KEGG   ORTHOLOGY: K11424Help
Entry
K11424                      KO                                     
Name
WHSC1, MMSET, NSD2
Definition
histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Disease
H00010  
Multiple myeloma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
Chromosome [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2
BRITE hierarchy
Other DBs
Genes
HSA: 
7468(WHSC1)
PTR: 
461070(WHSC1)
PPS: 
100993332(WHSC1)
GGO: 
101140725(WHSC1)
PON: 
100433878(WHSC1)
MCC: 
MMU: 
107823(Whsc1)
RNO: 
680537(Whsc1)
CFA: 
479077(WHSC1)
AML: 
FCA: 
101083169(WHSC1)
BTA: 
540769(WHSC1)
SSC: 
100515039(WHSC1)
ECB: 
100051090(WHSC1)
MDO: 
100022914(WHSC1)
SHR: 
100913447(WHSC1)
OAA: 
100086259(WHSC1)
GGA: 
422897(WHSC1)
MGP: 
100543303(WHSC1)
TGU: 
100222807(WHSC1)
XLA: 
431996(whsc1)
XTR: 
100125213(whsc1)
DRE: 
100000709(whsc1)
TRU: 
101064304
OLA: 
101172132
BFO: 
BRAFLDRAFT_99284
CIN: 
100175354(whsc1)
SPU: 
580047
DME: 
Dmel_CG4976(Mes-4)
DPO: 
Dpse_GA18567
DAN: 
Dana_GF16138
DER: 
Dere_GG12082
DPE: 
Dper_GL23881
DSE: 
Dsec_GM16309
DSI: 
Dsim_GD18047
DWI: 
Dwil_GK14418
DYA: 
Dyak_GE10528
DGR: 
Dgri_GH19166
DMO: 
Dmoj_GI23270
DVI: 
Dvir_GJ10771
AGA: 
AgaP_AGAP004656
AAG: 
AaeL_AAEL010414
CQU: 
CpipJ_CPIJ011088
AME: 
100577330
NVI: 
100116149(Mes-4)
TCA: 
662527
API: 
100161826
PHU: 
Phum_PHUM433670
ISC: 
IscW_ISCW004542
SMM: 
Smp_160700
NVE: 
NEMVE_v1g183768
HMG: 
100200866
TAD: 
TRIADDRAFT_31338
AQU: 
100632445
MBR: 
MONBRDRAFT_33094
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
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