KEGG ORTHOLOGY: K11413

ORTHOLOGY: K11413

Entry

K11413                      KO

Symbol

SIRT3, SIR2L3

Name

NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]

Pathway

map00760

Nicotinate and nicotinamide metabolism

map01100

Metabolic pathways

map05230

Central carbon metabolism in cancer

Reaction

R10633

R10634

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3

Other DBs

GO:

0034979

Genes

HSA:	23410(SIRT3)

PTR:	450911(SIRT3)

PPS:	100973326(SIRT3)

GGO:	101126809(SIRT3)

PON:	100453970(SIRT3)

NLE:	100604320(SIRT3)

HMH:	116466558(SIRT3)

MCC:	720737(SIRT3)

MCF:	102142238(SIRT3)

MTHB:

126936316

MNI:	105494169(SIRT3)

CSAB:

103234991(SIRT3)

CATY:

105577180(SIRT3)

PANU:

100997286(SIRT3)

TGE:	112606036(SIRT3)

MLEU:

105530799(SIRT3)

RRO:	104672643(SIRT3)

RBB:	108538000(SIRT3)

TFN:	117081578(SIRT3)

PTEH:

111520566(SIRT3)

CANG:

105503183(SIRT3)

CJC:	100386098(SIRT3)

SBQ:	101050089(SIRT3)

CIMI:

108298293(SIRT3)

CSYR:

103254939

MMUR:

105874078(SIRT3)

LCAT:

123642989(SIRT3)

PCOQ:

105816543(SIRT3)

OGA:	100962343(SIRT3)

MMU:	64384(Sirt3)

MCAL:

110297529(Sirt3)

MPAH:

110334277(Sirt3)

RNO:	293615(Sirt3)

MCOC:

116103195(Sirt3)

ANU:	117709494(Sirt3)

MUN:	110553899(Sirt3)

CGE:	100762304(Sirt3)

MAUA:

101841665(Sirt3)

PROB:

127228513(Sirt3)

PLEU:

114693438(Sirt3)

MORG:

121458149(Sirt3)

MFOT:

126498264

AAMP:

119808247(Sirt3)

NGI:	103751056(Sirt3)

HGL:	101697494(Sirt3)

CPOC:

100714713(Sirt3)

CCAN:

109691498(Sirt3)

DORD:

105998614(Sirt3)

DSP:	122095019(Sirt3)

PLOP:

125362242(Sirt3)

NCAR:

124958475

MMMA:

107156918(Sirt3)

OPI:	101536062(SIRT3)

TUP:	102502361(SIRT3)

GVR:	103602147(SIRT3)

CFA:	475933(SIRT3)

CLUD:

112663554(SIRT3)

VVP:	112914416(SIRT3)

VLG:	121501456(SIRT3)

NPO:	129494303(SIRT3)

AML:	100468963(SIRT3)

UMR:	103671025(SIRT3)

UAH:	113248769(SIRT3)

UAR:	123775543(SIRT3)

ELK:

111149798

LLV:

125079297

MPUF:

101672731(SIRT3)

MNP:	132016241(SIRT3)

MLK:	131818537(SIRT3)

NVS:	122913205(SIRT3)

ORO:	101370518(SIRT3)

EJU:	114201523(SIRT3)

ZCA:	113914000(SIRT3)

MLX:	118016233(SIRT3)

NSU:	110582210(SIRT3)

LWW:	102739910(SIRT3)

FCA:	101087609(SIRT3)

PYU:	121022774(SIRT3)

PCOO:

112852121(SIRT3)

PBG:	122484196(SIRT3)

PVIV:

125176267(SIRT3)

LRUF:

124527515

PTG:	102948876(SIRT3)

PPAD:

109259795(SIRT3)

PUC:

125937742

AJU:

106987944

HHV:	120223429(SIRT3)

BTA:	614027(SIRT3)

BOM:	102274743(SIRT3)

BBUB:

102403716(SIRT3)

BBIS:

104983503(SIRT3)

CHX:	102181661(SIRT3)

OAS:	101105454(SIRT3)

BTAX:

128068683(SIRT3)

ODA:	120874226(SIRT3)

CCAD:

122430539(SIRT3)

MBEZ:

129548581(SIRT3)

SSC:	100125971(SIRT3)

CFR:	102512075(SIRT3)

CBAI:

105064452(SIRT3)

CDK:	105105732(SIRT3)

VPC:	102539977(SIRT3)

BACU:

103011694(SIRT3)

BMUS:

118900219(SIRT3)

LVE:	103073899(SIRT3)

OOR:	101288599(SIRT3)

DLE:	111170308(SIRT3)

PCAD:

102992890

PSIU:

116757516(SIRT3)

NASI:

112392078

ECB:	100054908(SIRT3)

EPZ:	103539966(SIRT3)

EAI:	106843865(SIRT3)

MYB:	102252773(SIRT3)

MMYO:

118648968(SIRT3)

PKL:	118713658(SIRT3)

EFUS:

114229034(SIRT3)

MNA:	107544448(SIRT3)

DRO:	112317110(SIRT3)

SHON:

118974905(SIRT3)

AJM:	119060969(SIRT3)

PDIC:

114500668(SIRT3)

PHAS:

123807298(SIRT3)

MMF:	118643122(SIRT3)

PPAM:

129073147(SIRT3)

HAI:	109378085(SIRT3)

RFQ:	117030090(SIRT3)

PALE:

102887102(SIRT3)

PGIG:

120614163(SIRT3)

PVP:	105309811(SIRT3)

RAY:	107506500(SIRT3)

MJV:	108384848(SIRT3)

SARA:

101551453(SIRT3)

SETR:

126019039(SIRT3)

LAV:	100654664(SIRT3)

TMU:

101348992

ETF:	101642648(SIRT3)

DNM:	101418583(SIRT3)

MDO:	100030763(SIRT3)

GAS:	123251135(SIRT3)

SHR:	100924073(SIRT3)

AFZ:

127541155

PCW:	110203709(SIRT3)

OAA:	100089118(SIRT3)

GGA:	422988(SIRT3)

PCOC:

116237927(SIRT3)

MGP:	100538676(SIRT3)

CJO:	107314282(SIRT3)

TPAI:

128085622(SIRT3)

LMUT:

125694907(SIRT3)

NMEL:

110401506(SIRT3)

APLA:

101794570(SIRT3)

ACYG:

106047042(SIRT3)

CATA:

118244236(SIRT3)

AFUL:

116489366(SIRT3)

TGU:	100225810(SIRT3)

LSR:	110467555(SIRT3)

SCAN:

103826814(SIRT3)

PMOA:

120500988(SIRT3)

OTC:	121334796(SIRT3)

PRUF:

121352278(SIRT3)

GFR:	102035189(SIRT3)

FAB:	101821658(SIRT3)

OMA:	130253958(SIRT3)

PHI:	102106576(SIRT3)

PMAJ:

107205276(SIRT3)

CCAE:

111930585(SIRT3)

CCW:	104684530(SIRT3)

CBRC:

103614562(SIRT3)

ETL:	114063308(SIRT3)

ZAB:	102067392(SIRT3)

ACHL:

103799582(SIRT3)

SVG:	106854803(SIRT3)

MMEA:

130581626(SIRT3)

HRT:	120753941(SIRT3)

FPG:	101914765(SIRT3)

FCH:	102049786(SIRT3)

CLV:	102089394(SIRT3)

EGZ:	104127879(SIRT3)

NNI:	104011402(SIRT3)

PCRI:

104035100(SIRT3)

PLET:

104617382(SIRT3)

PCAO:

104047924(SIRT3)

ACUN:

113481210(SIRT3)

TALA:

104365567(SIRT3)

PADL:

103925062(SIRT3)

AFOR:

103906283(SIRT3)

ACHC:

115351893(SIRT3)

HALD:

104313998(SIRT3)

HLE:	104832070(SIRT3)

AGEN:

126047546

GCL:

127016599

CCRI:

104156542(SIRT3)

CMAC:

104478032(SIRT3)

MUI:

104534860

BREG:

104632830(SIRT3)

FGA:	104071129(SIRT3)

GSTE:

104252105(SIRT3)

LDI:	104345363(SIRT3)

MNB:	103780638(SIRT3)

OHA:	104333129(SIRT3)

NNT:	104406670(SIRT3)

SHAB:

115607579(SIRT3)

DPUB:

104297529(SIRT3)

PGUU:

104459668(SIRT3)

ACAR:

104524771(SIRT3)

CPEA:

104392097(SIRT3)

AVIT:

104281120(SIRT3)

CVF:	104282470(SIRT3)

RTD:	128908406(SIRT3)

CUCA:

104057244(SIRT3)

TEO:	104377873(SIRT3)

BRHI:

104499785(SIRT3)

AAM:	106489140(SIRT3)

AROW:

112973758(SIRT3)

NPD:	112948055(SIRT3)

TGT:	104574670(SIRT3)

DNE:	112993819(SIRT3)

SCAM:

104149781(SIRT3)

ASN:	102384882(SIRT3)

AMJ:	102562277(SIRT3)

CPOO:

109318161(SIRT3)

GGN:	109299263(SIRT3)

PSS:	102457485(SIRT3)

CMY:	102935907(SIRT3)

CCAY:

125638240(SIRT3)

DCC:	119858071(SIRT3)

CPIC:

101933048(SIRT3)

TST:	117877399(SIRT3)

CABI:

116836380(SIRT3)

MRV:	120404419(SIRT3)

ACS:	100555836(sirt3)

ASAO:

132771851(SIRT3)

PVT:	110086196(SIRT3)

SUND:

121935192(SIRT3)

PBI:	103067152(SIRT3)

PMUR:

107294462(SIRT3) 107300980

CTIG:

120312461(SIRT3)

TSR:	106547596(SIRT3)

PGUT:

117667005(SIRT3)

APRI:

131184523(SIRT3)

PTEX:

113440348(SIRT3)

VKO:	123021329(SIRT3)

PMUA:

114600420(SIRT3)

PRAF:

128417515(SIRT3)

ZVI:	118088914(SIRT3)

HCG:	128337799(SIRT3)

GJA:	107112732(SIRT3)

STOW:

125427235(SIRT3)

EMC:	129325109(SIRT3)

XLA:	108715195(sirt3.1.S) 734623(sirt3.2.L)

XTR:	100145681(sirt3.2) 100487410(sirt3.1)

NPR:	108787963 108795891

RTEM:

120917267(SIRT3) 120932667

BBUF:

120980349(SIRT3) 121007545

BGAR:

122920369(SIRT3) 122926538

MUO:	115468983(SIRT3)

DRE:	557125(si:dkey-103i16.6) 558775(sirt3)

SRX:	107712611 107730173 107749280

SANH:

107663051 107664689 107672161

SGH:	107553976 107561440 107600351

CCAR:

109082995

CAUA:

113106362(sirt3) 113118268

CGIB:

127961116 127977187(si:dkey-103i16.6)

PTET:

122348020(sirt3) 122362709(si:dkey-103i16.6)

LROH:

127168943(sirt3) 127181158(si:dkey-103i16.6)

OMC:	131524054(si:dkey-103i16.6) 131544508(sirt3)

PPRM:

120462016(si:dkey-103i16.6) 120492756(sirt3)

RKG:	130094786(si:dkey-103i16.6) 130100339(sirt3)

MAMB:

125253836(si:dkey-103i16.6) 125265819(sirt3)

CIDE:

127499947(si:dkey-103i16.6) 127516672

MASI:

127411845 127417378

TROS:

130555068(sirt3) 130563226(si:dkey-103i16.6)

TDW:	130428573(sirt3) 130435502(si:dkey-103i16.6)

MANU:

129418874(si:dkey-103i16.6) 129451653(sirt3)

IPU:	108264662(si:dkey-103i16.6) 108270931

IFU:	128606613(si:dkey-103i16.6) 128613761(sirt3)

PHYP:

113534831 113536463(sirt3)

SMEO:

124391500(sirt3) 124395567(si:dkey-103i16.6)

TFD:	113646657(sirt3) 113652438(si:dkey-103i16.6)

TVC:	132842631(sirt3) 132851358(si:dkey-103i16.6)

AMEX:

103043515 103044645(sirt3)

CMAO:

118817950(si:dkey-103i16.6) 118819368(sirt3)

EEE:	113578364(sirt3) 113589963

CHAR:

105892937(sirt3) 105911299(si:dkey-103i16.6)

TRU:	101066119 101067563(sirt3)

TFS:	130518814(sirt3) 130536027(si:dkey-103i16.6)

TNG:	GSTEN00022785G001

LCO:	104936507 104937696

NCC:	104948251 104965729(sirt3)

TBEN:

117471565(sirt3) 117491502(si:dkey-103i16.6)

CGOB:

115009559 115027046(sirt3)

PGEO:

117447905(si:dkey-103i16.6) 117463578(sirt3)

GACU:

117533645(sirt3) 117545689(si:dkey-103i16.6)

EMAC:

134860268(si:dkey-103i16.6) 134863312(sirt3)

ELY:	117259276(sirt3) 117261914(si:dkey-103i16.6)

EFO:	125881086(sirt3) 125887348(si:dkey-103i16.6)

PLEP:

121937964 121950324(si:dkey-103i16.6)

SLUC:

116062566(si:dkey-103i16.6) 116067290(sirt3)

ECRA:

117941237(sirt3) 117949565(si:dkey-103i16.6)

ESP:	116687214(sirt3) 116693552

PFLV:

114557257(sirt3) 114560259

GAT:	120809870 120812723 120814993(sirt3)

PPUG:

119195804(si:dkey-103i16.6) 119224969(sirt3)

AFB:	129106454(sirt3) 129108022(si:dkey-103i16.6)

CLUM:

117728693(sirt3) 117732709(si:dkey-103i16.6)

PSWI:

130193032(sirt3) 130195004(si:dkey-103i16.6)

MSAM:

119890223(sirt3) 119894261(si:dkey-103i16.6)

SCHU:

122875128(si:dkey-103i16.6) 122877377(sirt3)

CUD:	121510582(sirt3) 121514920(si:dkey-103i16.6)

ALAT:

119017919(sirt3) 119024364(si:dkey-103i16.6)

MZE:	101471570 101474545(sirt3)

ONL:	100692411 100693812(sirt3)

OAU:	116318280(si:dkey-103i16.6) 116334284(sirt3)

OLA:	101161471(sirt3) 101165477

OML:	112141986(sirt3) 112152513(si:dkey-103i16.6)

CSAI:

133419708(sirt3) 133444776(si:dkey-103i16.6)

XMA:	102221405(sirt3) 102237357

XCO:	114143546(sirt3) 114156786

XHE:	116719278(sirt3)

PRET:

103463032(sirt3) 103466083

PFOR:

103133698 103155218(sirt3)

PLAI:

106949361(sirt3) 106950932

PMEI:

106909191(sirt3) 106916066

GAF:	122824620(sirt3) 122835474(si:dkey-103i16.6)

PPRL:

129356384 129356655 129363849(si:dkey-103i16.6)

CVG:	107082761(sirt3) 107104162

CTUL:

119780599(sirt3) 119793041(si:dkey-103i16.6)

GMU:	124866511(sirt3) 124882421(si:dkey-103i16.6)

NFU:	107382055(sirt3) 107388944

KMR:	108239958(si:dkey-103i16.6) 108249846(sirt3)

ALIM:

106513124(sirt3) 106515597

NWH:	119415654(si:dkey-103i16.6)

AOCE:

111582551(sirt3) 111586640

MCEP:

125005433(sirt3) 125014902

CSEM:

103378865(sirt3) 103380163

POV:	109624168 109646116(sirt3)

SSEN:

122772393(sirt3) 122775915(si:dkey-103i16.6)

HHIP:

117759158(sirt3) 117762865(si:dkey-103i16.6)

HSP:	118108308(sirt3) 118109674(si:dkey-103i16.6)

SMAU:

118315567(si:dkey-103i16.6)

LCF:	108875294(si:dkey-103i16.6) 108894168

SDU:	111223343(sirt3) 111228405

SLAL:

111656651(sirt3) 111661779

XGL:	120790500(sirt3) 120793035(si:dkey-103i16.6)

HCQ:	109514431(sirt3) 109531260

SSCV:

125967092 125970395(si:dkey-103i16.6)

SBIA:

133498653(sirt3) 133501788(si:dkey-103i16.6)

PEE:	133395600(sirt3) 133403318(si:dkey-103i16.6)

PTAO:

133473350(sirt3) 133478337(si:dkey-103i16.6)

BPEC:

110163823 110164021(sirt3)

MALB:

109966902 109971564(sirt3)

BSPL:

114851854(sirt3) 114857005(si:dkey-103i16.6)

SJO:	128354968(sirt3) 128358697(si:dkey-103i16.6)

SASA:

106561415 106587827 106592787(SIRT3)

STRU:

115166719 115197379 115203601

OTW:	112218731(si:dkey-103i16.6) 112240896(sirt3)

OMY:	110497810(si:dkey-103i16.6) 110526845 110526847

OGO:	124019858 124019886 124023653 124035008(si:dkey-103i16.6)

ONE:	115116328 115134104

OKI:	109867695 109877165 116371138

OKE:	118380616(sirt3) 118395807(si:dkey-103i16.6)

SALP:

111962500(sirt3)

SNH:	120037906 120037907 120066412(si:dkey-103i16.6)

CCLU:

121532261(si:dkey-103i16.6) 121583051(sirt3)

ELS:	105007371(sirt3) 105022153

SFM:	108935931 108942368(sirt3)

PKI:	111838705 111859490(sirt3)

AANG:

118215292(sirt3) 118219001(si:dkey-103i16.6)

LOC:	102692048(sirt3) 102694551

PSPA:

121319693(si:dkey-103i16.6) 121329928

ARUT:

117415213 117432270 117434777

PSEX:

120516448 120534221(si:dkey-103i16.6)

LCM:	102363985(SIRT3) 102364335

CMK:	103179899(si:dkey-103i16.6)

RTP:	109928812(sirt3)

CPLA:

122557755

HOC:	132824455(sirt3)

LERI:

129705537

PMRN:

116940004(SIRT3)

LRJ:

133350224

BFO:

118413992

BBEL:

109465588

CIN:	494364(sir2-a)

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

HVI:

MQU:

ZNE:

CSEC:

SGRE:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

LPOL:

TSP:

OBI:

OSN:

LAK:

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

TAD:	TRIADDRAFT_19190 TRIADDRAFT_52084

AQU:

100638465

EHX:	EMIHUDRAFT_65804 EMIHUDRAFT_77385

» show all

Reference

PMID:18794531

Authors

Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T

Title

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.

Journal

Proc Natl Acad Sci U S A 105:14447-52 (2008)
DOI:10.1073/pnas.0803790105

Sequence

[hsa:23410] [mmu:64384]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (1480)   
   KEGG GENES (558)   
   KEGG MGENES (97)   
   RefGene (821)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (1496)   

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