KEGG   ORTHOLOGY: K11411Help
Entry
K11411                      KO                                     

Name
SIRT1, SIR2L1
Definition
NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
Pathway
FoxO signaling pathway
AMPK signaling pathway
Amphetamine addiction
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
   04152 AMPK signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
  Substance dependence
   05031 Amphetamine addiction
    K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
23411(SIRT1)
PTR: 
466088(SIRT1)
PPS: 
100984983(SIRT1)
GGO: 
101147879(SIRT1)
PON: 
100443901(SIRT1)
MCC: 
695682(SIRT1)
MCF: 
102134009(SIRT1)
MMU: 
93759(Sirt1)
RNO: 
309757(Sirt1)
CGE: 
HGL: 
101720282(Sirt1)
TUP: 
102484296(SIRT1)
CFA: 
489012(SIRT1)
AML: 
FCA: 
101087610(SIRT1)
PTG: 
102963908(SIRT1)
BTA: 
613629(SIRT1)
BOM: 
102276604(SIRT1)
PHD: 
102338846(SIRT1)
CHX: 
102180824(SIRT1)
SSC: 
751859(SIRT1)
CFR: 
102515768(SIRT1)
ECB: 
100072571(SIRT1)
MYB: 
102240165(SIRT1)
MYD: 
102756748(SIRT1)
PALE: 
102880351(SIRT1)
MDO: 
100015574(SIRT1)
SHR: 
100920847(SIRT1)
OAA: 
100077037(SIRT1)
GGA: 
423646(SIRT1)
MGP: 
100540948(SIRT1)
TGU: 
100229233(SIRT1)
FAB: 
101810475(SIRT1)
PHI: 
102101980(SIRT1)
APLA: 
101799275(SIRT1)
FPG: 
101912911(SIRT1)
FCH: 
102058467(SIRT1)
CLV: 
102091510(SIRT1)
ASN: 
102369643(SIRT1)
PSS: 
102446525(SIRT1)
CMY: 
102930541(SIRT1)
ACS: 
XLA: 
100036963(sirt1)
XTR: 
100145679(sirt1)
DRE: 
797132(sirt1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348704(SIRT1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AME: 
411917(Sir2)
NVI: 
TCA: 
API: 
PHU: 
ISC: 
CEL: 
CELE_R11A8.4(sir-2.1)
CBR: 
CBG23756(Cbr-sir-2.1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
AQU: 
CME: 
CCP: 
DDI: 
DPP: 
DFA: 
DFA_08068(sir2D)
ACAN: 
PIF: 
GTT: 
TVA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Saunders LR, Verdin E
  Title
Sirtuins: critical regulators at the crossroads between cancer and aging.
  Journal
Oncogene 26:5489-504 (2007)

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