KEGG ORTHOLOGY: K11540

ORTHOLOGY: K11540

Entry

K11540                      KO

Symbol

CAD

Name

carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]

Pathway

map00240

Pyrimidine metabolism

map00250

Alanine, aspartate and glutamate metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00051

De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP

Reaction

R00256

L-glutamine amidohydrolase

R00575

HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

R01395

ATP:carbamate phosphotransferase

R01397

carbamoyl-phosphate:L-aspartate carbamoyltransferase

R01993

(S)-dihydroorotate amidohydrolase

R10948

ATP:HCO3- phosphotransferase

R10949

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Metallo peptidases
  Family M38: beta-aspartyl dipeptidase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase

Other DBs

GO:	0004088 0004070 0004151

Genes

HSA:

790(CAD)

PTR:	470338(CAD)

PPS:	100989545(CAD)

GGO:	101138023(CAD)

PON:	100444071(CAD)

NLE:	100604681(CAD)

HMH:	116480471(CAD)

MCC:	699460(CAD)

MCF:	102128048(CAD)

MTHB:

126933727

MNI:	105479760(CAD)

CSAB:

103220607(CAD)

CATY:

105578472(CAD)

PANU:

100997394(CAD)

TGE:	112605411(CAD)

MLEU:

105533983(CAD)

RRO:	104668500(CAD)

RBB:	108532706(CAD)

TFN:	117062568(CAD)

PTEH:

111554402(CAD)

CANG:

105517363(CAD)

CJC:	100405052(CAD)

SBQ:	101034080(CAD)

CIMI:

108315922(CAD)

CSYR:

103251601(CAD)

MMUR:

105884399(CAD)

LCAT:

123636721(CAD)

PCOQ:

105816938(CAD)

OGA:	100953236(CAD)

MMU:	69719(Cad)

MCAL:

110294100(Cad)

MPAH:

110324844(Cad)

RNO:	24240(Cad)

MCOC:

116079655(Cad)

ANU:	117716943(Cad)

MUN:	110547690(Cad)

CGE:	100689232(Cad)

MAUA:

101843763(Cad)

PROB:

127220084(Cad)

PLEU:

114696717(Cad)

MORG:

121433026 121439634

MFOT:

126492237

AAMP:

119806436(Cad)

NGI:	103735684(Cad)

HGL:	101710382(Cad)

CPOC:

100727133(Cad)

CCAN:

109679699(Cad)

DORD:

105983698(Cad)

DSP:	122122523(Cad)

PLOP:

125356640(Cad)

NCAR:

124962757

MMMA:

107137422(Cad)

OCU:

100352236

OPI:	101536661(CAD)

TUP:	102478104(CAD)

GVR:	103600395(CAD)

CFA:	483009(CAD)

CLUD:

112664634(CAD)

VVP:	112908478(CAD)

VLG:	121490826(CAD)

NPO:	129511123(CAD)

AML:	100465885(CAD)

UMR:

103671649

UAH:	113271052(CAD)

UAR:	123799913(CAD)

ELK:

111158365

LLV:

125108295

MPUF:

101676555(CAD)

MNP:	132021217(CAD)

MLK:	131840626(CAD)

NVS:	122915225(CAD)

ORO:	101382379(CAD)

EJU:	114205877(CAD)

ZCA:	113938732(CAD)

MLX:	118007689(CAD)

NSU:	110587291(CAD)

LWW:	102745802(CAD)

FCA:	101091102(CAD)

PYU:	121044255(CAD)

PCOO:

112864353(CAD)

PBG:	122497338(CAD)

PVIV:

125161841(CAD)

LRUF:

124503295

PTG:	102971909(CAD)

PPAD:

109266874(CAD)

PUC:

125937592

AJU:

106967912

HHV:	120235931(CAD)

BTA:	504261(CAD)

BOM:	102271526(CAD)

BIU:	109566291(CAD)

BBUB:

102389153(CAD)

BBIS:

104989128(CAD)

CHX:	102179779(CAD)

OAS:	101115776(CAD)

BTAX:

128055081(CAD)

ODA:	120851563(CAD)

CCAD:

122441948 122441949

MBEZ:

129539167(CAD)

SSC:	100624530(CAD)

CFR:	102513447(CAD)

CBAI:

105063833(CAD)

CDK:	105098535(CAD)

VPC:	102528462(CAD)

BACU:

103012656(CAD)

BMUS:

118905812(CAD)

LVE:	103070440(CAD)

OOR:	101271999(CAD)

DLE:	111174963(CAD)

PCAD:

102988062(CAD)

PSIU:

116764433(CAD)

NASI:

112412797(CAD)

ECB:	100055366(CAD)

EPZ:	103546468(CAD)

EAI:	106837038(CAD)

MYB:	102255715(CAD)

MYD:	102767883(CAD)

MMYO:

118669180(CAD)

MLF:	102440221(CAD)

PKL:	118717193(CAD)

EFUS:

103305521(CAD)

MNA:	107534438(CAD)

DRO:	112297782(CAD)

SHON:

119001345(CAD)

AJM:	119050384(CAD)

PDIC:

114498575(CAD)

PHAS:

123822469(CAD)

MMF:	118630710(CAD)

PPAM:

129066910(CAD)

HAI:	109380279(CAD)

RFQ:	117033242(CAD)

PALE:

102896266(CAD)

PGIG:

120621846(CAD)

PVP:	105289732(CAD)

RAY:	107502147(CAD)

MJV:	108391199(CAD)

TOD:	119259464(CAD)

SARA:

101556833(CAD)

SETR:

126023848(CAD)

LAV:	100656120(CAD)

TMU:

101359976

ETF:	101650987(CAD)

DNM:	101434818(CAD)

MDO:	100026061(CAD)

GAS:	123234990(CAD)

SHR:	100930182(CAD)

AFZ:

127548741

PCW:	110206480(CAD)

OAA:	100085020(CAD)

GGA:	428659(CAD)

PCOC:

116230667(CAD)

MGP:	100547622(CAD)

CJO:	107312305(CAD)

TPAI:

128082993(CAD)

LMUT:

125689345(CAD)

NMEL:

110396876(CAD)

APLA:

119716457(CAD)

ACYG:

106049900(CAD)

CATA:

118259029(CAD)

AFUL:

116488248(CAD)

TGU:	100221353(CAD)

LSR:	110478515(CAD)

SCAN:

103824593(CAD)

PMOA:

120502873(CAD)

OTC:	121336253(CAD)

PRUF:

121355675(CAD)

GFR:	102044833(CAD)

FAB:	101809093(CAD)

OMA:	130251318(CAD)

PHI:	102101862(CAD)

PMAJ:

107198724(CAD)

CCAE:

111927462(CAD)

CCW:	104684514(CAD)

CBRC:

103615210(CAD)

ETL:	114069993(CAD)

ZAB:	102074924(CAD)

SVG:	106860398(CAD)

HRT:	120750298(CAD)

FPG:	101915663(CAD)

FCH:	102055000(CAD)

CLV:	102091228(CAD)

NNI:	104009152(CAD)

TALA:

116965192(CAD)

AFOR:

103901427(CAD)

ACHC:

115350975(CAD)

HLE:	104830758(CAD)

AGEN:

126046342

NNT:	104404545(CAD)

SHAB:

115609790(CAD)

DPUB:

104308333(CAD)

CPEA:

104392375(CAD)

RTD:	128907546(CAD)

CUCA:

104068795(CAD)

AROW:

112961056(CAD)

NPD:	112955776(CAD)

DNE:	112996580(CAD)

ASN:	102374540(CAD)

AMJ:	102564082(CAD)

CPOO:

109311574(CAD)

GGN:	109300219(CAD)

CMY:	102941481(CAD)

CCAY:

125634841(CAD)

CPIC:

101931696(CAD)

CABI:

116827143(CAD)

MRV:	120401308(CAD)

ASAO:

132761756(CAD)

PVT:	110086992(CAD)

SUND:

121931149(CAD)

PBI:	103060670(CAD)

PMUR:

107286448(CAD)

CTIG:

120309166(CAD)

TSR:	106545894(CAD)

PGUT:

117667631(CAD)

APRI:

131188957(CAD)

PTEX:

113441592(CAD)

NSS:	113414613(CAD)

VKO:	123018738(CAD)

PMUA:

114595016(CAD)

PRAF:

128411533(CAD)

ZVI:	118082583(CAD)

HCG:	128325350(CAD)

GJA:	107113765(CAD)

STOW:

125443580(CAD)

EMC:	129336255(CAD)

XLA:	108716059(cad.L)

XTR:	100125119(cad)

NPR:	108803083(CAD)

RTEM:

120935968(CAD)

BBUF:

120996996(CAD)

BGAR:

122923352 122934160(CAD)

MUO:	115466986(CAD)

GSH:	117357148(CAD)

DRE:	266992(cad)

SRX:	107727603(cad)

SANH:

107676241(cad)

SGH:

107602171

CAUA:

113051032 113120429

CGIB:

127938155 127984107

PTET:

122324972(cad)

LROH:

127182475(cad)

OMC:	131526920(cad)

PPRM:

120493808(cad)

RKG:	130103174(cad)

MAMB:

125278356(cad)

CIDE:

127501884

MASI:

127410052 127415950

TROS:

130565431(cad)

TDW:	130434159(cad)

MANU:

129429072(cad)

IPU:

108256234

IFU:	128621636(cad)

PHYP:

113528723(cad)

SMEO:

124400907(cad)

TFD:	113643371(cad)

TVC:	132854368(cad)

AMEX:

103044710(cad)

CMAO:

118815206(cad)

EEE:	113571203(cad)

CHAR:

105901561(cad)

TRU:	101071903(cad)

TFS:	130516171(cad)

TNG:	GSTEN00009790G001

LCO:	104928828(cad)

TBEN:

117475139(cad)

CGOB:

115028885

PGEO:

117439889(cad)

GACU:

117535928(cad)

EMAC:

134877169(cad)

ELY:	117270809(cad)

EFO:	125896704(cad)

PLEP:

121955190(cad)

SLUC:

116060328(cad)

ECRA:

117961481(cad)

ESP:	116706285(cad)

PFLV:

114572997(cad)

GAT:	120807858(cad)

PPUG:

119194586(cad)

AFB:	129107088(cad)

CLUM:

117727228(cad)

PSWI:

130202573(cad)

MSAM:

119909048(cad)

SCHU:

122863008(cad)

CUD:	121521324(cad)

ALAT:

119012526(cad)

MZE:

101477088

ONL:	100700233(cad)

OAU:	116325347(cad)

OLA:	101175119(cad)

OML:	112157887(cad)

CSAI:

133464431(cad)

XMA:	102224683(cad)

XCO:	114158728(cad)

XHE:	116734268(cad)

PRET:

103457308(cad)

PFOR:

103129222(cad)

PLAI:

106949231(cad)

PMEI:

106917232(cad)

GAF:	122825206(cad)

PPRL:

129375368(cad)

CVG:	107083521(cad)

CTUL:

119795903(cad)

GMU:	124882183(cad)

NFU:	107377848(cad)

KMR:	108247065(cad)

ALIM:

106530344(cad)

NWH:	119418633(cad)

AOCE:

111565465(cad)

CSEM:

103381268(cad)

POV:	109645101(cad)

SSEN:

122784146(cad)

HHIP:

117758003(cad)

HSP:	118099395(cad)

SMAU:

118290347(cad)

LCF:

108890455

SDU:	111235926(cad)

SLAL:

111672610(cad)

XGL:	120788870(cad)

HCQ:	109523514(cad)

SSCV:

125990673

SBIA:

133496534(cad)

PEE:	133416911(cad)

PTAO:

133468452(cad)

BPEC:

110167003(cad)

MALB:

109970556(cad)

BSPL:

114849631(cad)

SJO:	128377168(cad)

SASA:

106571444 106607850

STRU:

115174751 115192272(cad)

OTW:	112250349 112261904

OMY:	100135860(cpsaseii) 110522267(cad)

OGO:	123990792 124019348

ONE:	115107794 115139375(cad)

OKI:	109866262(cad) 109900780

OKE:	118386940 118398613(cad)

SALP:

111954105 112068127(cad)

SNH:	120019759 120024029

CCLU:

121548885(cad) 121552604

ELS:	105017763(cad)

SFM:	108925182(cad)

PKI:	111854017(cad)

AANG:

118229767(cad)

LOC:	102697989(cad)

PSPA:

121315552(cad)

ARUT:

117402726(cad)

PSEX:

120526095(cad)

LCM:	102353472(CAD)

CMK:	103185793(cad)

RTP:	109935824(cad)

CPLA:

122543481(cad)

HOC:	132833411(cad)

LERI:

129697189(cad)

PMRN:

116953099(CAD)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG18572(r)

DER:

6550003

DSE:

6617969

DSI:	Dsimw501_GD24842(Dsim_r)

DYA:	Dyak_GE17287

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15230

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108371347 108374780 108378251

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ007153

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115883357 115891909

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMAN:

MSEX:

DPL:	KGM_205071B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:	126367590 126376456

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM000420

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_187511

DMK:

DPZ:

PVM:

PCHN:

PMOO:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_D2085.1(pyr-1)

CBR:	CBG_00515(Cbr-pyr-1)

CRQ:	GCK72_004896

NAI:	NECAME_08218

HRO:	HELRODRAFT_186717

LGI:	LOTGIDRAFT_190512

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106170881 106173663

SMM:	Smp_186670

SHX:	MS3_00005261

NVE:	5499589 5509221

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114535055 114537690

XEN:

124450795

HMG:	100208851(cad)

HSY:

130653926

TAD:	TRIADDRAFT_29177

AQU:

100635388

CME:	CYME_CMQ255C

GSL:	Gasu_42540

CCP:	CHC_T00010056001

MBR:	MONBRDRAFT_37518

SRE:	PTSG_03067

DDI:	DDB_G0276335(pyr1-3)

DPP:	DICPUDRAFT_31008

DFA:	DFA_05982(pyr1-3)

ACAN:

ACA1_267180

GTT:	GUITHDRAFT_160213

» show all

Reference

PMID:8619816

Authors

Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M

Title

Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.

Journal

Biochem Biophys Res Commun 219:249-55 (1996)
DOI:10.1006/bbrc.1996.0213

Sequence

[hsa:790]

Reference

PMID:24332717

Authors

Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S

Title

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.

Journal

Structure 22:185-98 (2014)
DOI:10.1016/j.str.2013.10.016

Sequence

[hsa:790]

DBGET integrated database retrieval system