KEGG ORTHOLOGY: K11832

ORTHOLOGY: K11832

Entry

K11832                      KO

Symbol

USP1

Name

ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]

Pathway

map03460

Fanconi anemia pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
   03400 DNA repair and recombination proteins
    K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
Ubiquitin system [BR:ko04121]
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    Other FA pathway factors
     K11832  USP1; ubiquitin carboxyl-terminal hydrolase 1

Other DBs

GO:

0004843

Genes

HSA:	7398(USP1)

PTR:	456901(USP1)

PPS:	100982030(USP1)

GGO:	101124390(USP1)

PON:	100443075(USP1)

NLE:	100593568(USP1)

HMH:	116457511(USP1)

MCC:	695157(USP1)

MCF:	102140426(USP1)

MTHB:

126933549

MNI:	105495173(USP1)

CSAB:

103224705(USP1)

CATY:

105595947(USP1)

PANU:

101020260(USP1)

TGE:	112616166(USP1)

MLEU:

105545882(USP1)

RRO:	104668056(USP1)

RBB:	108532907(USP1)

TFN:	117092006(USP1)

PTEH:

111528267(USP1)

CANG:

105511046(USP1)

CJC:	100411303(USP1)

SBQ:	101037206(USP1)

CIMI:

108301072 108313254(USP1)

CSYR:

103266917(USP1)

MMUR:

105872805(USP1)

LCAT:

123635579(USP1)

PCOQ:

105806340(USP1)

OGA:	100966583(USP1)

MMU:	230484(Usp1)

MCAL:

110292834(Usp1)

MPAH:

110323098(Usp1)

RNO:	313387(Usp1)

MCOC:

116096272(Usp1)

ANU:	117708812(Usp1)

MUN:	110564584(Usp1)

CGE:	100754655(Usp1)

MAUA:

101832898(Usp1)

PROB:

127224966(Usp1)

PLEU:

114687263 114693745(Usp1) 114708308

MORG:

121448641(Usp1)

MFOT:

126498061

AAMP:

119817702(Usp1)

NGI:	103745294(Usp1)

HGL:	101716794(Usp1)

CPOC:

100722039(Usp1)

CCAN:

109686141(Usp1)

DORD:

105988775(Usp1)

DSP:	122106175(Usp1)

PLOP:

125355242(Usp1)

NCAR:

124984847

MMMA:

107141698(Usp1)

OCU:

100358366

OPI:	101527197 101533649(USP1)

TUP:	102496372(USP1)

GVR:	103606770(USP1)

CFA:	479549(USP1)

CLUD:

112647143(USP1)

VVP:	112926075(USP1)

VLG:	121474093 121499407(USP1)

NPO:	129496712(USP1)

AML:	100473360(USP1)

UMR:	103663070(USP1)

UAH:	113254591(USP1)

UAR:	123795364(USP1)

ELK:

111143364

LLV:

125096798

MPUF:

101689117(USP1)

MNP:	132000953(USP1)

MLK:	131810206(USP1)

NVS:	122900036(USP1)

ORO:	101365740(USP1)

EJU:	114212154(USP1)

ZCA:	113937168(USP1)

MLX:	118019334(USP1)

NSU:	110571788(USP1)

LWW:	102730546(USP1)

FCA:	101080903(USP1)

PYU:	121027234(USP1)

PCOO:

112872172(USP1)

PBG:	122480583(USP1)

PVIV:

125172209(USP1)

LRUF:

124515230

PTG:	102965527(USP1)

PPAD:

109266754(USP1)

PUC:

125913436

AJU:

106975049

HHV:	120247407(USP1)

BTA:	516328(USP1)

BOM:	102275237(USP1)

BIU:	109556215(USP1)

BBUB:

102393164(USP1)

BBIS:

104984244(USP1)

CHX:	102187448(USP1)

OAS:	101107236(USP1)

BTAX:

128045246(USP1)

ODA:	120857059(USP1)

CCAD:

122435272 122436888(USP1)

MBEZ:

129541447(USP1)

SSC:	100523071(USP1)

CFR:	102522295(USP1)

CBAI:

105064771(USP1)

CDK:	105096281(USP1)

VPC:	102539492(USP1)

BACU:

103008560(USP1)

BMUS:

118894109(USP1) 118894667

LVE:	103085454(USP1)

OOR:	101277953(USP1)

DLE:	111178475(USP1) 111178911

PCAD:

102978562(USP1) 102984090 102992319

PSIU:

116761989(USP1)

NASI:

112396630(USP1)

ECB:	100070397(USP1)

EPZ:	103557297(USP1)

EAI:	106839757(USP1)

MYB:	102252055(USP1)

MYD:	102751651(USP1)

MMYO:

118676476 118676477 118676478 118677649(USP1)

MLF:	102436768(USP1)

PKL:	118724668(USP1)

EFUS:

103284079(USP1)

MNA:	107533772(USP1)

DRO:	112309306(USP1)

SHON:

118985212(USP1)

AJM:	119042491(USP1)

PDIC:

114496049(USP1)

PHAS:

123816486(USP1)

MMF:	118626865(USP1) 118628749

PPAM:

129070861(USP1)

HAI:	109389715(USP1)

RFQ:	117027186(USP1)

PALE:

102898461(USP1)

PGIG:

120622068(USP1)

PVP:	105298349(USP1)

RAY:	107508512(USP1)

MJV:	108408077(USP1)

TOD:	119237240(USP1)

SARA:

101557055(USP1)

SETR:

126010802(USP1) 126020937

LAV:	100668820(USP1)

TMU:

101350476

ETF:	101653309(USP1)

DNM:	101435178(USP1)

MDO:	100031700(USP1)

GAS:	123256097(USP1)

SHR:	100919331(USP1)

AFZ:

127563220

PCW:	110212898(USP1)

OAA:	103165248(USP1)

GGA:	424685(USP1)

PCOC:

116235457(USP1)

MGP:	100550349(USP1)

CJO:	107317711(USP1)

TPAI:

128072722(USP1)

LMUT:

125692959(USP1)

NMEL:

110402765(USP1)

APLA:

101791738(USP1)

ACYG:

106032976(USP1)

CATA:

118256988(USP1)

AFUL:

116491784(USP1)

TGU:	100218324(USP1)

LSR:	110477240(USP1)

SCAN:

103815064(USP1)

PMOA:

120503271(USP1)

OTC:	121344911(USP1)

PRUF:

121362247(USP1)

GFR:	102033112(USP1)

FAB:	101819959(USP1)

OMA:	130256434(USP1)

PHI:	102114174(USP1)

PMAJ:

107208143(USP1)

CCAE:

111932978(USP1)

CCW:	104695142(USP1)

CBRC:

103615063(USP1)

ETL:	114057164(USP1)

ZAB:	102068468(USP1)

ACHL:

103797687(USP1)

SVG:	106849731(USP1)

MMEA:

130576038(USP1)

HRT:	120756377(USP1)

FPG:	101920556(USP1)

FCH:	102058157(USP1)

CLV:	102096717(USP1)

EGZ:	104123936(USP1)

NNI:	104009255(USP1)

PCRI:

104027887(USP1)

PLET:

104622776(USP1)

EHS:	104509011(USP1)

PCAO:

104050379(USP1)

ACUN:

113482797(USP1)

TALA:

104357249(USP1)

PADL:

103913330(USP1)

AFOR:

103905671(USP1)

ACHC:

115348728(USP1)

HALD:

104321985(USP1)

HLE:	104840980(USP1)

AGEN:

126041975

GCL:

127019237

CCRI:

104159129(USP1)

CSTI:

104563366(USP1)

CMAC:

104477030(USP1)

MUI:	104542056(USP1)

BREG:

104643191(USP1)

FGA:	104078867(USP1)

GSTE:

104256534(USP1)

LDI:	104352171(USP1)

MNB:	103773238(USP1)

OHA:	104328009(USP1)

NNT:	104411994(USP1)

SHAB:

115611584(USP1)

DPUB:

104308773(USP1)

PGUU:

104469309(USP1)

ACAR:

104526401(USP1)

CPEA:

104397940(USP1)

AVIT:

104267638(USP1)

CVF:	104285515(USP1)

RTD:	128914129(USP1)

CUCA:

104066551(USP1)

TEO:	104374826(USP1)

BRHI:

104494271(USP1)

AAM:	106490530(USP1)

AROW:

112970281(USP1)

NPD:	112948491(USP1)

TGT:	104577106(USP1)

DNE:	112988263(USP1)

SCAM:

104152977(USP1)

ASN:	102384046(USP1)

AMJ:	102558353(USP1)

CPOO:

109307548(USP1)

GGN:	109286580(USP1)

PSS:	102446936(USP1)

CMY:	102935301(USP1)

CCAY:

125641204(USP1)

DCC:	119860058(USP1)

CPIC:

101943153(USP1)

TST:	117881571(USP1)

CABI:

116833788(USP1)

MRV:	120370317(USP1)

ACS:	100560711(usp1)

ASAO:

132773998(USP1)

PVT:	110086663(USP1)

SUND:

121929611(USP1)

PBI:	103053739(USP1)

PMUR:

107287082(USP1)

CTIG:

120306242(USP1)

TSR:	106542333(USP1)

PGUT:

117664314(USP1)

APRI:

131196209(USP1)

PTEX:

113447948 113448000

NSS:	113411076(USP1)

VKO:	123023623(USP1)

PMUA:

114598905(USP1)

PRAF:

128415671(USP1)

ZVI:	118088897(USP1)

HCG:	128323486(USP1)

GJA:	107113835(USP1)

STOW:

125433174(USP1)

EMC:	129330242(USP1)

XLA:	398530(usp1.L) 447465(usp1.S)

XTR:	780036(usp1)

NPR:	108784907(USP1)

RTEM:

120946078(USP1)

BBUF:

120979077(USP1)

BGAR:

122943925(USP1)

MUO:	115471751(USP1)

GSH:	117346947(USP1)

DRE:	322007(usp1)

SRX:	107717136(usp1) 107731620

SANH:

107692387(usp1) 107704506

SGH:	107556553(usp1) 107591200

CCAR:

109102691 109105643

CAUA:

113050555 113100349

CGIB:

127959229 128015632

PTET:

122346503(usp1)

LROH:

127167326(usp1)

OMC:	131542951(usp1)

PPRM:

120493066(usp1)

RKG:	130091239(usp1)

MAMB:

125273986(usp1)

CIDE:

127514993

MASI:

127445812 127448866

TROS:

130557116(usp1)

TDW:	130424525(usp1)

MANU:

129451287(usp1)

IPU:

108271857

IFU:	128615178(usp1)

PHYP:

113528206(usp1)

SMEO:

124385107(usp1)

TFD:	113643232(usp1)

TVC:	132844302(usp1)

AMEX:

103031820(usp1)

CMAO:

118807967(usp1)

EEE:	113587817(usp1)

CHAR:

105913187(usp1)

TRU:	101070932(usp1)

TFS:	130528232(usp1)

TNG:	GSTEN00033578G001

LCO:	104919030(usp1)

NCC:	104962141(usp1)

TBEN:

117495289(usp1)

CGOB:

115007028(usp1)

PGEO:

117445319(usp1)

GACU:

117542898(usp1)

EMAC:

134869382(usp1)

ELY:	117253822(usp1)

EFO:	125896209(usp1)

PLEP:

121941312(usp1)

SLUC:

116039191(usp1)

ECRA:

117950943(usp1)

ESP:	116695007(usp1)

PFLV:

114560950(usp1)

GAT:	120823427(usp1)

PPUG:

119216875(usp1)

AFB:	129094532(usp1)

CLUM:

117729264(usp1)

PSWI:

130194391(usp1)

MSAM:

119900397(usp1)

SCHU:

122877210(usp1)

CUD:	121512207(usp1)

ALAT:

119028028(usp1)

MZE:	101483960(usp1)

ONL:	100692281(usp1)

OAU:	116336389(usp1)

OLA:	101167111(usp1)

OML:	112150249(usp1)

CSAI:

133458612(usp1)

XMA:	102223254(usp1)

XCO:	114151567(usp1)

XHE:	116726477(usp1)

PRET:

103463056(usp1)

PFOR:

103137211(usp1)

PLAI:

106949719(usp1)

PMEI:

106919399(usp1)

GAF:	122838023(usp1)

PPRL:

129374941(usp1)

CVG:	107097924(usp1)

CTUL:

119778909(usp1)

GMU:	124874477(usp1)

NFU:	107392927(usp1)

KMR:	108238474(usp1)

ALIM:

106521633(usp1)

NWH:	119407715(usp1)

AOCE:

111575417(usp1)

MCEP:

125009970(usp1)

CSEM:

103396022(usp1)

POV:	109636658(usp1)

SSEN:

122780900(usp1)

HHIP:

117759740(usp1)

HSP:	118121176(usp1)

SMAU:

118318685(usp1)

LCF:	108887066 108893032

SDU:	111238180(usp1)

SLAL:

111645371(usp1)

XGL:	120790687(usp1)

HCQ:	109530541(usp1)

SSCV:

125973177

SBIA:

133503609(usp1)

PEE:	133406371(usp1)

PTAO:

133481110(usp1)

BPEC:

110160059(usp1)

MALB:

109961716(usp1)

BSPL:

114853995(usp1)

SJO:	128361690(usp1)

SASA:

106560492(usp1)

STRU:

115158737(usp1)

OTW:	112251370(usp1)

OMY:	110524022(usp1)

OGO:	123996646(usp1)

ONE:	115119667(usp1)

OKI:	109902860(usp1)

OKE:	118393825(usp1)

SALP:

111971234 112080674

SNH:	120055031(usp1)

CCLU:

121533800(usp1)

ELS:	105011905(usp1)

SFM:	108935346(usp1)

PKI:	111834809(usp1)

AANG:

118225616(usp1)

LOC:	102693233(usp1)

PSPA:

121327106 121331204

ARUT:

117410966 117416629

PSEX:

120514197(usp1)

LCM:	102364423(USP1)

CMK:	103188830(usp1)

RTP:	109914306(usp1)

CPLA:

122554440(usp1)

HOC:	132819052(usp1)

LERI:

129701108(usp1)

PMRN:

116951850(USP1)

LRJ:	133348963(USP1)

BFO:

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG15817(Usp1)

DER:

6554872

DSE:

6612679

DSI:	Dsimw501_GD21429(Dsim_GD21429)

DYA:	Dyak_GE23847

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10403

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101901131 131805396

SCAC:

106092896

LCQ:

111687911

LSQ:	119611371 119613202

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ014662

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208930

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105388910 105396357

PGW:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103510480 103520630

CLEC:

106669715

HHAL:

106691381

NLU:

111046836

PHU:	Phum_PHUM411860

FOC:

TPAL:

ZNE:

CSEC:

BROR:

DPX:	DAPPUDRAFT_333124

DMK:

116924981

DPZ:	124325142 124325537

PVM:

MNZ:

EAF:

LSM:

ABRU:

LGI:	LOTGIDRAFT_155173

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

CCP:	CHC_T00003069001

MBR:	MONBRDRAFT_27754

» show all

Reference

PMID:15694335

Authors

Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R

Title

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Journal

Mol Cell 17:331-9 (2005)
DOI:10.1016/j.molcel.2005.01.008

Sequence

[hsa:7398]

Reference

PMID:21482670

Authors

Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD

Title

The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination.

Journal

Mol Cell Biol 31:2462-9 (2011)
DOI:10.1128/MCB.05058-11

Sequence

[gga:424685]

All links

Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1576)   
   KEGG GENES (604)   
   KEGG MGENES (160)   
   RefGene (806)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (1587)   

Download RDF

DBGET integrated database retrieval system