

CBRC:

103615933(MYL2)

ETL:	114062679(MYL2)

ZAB:	102072489(MYL2)

ACHL:

103805085(MYL2)

SVG:	106852413(MYL2)

MMEA:

130580364(MYL2)

HRT:	120760725(MYL2)

FPG:	101916533(MYL2)

FCH:	102046529(MYL2)

CLV:	102085726 102098030

EGZ:	104122714(MYL2)

NNI:	104019401(MYL2)

PCRI:

PLET:

EHS:

PCAO:

ACUN:

113486078(MYL2)

TALA:

104362641(MYL2)

PADL:

103914543(MYL2)

AFOR:

103902775(MYL2)

ACHC:

115345956(MYL2)

HALD:

104316991

HLE:	104840869(MYL2)

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

104638679(MYL2)

FGA:	104074066(MYL2)

GSTE:

104252284

LDI:	104346517(MYL2)

OHA:	104335849(MYL2)

NNT:	104410426(MYL2)

SHAB:

115614657(MYL2)

DPUB:

104308415(MYL2)

PGUU:

104471158

ACAR:

104529285(MYL2)

CPEA:

104389432(MYL2)

AVIT:

104270672

CVF:	104282221(MYL2)

RTD:	128917078(MYL2)

CUCA:

104058811(MYL2)

TEO:	104375552 104375943

BRHI:

104494937

AAM:	106495672(MYL2)

AROW:

112962520(MYL2)

NPD:	112949409(MYL2)

TGT:	104564619(MYL2)

DNE:	112991843(MYL2)

SCAM:

104138774(MYL2)

ASN:	102375176(MYL2)

AMJ:	102563829(MYL2)

CPOO:

109312653(MYL2)

GGN:	109290663(MYL2)

PSS:	102449621(MYL2)

CMY:	102937866(MYL2)

CCAY:

125623103(MYL2)

DCC:	119843723(MYL2)

CPIC:

101931587(MYL2)

TST:	117888105(MYL2)

CABI:

116836760(MYL2)

MRV:	120385881(MYL2)

ACS:	100566191(myl2)

ASAO:

132781671(MYL2)

PVT:	110083871(MYL2)

SUND:

121916624(MYL2)

PBI:	103055734(MYL2)

PMUR:

107286997(MYL2)

CTIG:

120316716(MYL2)

TSR:	106548632(MYL2)

PGUT:

117672242(MYL2)

APRI:

131185562(MYL2)

PTEX:

113448652(MYL2)

NSS:	113424905(MYL2)

VKO:	123028625(MYL2)

PMUA:

114602734(MYL2)

PRAF:

128419950(MYL2) 128419954

ZVI:	118087852(MYL2)

HCG:	128338183(MYL2)

GJA:	107112184(MYL2)

EMC:	129341209(MYL2)

XLA:	108697104(myl2.L) 447131(myl2.S)

XTR:	100135705(myl2)

NPR:	108788538(MYL2)

RTEM:

120933222(MYL2)

BBUF:

120988545(MYL2)

BGAR:

122934995(MYL2)

MUO:	115480662(MYL2)

GSH:	117365538(MYL2)

DRE:	100537244(myl2a) 677750(myl2b)

SRX:	107714591 107720970 107743076

SANH:

107670978 107699636 107701848

SGH:	107552143 107553045 107563425 107567947

CCAR:

109049019 109066430 109089231 109095081 109095082

CAUA:

113052724 113070124 113094322 113106710

CGIB:

127957130 127963050 128019022

PTET:

122344699(myl2a) 122351012(myl2b)

LROH:

127165543(myl2a) 127170142(myl2b)

OMC:	131541642(myl2a) 131545696(myl2b)

PPRM:

120471636(myl2a) 120481296(myl2b)

RKG:	130091476(myl2b) 130101114(myl2a)

MAMB:

125266219(myl2a) 125279421(myl2b)

CIDE:

127512736 127513170 127518134

MASI:

127414810 127423743 127424090 127433474

TROS:

130545502(myl2a) 130568635(myl2b)

TDW:	130407175(myl2b) 130418852(myl2a)

MANU:

129414642(myl2b) 129439554(myl2a)

AMEX:

103044021 103047490

CMAO:

118812921(myl2b) 118814800(myl2a)

EEE:	113571031 113583613

CHAR:

105891597(myl2b) 105902524(myl2a)

TRU:	101064268 101071916

TFS:	130524329(myl2a) 130525264(myl2b)

TNG:	GSTEN00021603G001 GSTEN00035940G001

LCO:	104926365 104927948

NCC:	104965458(myl2)

TBEN:

117484785(myl2b) 117486540(myl2a)

CGOB:

115008190 115013484

PGEO:

117441865 117446801(myl2a)

GACU:

117539054(myl2b) 117561898(myl2a)

EMAC:

134873754(myl2b) 134882188(myl2a)

ELY:	117252834(myl2b) 117256336(myl2a)

EFO:	125890356(myl2b) 125895371(myl2a)

PLEP:

121944028(myl2b) 121949397(myl2a)

SLUC:

116034528(myl2a) 116051677(myl2b)

ECRA:

117943540(myl2a) 117945295(myl2b)

ESP:	116686662 116687400 116689310

PFLV:

114553906 114555838

GAT:	120831367(myl2b) 120835062

PPUG:

119224624(myl2b) 119229953(myl2a)

AFB:	129100863(myl2b) 129105345(myl2a)

CLUM:

117736120(myl2b)

PSWI:

130196123(myl2b)

MSAM:

119886341(myl2a) 119892516(myl2b)

SCHU:

122868939(myl2a) 122877065(myl2b)

CUD:	121506915(myl2a)

ALAT:

119019638(myl2b) 119020424(myl2a)

MZE:	101478915 101482094

ONL:	100690118 100699907

OAU:	116322671(myl2b) 116326444(myl2a)

OLA:	101155507 101162219

OML:	112145777(myl2a) 112148199(myl2b)

CSAI:

133449491(myl2a) 133451434(myl2b)

XMA:	102221311 102235799

XCO:	114135493 114155283

XHE:	116709730 116729368

PRET:

103464970 103469530

PFOR:

103139559 103152403 103152405

PLAI:

106956971 106957696

PMEI:

106927814 106931433 106931922

GAF:	122828833(myl2b) 122834448(myl2a)

PPRL:

129358361(myl2a) 129372956(myl2b)

CVG:	107093673 107097276

CTUL:

119775438 119780128(myl2a)

GMU:	124856367(myl2a) 124877393(myl2b)

NFU:	107385499 107393500

KMR:	108234899(myl2b) 108239856(myl2a)

ALIM:

106518399 106529458

NWH:	119412224(myl2a) 119414137(myl2b)

AOCE:

111567162 111577851

MCEP:

125006804(myl2a) 125011690(myl2b)

CSEM:

103386220 103397433(myl2)

POV:	109629026 109633730

SSEN:

122767930(myl2a) 122769809(myl2b)

HHIP:

117761187(myl2a) 117768350(myl2b)

HSP:	118105431(myl2a) 118115569(myl2b)

SMAU:

118309247(myl2a) 118313622(myl2b)

LCF:	108878787(myl2b) 108899709(myl2a)

SDU:	111221531 111226251

SLAL:

111647905 111670903

XGL:	120805274(myl2b) 120807528(myl2a)

HCQ:

109522138

SSCV:

125977049

SBIA:

133507267(myl2a)

PTAO:

133484071(myl2a)

BPEC:

110153909

MALB:

109955954 109959694

BSPL:

114856279(myl2a) 114862013(myl2b)

SJO:	128355058(myl2a) 128365484(myl2b)

SASA:

100196342(mlrv) 106583376 106585309

STRU:

115149859 115208045

OTW:	112215535 112255301

OMY:

110494139

OGO:

124004291

ONE:	115131599 115143004

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:

SFM:	108933343(myl2)

PKI:	111842153(myl2)

AANG:

118206732(myl2b) 118212664

LOC:	102682260(myl2)

PSPA:

121296803 121300097

ARUT:

117426294 117427756

PSEX:

120540966

LCM:	102362592(MYL2)

CMK:

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:24184274

Authors

Stevens L, Bastide B, Hedou J, Cieniewski-Bernard C, Montel V, Cochon L, Dupont E, Mounier Y

Title

Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures.

Journal

Arch Biochem Biophys 540:125-32 (2013)
DOI:10.1016/j.abb.2013.10.016

Reference

PMID:2704627

Authors

Dalla Libera L, Hoffmann E, Floroff M, Jackowski G

Title

Isolation and nucleotide sequence of the cDNA encoding human ventricular myosin light chain 2.

Journal

Nucleic Acids Res 17:2360 (1989)
DOI:10.1093/nar/17.6.2360

Sequence

[hsa:4633]

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   KEGG BRITE (2)   
Pathway (28)   
   KEGG PATHWAY (28)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (1)   
   KEGG DRUG (1)   
Gene (1657)   
   KEGG GENES (487)   
   KEGG MGENES (26)   
   RefGene (1139)   
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Literature (2)   
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