KEGG   ORTHOLOGY: K11424Help
Entry
K11424                      KO                                     

Name
WHSC1, MMSET, NSD2
Definition
histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Disease
H00010  
Multiple myeloma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Chromosome [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
BRITE hierarchy
Other DBs
Genes
HSA: 
7468(WHSC1)
PTR: 
461070(WHSC1)
PPS: 
100993332(WHSC1)
GGO: 
101140725(WHSC1)
PON: 
100433878(WHSC1)
NLE: 
100586897(WHSC1)
MCC: 
100429321(WHSC1)
MCF: 
102132914(WHSC1)
RRO: 
104678937(WHSC1)
CJC: 
100407883(WHSC1)
MMU: 
107823(Whsc1)
RNO: 
680537(Whsc1)
CGE: 
100763780(Whsc1)
NGI: 
103741129(Whsc1)
HGL: 
101709487(Whsc1)
OCU: 
100347860(WHSC1)
TUP: 
102501548(WHSC1)
CFA: 
479077(WHSC1)
AML: 
100482078(WHSC1)
UMR: 
103676545(WHSC1)
FCA: 
101083169(WHSC1)
PTG: 
BTA: 
540769(WHSC1)
BOM: 
102264389(WHSC1)
PHD: 
102325434(WHSC1)
CHX: 
OAS: 
101103648(WHSC1)
SSC: 
100515039(WHSC1)
CFR: 
102513372(WHSC1)
BACU: 
102998442(WHSC1)
LVE: 
103085661(WHSC1)
ECB: 
100051090(WHSC1)
MYB: 
102253280(WHSC1)
MYD: 
102775482(WHSC1)
PALE: 
MDO: 
100022914(WHSC1)
SHR: 
100913447(WHSC1)
OAA: 
100086259(WHSC1)
GGA: 
422897(WHSC1)
MGP: 
100543303(WHSC1)
APLA: 
101792888(WHSC1)
TGU: 
100222807(WHSC1)
GFR: 
102033219(WHSC1)
FAB: 
101814945(WHSC1)
PHI: 
102113544(WHSC1)
CCW: 
104690790(WHSC1)
FPG: 
101916059(WHSC1)
FCH: 
102059826(WHSC1)
CLV: 
102095738(WHSC1)
ASN: 
102372149(WHSC1)
AMJ: 
102573644(WHSC1)
PSS: 
102464028(WHSC1)
CMY: 
102940729(WHSC1)
ACS: 
100563747(whsc1)
PBI: 
103055475(WHSC1)
XLA: 
431996(whsc1)
XTR: 
100125213(whsc1)
DRE: 
100000709(whsc1)
TRU: 
101064304(whsc1)
MZE: 
OLA: 
101172132(whsc1)
XMA: 
102228489(whsc1)
LCM: 
102363237(WHSC1)
CMK: 
103183116(whsc1)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
Dyak_GE10528(dyak_GLEANR_10445)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
100116149(Mes-4)
TCA: 
PXY: 
API: 
PHU: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CCP: 
MBR: 
SRE: 
SPAR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
  Sequence
[hsa:7468]
Reference
  Authors
Kim JY, Kee HJ, Choe NW, Kim SM, Eom GH, Baek HJ, Kook H, Kook H, Seo SB
  Title
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
  Journal
Mol Cell Biol 28:2023-34 (2008)
  Sequence
[hsa:7468] [mmu:107823]

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