K10808                      KO                                     

ribonucleoside-diphosphate reductase subunit M2 [EC:]
ko00230  Purine metabolism
ko00240  Pyrimidine metabolism
ko00480  Glutathione metabolism
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko04115  p53 signaling pathway
M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
H00469  Mitochondrial DNA depletion syndrome (MDS)
H01118  Progressive external ophthalmoplegia (PEO)
H01390  Mitochondrial neurogastrointestinal encephalomyopathy
KEGG Orthology (KO) [BR:ko00001]
  Nucleotide metabolism
   00230 Purine metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
   00240 Pyrimidine metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
  Metabolism of other amino acids
   00480 Glutathione metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
  Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Pyrimidine metabolism
    M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
     K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor  ribonucleoside-diphosphate reductase
     K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
BRITE hierarchy
Other DBs
RN: R02017 R02019 R02024 R08363 R08364 R11893
GO: 0004748
HSA: 50484(RRM2B) 6241(RRM2)
PTR: 459024(RRM2) 472832(RRM2B)
PPS: 100978164(RRM2B) 100991344(RRM2)
GGO: 101128993(RRM2) 101133309(RRM2B) 109028084
PON: 100172878(RRM2B) 100435953(RRM2)
NLE: 100579408(RRM2) 100599865(RRM2B)
MCC: 703138(RRM2) 707062(RRM2B)
MCF: 101865103(RRM2) 101865579(RRM2B)
CSAB: 103220834(RRM2) 103237238(RRM2B)
RRO: 104655148(RRM2B) 104675204(RRM2)
RBB: 108516338(RRM2) 108520195(RRM2B)
CJC: 100406418(RRM2B) 100409431(RRM2)
SBQ: 101041324(RRM2) 101045651(RRM2B) 101053858
MMU: 20135(Rrm2) 382985(Rrm2b)
RNO: 299976(Rrm2b) 362720(Rrm2)
CGE: 100752542(Rrm2) 100768429(Rrm2b)
NGI: 103747619(Rrm2) 103751596(Rrm2b)
HGL: 101700655(Rrm2) 101718446(Rrm2b)
CCAN: 109695860(Rrm2b) 109695921(Rrm2)
OCU: 100337711(RRM2B) 100346325(RRM2)
TUP: 102493707(RRM2) 102496069(RRM2B)
CFA: 481988(RRM2B) 482963(RRM2)
AML: 100467675(RRM2B) 100484524(RRM2)
UMR: 103660736(RRM2) 103661517(RRM2B)
FCA: 101087987(RRM2) 101099777(RRM2B)
PTG: 102950263(RRM2) 102950840(RRM2B)
AJU: 106980049(RRM2B) 106987069(RRM2)
BTA: 508167(RRM2) 528960(RRM2B)
BOM: 102267033(RRM2B) 102280923(RRM2)
BIU: 109566395(RRM2) 109568552(RRM2B)
CHX: 102173102(RRM2B) 102185371(RRM2)
OAS: 101118093(RRM2) 101123639(RRM2B)
SSC: 100157205(RRM2B) 100316853(RRM2)
CFR: 102509951(RRM2) 102517591(RRM2B)
CDK: 105090530(RRM2B) 105091241(RRM2)
BACU: 103001800(RRM2B) 103002730(RRM2)
LVE: 103084791(RRM2) 103085179(RRM2B)
OOR: 101270798(RRM2) 101273644(RRM2B) 105748332
ECB: 100062030(RRM2B) 100072410(RRM2)
EPZ: 103549301(RRM2) 103565153(RRM2B)
EAI: 106823043(RRM2B) 106847469(RRM2)
MYB: 102239344(RRM2B) 102255694(RRM2)
MYD: 102762533(RRM2B) 102768249(RRM2)
HAI: 109374753(RRM2B) 109386651(RRM2)
RSS: 109434203(RRM2B) 109443237 109456133(RRM2)
PALE: 102895346(RRM2B) 102895581(RRM2)
LAV: 100664945(RRM2) 100673076(RRM2B)
MDO: 100030856(RRM2B) 100031990(RRM2)
SHR: 100914438(RRM2B) 100934573(RRM2)
OAA: 100073529(RRM2) 100077581(RRM2B)
GGA: 420253(RRM2B) 421936(RRM2)
MGP: 100550027(RRM2B) 100550737(RRM2)
CJO: 107310462(RRM2B) 107312233(RRM2)
APLA: 101794665(RRM2) 101798489(RRM2B)
ACYG: 106030813(RRM2) 106035272(RRM2B)
TGU: 100231721(RRM2) 100231760(RRM2B)
GFR: 102033491(RRM2) 102036141(RRM2B)
FAB: 101815464(RRM2) 101819545(RRM2B)
PHI: 102105482(RRM2) 102105901(RRM2B)
PMAJ: 107199938(RRM2B) 107202615(RRM2)
CCW: 104685508(RRM2) 104692711(RRM2B)
FPG: 101924453(RRM2) 101924710(RRM2B)
FCH: 102054305(RRM2B) 102056241(RRM2)
CLV: 102089725(RRM2B) 102098900(RRM2)
EGZ: 104125884(RRM2B) 104127145(RRM2)
AAM: 106483902(RRM2B) 106494774(RRM2)
ASN: 102370540(RRM2) 102379850(RRM2B)
AMJ: 102572985(RRM2) 106737166(RRM2B)
PSS: 102452484(RRM2) 102463887(RRM2B)
CMY: 102929591(RRM2) 102938774(RRM2B)
CPIC: 101930869(RRM2B) 101935883(RRM2)
ACS: 100566226(rrm2b) 100568029(rrm2)
PVT: 110073795(RRM2B) 110080600(RRM2)
PBI: 103049984(RRM2) 103062671
GJA: 107109636(RRM2) 107124672(RRM2B)
XLA: 108695407 379056(rrm2b.S) 380465(rrm2.2.L) 443815(rrm2.1.L)
XTR: 100144925(rrm2b) 394645(rrm2.1) 493274(rrm2.2)
NPR: 108789065(RRM2B) 108789865(RRM2)
DRE: 100330864 30733(rrm2) 368909(rrm2b)
IPU: 100304963(rrm2) 108256937
AMEX: 103024314(rrm2) 103028967
LCO: 104918649(rrm2b) 104938413
NCC: 104957091
XMA: 102221232(rrm2) 102232339(rrm2b)
PRET: 103457161(rrm2) 103472431(rrm2b)
CSEM: 103381368(rrm2) 103394411
BPEC: 110163838 110167389(rrm2b)
SASA: 100194994(rir2) 106570792 106607664(rrm2)
ELS: 105017811(rrm2) 105027716(rrm2b)
SFM: 108919262 108929424(rrm2)
LCM: 102361010(RRM2)
CMK: 103180951(rrm2) 103185624
CIN: 100175066(rrm2)
SPU: 577596
DME: Dmel_CG8975(RnrS)
DSI: Dsimw501_GD25870(Dsim_GD25870)
MDE: 101897812
AAG: 5573705
AME: 414008(RnrS)
BIM: 100741599
BTER: 100646244
ACEP: 105620921
PBAR: 105430864
HST: 105191222
CFO: 105255837
LHU: 105667883
NVI: 100114323
TCA: 657724
DPA: 109538900
NVL: 108566059
BMOR: 100873153(RnrS)
PMAC: 106713913
PRAP: 110994951
DNX: 107167809
ZNE: 110833949
FCD: 110852546
CEL: CELE_C03C10.3(rnr-2)
CBR: CBG20205(Cbr-rnr-2)
BMY: Bm1_34225
TSP: Tsp_04092
CRG: 105336299
MYI: 110454415
OBI: 106881801
LAK: 106178433
SHX: MS3_08998
ADF: 107335754
HMG: 100211917
AQU: 100638359
ATH: AT3G23580(RNR2A) AT3G27060(TSO2)
TCC: 18602878
GRA: 105796620
LJA: Lj0g3v0328799.1(Lj0g3v0328799.1) Lj1g3v3631770.1(Lj1g3v3631770.1) Lj1g3v4361110.1(Lj1g3v4361110.1) Lj4g3v2379450.1(Lj4g3v2379450.1)
CSV: 101222416
CMO: 103491720
POP: 7481626
NTO: 104112191
DOSA: Os06t0127900-01(Os06g0127900) Os06t0257450-01(Os06g0257450)
ATS: 109769404(LOC109769404)
ZMA: 100192012(TIDP3470) 100284475
EGU: 105032431
ERC: Ecym_6011
KMX: KLMA_30199(RNR2)
NCS: NCAS_0A06890(NCAS0A06890) NCAS_0D02000(NCAS0D02000)
NDI: NDAI_0C02780(NDAI0C02780) NDAI_0D01950(NDAI0D01950)
TPF: TPHA_0E03210(TPHA0E03210) TPHA_0E03220(TPHA0E03220) TPHA_0N00550(TPHA0N00550) TPHA_0N00560(TPHA0N00560)
TBL: TBLA_0C05960(TBLA0C05960) TBLA_0H02160(TBLA0H02160) TBLA_0H02170(TBLA0H02170)
TDL: TDEL_0E04490(TDEL0E04490)
KAF: KAFR_0D01760(KAFR0D01760) KAFR_0J00620(KAFR0J00620)
PIC: PICST_70259(RNR2)
CAUR: QG37_01077
SLB: AWJ20_3075(RNR2)
NCR: NCU07887
MGR: MGG_06408
MAW: MAC_08322
MAJ: MAA_03602
CMT: CCM_05761
MBE: MBM_01126
ANI: AN0067.2
ANG: ANI_1_944124(An14g06870)
ABE: ARB_03411
TVE: TRV_01368
PTE: PTT_10664
SPO: SPBC25D12.04(suc22)
MGL: MGL_1758
DDI: DDB_G0272616(rnrB-1) DDB_G0274021(rnrB-2) DDB_G0291764
PYO: PY17X_1039000(PY03671) PY17X_1217400(PY07154)
PCB: PCHAS_103740(PC000254.04.0) PCHAS_121490(PC000747.01.0)
TPV: TP01_0725
BBO: BBOV_IV006460(23.m06516) BBOV_IV010610(23.m06273)
CPV: cgd6_690
SMIN: v1.2.003760.t1(symbB.v1.2.003760.t1) v1.2.026582.t1(symbB.v1.2.026582.t1) v1.2.032751.t1(symbB.v1.2.032751.t1)
VG: 11107163(YKV020c) 1485926(CPXV051_CDS) 16511831(pdul_cds_481) 28340333(PTPV-Aus-006) 29057618(BIZ96_gp040) 29063987(BI079_gp040) 6295440(rr2) 8887768(rr2b) 928921(C10L)
 » show all
Qiu W, Zhou B, Darwish D, Shao J, Yen Y
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
Biochem Biophys Res Commun 340:428-34 (2006)
[hsa:6241 50484]
Guittet O, Hakansson P, Voevodskaya N, Fridd S, Graslund A, Arakawa H, Nakamura Y, Thelander L
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
J Biol Chem 276:40647-51 (2001)
Nguyen HH, Ge J, Perlstein DL, Stubbe J
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly.
Proc Natl Acad Sci U S A 96:12339-44 (1999)

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