KEGG   ORTHOLOGY: K11424Help
Entry
K11424                      KO                                     

Name
WHSC1, MMSET, NSD2
Definition
histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
Pathway
ko00310  Lysine degradation
ko05202  Transcriptional misregulation in cancer
Disease
H00010  Multiple myeloma
H01773  4p deletion syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0018024
Genes
HSA: 7468(NSD2)
PTR: 461070(NSD2)
PPS: 100993332(NSD2)
GGO: 101140725(NSD2)
PON: 100433878(NSD2)
NLE: 100586897(NSD2)
MCC: 100429321(NSD2)
MCF: 102132914(NSD2)
CSAB: 103246476(NSD2)
RRO: 104678937(NSD2)
CJC: 100407883(NSD2)
SBQ: 101052056(WHSC1)
MMU: 107823(Nsd2)
RNO: 680537(Nsd2)
CGE: 100763780(Nsd2)
NGI: 103741129(Nsd2)
HGL: 101709487(Nsd2)
CCAN: 109694996(Nsd2)
OCU: 100347860(NSD2)
TUP: 102501548(NSD2)
CFA: 479077(NSD2)
AML: 100482078(NSD2)
UMR: 103676545(NSD2)
ORO: 101380855(WHSC1)
FCA: 101083169(NSD2)
PTG: 102959131(WHSC1) 102965041
AJU: 106978842(NSD2) 106978864
BTA: 540769(NSD2)
BOM: 102264389(NSD2)
BIU: 109560728(NSD2)
PHD: 102325434(NSD2)
CHX: 102186471(NSD2)
OAS: 101103648(WHSC1)
SSC: 100515039(NSD2)
CFR: 102513372(NSD2)
CDK: 105100861(NSD2)
BACU: 102998442(NSD2)
LVE: 103085661(NSD2)
OOR: 101272234(WHSC1)
ECB: 100051090(NSD2)
EPZ: 103540385(NSD2)
EAI: 106823803(NSD2)
MYB: 102253280(NSD2)
MYD: 102775482(NSD2)
HAI: 109390921(NSD2)
RSS: 109434985(NSD2)
PALE: 102877851 102897218(WHSC1)
LAV: 100673480(NSD2)
TMU: 101350220
MDO: 100022914(NSD2)
SHR: 100913447(NSD2)
OAA: 100086259(NSD2)
GGA: 422897(WHSC1)
MGP: 100543303(WHSC1)
CJO: 107313892(NSD2)
APLA: 101792888(NSD2)
ACYG: 106034357(WHSC1)
TGU: 100222807(NSD2)
GFR: 102033219(NSD2)
FAB: 101814945(NSD2)
PHI: 102113544(NSD2)
PMAJ: 107202885(WHSC1)
CCW: 104690790(NSD2)
FPG: 101916059(NSD2)
FCH: 102059826(NSD2)
CLV: 102095738(NSD2)
EGZ: 104130173(WHSC1)
AAM: 106498711(NSD2)
ASN: 102372149(NSD2)
AMJ: 102573644(NSD2)
PSS: 102464028(NSD2)
CMY: 102940729(NSD2)
CPIC: 101932511(NSD2)
ACS: 100563747(nsd2)
PVT: 110085590(NSD2)
PBI: 103055475(NSD2)
GJA: 107121904(NSD2)
XLA: 108697691(nsd2.L) 431996(nsd2.S)
XTR: 100125213(nsd2)
NPR: 108788842(WHSC1)
DRE: 100000709(nsd2)
IPU: 108263739(nsd2)
AMEX: 103021320(nsd2)
TRU: 101064304(nsd2)
LCO: 104926795(nsd2)
MZE: 101475058(nsd2)
OLA: 101172132(nsd2)
XMA: 102228489(nsd2)
NFU: 107391900
CSEM: 103383239(whsc1)
LCF: 108889160
HCQ: 109520165(nsd2)
BPEC: 110171104(nsd2)
ELS: 105015872(nsd2)
SFM: 108920768(whsc1)
LCM: 102363237(NSD2)
CMK: 103183116(nsd2)
CIN: 100184753(whsc1)
SPU: 580047
APLC: 110979905
SKO: 100373849
DME: Dmel_CG4976(NSD)
DSI: Dsimw501_GD18047(Dsim_GD18047)
MDE: 101899586
AAG: 5573316
BIM: 100743680
BTER: 100649537
AEC: 105142910
ACEP: 105621434
HST: 105182266
CFO: 105253793
LHU: 105679941
PGC: 109859534
NVI: 100116149(Mes-4)
TCA: 662527
DPA: 109533690
NVL: 108556555
PXY: 105396524
API: 100161826
DNX: 107165982
ZNE: 110831774
FCD: 110850728
DPX: DAPPUDRAFT_299753(MES-4)
TUT: 107370843
CRG: 105340795
MYI: 110441593
EPA: 110235939
ADF: 107334404
HMG: 100200866
AQU: 100632445
PPP: 112277788
SPAR: SPRG_10189
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
  Sequence
[hsa:7468]
Reference
  Authors
Kim JY, Kee HJ, Choe NW, Kim SM, Eom GH, Baek HJ, Kook H, Kook H, Seo SB
  Title
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
  Journal
Mol Cell Biol 28:2023-34 (2008)
DOI:10.1128/MCB.02130-07
  Sequence
[hsa:7468] [mmu:107823]

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