| | ORTHOLOGY: K11424 | |
Entry |
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Symbol |
WHSC1, MMSET, NSD2
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Name |
[histone H3]-lysine36 N-dimethyltransferase NSD2 [EC: 2.1.1.357]
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Pathway |
map05202 | Transcriptional misregulation in cancer |
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Reaction |
R04866 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
R04867 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
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Disease |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
K11424 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
K11424 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins
K11424 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.357 [histone H3]-lysine36 N-dimethyltransferase
K11424 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
K11424 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD |
Title |
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. |
Journal |
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Sequence |
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Reference |
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Authors |
Kim JY, Kee HJ, Choe NW, Kim SM, Eom GH, Baek HJ, Kook H, Kook H, Seo SB |
Title |
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. |
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Sequence |
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