KEGG ORTHOLOGY: K11411

ORTHOLOGY: K11411

Entry

K11411                      KO

Symbol

SIRT1, SIR2L1

Name

NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]

Pathway

map00760

Nicotinate and nicotinamide metabolism

map01100

Metabolic pathways

map04068

FoxO signaling pathway

map04148

Efferocytosis

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04212

Longevity regulating pathway - worm

map04213

Longevity regulating pathway - multiple species

map04218

Cellular senescence

map04310

Wnt signaling pathway

map04922

Glucagon signaling pathway

map04936

Alcoholic liver disease

map05031

Amphetamine addiction

map05206

MicroRNAs in cancer

Reaction

R10633

R10634

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
   04068 FoxO signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
   04152 AMPK signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
  09143 Cell growth and death
   04218 Cellular senescence
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
  09149 Aging
   04211 Longevity regulating pathway
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
   04212 Longevity regulating pathway - worm
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
   04213 Longevity regulating pathway - multiple species
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
  09165 Substance dependence
   05031 Amphetamine addiction
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
   03029 Mitochondrial biogenesis
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1

Other DBs

GO:

0034979

Genes

HSA:	23411(SIRT1)

PTR:	107966703(SIRT1)

PPS:	100984983(SIRT1)

GGO:	101147879(SIRT1)

PON:	100443901(SIRT1)

NLE:	100605499(SIRT1)

HMH:	116458587(SIRT1)

MCC:	695682(SIRT1)

MCF:	102134009(SIRT1)

MTHB:

126962950

MNI:	105466131(SIRT1)

CSAB:

103216104(SIRT1)

CATY:

105597228(SIRT1)

PANU:

101006670(SIRT1)

TGE:	112632129(SIRT1)

MLEU:

105549497(SIRT1)

RRO:	104671788(SIRT1)

RBB:	108514897(SIRT1)

TFN:	117082466(SIRT1)

PTEH:

111537942(SIRT1)

CANG:

105501058(SIRT1)

CJC:	100395149(SIRT1)

SBQ:	101029573(SIRT1)

CIMI:

108285090(SIRT1)

CSYR:

103264607(SIRT1)

MMUR:

105870235(SIRT1)

LCAT:

123649770(SIRT1)

PCOQ:

105821946(SIRT1)

OGA:	100966528(SIRT1)

MMU:	93759(Sirt1)

MCAL:

110303892(Sirt1)

MPAH:

110326468(Sirt1)

RNO:	309757(Sirt1)

MCOC:

116075265(Sirt1)

ANU:	117724644(Sirt1)

MUN:	110554873(Sirt1)

CGE:	100763298(Sirt1)

MAUA:

101836019(Sirt1)

PROB:

127224056(Sirt1)

PLEU:

114701128(Sirt1)

MORG:

121451034(Sirt1)

MFOT:

126500845

AAMP:

119822232(Sirt1)

NGI:	103733767(Sirt1)

HGL:	101720282(Sirt1)

CPOC:

100717014(Sirt1)

CCAN:

109681555(Sirt1)

DORD:

105986341(Sirt1)

DSP:	122122290(Sirt1)

PLOP:

125346380(Sirt1)

NCAR:

124985129

MMMA:

107154762(Sirt1)

OCU:

100349271

OPI:	101534216(SIRT1)

TUP:	102484296(SIRT1)

GVR:	103585976(SIRT1)

CFA:	489012(SIRT1)

CLUD:

112651335(SIRT1)

VVP:	112927672(SIRT1)

VLG:	121487787(SIRT1)

NPO:	129509439(SIRT1)

AML:	100484328(SIRT1)

UMR:	103667762(SIRT1)

UAH:	113259105(SIRT1)

UAR:	123782872(SIRT1)

ELK:

111145159

LLV:

125084753

MPUF:

101685196(SIRT1)

MNP:	132016307(SIRT1)

MLK:	131828905(SIRT1)

NVS:	122900725(SIRT1)

ORO:	101382490(SIRT1)

EJU:	114214155(SIRT1)

ZCA:	113923537(SIRT1)

MLX:	118017855 118018619

NSU:	110589139(SIRT1)

LWW:	102739251(SIRT1)

FCA:	101087610(SIRT1)

PYU:	121036697(SIRT1)

PCOO:

112854631(SIRT1)

PBG:	122492811(SIRT1)

PVIV:

125147963(SIRT1)

LRUF:

124506847

PTG:	102963908(SIRT1)

PPAD:

109264323(SIRT1)

PUC:

125932669

AJU:

106967135

HHV:	120232500(SIRT1)

BTA:	613629(SIRT1)

BOM:	102276604(SIRT1)

BIU:	109553808(SIRT1)

BBUB:

102409911(SIRT1)

BBIS:

104997542(SIRT1)

CHX:	102180824(SIRT1)

OAS:	101102956(SIRT1)

BTAX:

128048381(SIRT1)

ODA:	120865204(SIRT1)

CCAD:

122446493(SIRT1)

MBEZ:

129555789(SIRT1)

SSC:	751859(SIRT1)

CFR:	102515768(SIRT1)

CBAI:

105066389(SIRT1)

CDK:	105093901(SIRT1)

VPC:	102525222(SIRT1)

BACU:

103011001(SIRT1)

BMUS:

118882663(SIRT1)

LVE:	103080304(SIRT1)

OOR:	101279007(SIRT1)

DLE:	111183434(SIRT1)

PCAD:

102993364(SIRT1)

PSIU:

116741518(SIRT1)

NASI:

112413531(SIRT1)

ECB:	100072571(SIRT1)

EPZ:	103562180(SIRT1)

EAI:	106844414(SIRT1)

MYB:	102240165(SIRT1)

MYD:	102756748(SIRT1)

MMYO:

118670064(SIRT1)

MLF:	102421566(SIRT1)

PKL:	118719190(SIRT1)

EFUS:

103289525(SIRT1)

MNA:	107526052(SIRT1)

DRO:	112305485(SIRT1)

SHON:

118998482(SIRT1)

AJM:	119048700(SIRT1)

PDIC:

114495975(SIRT1)

PHAS:

123821051(SIRT1)

MMF:	118628493 118632263(SIRT1)

PPAM:

129069947(SIRT1)

HAI:	109371987(SIRT1)

RFQ:	117035946(SIRT1)

PALE:

102880351(SIRT1)

PGIG:

120609435(SIRT1)

PVP:	105301705(SIRT1)

RAY:	107501303(SIRT1)

MJV:	108407546(SIRT1)

TOD:	119233504(SIRT1)

SARA:

101541735(SIRT1)

SETR:

125995006(SIRT1)

LAV:	100667672(SIRT1)

TMU:

101342951

ETF:	101655735(SIRT1)

DNM:	101424120(SIRT1)

MDO:	100015574(SIRT1)

GAS:	123234414(SIRT1)

SHR:	100920847(SIRT1)

AFZ:

127552112

PCW:	110216385(SIRT1)

OAA:	100077037(SIRT1)

GGA:	423646(SIRT1)

PCOC:

116234997(SIRT1)

MGP:	100540948(SIRT1)

CJO:	107315730(SIRT1)

TPAI:

128078110(SIRT1)

LMUT:

125693583(SIRT1)

NMEL:

110399426(SIRT1)

APLA:

101799275(SIRT1)

ACYG:

106031113(SIRT1)

CATA:

118245377(SIRT1)

AFUL:

116491373(SIRT1)

TGU:	100229233(SIRT1)

LSR:	110469870(SIRT1)

SCAN:

103821200(SIRT1)

PMOA:

120496121(SIRT1)

OTC:	121348086(SIRT1)

PRUF:

121365690(SIRT1)

GFR:	102038978(SIRT1)

FAB:	101810475(SIRT1)

OMA:	130254690(SIRT1)

PHI:	102101980(SIRT1)

PMAJ:

107206664(SIRT1)

CCAE:

111931513(SIRT1)

CCW:	104690233(SIRT1)

CBRC:

103623727(SIRT1)

ETL:	114064018(SIRT1)

ZAB:	102064938(SIRT1)

ACHL:

103811067(SIRT1)

SVG:	106857307(SIRT1)

MMEA:

130580385(SIRT1)

HRT:	120755566(SIRT1)

FPG:	101912911(SIRT1)

FCH:	102058467(SIRT1)

CLV:	102091510(SIRT1)

EGZ:	104124613(SIRT1)

NNI:	104013536(SIRT1)

PCRI:

104030674(SIRT1)

PLET:

104617559(SIRT1)

EHS:

104512442

PCAO:

104053406(SIRT1)

ACUN:

113481816(SIRT1)

TALA:

104358012(SIRT1)

PADL:

103918614(SIRT1)

AFOR:

103908229(SIRT1)

ACHC:

115347961(SIRT1)

HALD:

104316408

HLE:	104839601(SIRT1)

AGEN:

126042538

GCL:

127017524

CCRI:

104158384(SIRT1)

CSTI:

104551471(SIRT1)

CMAC:

104483233(SIRT1)

MUI:	104534358(SIRT1)

BREG:

104638414(SIRT1)

FGA:	104070307(SIRT1)

GSTE:

104261468(SIRT1)

LDI:	104346099(SIRT1)

MNB:	103777265(SIRT1)

OHA:	104338399(SIRT1)

NNT:	104406921(SIRT1)

SHAB:

115608353(SIRT1)

DPUB:

104306206(SIRT1)

PGUU:

104468886(SIRT1)

ACAR:

104524190(SIRT1)

CPEA:

104386297(SIRT1)

AVIT:

104277514(SIRT1)

CVF:	104294417(SIRT1)

RTD:	128910835(SIRT1)

CUCA:

104065685(SIRT1)

TEO:	104377448(SIRT1)

BRHI:

104494936(SIRT1)

AAM:	106486965(SIRT1)

AROW:

112963158(SIRT1)

NPD:	112950210(SIRT1)

TGT:	104580153(SIRT1)

DNE:	112986862(SIRT1)

SCAM:

104144887(SIRT1)

ASN:	102369643(SIRT1)

AMJ:	102561292(SIRT1)

CPOO:

109312550(SIRT1)

GGN:	109291012(SIRT1)

PSS:	102446525(SIRT1)

CMY:	102930541(SIRT1)

DCC:	119858886(SIRT1)

CPIC:

101935658(SIRT1)

TST:	117879920(SIRT1)

CABI:

116833626(SIRT1)

MRV:	120409238(SIRT1)

ACS:	100564010(sirt1)

ASAO:

132771204(SIRT1)

PVT:	110087595(SIRT1)

SUND:

121926399(SIRT1)

PBI:	103054603(SIRT1)

PMUR:

107288080(SIRT1)

CTIG:

120299640(SIRT1)

TSR:	106539436(SIRT1)

PGUT:

117678012(SIRT1)

APRI:

131200792(SIRT1)

PTEX:

113445415(SIRT1)

NSS:	113415404(SIRT1)

VKO:	123018392(SIRT1)

PMUA:

114597181(SIRT1)

PRAF:

128413901(SIRT1)

ZVI:	118096657(SIRT1)

HCG:	128351110(SIRT1)

GJA:	107120476(SIRT1)

STOW:

125438198(SIRT1)

EMC:	129332073(SIRT1)

XLA:	100036963(sirt1.L) 108697451(sirt1.S)

XTR:	100145679(sirt1)

NPR:	108801625(SIRT1)

RTEM:

120947134(SIRT1)

BBUF:

121005533(SIRT1)

BGAR:

122942172(SIRT1)

MUO:	115470176(SIRT1)

GSH:	117359243(SIRT1)

DRE:	797132(sirt1)

SRX:	107728320 107750137

SANH:

107689352 107689753

SGH:	107562394 107565065

CCAR:

109064745 109080283 109093639

CAUA:

113056620 113080433 113112328

CGIB:

127970677 128025842

PTET:

122356828(sirt1)

LROH:

127175514(sirt1)

OMC:	131551763(sirt1)

PPRM:

120460788(sirt1)

RKG:	130068986(sirt1)

MAMB:

125276486(sirt1)

CIDE:

127524433

MASI:

127411932 127414368

TROS:

130558770(sirt1)

TDW:	130432165(sirt1)

MANU:

129415476(sirt1)

IPU:

108261052

IFU:	128605330(sirt1)

PHYP:

113542038(sirt1)

SMEO:

124376459(sirt1)

TFD:	113655350(sirt1)

TVC:	132847057(sirt1)

AMEX:

103031674(sirt1)

CMAO:

118810738(sirt1)

EEE:	113567518(sirt1)

CHAR:

105906114(sirt1)

TRU:	101061405(sirt1)

TFS:	130533909(sirt1)

TNG:	GSTEN00024551G001

LCO:	104921892(sirt1)

NCC:	104964612(sirt1)

TBEN:

117499751(sirt1)

CGOB:

115019999(sirt1)

PGEO:

117459364(sirt1)

GACU:

117552426(sirt1)

EMAC:

134858525(sirt1)

ELY:	117248701(sirt1)

EFO:	125903879(sirt1)

PLEP:

121954969(sirt1)

SLUC:

116039388(sirt1)

ECRA:

117960531(sirt1)

ESP:	116676151(sirt1)

PFLV:

114572435(sirt1)

GAT:	120820236(sirt1)

PPUG:

119214011(sirt1)

AFB:	129092252(sirt1)

CLUM:

117744020(sirt1)

PSWI:

130206930(sirt1)

MSAM:

119916849(sirt1)

SCHU:

122884868(sirt1)

CUD:	121511152(sirt1)

ALAT:

119033184(sirt1)

MZE:	101480414(sirt1)

ONL:	100700447(sirt1)

OAU:	116318772(sirt1)

OLA:	101175344(sirt1)

OML:	112161794(sirt1)

CSAI:

133463614(sirt1)

XMA:	102222322(sirt1)

XCO:	114138276(sirt1)

XHE:	116713492(sirt1)

PRET:

103477104(sirt1)

PFOR:

103148255(sirt1)

PLAI:

106951797(sirt1)

PMEI:

106920951(sirt1)

GAF:	122842255(sirt1)

PPRL:

129352652(sirt1)

CVG:	107088648(sirt1)

CTUL:

119782891(sirt1)

GMU:	124859127(sirt1)

NFU:	107375374(sirt1)

KMR:	108240687(sirt1)

ALIM:

106525621(sirt1)

NWH:	119417560(sirt1)

AOCE:

111573092(sirt1)

MCEP:

125018345(sirt1)

CSEM:

103391355(sirt1)

POV:	109634091(sirt1)

SSEN:

122781865(sirt1)

HHIP:

117775685(sirt1)

HSP:	118119243(sirt1)

SMAU:

118283453(sirt1)

LCF:

108886237

SDU:	111220735(sirt1)

SLAL:

111669537(sirt1)

XGL:	120796605(sirt1)

HCQ:

109523155

SSCV:

125978801

SBIA:

133509367(sirt1)

PEE:	133410209(sirt1)

PTAO:

133485340(sirt1)

BPEC:

110162160(sirt1)

MALB:

109961229(sirt1)

BSPL:

114870668(sirt1)

SJO:	128372556(sirt1)

SASA:

106576833(sirt1) 106604510

STRU:

115152999 115194015

OTW:	112252524 112252789

OMY:	110502261 110526236

OGO:	124038101 124041450

ONE:	115113398 115135319

OKI:	109889761 109899577

OKE:	118369489 118402183

SALP:

111951852 111978286

SNH:	120017513 120046452

CCLU:

121553217 121568758

ELS:	105028637(sirt1)

SFM:	108932694(sirt1)

PKI:	111855069(sirt1)

AANG:

118218307(sirt1)

LOC:	102695850(sirt1)

PSPA:

121321631 121326144

ARUT:

117414652 117418272 117973487

PSEX:

120514614(sirt1)

LCM:	102348704(SIRT1)

CMK:	103181092(sirt1)

RTP:	109912079(sirt1)

CPLA:

122561006(sirt1)

HOC:	132826196(sirt1)

LERI:

129704215(sirt1)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:	105443501 591711

APLC:

110973619

AJC:

117105934

SKO:

100368502

DME:	Dmel_CG5216(Sirt1)

DER:

6541429

DSE:

6617804

DSI:	Dsimw501_GD23867(Dsim_GD23867)

DYA:	Dyak_GE18618

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18096

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM569840

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_290541(SIR2)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

UDV:

LPOL:

PMEO:

CEL:	CELE_R11A8.4(sir-2.1)

CBR:	CBG_23756(Cbr-sir-2.1)

CRQ:	GCK72_014969

NAI:	NECAME_02337

BMY:	BM_BM418(Bma-sir-2.1)

LOA:	LOAG_18815

TSP:

Tsp_07421

HRO:	HELRODRAFT_66888

LGI:	LOTGIDRAFT_108079

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111119924 111121723

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_138640

SHX:	MS3_00004273(SIRT1_1)

OVI:	T265_08445

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

CME:	CYME_CMT600C

PSTR:

Pst134EA_025675

SRE:	PTSG_04740

DDI:	DDB_G0289967(sir2D)

DPP:	DICPUDRAFT_84948

DFA:	DFA_08068(sir2D)

ACAN:

ACA1_174690

PIF:	PITG_06363 PITG_10164

PSOJ:

PHYSODRAFT_313641 PHYSODRAFT_347828

SPAR:

SPRG_10369

TVA:	TVAG_2v0996460

» show all

Reference

PMID:11672523

Authors

Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA

Title

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

Journal

Cell 107:149-59 (2001)
DOI:10.1016/S0092-8674(01)00527-X

Sequence

[hsa:23411]

Reference

PMID:17936707

Authors

Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L

Title

SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Journal

Mol Cell 28:91-106 (2007)
DOI:10.1016/j.molcel.2007.07.032

Sequence

[hsa:23411] [mmu:93759]

Reference

PMID:10381378

Authors

Frye RA

Title

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.

Journal

Biochem Biophys Res Commun 260:273-9 (1999)
DOI:10.1006/bbrc.1999.0897

Sequence

[hsa:23411]

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Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (2552)   
   KEGG GENES (633)   
   KEGG MGENES (301)   
   RefGene (1611)   
   OC (7)   
Literature (3)   
   PubMed (3)   
All databases (2593)   

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