KEGG   ORTHOLOGY: K10601Help
Entry
K10601                      KO                                     

Name
SYVN1, HRD1
Definition
E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
Module
M00403  HRD1/SEL1 ERAD complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin
   04120 Ubiquitin mediated proteolysis
    K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Protein processing
    M00403  HRD1/SEL1 ERAD complex
     K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10601  SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin
BRITE hierarchy
Genes
HSA: 84447(SYVN1)
PTR: 466660(SYVN1)
PPS: 100972671(SYVN1)
GGO: 101135120(SYVN1)
PON: 100436053(SYVN1)
NLE: 100581754(SYVN1)
MCC: 716698(SYVN1)
MCF: 102115645(SYVN1)
CSAB: 103230099(SYVN1)
RRO: 104662825(SYVN1)
RBB: 108543228(SYVN1)
CJC: 100411217(SYVN1)
SBQ: 101032451(SYVN1)
MMU: 74126(Syvn1)
RNO: 361712(Syvn1)
CGE: 100765313(Syvn1)
NGI: 103724975(Syvn1)
HGL: 101697993(Syvn1)
CCAN: 109687157(Syvn1)
OCU: 100354913(SYVN1)
TUP: 102481661(SYVN1)
CFA: 483746(SYVN1)
AML: 100468658(SYVN1)
UMR: 103679571(SYVN1)
ORO: 101362386(SYVN1)
FCA: 101084316(SYVN1)
PTG: 102954873(SYVN1)
AJU: 106971149(SYVN1)
BTA: 508358(SYVN1)
BOM: 102270672(SYVN1)
BIU: 109554397(SYVN1)
PHD: 102343102(SYVN1)
CHX: 102171307(SYVN1)
OAS: 101121218(SYVN1)
SSC: 100514334(SYVN1)
CFR: 102508253(SYVN1)
CDK: 105102642(SYVN1)
BACU: 103012365(SYVN1)
LVE: 103070029(SYVN1)
OOR: 101286505(SYVN1)
ECB: 100050962(SYVN1)
EPZ: 103559148(SYVN1)
EAI: 106833593(SYVN1)
MYB: 102261948(SYVN1)
MYD: 102773565(SYVN1)
HAI: 109384264(SYVN1)
RSS: 109450399(SYVN1)
PALE: 102891602(SYVN1)
LAV: 100663084(SYVN1)
TMU: 101342025
MDO: 100017483(SYVN1)
SHR: 100928155(SYVN1)
GGA: 100859884(SYVN1)
CJO: 107307383(SYVN1)
APLA: 101794098(SYVN1)
ACYG: 106029455(SYVN1)
GFR: 102043337(SYVN1)
FAB: 101817835(SYVN1)
PHI: 102102595(SYVN1) 106628740
PMAJ: 107199343(SYVN1)
FPG: 101918658(SYVN1)
FCH: 102058913(SYVN1)
CLV: 102094938(SYVN1)
EGZ: 104132588(SYVN1)
AAM: 106485370(SYVN1) 106486183
ASN: 102375832(SYVN1)
AMJ: 102560833(SYVN1)
PSS: 102457760(SYVN1)
CMY: 102940783(SYVN1)
CPIC: 101936408(SYVN1)
ACS: 100559426(syvn1)
PVT: 110083748(SYVN1)
PBI: 103062406(SYVN1)
GJA: 107111052(SYVN1)
XLA: 431869(syvn1.L) 494996(syvn1.S)
XTR: 100327246(syvn1)
NPR: 108785277(SYVN1)
DRE: 335226(syvn1)
SANH: 107662029 107664765(syvn1)
CCAR: 109109631
IPU: 108268933(syvn1)
AMEX: 103032650(syvn1)
TRU: 101068397(syvn1)
LCO: 104932274(syvn1)
NCC: 104945001(syvn1)
MZE: 101464073(syvn1)
OLA: 101157789(syvn1)
XMA: 102229028(syvn1)
PRET: 103471033(syvn1)
NFU: 107377924(syvn1)
CSEM: 103391137(syvn1)
LCF: 108878863(syvn1)
HCQ: 109515781(syvn1)
BPEC: 110168339(syvn1)
ELS: 105005995(syvn1)
SFM: 108923082(syvn1)
LCM: 102347402(SYVN1)
CMK: 103172327(syvn1)
CIN: 100182895
SPU: 579528
APLC: 110982669
SKO: 100370827
DME: Dmel_CG1937(sip3)
DSI: Dsimw501_GD21603(Dsim_GD21603)
MDE: 101892673
AAG: 5565265
AME: 100576667
BIM: 100742832
BTER: 100651003
SOC: 105203101
AEC: 105143531
ACEP: 105620817
PBAR: 105425671
HST: 105186597
CFO: 105249788
LHU: 105676621
PGC: 109857509
NVI: 100116247
TCA: 663272
DPA: 109540027
BMOR: 100862840
PMAC: 106721684
PRAP: 110997431
PXY: 105382410
API: 100164346
DNX: 107163888
ZNE: 110831433
FCD: 110859228
TUT: 107363739
CEL: CELE_F55A11.3(sel-11)
CBR: CBG23271(Cbr-hrd-1)
BMY: Bm1_28085
TSP: Tsp_03010
CRG: 105343343
MYI: 110457024
OBI: 106883391
LAK: 106166555
SHX: MS3_05379
EPA: 110247282
ADF: 107354898
AQU: 100636118
ATH: AT1G65040(Hrd1B) AT3G16090(Hrd1A)
CPAP: 110816318
CIT: 102610175
TCC: 18590133
EGR: 104424282
VAR: 108320905
CCAJ: 109810890
ADU: 107481943
AIP: 107628176
LJA: Lj1g3v0129510.1(Lj1g3v0129510.1) Lj2g3v2125400.1(Lj2g3v2125400.1) Lj6g3v0933510.1(Lj6g3v0933510.1)
FVE: 101299133
PPER: 18787188
PMUM: 103333507
PAVI: 110758594
ZJU: 107414861
CSV: 101215351
CMO: 103495570
MCHA: 111011717
CMAX: 111482600
RCU: 8283078
JCU: 105649012
JRE: 109012480
VVI: 100252838
CANN: 107862950
INI: 109146511
BVG: 104888022
SOE: 110786095
OSA: 4340826
DOSA: Os06t0301000-01(Os06g0301000)
OBR: 102719213
ATS: 109752136(LOC109752136) 109757290(LOC109757290)
PDA: 103716829
EGU: 105060636
MUS: 103973402
DCT: 110111678
ATR: 18448598
APRO: F751_3543
SCE: YOL013C(HRD1)
ERC: Ecym_3048
KMX: KLMA_10257(HRD1)
NCS: NCAS_0D02010(NCAS0D02010)
NDI: NDAI_0C02770(NDAI0C02770)
TPF: TPHA_0F02480(TPHA0F02480)
TBL: TBLA_0B00560(TBLA0B00560)
TDL: TDEL_0G04250(TDEL0G04250)
KAF: KAFR_0A05240(KAFR0A05240)
CAL: CAALFM_CR06470WA(CaO19.719)
SLB: AWJ20_1592(HRD1) AWJ20_897
NCR: NCU04633
NTE: NEUTE1DRAFT144610(NEUTE1DRAFT_144610)
MGR: MGG_09205
MAW: MAC_08572
MAJ: MAA_03681
CMT: CCM_03981
MBE: MBM_09937
ANI: AN1488.2
ANG: ANI_1_2010144(An16g07970)
ABE: ARB_06440
TVE: TRV_01111
PTE: PTT_19350
SPO: SPBC17D11.02c(hrd1)
CNE: CNH01290
CNB: CNBL1240
ABP: AGABI1DRAFT37502(AGABI1DRAFT_37502)
ABV: AGABI2DRAFT69892(AGABI2DRAFT_69892)
MGL: MGL_1081
DFA: DFA_03857
EHI: EHI_166440(125.t00010)
PFA: PF14_0215
PYO: PY17X_1022800(PY00025)
PCB: PCHAS_102170(PC000714.01.0)
CPV: cgd8_2560
SMIN: v1.2.035763.t1(symbB.v1.2.035763.t1)
PTI: PHATRDRAFT_49801(hHrd1)
SPAR: SPRG_06240
GTT: GUITHDRAFT_91104(HRD1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yamasaki S, Yagishita N, Nishioka K, Nakajima T
  Title
The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
  Journal
Cell Cycle 6:1319-23 (2007)
DOI:10.4161/cc.6.11.4277
  Sequence
[hsa:84447] [mmu:74126]
Reference
  Authors
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y
  Title
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
  Journal
J Neurochem 99:1456-69 (2006)
DOI:10.1111/j.1471-4159.2006.04155.x
  Sequence
[hsa:84447]
Reference
  Authors
Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T
  Title
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
  Journal
EMBO J 26:113-22 (2007)
DOI:10.1038/sj.emboj.7601490
  Sequence
[hsa:84447] [mmu:74126] [dme:Dmel_CG1937]

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