KEGG   ORTHOLOGY: K11540Help
Entry
K11540                      KO                                     

Name
CAD
Definition
carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
Pathway
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Module
M00051  
Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Pyrimidine metabolism
    M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C26: gamma-glutamyl hydrolase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 Metallo Peptidases
  Family M38: beta-aspartyl dipeptidase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
BRITE hierarchy
Other DBs
Genes
HSA: 
790(CAD)
PTR: 
470338(CAD)
PPS: 
GGO: 
PON: 
MCC: 
699460(CAD)
MCF: 
MMU: 
69719(Cad)
RNO: 
24240(Cad)
CGE: 
HGL: 
TUP: 
CFA: 
483009(CAD)
AML: 
FCA: 
PTG: 
BTA: 
504261(CAD)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
428659(CAD)
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
CMY: 
PBI: 
XTR: 
DRE: 
266992(cad)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
410408(Cad)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG00515(Cbr-pyr-1)
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
GSL: 
CCP: 
MBR: 
DDI: 
DDB_G0276335(pyr1-3)
DPP: 
DFA: 
DFA_05982(pyr1-3)
ACAN: 
NGD: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8619816
  Authors
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M
  Title
Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
  Journal
Biochem Biophys Res Commun 219:249-55 (1996)
Reference
  Authors
Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S
  Title
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.
  Journal
Structure 22:185-98 (2014)

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